OOIR: Observatory of International Research

Papers

(The TQCC of Biofabrication is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
From microtissues to organs: the future of reconstructive surgery with organ building block-based bioprinting	138
Development of immunocompetent full thickness skin tissue constructs to model skin fibrosis for high-throughput drug screening	100
Spheroid on-demand printing and drug screening of endothelialized hepatocellular carcinoma model at different stages	89
Cancer cell migration depends on adjacent ASC and adipose spheroids in a 3D bioprinted breast cancer model	77
Microfluidic-based platforms for cell-to-cell communication studies	66
A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin	62
Cell-laden bioink circulation-assisted inkjet-based bioprinting to mitigate cell sedimentation and aggregation	62
Suspension bath bioprinting and maturation of anisotropic meniscal constructs	56
Enhanced gelatin methacryloyl nanohydroxyapatite hydrogel for high-fidelity 3D printing of bone tissue engineering scaffolds	56
3D bioprinted vascularized lung cancer organoid models with underlying disease capable of more precise drug evaluation	56
In vitro vascularization of hydrogel-based tissue constructs via a combined approach of cell sheet engineering and dynamic perfusion cell culture	55
3D bioprinted extracellular vesicles for tissue engineering—a perspective	55
A microvascularized in vitro liver model for disease modeling and drug discovery	53
Formation of functionally robust human neocartilage from multiple donors using highly expanded costochondral cells	52
Biochemical and immunomodulatory insights of extracellular matrix from decellularized human whole cervix: recellularization and in vivo ECM remodeling interplay	52
High-throughput microgel biofabrication via air-assisted co-axial jetting for cell encapsulation, 3D bioprinting, and scaffolding applications	51
Cartilage tissue engineering by extrusion bioprinting utilizing porous hyaluronic acid microgel bioinks	50
Biofabrication of a tri-layered 3D-bioprinted CSC-based malignant melanoma model for personalized cancer treatment	49
Injectable rBMSCs-laden hydrogel microspheres loaded with naringin for osteomyelitis treatment	46
A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions	46
Acetylcholine-loaded nanoparticles protect against doxorubicin-induced toxicity in in vitro cardiac spheroids	46
3D bioprinted cell-laden GrooveNeuroTube: a multifunctional platform for ex vivo neural cell migration and growth studies	46
Biofabricated nanomaterials in sustainable agriculture: insights, challenges and prospects	46
Study of paraquat-induced pulmonary fibrosis using biomimetic micro-lung chips	46
Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits	45

Fabrication of bioinspired grid-crimp micropatterns by melt electrospinning writing for bone–ligament interface study	45
From local to global matrix organization by fibroblasts: a 4D laser-assisted bioprinting approach	44
Bilayer silk fibroin/sodium alginate scaffold promotes vascularization and advances inflammation stage in full-thickness wound	43
In vitro osteogenesis of hMSCs on collagen membranes embedded within LEGO^®-inspired 3D printed PCL constructs for mandibular bone repair	43
Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors	43
Bioassembly of hemoglobin-loaded photopolymerizable spheroids alleviates hypoxia-induced cell death	42
Freeform printing of thermoresponsive poly(2-cyclopropyl-oxazoline) as cytocompatible and on-demand dissolving template of hollow channel networks in cell-laden hydrogels	42
On-chip human lymph node stromal network for evaluating dendritic cell and T-cell trafficking	41
Support-less ceramic 3D printing of bioceramic structures using a hydrogel bath	41
3D bioprinted in vitro epilepsy models for pharmacological evaluation in temporal lobe epilepsy	41
The Batch-Resourcing Angiogenesis Tool (BRAT) to enable high-throughput microscopy screening of microvascular networks	41
Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues	40
In vitro circulation model driven by tissue-engineered dome-shaped cardiac tissue	38
Biohybrid tensegrity actuator driven by selective contractions of multiple skeletal muscle tissues	38
Recent trends in embedded 3D bioprinting of vascularized tissue constructs	38
A hepatic zonation chip with an oxygen concentration gradient embracing the spatial distribution of metabolic function	38
Fabrication of 3D engineered intestinal tissue producing abundant mucus by air–liquid interface culture using paper-based dual-layer scaffold	37
Editorial: Special Issue on biofabrication of cartilage, bone and their interface	37
Assessment and process optimization of high throughput biofabrication of immunocompetent breast cancer model for drug screening applications	35
The bioengineering of perfusable endocrine tissue with anastomosable blood vessels	35
Efficient one-step immobilization of DNA probes on 1DZnO nanoplatforms targeting a low-mutation region of SARS-CoV-2	35
Engineering an organoid culture system for enhanced murine and human hematopoietic stem and progenitor cell self-renewal and expansion	35
Fibrinogen-based cell and spheroid sheets manipulating and delivery for mouse hindlimb ischemia	35
Scale-out production of extracellular vesicles derived from natural killer cells via mechanical stimulation in a seesaw-motion bioreactor for cancer therapy	34
Mimicking sarcolemmal damage in vitro: a contractile 3D model of skeletal muscle for drug testing in Duchenne muscular dystrophy	34
Efficient fabrication of 3D bioprinted functional sensory neurons using an inducible Neurogenin-2 human pluripotent stem cell line	34
3D bioprinting approaches for spinal cord injury repair	34
Modular assembly of bioprinted perfusable blood vessel and tracheal epithelium for studying inflammatory respiratory diseases	33
Pillar electrodes embedded in the skeletal muscle tissue for selective stimulation of biohybrid actuators with increased contractile distance	33
Biofabrication of microstructured bacterial ecosystems using chaotic bioprinting: advancing in vitro research for microbial engineering	32
Pneumatic conveying inkjet bioprinting for the processing of living cells	32
Uniform cerebral organoid culture on a pillar plate by simple and reproducible spheroid transfer from an ultralow attachment well plate	31
Advances in biomaterials-based tissue engineering for regeneration of female reproductive tissues	31
Fabrication of a tailor-made conductive polyaniline/ascorbic acid-coated nanofibrous mat as a conductive and antioxidant cell-free cardiac patch	31
Computer-aided patterning of PCL microspheres to build modular scaffolds featuring improved strength and neovascularized tissue integration	30
Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors	30
A thermogelling organic-inorganic hybrid hydrogel with excellent printability, shape fidelity and cytocompatibility for 3D bioprinting	30
Development of a bioreactor and volumetric bioprinting protocol to enable perfused culture of biofabricated human epithelial mammary ducts and endothelial constructs	30
Printing GelMA bioinks: a strategy for building in vitro model to study nanoparticle-based minocycline release and cellular protection under oxidative stress	29
Mechanically and biologically promoted cell-laden constructs generated using tissue-specific bioinks for tendon/ligament tissue engineering applications	29
Generating human skeletal myoblast spheroids for vascular myogenic tissue engineering	29
Engineered tumor microspheres via microfluidics and decellularized extracellular matrix for high-throughput organoid-based drug screening	29
Engineering anisotropic tissue analogues: harnessing synergistic potential of extrusion-based bioprinting and extracellular matrix-based bioink	29
Placing biofabrication into the context of human disease modeling	28
Enhancement of properties of a cell-laden GelMA hydrogel-based bioink via calcium phosphate phase transition	28
Co-axial printing of convoluted proximal tubule for kidney disease modeling	28
Testis on a chip—a microfluidic three-dimensional culture system for the development of spermatogenesis in-vitro	28
Constraint based Bayesian optimization of bioink precursor: a machine learning framework	28
Recent trends in the development of in vitro 3D kidney models	28
Hybrid fabrication of photo-clickable vascular hydrogels with additive manufactured titanium implants for enhanced osseointegration and vascularized bone formation	27

Integration of bioprinting advances and biomechanical strategies for in vitro lung modelling	27
Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs)	27
Cation-crosslinked κ-carrageenan sub-microgel medium for high-quality embedded bioprinting	27
Biomimetic human skin model patterned with rete ridges	26
Core–shell microbead-based 3D vascularized glioma tumor model for effective drug testing	26
FRESH 3D bioprinting a contractile heart tube using human stem cell-derived cardiomyocytes	26
Constructing high-strength nano-micro fibrous woven scaffolds with native-like anisotropic structure and immunoregulatory function for tendon repair and regeneration	26
Photoacoustic imaging of 3D-printed vascular networks	26
Current advances in engineering meniscal tissues: insights into 3D printing, injectable hydrogels and physical stimulation based strategies	26
Complex in vitro models positioned for impact to drug testing in pharma: a review	26
The interface stiffness and topographic feature dictate interfacial invasiveness of cancer spheroids	25
Targeted micro-heterogeneity in bioinks allows for 3D printing of complex constructs with improved resolution and cell viability	25
Additive manufacturing and performance of bioceramic scaffolds with different hollow strut geometries	24
Development of a high-throughput micropatterned agarose scaffold for consistent and reproducible hPSC-derived liver organoids	24
Long-term in vitro maintenance of plasma cells in a hydrogel-enclosed human bone marrow microphysiological 3D model system	24
In vitro long term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application for in vivo	24
Current progress of in vitro vascular models on microfluidic chips	24
3D hydrogel microfibers promote the differentiation of encapsulated neural stem cells and facilitate neuron protection and axon regrowth after complete transactional spinal cord injury	24
A novel solution for real-time in-situ cell distribution monitoring in 3D bioprinting via fluorescence imaging	24
Local extensional flows promote long-range fiber alignment in 3D collagen hydrogels	23
Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling	23
Stress-free cell aggregation by using the CEPT cocktail enhances embryoid body and organoid fitness	23
Design and bioprinting for tissue interfaces	23
Functional imaging of 3D bioprinted microalgal constructs and simulation of their photosynthetic performance	23
Simulating big mechanically-active culture systems (BigMACS) using paired biomechanics-histology FEA modelling to derive mechanobiology design relationships	23
Novel in situ and rapid self-gelation recombinant collagen-like protein hydrogel for wound regeneration: mediated by metal coordination crosslinking and reinforced by electro-oxidized tea polyphenols	23
High resolution melt electro-written scaffolds promote alignment of human skeletal muscle cells	23
Biofabrication of biomimetic undulating microtopography at the dermal-epidermal junction and its effects on the growth and differentiation of epidermal cells	23
Self-assembled innervated vasculature-on-a-chip to study nociception	23
Rational design of 3D-printed scaffolds for breast tissue engineering using structural analysis	23
Microfluidic bioprinting as a tool to produce hiPSCs-derived renal organoids	22
3D engineering of diseased blood vessels for integrative in vitro–in silico mechanobiology study	22
3D bioprinted tumor model with extracellular matrix enhanced bioinks for nanoparticle evaluation	22
An open-source bioink database for microextrusion 3D printing	22
Advancing extrusion-based embedded 3D bioprinting via scientific, engineering, and process innovations	21
3D printed bioactive coated scaffolds boost osteogenesis and angiogenesis via the regulation of scaffold microstructure	21
Biofabrication & cryopreservation of tissue engineered constructs for on-demand applications	21
Soft pneumatic actuators for mimicking multi-axial femoropopliteal artery mechanobiology	21
Additive manufacturing of silicon nitride fiber-reinforced polyetheretherketone composites with enhanced mechanical strength and multifunctional bioactivity for load-bearing bone defect repair	21
Non-destructive luminescence and PET imaging to monitor tissue microenvironment in microphysiological systems during brain metastasis using dissociated cerebral organoids	21
Highly compliant biomimetic scaffolds for small diameter tissue-engineered vascular grafts (TEVGs) produced via melt electrowriting (MEW)	21
Incorporating biomechanics as a key evaluation metric for organoids	21
Versatile xanthan gum-based support bath material compatible with multiple crosslinking mechanisms: rheological properties, printability, and cytocompatibility study	21
A parallelized, perfused 3D triculture model of leukemia for in vitro drug testing of chemotherapeutics	21
Bioprinting of pre-vascularized constructs for enhanced in vivo neo-vascularization	21
Surface slicing and toolpath planning for in-situ bioprinting of skin implants	20
3D melt electrowritten MXene-reinforced scaffolds for tissue engineering applications	20
In vitro bioprinted 3D model enhancing osteoblast-to-osteocyte differentiation	20
Regolith-supported biofabrication: 3D bioprinting of living, photosynthetically active structures using Lunar and Martian regolith simulants	20
Digital light processing-bioprinted poly-NAGA-GelMA-based hydrogel lenticule for precise refractive errors correction	20
Construction of highly vascularized hepatic spheroids of primary hepatocytes via pro-angiogenic strategy in vitro	20
High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells	20
An immunocompetent human kidney on-a-chip model to study renal inflammation and immune-mediated injury	19
Comparison study on hyaline cartilage versus fibrocartilage formation in a pig model by using 3D-bioprinted hydrogel and hybrid constructs	19
Calcium supplementation of bioinks reduces shear stress-induced cell damage during bioprinting	19
3D bioprinted epicardial patch of GelMA containing VEGF-loaded chitosan nanoparticles and human bone marrow mesenchymal stem cells for the treatment of myocardial infarction	19
Recent progress of organ-on-a-chip towards cardiovascular diseases: advanced design, fabrication, and applications	18
In vitro three-dimensional volumetric printing of vitreous body models using decellularized extracellular matrix bioink	18
Ionically annealed zwitterionic microgels for bioprinting of cartilaginous constructs	18
Development of a plasma-based 3D printing system for enhancing the biocompatibility of 3D scaffold	18
Using a micro-device with a deformable ceiling to probe stiffness heterogeneities within 3D cell aggregates	18
Antibacterial, ROS scavenging and angiogenesis promoting ϵ-Polylysine/gelatin based hydrogel containing CTLP to regulate macrophages for pressure ulcer healing	18
3D bioprinting in tissue engineering: current state-of-the-art and challenges towards system standardization and clinical translation	18
Fused deposition modeling of defect-specific conformable bone grafts from 13-93B3 polymer-bioglass composites	18
Construction of a three-dimensional urothelium on-chip with barrier function based on urinary flow microenvironment	17
Tailoring agarose fluid gels for use in suspension bath bioprinting and culture of spheroid-based bioinks	17
Efficient wet-spinning of pre-aligned microtissues for 3D bioprinting complex tissue alignment	17
Ultrasound standing wave spatial patterning of human umbilical vein endothelial cells for 3D micro-vascular networks formation	17
Particulate ECM biomaterial ink is 3D printed and naturally crosslinked to form structurally-layered and lubricated cartilage tissue mimics	17
Closed-loop vasculature network design for bioprinting large, solid tissue scaffolds	17
A microphysiological model of bone development and regeneration	17
Co-axial hydrogel spinning for facile biofabrication of prostate cancer-like 3D models	17
Fixation method of a single muscle fiber by magnetic force for stretching, transportation, and evaluation of mechanical properties	17
Pharmacy 3D printing	16
miRNA induced 3D bioprinted-heterotypic osteochondral interface	16
Exploring bio-nanomaterials as antibiotic allies to combat antimicrobial resistance	16
Bio-3D printing with smooth muscle cells derived from human iPSCs via neural crest and its application for the tracheal regeneration	16
Comparison of in-situ versus ex-situ delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting	16
Interstitial fluid flow contributes to prostate cancer invasion and migration to bone; study conducted using a novel horizontal flow bioreactor	16
A cell bank paradigm for preclinical evaluation of an analogous cellular product for an allogeneic cell therapy	16