OOIR: Observatory of International Research

Papers

(The TQCC of Biofabrication is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Microfluidic-based platforms for cell-to-cell communication studies	102
Biochemical and immunomodulatory insights of extracellular matrix from decellularized human whole cervix: recellularization and in vivo ECM remodeling interplay	79
A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin	75
Development of immunocompetent full thickness skin tissue constructs to model skin fibrosis for high-throughput drug screening	71
3D bioprinted tissue-specific spheroidal multicellular microarchitectures for advanced cell therapy	64
Cancer cell migration depends on adjacent ASC and adipose spheroids in a 3D bioprinted breast cancer model	63
Spheroid on-demand printing and drug screening of endothelialized hepatocellular carcinoma model at different stages	58
Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing	57
A microvascularized in vitro liver model for disease modeling and drug discovery	56
3D bioprinted extracellular vesicles for tissue engineering—a perspective	55
Norbornene-functionalized methylcellulose as a thermo- and photo-responsive bioink	53
In vitro vascularization of hydrogel-based tissue constructs via a combined approach of cell sheet engineering and dynamic perfusion cell culture	51
Cell-laden bioink circulation-assisted inkjet-based bioprinting to mitigate cell sedimentation and aggregation	51
A scalable coaxial bioprinting technology for mesenchymal stem cell microfiber fabrication and high extracellular vesicle yield	51
3D bioprinted vascularized lung cancer organoid models with underlying disease capable of more precise drug evaluation	50
Enhanced gelatin methacryloyl nanohydroxyapatite hydrogel for high-fidelity 3D printing of bone tissue engineering scaffolds	49
Suspension bath bioprinting and maturation of anisotropic meniscal constructs	49
Influence of asymmetric microchannels in the structure and function of engineered neuronal circuits	48
Biofabrication of a tri-layered 3D-bioprinted CSC-based malignant melanoma model for personalized cancer treatment	47
Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors	46
Fabrication of bioinspired grid-crimp micropatterns by melt electrospinning writing for bone–ligament interface study	45
Biofabricated nanomaterials in sustainable agriculture: insights, challenges and prospects	45
Study of paraquat-induced pulmonary fibrosis using biomimetic micro-lung chips	45
Injectable rBMSCs-laden hydrogel microspheres loaded with naringin for osteomyelitis treatment	43
Acetylcholine-loaded nanoparticles protect against doxorubicin-induced toxicity in in vitro cardiac spheroids	43

A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions	41
Bilayer silk fibroin/sodium alginate scaffold promotes vascularization and advances inflammation stage in full-thickness wound	40
High-throughput microgel biofabrication via air-assisted co-axial jetting for cell encapsulation, 3D bioprinting, and scaffolding applications	40
From local to global matrix organization by fibroblasts: a 4D laser-assisted bioprinting approach	40
Cartilage tissue engineering by extrusion bioprinting utilizing porous hyaluronic acid microgel bioinks	39
Biohybrid tensegrity actuator driven by selective contractions of multiple skeletal muscle tissues	39
Bioassembly of hemoglobin-loaded photopolymerizable spheroids alleviates hypoxia-induced cell death	39
3D bioprinted in vitro epilepsy models for pharmacological evaluation in temporal lobe epilepsy	39
Enhanced vascularization and de novo tissue formation in hydrogels made of engineered RGD-tagged spider silk proteins in the arteriovenous loop model	39
Support-less ceramic 3D printing of bioceramic structures using a hydrogel bath	38
In vitro circulation model driven by tissue-engineered dome-shaped cardiac tissue	37
Freeform printing of thermoresponsive poly(2-cyclopropyl-oxazoline) as cytocompatible and on-demand dissolving template of hollow channel networks in cell-laden hydrogels	36
In vitro osteogenesis of hMSCs on collagen membranes embedded within LEGO^®-inspired 3D printed PCL constructs for mandibular bone repair	36
On-chip human lymph node stromal network for evaluating dendritic cell and T-cell trafficking	36
Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues	35
Engineering anisotropic tissue analogues: harnessing synergistic potential of extrusion-based bioprinting and extracellular matrix-based bioink	35
Recent trends in embedded 3D bioprinting of vascularized tissue constructs	35
Study of the process-induced cell damage in forced extrusion bioprinting	35
Bioprinting of dual ECM scaffolds encapsulating limbal stem/progenitor cells in active and quiescent statuses	35
Editorial: Special Issue on biofabrication of cartilage, bone and their interface	35
Uniform cerebral organoid culture on a pillar plate by simple and reproducible spheroid transfer from an ultralow attachment well plate	34
Fibrinogen-based cell and spheroid sheets manipulating and delivery for mouse hindlimb ischemia	34
Fabrication of 3D engineered intestinal tissue producing abundant mucus by air–liquid interface culture using paper-based dual-layer scaffold	34
Sporadic cell death in macroscale 3D tumor grafts with high drug resistance by activating cell-ECM interactions	33
Enhancement of properties of a cell-laden GelMA hydrogel-based bioink via calcium phosphate phase transition	33
The bioengineering of perfusable endocrine tissue with anastomosable blood vessels	33
Efficient one-step immobilization of DNA probes on 1DZnO nanoplatforms targeting a low-mutation region of SARS-CoV-2	32
Modular assembly of bioprinted perfusable blood vessel and tracheal epithelium for studying inflammatory respiratory diseases	32
Pneumatic conveying inkjet bioprinting for the processing of living cells	32
Assessment and process optimization of high throughput biofabrication of immunocompetent breast cancer model for drug screening applications	32
Generating human skeletal myoblast spheroids for vascular myogenic tissue engineering	31
Fabrication of a tailor-made conductive polyaniline/ascorbic acid-coated nanofibrous mat as a conductive and antioxidant cell-free cardiac patch	31
Recent advancements in the bioprinting of vascular grafts	31
Magnetism-controlled assembly of composite stem cell spheroids for the biofabrication of contraction-modulatory 3D tissue	31
Mimicking sarcolemmal damage in vitro: a contractile 3D model of skeletal muscle for drug testing in Duchenne muscular dystrophy	31
Advances in biomaterials-based tissue engineering for regeneration of female reproductive tissues	31
Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors	30
Computer-aided patterning of PCL microspheres to build modular scaffolds featuring improved strength and neovascularized tissue integration	30
Mechanically and biologically promoted cell-laden constructs generated using tissue-specific bioinks for tendon/ligament tissue engineering applications	30
Efficient fabrication of 3D bioprinted functional sensory neurons using an inducible Neurogenin-2 human pluripotent stem cell line	29
Efficient fabrication of monodisperse hepatocyte spheroids and encapsulation in hybrid hydrogel with controllable extracellular matrix effect	29
Testis on a chip—a microfluidic three-dimensional culture system for the development of spermatogenesis in-vitro	29
A thermogelling organic-inorganic hybrid hydrogel with excellent printability, shape fidelity and cytocompatibility for 3D bioprinting	29
Pillar electrodes embedded in the skeletal muscle tissue for selective stimulation of biohybrid actuators with increased contractile distance	29
Cation-crosslinked κ-carrageenan sub-microgel medium for high-quality embedded bioprinting	28
Scale-out production of extracellular vesicles derived from natural killer cells via mechanical stimulation in a seesaw-motion bioreactor for cancer therapy	28
Development of a bioreactor and volumetric bioprinting protocol to enable perfused culture of biofabricated human epithelial mammary ducts and endothelial constructs	28
Multi-material digital light processing bioprinting of hydrogel-based microfluidic chips	28
Printing GelMA bioinks: a strategy for building in vitro model to study nanoparticle-based minocycline release and cellular protection under oxidative stress	28
3D bioprinting approaches for spinal cord injury repair	28

Integration of bioprinting advances and biomechanical strategies for in vitro lung modelling	27
Placing biofabrication into the context of human disease modeling	27
Photoacoustic imaging of 3D-printed vascular networks	26
Co-axial printing of convoluted proximal tubule for kidney disease modeling	26
Constraint based Bayesian optimization of bioink precursor: a machine learning framework	26
Recent trends in the development of in vitro 3D kidney models	26
Spatial micro-variation of 3D hydrogel stiffness regulates the biomechanical properties of hMSCs	26
FRESH 3D bioprinting a contractile heart tube using human stem cell-derived cardiomyocytes	26
Hybrid fabrication of photo-clickable vascular hydrogels with additive manufactured titanium implants for enhanced osseointegration and vascularized bone formation	25
Biomimetic human skin model patterned with rete ridges	25
Complex in vitro models positioned for impact to drug testing in pharma: a review	24
Constructing high-strength nano-micro fibrous woven scaffolds with native-like anisotropic structure and immunoregulatory function for tendon repair and regeneration	24
A novel solution for real-time in-situ cell distribution monitoring in 3D bioprinting via fluorescence imaging	24
Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs)	24
Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells	24
Development of a high-throughput micropatterned agarose scaffold for consistent and reproducible hPSC-derived liver organoids	23
Design and bioprinting for tissue interfaces	23
Long-term in vitro maintenance of plasma cells in a hydrogel-enclosed human bone marrow microphysiological 3D model system	23
Current progress of in vitro vascular models on microfluidic chips	23
Targeted micro-heterogeneity in bioinks allows for 3D printing of complex constructs with improved resolution and cell viability	23
Local extensional flows promote long-range fiber alignment in 3D collagen hydrogels	22
Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling	22
Additive manufacturing and performance of bioceramic scaffolds with different hollow strut geometries	22
Current advances in engineering meniscal tissues: insights into 3D printing, injectable hydrogels and physical stimulation based strategies	22
Bio-3D printing iPSC-derived human chondrocytes for articular cartilage regeneration	22
The spatial arrangement of cells in a 3D-printed biomimetic spinal cord promotes directional differentiation and repairs the motor function after spinal cord injury	21
In vitro long term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application for in vivo engraftment	21
The interface stiffness and topographic feature dictate interfacial invasiveness of cancer spheroids	21
Self-assembled innervated vasculature-on-a-chip to study nociception	21
3D hydrogel microfibers promote the differentiation of encapsulated neural stem cells and facilitate neuron protection and axon regrowth after complete transactional spinal cord injury	21
Stress-free cell aggregation by using the CEPT cocktail enhances embryoid body and organoid fitness	21
Simulating big mechanically-active culture systems (BigMACS) using paired biomechanics-histology FEA modelling to derive mechanobiology design relationships	20
Biofabrication of biomimetic undulating microtopography at the dermal-epidermal junction and its effects on the growth and differentiation of epidermal cells	20
Rational design of 3D-printed scaffolds for breast tissue engineering using structural analysis	20
Advancing extrusion-based embedded 3D bioprinting via scientific, engineering, and process innovations	20
3D engineering of diseased blood vessels for integrative in vitro–in silico mechanobiology study	20
Versatile xanthan gum-based support bath material compatible with multiple crosslinking mechanisms: rheological properties, printability, and cytocompatibility study	20
Simultaneous 2D and 3D cell culture array for multicellular geometry, drug discovery and tumor microenvironment reconstruction	20
Novel in situ and rapid self-gelation recombinant collagen-like protein hydrogel for wound regeneration: mediated by metal coordination crosslinking and reinforced by electro-oxidized tea polyphenols	20
Surface slicing and toolpath planning for in-situ bioprinting of skin implants	19
Incorporating biomechanics as a key evaluation metric for organoids	19
In vitro bioprinted 3D model enhancing osteoblast-to-osteocyte differentiation	19
Using a micro-device with a deformable ceiling to probe stiffness heterogeneities within 3D cell aggregates	19
Recent progress of organ-on-a-chip towards cardiovascular diseases: advanced design, fabrication, and applications	19
Construction of highly vascularized hepatic spheroids of primary hepatocytes via pro-angiogenic strategy in vitro	19
3D bioprinted tumor model with extracellular matrix enhanced bioinks for nanoparticle evaluation	19
A parallelized, perfused 3D triculture model of leukemia for in vitro drug testing of chemotherapeutics	19
Bioprinting of pre-vascularized constructs for enhanced in vivo neo-vascularization	19
Digital light processing-bioprinted poly-NAGA-GelMA-based hydrogel lenticule for precise refractive errors correction	19
Antibacterial, ROS scavenging and angiogenesis promoting ϵ-Polylysine/gelatin based hydrogel containing CTLP to regulate macrophages for pressure ulcer healing	19
An immunocompetent human kidney on-a-chip model to study renal inflammation and immune-mediated injury	19
An open-source bioink database for microextrusion 3D printing	19
Comparison study on hyaline cartilage versus fibrocartilage formation in a pig model by using 3D-bioprinted hydrogel and hybrid constructs	19
In vitro three-dimensional volumetric printing of vitreous body models using decellularized extracellular matrix bioink	19
Double network laminarin-boronic/alginate dynamic bioink for 3D bioprinting cell-laden constructs	19
Development of a plasma-based 3D printing system for enhancing the biocompatibility of 3D scaffold	19
Soft pneumatic actuators for mimicking multi-axial femoropopliteal artery mechanobiology	19
Ionically annealed zwitterionic microgels for bioprinting of cartilaginous constructs	18
Closed-loop vasculature network design for bioprinting large, solid tissue scaffolds	18
Biofabrication & cryopreservation of tissue engineered constructs for on-demand applications	18
Construction of a three-dimensional urothelium on-chip with barrier function based on urinary flow microenvironment	18
High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells	18
Calcium supplementation of bioinks reduces shear stress-induced cell damage during bioprinting	18
Highly compliant biomimetic scaffolds for small diameter tissue-engineered vascular grafts (TEVGs) produced via melt electrowriting (MEW)	18
miRNA induced 3D bioprinted-heterotypic osteochondral interface	17
Comparison of in-situ versus ex-situ delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting	17
A cell bank paradigm for preclinical evaluation of an analogous cellular product for an allogeneic cell therapy	17
Engineering strategies for the construction of oriented and functional skeletal muscle tissues	17
Particulate ECM biomaterial ink is 3D printed and naturally crosslinked to form structurally-layered and lubricated cartilage tissue mimics	17
Co-axial hydrogel spinning for facile biofabrication of prostate cancer-like 3D models	17
Fixation method of a single muscle fiber by magnetic force for stretching, transportation, and evaluation of mechanical properties	17
A microphysiological model of bone development and regeneration	17
Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling	17
Pharmacy 3D printing	17