OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Cardiology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF	732
Antibody treatment to deplete transthyretin amyloid deposits in the heart	531
Sacubitril–valsartan shows benefit in heart failure with ejection fraction of >40%	455
LIPC variant in combined hypocholesterolaemia	373
Intravascular imaging improves outcomes	336
Injectable and conductive cardiac patch	311
Travelling with heart failure: risk assessment and practical recommendations	291
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease	287
Accelerated reduction in global cardiovascular disease is essential to achieve the Sustainable Development Goals	279
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction	274
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective	266
Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications	265
Genetics and mechanisms of thoracic aortic disease	261
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults	253
Abbreviating DAPT reduces the risk of bleeding	240
Alternative defibrillation strategies improve outcomes	226
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale	218
Electron microscopy of cardiac 3D nanodynamics: form, function, future	217
Defining iron deficiency in patients with heart failure	213
Detection of subclinical hypertrophic cardiomyopathy	206
Think Aorta: aortic dissection awareness and perspectives from the patient	203
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course	203
European guidelines for hypertension in 2024: a comparison of key recommendations for clinical practice	203
Hallmarks of cardiovascular ageing	189
Contemporary coronary artery bypass graft surgery and subsequent percutaneous revascularization	177

A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice	173
Neuromodulation reduces inflammation in HFpEF	173
Extracellular matrix in vascular homeostasis and disease	170
Decongestion in heart failure: medical and device therapies	169
Preparticipation screening reduces SCD in young athletes	164
Increased degradation of desmosomal proteins in ACM	155
CSDE1 regulates LDL receptor levels	154
Catheter ablation improves outcomes in patients with AF and end-stage HF	149
No benefit of apoA-I infusion after myocardial infarction	147
LDL-cholesterol lowering with obicetrapib	146
Graded exercise therapy should not be recommended for patients with post-exertional malaise	146
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk	146
Prevention of atherosclerosis from childhood	128
Targeting immune cell recruitment in atherosclerosis	127
The oral microbiome in the pathophysiology of cardiovascular disease	124
Tailored therapeutics for cardiomyopathies	124
Reactive oxygen species in hypertension	121
Colchicine in acute coronary syndromes: the present and the possible future	117
Treatment of mild chronic hypertension in pregnancy reduces pre-eclampsia risk	112
RNA interference lowers triglyceride levels	110
Modelling pre-eclampsia and its cardiovascular effects	106
Reply to ‘Graded exercise therapy should not be recommended for patients with post-exertional malaise’	104
Donor macrophages influence rejection of transplanted hearts	101
Bempedoic acid prevents cardiovascular events in statin-intolerant patients	99
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine	97
Cardiac sarcomere turnover by unidirectional replacement of proteins	97
Promising novel siRNA for the treatment of hypertension	96
Semaglutide is beneficial in patients with HFpEF and obesity	95
Evidence does not support the reduction of added sugar intake from all food sources	90
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials	90
Global epidemiology of heart failure	89
BP management with a village-doctor-led strategy	87
Single-cell profiles of CHD and CM	84
An epigenome editing approach induces durable silencing of Pcsk9	82
CV benefits of finerenone in T2DM and CKD	81
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight	79
Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis	78
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms	78
The role of the molecular autopsy in sudden cardiac death in young individuals	77
Novel factor XIa inhibitor reduces bleeding compared with apixaban in atrial fibrillation	77
Development of a miniature, bioresorbable, light-activated pacemaker	75
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology	74
The gut metabolite imidazole propionate is a potential biomarker of and therapeutic target for atherosclerosis	74
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target	73
Heart transplantation: advances in expanding the donor pool and xenotransplantation	73
New insights into dietary cholesterol absorption	71
CNR1 antagonism attenuates cannabis-induced atherosclerosis	71
Efferocytosis in atherosclerosis	71
Gut bacteria can break down cholesterol	69
Low alcohol intake might lower CVD risk by reducing stress-related brain activity	69

Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy	68
Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization	66
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation	64
Improving medication adherence in cardiovascular disease	64
Renal denervation for hypertension	62
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis	62
Cardiovascular benefits of fermented foods and beverages: still up for debate	61
Mechanisms and treatment of pulmonary arterial hypertension	60
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis	59
Cardiovascular disease and cancer: shared risk factors and mechanisms	59
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention	57
Publisher Correction: Cardiac involvement in the long-term implications of COVID-19	57
Pacing with respiratory sinus arrhythmia improves outcomes in heart failure	57
Heart failure and obesity: novel insights leading to new treatment paradigms	56
A fresh look at coronary microembolization	55
Inclusion of remnant cholesterol improves risk prediction for ischaemic heart disease	54
Cardiac optogenetics: controlling the heart with light	53
RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia	50
Epigenetic editing in cardiovascular medicine: moving beyond the hype	50
The need for increased pragmatism in cardiovascular clinical trials	49
Metabolites matter for gut microbiota as a modifiable risk factor in cardiovascular diseases	48
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications	48
Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential	47
Blood pressure and its variability: classic and novel measurement techniques	45
The cardiac parasympathetic system has two parallel circuits	45
Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias	45
Inhibiting aldosterone synthase reduces blood pressure	44
Age-induced senescence impairs the neurovascular interface in the heart	43
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women	39
Sotatercept as add-on therapy for advanced PAH	36
Gout flares can precede cardiovascular events	36
Black In Cardio: promoting diversity and representation in the cardiovascular field	36
Phase separation of protein kinase A: a new paradigm in cardiac regulation?	33
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications	33
ASGR1 inhibition stimulates cholesterol excretion	33
Artificial intelligence-enhanced echocardiography in cardiovascular disease management	32
Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden	31
Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition	31
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries	31
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials	31
Consequences of ionizing radiation exposure to the cardiovascular system	30
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases	29
Surgery safer than endovascular therapy for CLTI	27
Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes	26
Genome editing prevents hypertrophic cardiomyopathy in mice	26
Publisher Correction: Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease	26
Characterization of the F8 gene: a silver lining in a dark cloud	26
A distinct platelet differentiation pathway is involved in age-related thrombocytosis	26
Benefit of early aortic valve surgery in asymptomatic, severe AS	26
Leadless and extravascular cardiac resynchronization therapy: the future for CRT?	25
Preserving the future of heart transplantation	25
Effects of lifestyle factors on leukocytes in cardiovascular health and disease	24
A role for lipophagy in atherosclerosis	23
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia	22
High troponin I levels predict death after surgery	20
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action	20
Posterior left pericardiotomy reduces AF incidence after cardiac surgery	20
Alain Cribier (1945–2024)	19
Unravelling the genetic heart–brain connection using MRI	19
Sustained BP reduction with renal denervation	19
Cardiac splicing as a diagnostic and therapeutic target	17
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease	17
Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity	17
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce	17
Charting the future of cardiology with large language model artificial intelligence	17
Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group	16
Contemporary pharmacological treatment and management of heart failure	16
The dynamic cardiac cellular landscape: visualization by molecular imaging	16
Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy	15
Mind the gap: sex-related differences in cardiovascular disease	14
The ongoing quest for the first total artificial heart as destination therapy	14
Current concepts and novel targets for antiplatelet therapy	13
The microtubule cytoskeleton in cardiac mechanics and heart failure	13
Cardiac involvement in the long-term implications of COVID-19	13
Epidemiology and prevention of venous thromboembolism	13
Single-cell transcriptomics for the assessment of cardiac disease	13
Repurposing drugs to treat cardiovascular disease in the era of precision medicine	13
Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine	13