Nature Reviews Cardiology

Article	Citations
LIPC variant in combined hypocholesterolaemia	939
Antibody treatment to deplete transthyretin amyloid deposits in the heart	457
Sacubitril–valsartan shows benefit in heart failure with ejection fraction of >40%	455
Intravascular imaging improves outcomes	403
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF	398
Accelerated reduction in global cardiovascular disease is essential to achieve the Sustainable Development Goals	394
Genetics and mechanisms of thoracic aortic disease	377
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction	368
Optimizing cardiovascular pharmacotherapy in older adults with frailty	308
The City Heartbeat Index as a benchmarking tool for urban cardiovascular health	302
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease	299
Takotsubo syndrome: pathophysiological insights and innovations in patient care	297
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults	288
Alternative defibrillation strategies improve outcomes	262
Detection of subclinical hypertrophic cardiomyopathy	247
Think Aorta: aortic dissection awareness and perspectives from the patient	247
HFpEF and MASLD: converging mechanisms and clinical implications	237
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course	232
Defining iron deficiency in patients with heart failure	226
Drug-coated balloon angioplasty for coronary and peripheral artery disease: latest evidence and clinical indications	226
Base editing and silencing of PCSK9 shows clinical promise in humans	225
European guidelines for hypertension in 2024: a comparison of key recommendations for clinical practice	223
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale	219
A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice	203
Hallmarks of cardiovascular ageing	203

Preparticipation screening reduces SCD in young athletes	195
Low-dose IL-2 therapy reduces arterial inflammation in acute coronary syndromes	163
No benefit of apoA-I infusion after myocardial infarction	159
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk	156
Catheter ablation improves outcomes in patients with AF and end-stage HF	153
Colchicine in acute coronary syndromes: the present and the possible future	146
Increased degradation of desmosomal proteins in ACM	139
CSDE1 regulates LDL receptor levels	137
Cardiac lymphatic dysfunction and repair in cardiovascular disease	136
LDL-cholesterol lowering with obicetrapib	129
Targeting immune cell recruitment in atherosclerosis	128
Reactive oxygen species in hypertension	124
Tailored therapeutics for cardiomyopathies	124
Decongestion in heart failure: medical and device therapies	122
The oral microbiome in the pathophysiology of cardiovascular disease	121
Extracellular matrix in vascular homeostasis and disease	121
Graded exercise therapy should not be recommended for patients with post-exertional malaise	113
Modelling pre-eclampsia and its cardiovascular effects	111
Donor macrophages influence rejection of transplanted hearts	111
Reply to ‘Graded exercise therapy should not be recommended for patients with post-exertional malaise’	109
Cardiac sarcomere turnover by unidirectional replacement of proteins	109
Bempedoic acid prevents cardiovascular events in statin-intolerant patients	106
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine	106
Promising novel siRNA for the treatment of hypertension	104
Semaglutide is beneficial in patients with HFpEF and obesity	102
Calculation methods for LDL cholesterol are evolving tools for accuracy in lipidology	100
RNA interference lowers triglyceride levels	99
Evidence does not support the reduction of added sugar intake from all food sources	97
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials	96
Local calcium dynamics and signalling in cardiomyocytes	95
Global epidemiology of heart failure	94
An epigenome editing approach induces durable silencing of Pcsk9	92
Single-cell profiles of CHD and CM	91
BP management with a village-doctor-led strategy	88
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight	86
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms	84
The role of the molecular autopsy in sudden cardiac death in young individuals	83
Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis	81
Development of a miniature, bioresorbable, light-activated pacemaker	77
The gut metabolite imidazole propionate is a potential biomarker of and therapeutic target for atherosclerosis	76
Tricuspid valve disease: updates on diagnostic imaging and intervention	73
Efferocytosis in atherosclerosis	70
Heart transplantation: advances in expanding the donor pool and xenotransplantation	70
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology	69
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target	69
CNR1 antagonism attenuates cannabis-induced atherosclerosis	68
Low alcohol intake might lower CVD risk by reducing stress-related brain activity	67
Baxdrostat beneficial in uncontrolled or resistant hypertension	65
PCSK9 inhibition for primary prevention of cardiovascular events	63
Gene–environment interactions in the pathogenesis of cardiovascular disease	59

Gut bacteria can break down cholesterol	58
Cardiovascular benefits of fermented foods and beverages: still up for debate	57
Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy	56
New insights into dietary cholesterol absorption	56
Renal denervation for hypertension	54
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation	54
Stenting for post-thrombotic syndrome	53
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis	52
Cardiovascular disease and cancer: shared risk factors and mechanisms	51
Mechanisms and treatment of pulmonary arterial hypertension	50
Improving medication adherence in cardiovascular disease	48
Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization	48
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis	47
Cardiac optogenetics: controlling the heart with light	42
RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia	41
The environmental exposome in heart failure risk and progression	41
Integration of cardiovascular and mental health: from concepts to the clinic	40
Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias	40
Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis	39
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention	38
Inclusion of remnant cholesterol improves risk prediction for ischaemic heart disease	38
Epigenetic editing in cardiovascular medicine: moving beyond the hype	37
Metabolites matter for gut microbiota as a modifiable risk factor in cardiovascular diseases	36
The need for increased pragmatism in cardiovascular clinical trials	36
Heart failure and obesity: novel insights leading to new treatment paradigms	35
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications	35
The cardiac parasympathetic system has two parallel circuits	34
Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential	34
Black In Cardio: promoting diversity and representation in the cardiovascular field	33
Artificial intelligence-enhanced echocardiography in cardiovascular disease management	33
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women	33
Colchicine in patients with cardiovascular disease	33
Gout flares can precede cardiovascular events	33
Inhibiting aldosterone synthase reduces blood pressure	31
Sotatercept as add-on therapy for advanced PAH	31
Phase separation of protein kinase A: a new paradigm in cardiac regulation?	31
ASGR1 inhibition stimulates cholesterol excretion	30
Age-induced senescence impairs the neurovascular interface in the heart	30
Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition	29
Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden	28
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials	27
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries	27
Consequences of ionizing radiation exposure to the cardiovascular system	27
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases	27
Surgery safer than endovascular therapy for CLTI	27
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications	27
Preserving the future of heart transplantation	26
Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes	26
A distinct platelet differentiation pathway is involved in age-related thrombocytosis	26
Characterization of the F8 gene: a silver lining in a dark cloud	26
Building the Australian Cardiovascular disease Data Commons	25
Residual cardiovascular risk in coronary artery disease: from pathophysiology to established and novel therapies	24
Leadless and extravascular cardiac resynchronization therapy: the future for CRT?	24
Vagal mechanoreceptors in the heart sense changes in blood volume	24
An ex vivo perfusion platform for the testing of cardiovascular interventional devices	24
Effects of lifestyle factors on leukocytes in cardiovascular health and disease	24
Publisher Correction: Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease	24
Genome editing prevents hypertrophic cardiomyopathy in mice	24
A role for lipophagy in atherosclerosis	23
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action	22
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce	22
Alain Cribier (1945–2024)	22
Mind the gap: sex-related differences in cardiovascular disease	21
Charting the future of cardiology with large language model artificial intelligence	21
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease	20
Unravelling the genetic heart–brain connection using MRI	20
Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity	20
Current concepts and novel targets for antiplatelet therapy	20
Non-coding RNAs in lipid metabolism and their roles in atherosclerosis	19
Single-cell transcriptomics for the assessment of cardiac disease	18
Cardiac epigenome in heart development and disease	18
Repurposing drugs to treat cardiovascular disease in the era of precision medicine	18
Cardiac splicing as a diagnostic and therapeutic target	17
The ongoing quest for the first total artificial heart as destination therapy	17
Contemporary pharmacological treatment and management of heart failure	16
Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine	16
Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group	16
Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	16
Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy	16
No benefit of PCI in ischaemic LV dysfunction	15

Epidemiology and prevention of venous thromboembolism	15
Smartphone-based digital screening increases AF detection rate	15
Optically induced tachycardia evokes anxiety in risky settings	15
Bone marrow adipocytes support fatty acid metabolism during MI-mediated emergency haematopoiesis	14
Reply to: ‘Evidence does not support the reduction of added sugar intake from all food sources’	14
BMAL1 and HIF2α are key regulators of circadian-dependent variations in myocardial injury	13
Inflammatory signalling in diabetic cardiomyopathy: molecular mechanisms and potential therapeutic strategies	13
Infused ECM targets leaky vessels and heals inflamed tissues	13
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis	13
Scientific journey from PSCK9 discovery in familial hypercholesterolaemia	12
Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine	12
Interatrial shunt devices for heart failure	12
Understanding atrial failure: from diagnosis to clinical implications	12
The burden of atrial fibrillation in the Asia–Pacific region	12
Protein glycosylation in cardiovascular health and disease	11
Liver-derived factor XI protects against HFpEF	11
Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop	11
Pregnancy among cardiologists: challenges and recommendations	11
Branched-chain amino acids in cardiovascular disease	11
Overcoming difficulties with resilience	10
Nuclear remodelling contributes to cardiac dysfunction during ageing	10
ANGPTL3-lowering strategies to address residual cardiovascular risk	10
Cholesterol crystals in the pathogenesis of atherosclerosis	10
Novel cardiovascular therapeutics and the risk of financial toxicity	10
Neuroimmune–arterial interfaces regulate atherosclerosis progression	9
Targeting macrophage–fibroblast interactions in the failing heart	9
Social media in modern cardiology: a tool for building community, visibility and impact	9
Improving the cardiovascular health care of transgender and non-binary persons	9
Reproductive options and genetic testing for patients with an inherited cardiac disease	9
Base editing therapy corrects long QT syndrome in mice	8
Environmental sustainability in cardiovascular practice: current challenges and future directions	8
The contribution of the exposome to the burden of cardiovascular disease	8
Neutrophil extracellular traps in immunothrombosis	8
Smartwatch detection of left ventricular dysfunction	8
Shaping the future of cardiovascular medicine in the new era of wearable devices	8
Immediate non-inferior to staged complete revascularization	7
Inherited risk of coronary artery disease: redefining care with imaging and genetics	7
No benefit of β-blockers after myocardial infarction with preserved ejection fraction	7
Benefits of ninerafaxstat in non-obstructive hypertrophic cardiomyopathy	7
Functional testing after PCI in high-risk patients	7
Cardiac myosin inhibitors for the treatment of obstructive and non-obstructive HCM	7
Iron deficiency and supplementation in heart failure	6
Solving the mystery of vaccine-induced immune thrombocytopenia and thrombosis	6
Promising findings for cell therapy in HFrEF	6
Effective CRISPR modulation of complex non-coding RNA loci	6
Author Correction: Traction force microscopy of cardiomyocytes	6
Beyond GLP1: modulating multiple nutrient-stimulated hormone pathways to reduce cardiovascular risk	6
2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease	6
Levothyroxine supplementation does not improve heart transplantation from brain-dead donors	6
Prehabilitation: evolving role in contemporary cardiac surgery	6
Clonal haematopoiesis: an emerging causal risk factor for atherosclerotic CVD	6
ANP produced from self-amplifying RNA improves cardiac function after MI	6
Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity	6
Anticoagulation in patients with atrial high-rate episodes	6
Tackling inflammation in atherosclerosis	5
Hypertension in 2025: are we ready for bold precision public health approaches worldwide?	5
Reply to ‘Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease’	5
Emerging AI tools for geospatially resolved cardiovascular risk	5
Clinical implications of perioperative and periprocedural myocardial infarction	5
Author Correction: Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms	5
Invasive and medical management approaches to non-acute myocardial ischaemic syndromes	5
Publisher Correction: Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	5
Artificially transplanted mitochondria in endothelial cells promote mitophagy	5
Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation	5
Roadmap for alleviating the manifestations of ageing in the cardiovascular system	5
Adverse professional life experiences may affect mental health among cardiologists	4
The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways	4
Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group	4
Migraines and cardiovascular disease: mechanisms and methodological challenges	4
Very high HDL-C levels are associated with higher mortality in patients with CAD	4
Our revered and mysterious heart	4
Immune and inflammatory mechanisms in hypertension	4
Cardiac fibroblasts and mechanosensation in heart development, health and disease	4
Autoimmune diseases and atherosclerotic cardiovascular disease	4
Young women with AMI have worse outcomes than men up to 1 year after discharge	4
Small extracellular vesicles from the infarcted heart can promote tumour growth	4
Caution needed with microaxial flow pumps during high-risk PCI	4
No benefit of routine steroids in infant heart surgery	4
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue	4
RAPID return to sinus rhythm after SVT using intranasal etripamil	4
Microbial metabolites reduce SBP in patients with resistant hypertension	4
Cardiovascular involvement in glycogen storage diseases	4
Gene therapy for cardiac arrhythmias	4
Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention	3
Author Correction: Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction	3
Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure	3
Myocardial infarction, stroke and arterial stenosis: time to reassess a major misunderstanding	3
Disrupting a cell-specific miRNA–CXCR4 interaction is atheroprotective in mice	3
Antihypertensive drugs can be taken in the morning or evening	3
Mouse substrain is ceNNTral to the cardiac response to transverse aortic constriction	3
Lipoprotein(a) in coronary artery disease	3
P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention	3
Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome	3
The molecular structure of LDL has finally been elucidated	3
Ethnic disparities in age of onset of hypertension	3