OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Urology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Genomic and phenotypic heterogeneity in prostate cancer	282
Epidemiology and genomics of prostate cancer in Asian men	140
The biology and rationale of targeting nectin-4 in urothelial carcinoma	117
Prognostic and predictive biomarkers for immunotherapy in advanced renal cell carcinoma	107
Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future	93
100 years of Bacillus Calmette–Guérin immunotherapy: from cattle to COVID-19	91
Sperm ion channels and transporters in male fertility and infertility	86
Molecular events in neuroendocrine prostate cancer development	84
Recurrence mechanisms of non-muscle-invasive bladder cancer — a clinical perspective	82
Resistance to second-generation androgen receptor antagonists in prostate cancer	77
Exercise-induced myokines and their effect on prostate cancer	74
Defining cisplatin eligibility in patients with muscle-invasive bladder cancer	71
Machine learning for sperm selection	54
Late adverse effects and quality of life in survivors of testicular germ cell tumour	50
Neoadjuvant hormonal therapy before radical prostatectomy in high-risk prostate cancer	47
Toilet-based continuous health monitoring using urine	43
Spatiotemporal trends in human semen quality	42
Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry	41
Bladder cancer, inflammageing and microbiomes	41
The cognitive effect of anticholinergics for patients with overactive bladder	40
Transient receptor potential channels in sensory mechanisms of the lower urinary tract	40
Redefining a sexual medicine paradigm: subclinical premature ejaculation as a new taxonomic entity	39
Human kidney stones: a natural record of universal biomineralization	38
Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets	38
Using PSMA imaging for prognostication in localized and advanced prostate cancer	38

A global approach to improving penile cancer care	37
Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group	37
Perspectives in primary hyperoxaluria — historical, current and future clinical interventions	36
Artificial intelligence in academic writing: a paradigm-shifting technological advance	36
Preoperative exercise interventions to optimize continence outcomes following radical prostatectomy	35
Complementary roles of surgery and systemic treatment in clear cell renal cell carcinoma	35
Advances in sperm analysis: techniques, discoveries and applications	34
Prostate zones and cancer: lost in transition?	34
Treatment and trials in non-metastatic castration-resistant prostate cancer	34
Salvage therapy for prostate cancer after radical prostatectomy	32
Cannabinoid signalling and effects of cannabis on the male reproductive system	32
Surgical ergonomics for urologists: a practical guide	32
Standardization of microbiome studies for urolithiasis: an international consensus agreement	31
Molecular determinants of disease severity in urinary tract infection	31
The dynamic roles of the bladder tumour microenvironment	31
The potential of CAR T cell therapy for prostate cancer	30
Quality checkpoints in the MRI-directed prostate cancer diagnostic pathway	29
Simulating nature in sperm selection for assisted reproduction	29
Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function	28
Urine biomarkers in bladder cancer — current status and future perspectives	27
Germline testing and genetic counselling in prostate cancer	27
Immune-based therapies in penile cancer	27
Incorporating palliative care principles to improve patient care and quality of life in urologic oncology	27
Using oncolytic viruses to ignite the tumour immune microenvironment in bladder cancer	26
Mechanisms of the intestinal and urinary microbiome in kidney stone disease	26
Evolution of the World Health Organization semen analysis manual: where are we?	26
The current role of MRI for guiding active surveillance in prostate cancer	26
Vaccines as treatments for prostate cancer	26
Regulation and role of CAMKK2 in prostate cancer	25
Practical considerations for prostate hypofractionation in the developing world	25
Cellular senescence as a possible link between prostate diseases of the ageing male	24
Immunomodulation therapy offers new molecular strategies to treat UTI	24
Optimizing the diagnosis and management of ductal prostate cancer	24
Advances in the selection of patients with prostate cancer for active surveillance	24
PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma	22
Surgical management of high-risk, localized prostate cancer	22
The endoplasmic reticulum stress response in prostate cancer	22
Landmarks in the evolution of prostate biopsy	21
Experimental in vitro, ex vivo and in vivo models in prostate cancer research	21
Artificial intelligence and urology: ethical considerations for urologists and patients	20
Patient-derived tumour models for personalized therapeutics in urological cancers	20
Animal models of naturally occurring stone disease	19
The future of PSMA PET and WB MRI as next-generation imaging tools in prostate cancer	19
The testosterone paradox of advanced prostate cancer: mechanistic insights and clinical implications	19
Genetic control of typical and atypical sex development	19
Considering the potential for gene-based therapy in prostate cancer	18
Fertility preservation in boys facing gonadotoxic cancer therapy	18
Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction	18
The International Penile Prosthesis Implant Consensus Forum: clinical recommendations and surgical principles on the inflatable 3-piece penile prosthesis implant	18
Obesity and prostate cancer — microenvironmental roles of adipose tissue	17

Surgical management of primary severe hypospadias in children: an update focusing on penile curvature	17
Effect of smoking, hypertension and lifestyle factors on kidney cancer — perspectives for prevention and screening programmes	16
Race and prostate cancer: genomic landscape	15
Sexual health and treatment-related sexual dysfunction in sexual and gender minorities with prostate cancer	15
Prostate luminal progenitor cells: from mouse to human, from health to disease	15
Circulating and urinary tumour DNA in urothelial carcinoma — upper tract, lower tract and metastatic disease	15
Lessons learned from the first 15 years of penile transplantation and updates to the Baltimore Criteria	14
Are sex disparities in COVID-19 a predictable outcome of failing men’s health provision?	14
Clinical use and implications of sexual devices and sexually explicit media	14
Inheritance of paternal lifestyles and exposures through sperm DNA methylation	14
Combination treatment in metastatic prostate cancer: is the bar too high or have we fallen short?	13
Current and emerging treatment options for premature ejaculation	13
The COVID-19 pandemic — what have urologists learned?	13
Advances in stem cell research for the treatment of primary hypogonadism	13
The androgen receptor in bladder cancer	13
Host–biomaterial interactions in mesh complications after pelvic floor reconstructive surgery	13
Microfluidics facilitating the use of small extracellular vesicles in innovative approaches to male infertility	13
Urinary biomarkers to mitigate diagnostic delay in bladder cancer during the COVID-19 era	13
Therapeutic potential of CDK4/6 inhibitors in renal cell carcinoma	13
Galectins as potential therapeutic targets in STIs in the female genital tract	12
Human in vitro spermatogenesis as a regenerative therapy — where do we stand?	12
MRI-guided active surveillance in prostate cancer: not yet ready for practice	12
Male infertility and somatic health — insights into lipid damage as a mechanistic link	12
Preclinical models of prostate cancer — modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo	12
Revolutionizing care for rare genitourinary tumours	12
Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration	12
Vitamins as regulators of calcium-containing kidney stones — new perspectives on the role of the gut microbiome	12
Calcium signalling pathways in prostate cancer initiation and progression	11
Principles and outcomes of gender-affirming vaginoplasty	11
Indications and characteristics of penile traction and vacuum erection devices	11
Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations	11
The potential role of the microbiota in prostate cancer pathogenesis and treatment	10
Molecular profile of bladder cancer progression to clinically aggressive subtypes	10
Clinical application of bladder MRI and the Vesical Imaging-Reporting And Data System	10
Frequency, morbidity and equity — the case for increased research on male fertility	10
Health-related quality of life after curative treatment for muscle-invasive bladder cancer	9
The placebo and nocebo effects in functional urology	9
Adjuvant therapy options in renal cell carcinoma — targeting the metastatic cascade	9
Outer membrane vesicle vaccines for Neisseria gonorrhoeae	9
Sex differences in bladder cancer: emerging data and call to action	9
Implementation of patient-reported outcome measures into health care for men with localized prostate cancer	9
From mucosal infection to successful cancer immunotherapy	8
Attention to detail and a permissive set-up: crucial for an effective TURBT	8
Signatures of metabolic diseases on spermatogenesis and testicular metabolism	8
Top, bottom or vers? Creating a more equitable health system for sexual and gender minority patients with prostate cancer	8
Shared decision-making before prostate cancer screening decisions	7
Pembrolizumab use in bladder cancer: a tale of two trials	7
Local anaesthetic techniques for performing transperineal prostate biopsy	7
Refining neoadjuvant therapy clinical trial design for muscle-invasive bladder cancer before cystectomy: a joint US Food and Drug Administration and Bladder Cancer Advocacy Network workshop	7
AI for prostate cancer diagnosis — hype or today’s reality?	7
Fighting the ‘other pandemic’ — systemic racism in urology	7
Genetic and biological drivers of prostate cancer disparities in Black men	7
Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia	6
An emerging role for immuno-nutrition in patients undergoing radical cystectomy	6
Patient-reported outcomes in metastatic renal cell carcinoma trials using combinations versus sunitinib as first-line treatment	6
Reducing the stigma of academic mental health can save lives	6
The shifting treatment paradigm of metastatic renal cell carcinoma	6
Diagnostic liquid biopsy biomarkers in renal cell cancer	6
Rising Black voices in urology — the next generation	6
Understanding and integrating cytoreductive nephrectomy with immune checkpoint inhibitors in the management of metastatic RCC	6
Improved phenotypic classification of male infertility to promote discovery of genetic causes	5
Supporting Black voices in urology	5
HIV pre-exposure prophylaxis and sexually transmitted infections: intersection and opportunity	5
Treatment de-escalation for stage II seminoma	5
Bladder EpiCheck for NMIBC	5
Biological determinants of PSMA expression, regulation and heterogeneity in prostate cancer	5
The unclear role of PET–CT in localized radiorecurrent prostate cancer	5
The future of patient-derived xenografts in prostate cancer research	5
Time for women-centred gynaecology	5