Nature Reviews Cardiology

Article	Citations
LIPC variant in combined hypocholesterolaemia	956
Antibody treatment to deplete transthyretin amyloid deposits in the heart	471
Sacubitril–valsartan shows benefit in heart failure with ejection fraction of >40%	469
Intravascular imaging improves outcomes	423
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF	412
Accelerated reduction in global cardiovascular disease is essential to achieve the Sustainable Development Goals	407
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction	401
The City Heartbeat Index as a benchmarking tool for urban cardiovascular health	375
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults	319
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease	308
Takotsubo syndrome: pathophysiological insights and innovations in patient care	307
Optimizing cardiovascular pharmacotherapy in older adults with frailty	306
Genetics and mechanisms of thoracic aortic disease	297
Alternative defibrillation strategies improve outcomes	270
Think Aorta: aortic dissection awareness and perspectives from the patient	260
Detection of subclinical hypertrophic cardiomyopathy	247
Base editing and silencing of PCSK9 shows clinical promise in humans	236
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale	235
Drug-coated balloon angioplasty for coronary and peripheral artery disease: latest evidence and clinical indications	235
Defining iron deficiency in patients with heart failure	231
European guidelines for hypertension in 2024: a comparison of key recommendations for clinical practice	229
HFpEF and MASLD: converging mechanisms and clinical implications	229
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course	211
Hallmarks of cardiovascular ageing	209
A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice	198

Preparticipation screening reduces SCD in young athletes	171
LDL-cholesterol lowering with obicetrapib	163
No benefit of apoA-I infusion after myocardial infarction	162
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk	157
Catheter ablation improves outcomes in patients with AF and end-stage HF	150
Colchicine in acute coronary syndromes: the present and the possible future	149
Increased degradation of desmosomal proteins in ACM	142
CSDE1 regulates LDL receptor levels	138
Tailored therapeutics for cardiomyopathies	135
Extracellular matrix in vascular homeostasis and disease	132
Targeting immune cell recruitment in atherosclerosis	132
Graded exercise therapy should not be recommended for patients with post-exertional malaise	128
Low-dose IL-2 therapy reduces arterial inflammation in acute coronary syndromes	128
Cardiac lymphatic dysfunction and repair in cardiovascular disease	128
Decongestion in heart failure: medical and device therapies	122
Reactive oxygen species in hypertension	118
Donor macrophages influence rejection of transplanted hearts	115
The oral microbiome in the pathophysiology of cardiovascular disease	115
Modelling pre-eclampsia and its cardiovascular effects	114
Reply to ‘Graded exercise therapy should not be recommended for patients with post-exertional malaise’	112
Cardiac sarcomere turnover by unidirectional replacement of proteins	110
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine	109
Bempedoic acid prevents cardiovascular events in statin-intolerant patients	109
Promising novel siRNA for the treatment of hypertension	108
Semaglutide is beneficial in patients with HFpEF and obesity	106
Calculation methods for LDL cholesterol are evolving tools for accuracy in lipidology	103
Evidence does not support the reduction of added sugar intake from all food sources	101
RNA interference lowers triglyceride levels	99
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials	99
Local calcium dynamics and signalling in cardiomyocytes	98
Global epidemiology of heart failure	97
An epigenome editing approach induces durable silencing of Pcsk9	95
Single-cell profiles of CHD and CM	91
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight	88
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms	86
The role of the molecular autopsy in sudden cardiac death in young individuals	83
Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis	80
Development of a miniature, bioresorbable, light-activated pacemaker	78
The gut metabolite imidazole propionate is a potential biomarker of and therapeutic target for atherosclerosis	76
Digital screening and decision-support tools in equitable preventive cardiology	73
Heart transplantation: advances in expanding the donor pool and xenotransplantation	73
Tricuspid valve disease: updates on diagnostic imaging and intervention	72
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology	71
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target	70
Efferocytosis in atherosclerosis	70
Low alcohol intake might lower CVD risk by reducing stress-related brain activity	68
Baxdrostat beneficial in uncontrolled or resistant hypertension	67
PCSK9 inhibition for primary prevention of cardiovascular events	66
Gut bacteria can break down cholesterol	63
Gene–environment interactions in the pathogenesis of cardiovascular disease	63

New insights into dietary cholesterol absorption	61
Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy	59
Improving medication adherence in cardiovascular disease	58
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation	58
Mechanisms and treatment of pulmonary arterial hypertension	57
Stenting for post-thrombotic syndrome	55
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis	55
Cardiovascular benefits of fermented foods and beverages: still up for debate	55
Cardiovascular disease and cancer: shared risk factors and mechanisms	50
Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization	48
Renal denervation for hypertension	48
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis	45
Cardiac optogenetics: controlling the heart with light	44
Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis	43
RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia	42
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications	41
Inclusion of remnant cholesterol improves risk prediction for ischaemic heart disease	41
Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential	41
Heart failure and obesity: novel insights leading to new treatment paradigms	40
Integration of cardiovascular and mental health: from concepts to the clinic	40
Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias	40
Epigenetic editing in cardiovascular medicine: moving beyond the hype	39
The environmental exposome in heart failure risk and progression	38
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention	38
Metabolites matter for gut microbiota as a modifiable risk factor in cardiovascular diseases	37
The cardiac parasympathetic system has two parallel circuits	37
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women	36
Black In Cardio: promoting diversity and representation in the cardiovascular field	36
Gout flares can precede cardiovascular events	35
Colchicine in patients with cardiovascular disease	33
Inhibiting aldosterone synthase reduces blood pressure	33
Sotatercept as add-on therapy for advanced PAH	33
Phase separation of protein kinase A: a new paradigm in cardiac regulation?	32
Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition	32
ASGR1 inhibition stimulates cholesterol excretion	32
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries	31
Age-induced senescence impairs the neurovascular interface in the heart	31
Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden	31
Consequences of ionizing radiation exposure to the cardiovascular system	30
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications	30
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials	29
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases	29
Artificial intelligence-enhanced echocardiography in cardiovascular disease management	28
Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes	28
Surgery safer than endovascular therapy for CLTI	28
Characterization of the F8 gene: a silver lining in a dark cloud	27
Preserving the future of heart transplantation	27
A distinct platelet differentiation pathway is involved in age-related thrombocytosis	27
Genome editing prevents hypertrophic cardiomyopathy in mice	26
Building the Australian Cardiovascular disease Data Commons	26
Leadless and extravascular cardiac resynchronization therapy: the future for CRT?	25
An ex vivo perfusion platform for the testing of cardiovascular interventional devices	25
Residual cardiovascular risk in coronary artery disease: from pathophysiology to established and novel therapies	25
A role for lipophagy in atherosclerosis	24
Effects of lifestyle factors on leukocytes in cardiovascular health and disease	24
Vagal mechanoreceptors in the heart sense changes in blood volume	24
Epidemiology of non-ischaemic dilated cardiomyopathy	24
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action	24
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce	23
Unravelling the genetic heart–brain connection using MRI	23
Alain Cribier (1945–2024)	23
Mind the gap: sex-related differences in cardiovascular disease	23
Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity	22
Single-cell transcriptomics for the assessment of cardiac disease	21
Cardiac epigenome in heart development and disease	21
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease	21
The ongoing quest for the first total artificial heart as destination therapy	19
Non-coding RNAs in lipid metabolism and their roles in atherosclerosis	19
Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy	18
Charting the future of cardiology with large language model artificial intelligence	18
Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group	18
Cardiac splicing as a diagnostic and therapeutic target	17
Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine	17
Optically induced tachycardia evokes anxiety in risky settings	16
Contemporary pharmacological treatment and management of heart failure	16
Epidemiology and prevention of venous thromboembolism	16
Current concepts and novel targets for antiplatelet therapy	16
Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	16
No benefit of PCI in ischaemic LV dysfunction	15
Smartphone-based digital screening increases AF detection rate	15

Bone marrow adipocytes support fatty acid metabolism during MI-mediated emergency haematopoiesis	15
BMAL1 and HIF2α are key regulators of circadian-dependent variations in myocardial injury	14
The burden of atrial fibrillation in the Asia–Pacific region	14
Reply to: ‘Evidence does not support the reduction of added sugar intake from all food sources’	14
Understanding atrial failure: from diagnosis to clinical implications	13
Infused ECM targets leaky vessels and heals inflamed tissues	12
Protein glycosylation in cardiovascular health and disease	12
Scientific journey from PSCK9 discovery in familial hypercholesterolaemia	12
Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine	12
Interatrial shunt devices for heart failure	12
Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop	11
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis	11
Inflammatory signalling in diabetic cardiomyopathy: molecular mechanisms and potential therapeutic strategies	11
Social media in modern cardiology: a tool for building community, visibility and impact	10
Pregnancy among cardiologists: challenges and recommendations	10
Overcoming difficulties with resilience	10
Branched-chain amino acids in cardiovascular disease	10
Novel cardiovascular therapeutics and the risk of financial toxicity	10
Liver-derived factor XI protects against HFpEF	10
Nuclear remodelling contributes to cardiac dysfunction during ageing	9
Reproductive options and genetic testing for patients with an inherited cardiac disease	9
ANGPTL3-lowering strategies to address residual cardiovascular risk	9
Shaping the future of cardiovascular medicine in the new era of wearable devices	9
Targeting macrophage–fibroblast interactions in the failing heart	8
Cholesterol crystals in the pathogenesis of atherosclerosis	8
Base editing therapy corrects long QT syndrome in mice	8
The contribution of the exposome to the burden of cardiovascular disease	8
Environmental sustainability in cardiovascular practice: current challenges and future directions	8
Improving the cardiovascular health care of transgender and non-binary persons	8
Neutrophil extracellular traps in immunothrombosis	8
Immediate non-inferior to staged complete revascularization	7
Cardiac myosin inhibitors for the treatment of obstructive and non-obstructive HCM	7
Iron deficiency and supplementation in heart failure	7
Smartwatch detection of left ventricular dysfunction	7
No benefit of β-blockers after myocardial infarction with preserved ejection fraction	7
Author Correction: Traction force microscopy of cardiomyocytes	7
Beyond GLP1: modulating multiple nutrient-stimulated hormone pathways to reduce cardiovascular risk	7
Functional testing after PCI in high-risk patients	7
Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy	7
Clonal haematopoiesis: an emerging causal risk factor for atherosclerotic CVD	7
Inherited risk of coronary artery disease: redefining care with imaging and genetics	7
ANP produced from self-amplifying RNA improves cardiac function after MI	6
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity	6
Anticoagulation in patients with atrial high-rate episodes	6
Emerging AI tools for geospatially resolved cardiovascular risk	6
2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease	6
Promising findings for cell therapy in HFrEF	6
Author Correction: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms	6
Solving the mystery of vaccine-induced immune thrombocytopenia and thrombosis	6
Levothyroxine supplementation does not improve heart transplantation from brain-dead donors	6
Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’	6
Publisher Correction: Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	5
Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group	5
Roadmap for alleviating the manifestations of ageing in the cardiovascular system	5
Artificially transplanted mitochondria in endothelial cells promote mitophagy	5
Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation	5
Effective CRISPR modulation of complex non-coding RNA loci	5
Tackling inflammation in atherosclerosis	5
The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways	5
Prehabilitation: evolving role in contemporary cardiac surgery	5
Clinical implications of perioperative and periprocedural myocardial infarction	5
Invasive and medical management approaches to non-acute myocardial ischaemic syndromes	5
Autoimmune diseases and atherosclerotic cardiovascular disease	5
Cardiac fibroblasts and mechanosensation in heart development, health and disease	5
Hypertension in 2025: are we ready for bold precision public health approaches worldwide?	5
Young women with AMI have worse outcomes than men up to 1 year after discharge	4
Adverse professional life experiences may affect mental health among cardiologists	4
No benefit of routine steroids in infant heart surgery	4
Cardiovascular involvement in glycogen storage diseases	4
ApoC-III inhibition: from regulatory approval to equitable implementation	4
RAPID return to sinus rhythm after SVT using intranasal etripamil	4
Immune and inflammatory mechanisms in hypertension	4
Microbial metabolites reduce SBP in patients with resistant hypertension	4
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue	4
Author Correction: 2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease	4
Migraines and cardiovascular disease: mechanisms and methodological challenges	4
Very high HDL-C levels are associated with higher mortality in patients with CAD	4
Small extracellular vesicles from the infarcted heart can promote tumour growth	4
A deepening digital divide in cardiovascular disease management	4
CD8+ T cells in atherosclerosis and coronary artery disease	4
Our revered and mysterious heart	4
P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention	3
Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome	3
Antihypertensive drugs can be taken in the morning or evening	3
Implementing an anti-bullying culture in cardiology	3
Ethnic disparities in age of onset of hypertension	3
Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure	3
Myocardial infarction, stroke and arterial stenosis: time to reassess a major misunderstanding	3
Disrupting a cell-specific miRNA–CXCR4 interaction is atheroprotective in mice	3
Six lessons learned from the use of SGLT2 inhibitors in patients with heart failure	3
The molecular structure of LDL has finally been elucidated	3
AIMing 2 treat atherosclerosis	3
Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention	3
Trade-offs between vessel-based and substrate-based nomenclatures for coronary heart diseases	3
Cardiac-resident macrophages protect against sepsis-induced cardiomyopathy	3