Nature Reviews Cardiology

Article	Citations
LIPC variant in combined hypocholesterolaemia	760
Antibody treatment to deplete transthyretin amyloid deposits in the heart	480
Sacubitril–valsartan shows benefit in heart failure with ejection fraction of >40%	382
Intravascular imaging improves outcomes	333
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF	302
Travelling with heart failure: risk assessment and practical recommendations	293
Injectable and conductive cardiac patch	284
Accelerated reduction in global cardiovascular disease is essential to achieve the Sustainable Development Goals	282
Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications	278
Genetics and mechanisms of thoracic aortic disease	276
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective	265
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction	242
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease	231
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults	229
Alternative defibrillation strategies improve outcomes	226
Think Aorta: aortic dissection awareness and perspectives from the patient	220
European guidelines for hypertension in 2024: a comparison of key recommendations for clinical practice	219
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course	217
Detection of subclinical hypertrophic cardiomyopathy	209
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale	206
Defining iron deficiency in patients with heart failure	196
Hallmarks of cardiovascular ageing	187
Electron microscopy of cardiac 3D nanodynamics: form, function, future	183
Contemporary coronary artery bypass graft surgery and subsequent percutaneous revascularization	183
Decongestion in heart failure: medical and device therapies	179

Neuromodulation reduces inflammation in HFpEF	176
A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice	169
Reactive oxygen species in hypertension	162
CSDE1 regulates LDL receptor levels	160
Preparticipation screening reduces SCD in young athletes	158
Tailored therapeutics for cardiomyopathies	155
No benefit of apoA-I infusion after myocardial infarction	153
Graded exercise therapy should not be recommended for patients with post-exertional malaise	153
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk	152
Catheter ablation improves outcomes in patients with AF and end-stage HF	151
LDL-cholesterol lowering with obicetrapib	140
Increased degradation of desmosomal proteins in ACM	138
Targeting immune cell recruitment in atherosclerosis	130
The oral microbiome in the pathophysiology of cardiovascular disease	129
Colchicine in acute coronary syndromes: the present and the possible future	120
Extracellular matrix in vascular homeostasis and disease	116
Prevention of atherosclerosis from childhood	115
Treatment of mild chronic hypertension in pregnancy reduces pre-eclampsia risk	112
Donor macrophages influence rejection of transplanted hearts	110
Modelling pre-eclampsia and its cardiovascular effects	106
Reply to ‘Graded exercise therapy should not be recommended for patients with post-exertional malaise’	103
RNA interference lowers triglyceride levels	102
Cardiac sarcomere turnover by unidirectional replacement of proteins	99
Bempedoic acid prevents cardiovascular events in statin-intolerant patients	99
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine	99
Evidence does not support the reduction of added sugar intake from all food sources	96
Promising novel siRNA for the treatment of hypertension	95
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials	93
Semaglutide is beneficial in patients with HFpEF and obesity	93
Global epidemiology of heart failure	92
An epigenome editing approach induces durable silencing of Pcsk9	85
Single-cell profiles of CHD and CM	84
Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis	82
BP management with a village-doctor-led strategy	82
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight	82
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms	80
Novel factor XIa inhibitor reduces bleeding compared with apixaban in atrial fibrillation	80
Efferocytosis in atherosclerosis	79
The role of the molecular autopsy in sudden cardiac death in young individuals	78
Development of a miniature, bioresorbable, light-activated pacemaker	75
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology	75
Heart transplantation: advances in expanding the donor pool and xenotransplantation	75
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target	74
The gut metabolite imidazole propionate is a potential biomarker of and therapeutic target for atherosclerosis	73
New insights into dietary cholesterol absorption	72
CNR1 antagonism attenuates cannabis-induced atherosclerosis	72
Low alcohol intake might lower CVD risk by reducing stress-related brain activity	71
Gut bacteria can break down cholesterol	70
Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy	68
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation	68

Cardiovascular benefits of fermented foods and beverages: still up for debate	68
Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization	67
Cardiovascular disease and cancer: shared risk factors and mechanisms	67
Renal denervation for hypertension	62
Baxdrostat beneficial in uncontrolled or resistant hypertension	62
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis	62
Mechanisms and treatment of pulmonary arterial hypertension	61
Improving medication adherence in cardiovascular disease	61
Pacing with respiratory sinus arrhythmia improves outcomes in heart failure	61
Publisher Correction: Cardiac involvement in the long-term implications of COVID-19	58
Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias	58
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis	58
RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia	55
Inclusion of remnant cholesterol improves risk prediction for ischaemic heart disease	53
Cardiac optogenetics: controlling the heart with light	53
Epigenetic editing in cardiovascular medicine: moving beyond the hype	52
The need for increased pragmatism in cardiovascular clinical trials	51
Metabolites matter for gut microbiota as a modifiable risk factor in cardiovascular diseases	51
Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis	49
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications	48
Heart failure and obesity: novel insights leading to new treatment paradigms	48
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention	47
A fresh look at coronary microembolization	46
Blood pressure and its variability: classic and novel measurement techniques	45
Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential	40
Inhibiting aldosterone synthase reduces blood pressure	39
The cardiac parasympathetic system has two parallel circuits	39
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women	38
Black In Cardio: promoting diversity and representation in the cardiovascular field	38
Sotatercept as add-on therapy for advanced PAH	36
Age-induced senescence impairs the neurovascular interface in the heart	36
Gout flares can precede cardiovascular events	35
Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition	34
Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden	34
Consequences of ionizing radiation exposure to the cardiovascular system	34
ASGR1 inhibition stimulates cholesterol excretion	32
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases	32
Phase separation of protein kinase A: a new paradigm in cardiac regulation?	32
Artificial intelligence-enhanced echocardiography in cardiovascular disease management	31
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials	30
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries	29
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications	29
Genome editing prevents hypertrophic cardiomyopathy in mice	28
A distinct platelet differentiation pathway is involved in age-related thrombocytosis	28
Benefit of early aortic valve surgery in asymptomatic, severe AS	28
Surgery safer than endovascular therapy for CLTI	28
Effects of lifestyle factors on leukocytes in cardiovascular health and disease	28
Building the Australian Cardiovascular disease Data Commons	26
Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes	23
Characterization of the F8 gene: a silver lining in a dark cloud	22
Publisher Correction: Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease	22
Leadless and extravascular cardiac resynchronization therapy: the future for CRT?	21
Preserving the future of heart transplantation	21
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action	21
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia	20
A role for lipophagy in atherosclerosis	20
High troponin I levels predict death after surgery	19
Sustained BP reduction with renal denervation	18
Unravelling the genetic heart–brain connection using MRI	18
Alain Cribier (1945–2024)	18
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce	18
Posterior left pericardiotomy reduces AF incidence after cardiac surgery	18
Charting the future of cardiology with large language model artificial intelligence	17
Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy	17
Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	16
Cardiac splicing as a diagnostic and therapeutic target	16
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease	16
The microtubule cytoskeleton in cardiac mechanics and heart failure	14
Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group	14
Mind the gap: sex-related differences in cardiovascular disease	14
Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity	14
The dynamic cardiac cellular landscape: visualization by molecular imaging	13
Cardiac involvement in the long-term implications of COVID-19	13
Current concepts and novel targets for antiplatelet therapy	13
Epidemiology and prevention of venous thromboembolism	13
Single-cell transcriptomics for the assessment of cardiac disease	13
The ongoing quest for the first total artificial heart as destination therapy	13
Contemporary pharmacological treatment and management of heart failure	13
Benefit of empagliflozin in acute heart failure	12
Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine	12

Bone marrow adipocytes support fatty acid metabolism during MI-mediated emergency haematopoiesis	12
Optically induced tachycardia evokes anxiety in risky settings	12
Secondary prophylaxis for RHD	12
Infused ECM targets leaky vessels and heals inflamed tissues	12
Repurposing drugs to treat cardiovascular disease in the era of precision medicine	12
Smartphone-based digital screening increases AF detection rate	12
No benefit of PCI in ischaemic LV dysfunction	12
Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop	11
Scientific journey from PSCK9 discovery in familial hypercholesterolaemia	11
BMAL1 and HIF2α are key regulators of circadian-dependent variations in myocardial injury	11
Reply to: ‘Evidence does not support the reduction of added sugar intake from all food sources’	11
The burden of atrial fibrillation in the Asia–Pacific region	11
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis	10
Pregnancy among cardiologists: challenges and recommendations	10
Protein glycosylation in cardiovascular health and disease	10
Statins promote efferocytosis in atherosclerotic plaques	10
Rejuvenating cardiomyocytes facilitates heart regeneration	10
Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine	10
Interatrial shunt devices for heart failure	10
Branched-chain amino acids in cardiovascular disease	10
Neuroimmune–arterial interfaces regulate atherosclerosis progression	9
Tricuspid repair during MV surgery slows the progression of tricuspid regurgitation	9
Targeting macrophage–fibroblast interactions in the failing heart	9
Overcoming difficulties with resilience	9
Environmental sustainability in cardiovascular practice: current challenges and future directions	9
Collateral cardiovascular damage during the COVID-19 pandemic	9
Nuclear remodelling contributes to cardiac dysfunction during ageing	9
The contribution of the exposome to the burden of cardiovascular disease	8
Novel cardiovascular therapeutics and the risk of financial toxicity	8
Improving the cardiovascular health care of transgender and non-binary persons	8
Cholesterol crystals in the pathogenesis of atherosclerosis	8
Reproductive options and genetic testing for patients with an inherited cardiac disease	8
Social media in modern cardiology: a tool for building community, visibility and impact	8
Liver-derived factor XI protects against HFpEF	8
Shaping the future of cardiovascular medicine in the new era of wearable devices	8
RNA-targeting and gene editing therapies for transthyretin amyloidosis	8
Smartwatch detection of left ventricular dysfunction	7
No benefit of β-blockers after myocardial infarction with preserved ejection fraction	7
The use of new CRISPR tools in cardiovascular research and medicine	7
Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?	7
Iron deficiency and supplementation in heart failure	7
Functional testing after PCI in high-risk patients	7
Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy	7
Author Correction: Traction force microscopy of cardiomyocytes	7
Cardiac myosin inhibitors for the treatment of obstructive and non-obstructive HCM	7
Base editing therapy corrects long QT syndrome in mice	7
Immediate non-inferior to staged complete revascularization	7
Clonal haematopoiesis: an emerging causal risk factor for atherosclerotic CVD	7
2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease	7
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity	7
Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’	6
Levothyroxine supplementation does not improve heart transplantation from brain-dead donors	6
Author Correction: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms	6
An all-virtual clinical trial to assess a heart failure drug	6
Artificially transplanted mitochondria in endothelial cells promote mitophagy	6
Promising findings for cell therapy in HFrEF	6
Tackling inflammation in atherosclerosis	5
Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group	5
Cardiac fibroblasts and mechanosensation in heart development, health and disease	5
Diversity in human genetics studies accelerates discovery and improves health care	5
Emerging AI tools for geospatially resolved cardiovascular risk	5
Hypertension in 2025: are we ready for bold precision public health approaches worldwide?	5
Anticoagulation in patients with atrial high-rate episodes	5
Prehabilitation: evolving role in contemporary cardiac surgery	5
Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation	5
Clinical implications of perioperative and periprocedural myocardial infarction	4
Autoimmune diseases and atherosclerotic cardiovascular disease	4
The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways	4
Microbial metabolites reduce SBP in patients with resistant hypertension	4
Our revered and mysterious heart	4
Small extracellular vesicles from the infarcted heart can promote tumour growth	4
Young women with AMI have worse outcomes than men up to 1 year after discharge	4
Adverse professional life experiences may affect mental health among cardiologists	4
Publisher Correction: Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	4
Pathophysiology and risk factors of peripartum cardiomyopathy	4
RAPID return to sinus rhythm after SVT using intranasal etripamil	4
Sex-chromosome mechanisms contribute to cardiac sex disparities	4
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue	4
Cardiovascular involvement in glycogen storage diseases	4
Immune and inflammatory mechanisms in hypertension	4
Effective CRISPR modulation of complex non-coding RNA loci	4
Roadmap for alleviating the manifestations of ageing in the cardiovascular system	4
Menopausal hormone therapy does not lower Lp(a)-associated CHD risk	4
Migraines and cardiovascular disease: mechanisms and methodological challenges	4
Changes to the gut microbiota drive the progression of cardiometabolic disease	4
Gene therapy for cardiac arrhythmias	4
No benefit of routine steroids in infant heart surgery	4
Left atrial appendage closure after ablation: the best OPTION for patients with AF?	3
Role of Helicobacter pylori screening after myocardial infarction	3
Inhibiting factor XIa to prevent thromboembolism	3
Myocardial infarction, stroke and arterial stenosis: time to reassess a major misunderstanding	3
Vagal circuits in the heart and gut can regulate cardiometabolism and stress responses	3
The molecular structure of LDL has finally been elucidated	3
Neuroendocrine regulatory effects of sex hormones on salt sensitivity of blood pressure	3
Pro-arrhythmic potential of proton-pump inhibitors	3