OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Cardiology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Three different therapies to target PCSK9	856
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF	613
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction	561
Antibody treatment to deplete transthyretin amyloid deposits in the heart	550
Sacubitril–valsartan shows benefit in heart failure with ejection fraction of >40%	468
LIPC variant in combined hypocholesterolaemia	417
Intravascular imaging improves outcomes	361
Injectable and conductive cardiac patch	328
Basophils promote healing after MI	283
Travelling with heart failure: risk assessment and practical recommendations	251
Accelerated reduction in global cardiovascular disease is essential to achieve the Sustainable Development Goals	246
Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications	236
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease	231
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective	227
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults	225
Genetics and mechanisms of thoracic aortic disease	212
Abbreviating DAPT reduces the risk of bleeding	203
Alternative defibrillation strategies improve outcomes	202
Heterogeneity of the post-infarct epicardium	196
Detection of subclinical hypertrophic cardiomyopathy	192
Defining iron deficiency in patients with heart failure	188
Electron microscopy of cardiac 3D nanodynamics: form, function, future	183
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale	181
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course	180
Contemporary coronary artery bypass graft surgery and subsequent percutaneous revascularization	175

Hallmarks of cardiovascular ageing	172
PPAR control of metabolism and cardiovascular functions	164
Neuromodulation reduces inflammation in HFpEF	150
Graded exercise therapy should not be recommended for patients with post-exertional malaise	148
A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice	148
Targeting immune cell recruitment in atherosclerosis	147
Decongestion in heart failure: medical and device therapies	145
Extracellular matrix in vascular homeostasis and disease	145
Genomic enhancers in cardiac development and disease	136
Increasing representation and diversity in cardiovascular clinical trial populations	134
Colchicine in acute coronary syndromes: the present and the possible future	132
A tailored cardiac rehabilitation for patients with acute heart failure	127
Preparticipation screening reduces SCD in young athletes	126
Increased degradation of desmosomal proteins in ACM	123
CSDE1 regulates LDL receptor levels	120
Catheter ablation improves outcomes in patients with AF and end-stage HF	119
No benefit of apoA-I infusion after myocardial infarction	113
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk	110
The oral microbiome in the pathophysiology of cardiovascular disease	107
Prevention of atherosclerosis from childhood	106
Reactive oxygen species in hypertension	102
Treatment of mild chronic hypertension in pregnancy reduces pre-eclampsia risk	102
Semaglutide is beneficial in patients with HFpEF and obesity	99
RNA interference lowers triglyceride levels	97
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials	96
Modelling pre-eclampsia and its cardiovascular effects	96
Reply to ‘Graded exercise therapy should not be recommended for patients with post-exertional malaise’	95
Bempedoic acid prevents cardiovascular events in statin-intolerant patients	91
Donor macrophages influence rejection of transplanted hearts	91
Cardiac sarcomere turnover by unidirectional replacement of proteins	88
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine	88
Promising novel siRNA for the treatment of hypertension	86
Evidence does not support the reduction of added sugar intake from all food sources	84
BP management with a village-doctor-led strategy	83
Global epidemiology of heart failure	83
Single-cell profiles of CHD and CM	81
An epigenome editing approach induces durable silencing of Pcsk9	78
CV benefits of finerenone in T2DM and CKD	77
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight	76
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms	72
Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis	72
Novel factor XIa inhibitor reduces bleeding compared with apixaban in atrial fibrillation	71
The role of the molecular autopsy in sudden cardiac death in young individuals	69
Heart transplantation: advances in expanding the donor pool and xenotransplantation	68
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target	67
Development of a miniature, bioresorbable, light-activated pacemaker	67
Efferocytosis in atherosclerosis	66
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology	65
Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy	64
CNR1 antagonism attenuates cannabis-induced atherosclerosis	62

New insights into dietary cholesterol absorption	62
Gut bacteria can break down cholesterol	61
A call for training programmes in cardiovascular genomics	59
Low alcohol intake might lower CVD risk by reducing stress-related brain activity	58
Renal denervation for hypertension	57
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation	56
Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization	56
Mechanisms and treatment of pulmonary arterial hypertension	56
Improving medication adherence in cardiovascular disease	56
Cardiovascular benefits of fermented foods and beverages: still up for debate	55
Cardiovascular disease and cancer: shared risk factors and mechanisms	54
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis	54
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis	53
Social disparities in COVID-19 prevention	53
RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia	52
Pacing with respiratory sinus arrhythmia improves outcomes in heart failure	52
Epigenetic editing in cardiovascular medicine: moving beyond the hype	51
Inclusion of remnant cholesterol improves risk prediction for ischaemic heart disease	50
Publisher Correction: Cardiac involvement in the long-term implications of COVID-19	50
A fresh look at coronary microembolization	50
Cardiac optogenetics: controlling the heart with light	49
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention	48
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications	45
The need for increased pragmatism in cardiovascular clinical trials	45
Blood pressure and its variability: classic and novel measurement techniques	43
Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential	42
Resurgence of renal denervation for resistant hypertension	42
Mending broken hearts with the help of epigenetic remodellers	42
Inhibiting aldosterone synthase reduces blood pressure	41
The cardiac parasympathetic system has two parallel circuits	41
Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition	39
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women	39
Age-induced senescence impairs the neurovascular interface in the heart	39
Boosting mitochondrial metabolism with dietary supplements in heart failure	38
Black In Cardio: promoting diversity and representation in the cardiovascular field	37
Phase separation of protein kinase A: a new paradigm in cardiac regulation?	36
Gout flares can precede cardiovascular events	34
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials	33
Sotatercept as add-on therapy for advanced PAH	33
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications	33
ASGR1 inhibition stimulates cholesterol excretion	33
Consequences of ionizing radiation exposure to the cardiovascular system	32
Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden	31
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases	30
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries	30
Surgery safer than endovascular therapy for CLTI	29
Genome editing prevents hypertrophic cardiomyopathy in mice	28
A distinct platelet differentiation pathway is involved in age-related thrombocytosis	28
Benefit of early aortic valve surgery in asymptomatic, severe AS	26
Select hPSC-CMs clonally expand in vivo	25
Cardiac fibroblasts contribute to sexually dimorphic responses to cardiac injury	25
Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes	24
Characterization of the F8 gene: a silver lining in a dark cloud	23
Publisher Correction: Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease	23
Preserving the future of heart transplantation	22
A role for lipophagy in atherosclerosis	22
Effects of lifestyle factors on leukocytes in cardiovascular health and disease	22
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia	21
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action	21
High troponin I levels predict death after surgery	20
LAAO during cardiac surgery prevents stroke	19
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease	19
Finerenone prevents atrial fibrillation in patients with CKD and diabetes	19
Unravelling the genetic heart–brain connection using MRI	19
Alain Cribier (1945–2024)	19
Posterior left pericardiotomy reduces AF incidence after cardiac surgery	19
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce	18
The microtubule cytoskeleton in cardiac mechanics and heart failure	17
Sustained BP reduction with renal denervation	17
Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	16
The dynamic cardiac cellular landscape: visualization by molecular imaging	15
Repurposing drugs to treat cardiovascular disease in the era of precision medicine	15
Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine	14
Charting the future of cardiology with large language model artificial intelligence	14
Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity	14
Cardiac splicing as a diagnostic and therapeutic target	14
Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy	13
The ongoing quest for the first total artificial heart as destination therapy	13
Current concepts and novel targets for antiplatelet therapy	13
Mind the gap: sex-related differences in cardiovascular disease	13