OOIR: Observatory of International Research

Papers

(The TQCC of Bioanalysis is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
A Brave New World?	27
Volumetric Absorptive Microsampling as An Effective Microsampling Technique for LC–MS/MS Bioanalysis of Biomarkers in Drug Discovery	27
Uncovering the Green Frontier: Harnessing Deep Eutectic Solvents for Sustainable Bioanalysis	27
Meet the Editorial Board – An Interview with Min Meng and Transitions from Small Regional Labs to Global CRO	25
Degradation of Vancomycin in External Quality Assessment Samples is a Factor to Underestimate Its Concentration	25
Biomarker Context-Of-Use: How Organizational Design Can Impact the Implementation of the Appropriate Biomarker Assay Strategy	24
Peripheral blood mononuclear cells isolation from mouse and rabbit blood to quantify active nucleotide and define brincidofovir dose for smallpox	22
Biomonitoring of Arsenic, Lead, Manganese and Mercury in Hair from a Presumably Exposed Uruguayan Child Population	22
Simple Method to Determine the Concentration and Incorporation Ratio of Ruthenium-Labeled Antibodies	20
Signal-to-noise Ratio to Assess Magnitude, Kinetics and Impact on Pharmacokinetics of the Immune Response to an Adalimumab Biosimilar	19
Adopting ambient ionization mass spectrometry into bioanalytical laboratories	19
Bioanalysis by LC-MS/MS and Preclinical Pharmacokinetic Interaction Study of Ribociclib and Oleanolic Acid	19
Patient-centric clinical trials: collaboration and innovation in bioanalytical and clinical operations	18
Determination of IQZ23 in Rat Plasma using LC-MS/MS: Consideration for Matrix Effect and Internal Standard Interference	17
High-Sensitivity Workflow for LC–MS-Based Analysis of GALNAC-Conjugated Oligonucleotides: A Case Study	17
Validation of Enantioseparation and Quantitation of an Active Metabolite of Abrocitinib in Human Plasma	14
Iron oxide nanozymes as versatile analytical tools: an overview of their application as detection technique	14
Lot-to-lot Reproducibility, Stability and Life Cycle Management of Antibody Reagents for Flow Cytometry	13
Handling Unstable Analytes: Literature Review and Expert Panel Survey by the Japan Bioanalysis Forum Discussion Group	13
Strategy and Validation of a Nonclinical Generic Plug-and-Play Antidrug Antibody Method for Human Monoclonal Antibody Biotherapeutics	13
An LC–MS/MS Method for Simultaneous Determination of LB-100 and Its Active Metabolite, Endothall, in Human Plasma	12
Recent advances in gold nanoparticle-based colorimetric aptasensors for chemical and biological analyses	12
Determination of carbamazepine in fingerprints: a feasibility study to evaluate adherence in epilepsy patients	12
Bioanalysis of free antisense oligonucleotide payload from antibody–oligonucleotide conjugate by hybridization LC-MS/MS	11
A comparison of branched DNA and reverse transcriptase quantitative polymerase chain reaction methodologies for quantitation of lipid nanoparticle encapsulated mRNA	11

Validation of an LC–MS/MS method for the determination of sotorasib, a KRAS ^G12C inhibitor, in human plasma	11
Diversity and Inclusion in the Bioanalytical Industry: An Interview with Anahita Keyhani	11
Special Focus Issue - Covid-19: Bioanalytical Considerations, Contributions and Lessons – Part 2	11
Perspectives on a Flexible Strategy for the Management of Nonregulated Bioanalysis	11
Ligand-binding assays vs chromatographic platforms for oligonucleotide quantification	10
Comparison of Assay Formats Used for the Detection of Pre-Existing Anti-Drug Antibodies Against Monoclonal Antibodies	10
Transforming drug discovery: the impact of AI and molecular simulation on R&D efficiency	9
Highlights of the 13th Japan Bioanalysis Forum Symposium	9
Bioanalysis Rising Star Award 2024: interviews with the finalists	9
The investigation of connection between anticoagulant therapy and vitamin K homologues in human determined by LC–MS/MS	9
Simultaneous Measurement of Mouse and Human Albumin in Chimeric Mice with Humanized Livers	9
Determination of meropenem in capillary plasma microsamples using LC–MS/MS	9
Considerations in Designing and Implementing a Bioanalytical Contract Research Organization Key Performance Indicator System	8
Method development for the quantification of lead levels in whole blood sampled on Mitra ^® with VAMS ^® tips by inductively coupled	8
Upfront Acid Treatment with Low Final pH: The Development and Testing of a Novel Method to Improve Drug Tolerance in Antidrug Antibody Assays	8
Internal standard variability: root cause investigation, parallelism for evaluating trackability and practical considerations	8
Inception and Development of a LC–MS/MS Assay for the Multiplexed Quantitation of Nine Human Drug Transporter Biomarkers	8
Olympic Anti-Doping Laboratory: The Analytical Technological Road From 2016 Rio De Janeiro to 2021 Tokyo	8
Novel Isoelectric Target Depletion (ITaD) Protocol Reduces the Need for Specific Reagents for Immunogenicity Testing	8
Highlights of the 15th Japan Bioanalysis Forum Symposium	8
Western Blotting: Evolution of an Old Analytical Method To a New Quantitative Tool for Biomarker Measurements	8
Critical Reagent Inventory Management System and Web Portal Specifically Optimized for Supporting External Clients	8
A Sensitive, Robust and High-Throughput Isotope Dilution LC–MS/MS Method for Quantifying Three Folate Forms in Serum	8
Determination of Amphetamines, Opioids, Cocaine Metabolites and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in Urine Using Biocompatible Solid-Phase Microextraction and Ultra-Performance LC–MS/MS	7
Chemical Derivatization in Combination with Supercritical Fluid Chromatography to Improve Resolution of Stereoisomers	7
Development and validation of bioanalytical methods to support clinical study of disitamab vedotin	7
Current and Effective Strategies for Critical Reagent Characterization, Storage, Stability, Retesting and Life Cycle Management for Ligand-Binding Assays and Flow Cytometry	7
COVID-19’s Impact on Bioanalytical Labs	7
Molecularly Imprinted Electrochemical Biosensor for Thrombin Detection by Comparing Different Monomers	7
Comparison of multiple bioanalytical assay platforms for the quantitation of siRNA therapeutics	7
Development and Validation of qPCR Methods for Nucleic Acid Biomarkers as a Drug Development Tool: Points to Consider	7
An Integrated Outsourcing Practice of Nonclinical LC–MS Bioanalysis and Toxicokinetics at Novartis small Molecule Drug Development	7
High Ionic Strength Dissociation Assay Reduces Dimeric Target Interference in Immunogenicity Testing	7
Revolutionizing depression diagnosis: earwax analysis for cortisol and beyond	7
An Eco-Friendly Ultra-Performance Liquid Chromatography–Mass Spectrometry Method for Quantification of Rivaroxaban and Ticagrelor in Rat Plasma: Grapefruit Interactions	6
Comparison of Requirements for Clinical Study of SARS-CoV-2 Antigen Test Kits in China, the USA and Europe	6
Cytochrome P450 Enzymes: A Review on Drug Metabolizing Enzyme Inhibition Studies in Drug Discovery and Development	6
Effect of Chronopharmacology and Food on in Vivo Pharmacokinetic Profile of Mavacamten	6
Perspective on High-Throughput Bioanalysis to Support In Vitro Assays in Early Drug Discovery	6
Greener Bioanalytical Sample Preparation. What is Next?	6
Ocular Bioanalysis of Moxifloxacin and Ketorolac Tromethamine in Rabbit Lacrimal Matrix Using Liquid Chromatography–Tandem Mass Spectrometry	6
Quantitative polymerase chain reaction in the bioanalytical laboratory and technical and scientific considerations for nonclinical and clinical assay characterization, validation and sample analysis	6
Biopharmaceutical Quality Control with Mass Spectrometry	6
Determination of aloesone in rat plasma by LC–MS/MS spectrometry and its application in a pharmacokinetic study	6
Special Focus Issue - Performing Flow Cytometry in Clinical Trials	6
DoE-assisted HPLC method development and validation of enzalutamide and repaglinide in rat plasma	6
HPLC Method for Simultaneous Estimation of Paclitaxel and Baicalein: Pharmaceutical and Pharmacokinetic Applications	6
Determination of Favipiravir in Human Plasma using Homogeneous Liquid–Liquid Microextraction followed by HPLC/UV	5
Development of LC–MS/MS Method for Cyanoenone Triterpenoid Determination to Support CNS Tissue Distribution Study	5
Validation of an HPLC Method for Estimation of Cefotaxime from Dried Blood Spot: Alternative to Plasma-Based PK Evaluation in Neonates	5

Fabry Disease Biomarkers in Patients Switched From Enzyme-Replacement Therapy to Migalastat Oral Chaperone Therapy	5
Advancements in Practical and Scientific Bioanalytical Approaches to Metabolism Studies in Drug Development	5
Quantification of a promising JNK inhibitor and nitrovasodilator IQ-1 and its major metabolite in rat plasma by LC–MS/MS	5
LC–MS/MS Methods for Direct Measurement of Sepiapterin and Tetrahydrobiopterin in Human Plasma and Clinical Applications	5
Multidimensional Chromatography Platforms: Status and Prospects	5
Rapid Development of Analytical Methods for Evaluating Pandemic Vaccines: A Covid-19 Perspective	5
Critical reagent considerations for immunogenicity assay development for bispecific biotherapeutic candidates	5
Single-Analyte Biomarker Assays for Pharmacodynamic or Safety Assessment During Biotherapeutic Development	5
Solid-Phase Microextraction for Assessment of Plasma Protein Binding, a Complement to Rapid Equilibrium Dialysis	5
Comparative pharmacokinetic study of Anisodamine Hydrobromide tablets and injection in septic acute lung injury rats	5
Role of miRNA-21 in cancer and its application in electrochemical bioanalysis	5
A Biomarker Assay Validation Approach Tailored to The Context of Use and Bioanalytical Platform	5
Quantitation of Ivosidenib in Human Plasma Via LC–MS/MS and its Application in Clinical Trials	5
Validation of High-Throughput, Semiquantitative Solid-Phase Sarscoronavirus-2 Serology Assays in Serum and Dried Blood Spot Matrices	5
Development and validation of an LC–MS/MS method for D- and L-2-hydroxyglutaric acid measurement in cerebrospinal fluid, urine and plasma: application to glioma	5
Novel assay format for total anti-adeno-associated virus antibody detection with low capsid consumption and built-in specificity control	4
Bioanalysis of tucatinib and metabolite, and a five-way cross-validation to support clinical pharmacokinetic analysis	4
High-resolution mass spectrometry for glycoproteomics	4
A comprehensive LC–MS based study of factors influencing biotinylation of critical reagents	4
Development and validation of an ELISA method for quantification of the anti-HER3 antibody HMBD-001 in human serum	4
Expanding Assay Range to Accommodate a Monoclonal Antibody Therapeutic Quantification in Blood and Cerebrospinal Fluid	4
A Validated Method for the Determination of Hematocrit in Dried Blood Spots Using Image Analysis	4
Characterization of Murine Lymphocyte Activation and Exhaustion Markers by a 14-Color Flow Cytometry Panel	4
Capillary Electrophoresis Mass Spectrometry for Metabolomics: Reflecting on the Next Steps	4
Pharmacokinetics and apparent Michaelis constant for metabolite conversion of sorafenib in healthy and hepatocellular carcinoma-bearing rats	4
Development of pseudotyped VSV-SARS-CoV-2 spike variants for the assessment of neutralizing antibodies	4
Cloud Solutions for GxP Laboratories: Considerations for Data Storage	4
LC–MS Bioanalysis of Protein Biomarkers and Protein Therapeutics in Formalin-Fixed Paraffin-Embedded Tissue Specimens	4
A Smartphone Digital Image Colorimetric Method Based on Nanoparticles for Determination of Lamotrigine	4
2024 White Paper on Recent Issues in Bioanalysis: Three Way-Cross Validation; Urine Clinical Analysis; Automated Methods; Regulatory Queries on Plasma Protein Binding; Automated Biospecimen Management	4
Utilizing Droplet Digital Polymerase Chain Reaction for siRNA Quantitation in Rodent Plasma and Tissue Via Stem-Loop Reverse Transcription	4
Insights and Future Trends in Bioanalysis: An Interview With Jing Tu	4
Simultaneous Quantification of Oxcarbazepine and Its Active Metabolite in Spiked Human Plasma Using Ultra Performance Liquid Chromatography–MS/MS	4
Thyroxine Biosensors: A Review on Progress and Challenges	4
Harmonization of Vaccine Ligand Binding Assays Validation	4
Pitfalls in bioanalytical work with a Japanese CRO or sponsor: from a project risk management perspective	4
Prediction of frozen virus stability based on degradation mechanisms, real-time data and modeling	4
Quantitative Determination of Cpd118, A Novel FBPase Inhibitor, in Dog Plasma by HPLC–MS/MS	4
Validation and Application of Hybridization Liquid Chromatography-Tandem Mass Spectrometry Methods for Quantitative Bioanalysis of Antisense Oligonucleotides	4
Quantification of MDR-TB drug JBD0131 and its metabolite in plasma via UPLC-MS/MS: application in first-in-human study	4
Artificial intelligence and blockchain in clinical trials: enhancing data governance efficiency, integrity, and transparency	4
Pharmacokinetics and Toxicity Considerations for Antibody–drug Conjugates: An Overview	3
Thalidomide Measurement in Plasma and Dried Plasma Spot by SPE Combined with UHPLC-MS/MS for Therapeutic Drug Monitoring	3
Moving into the cloud: a summary from a European Bioanalysis forum workshop on introducing cloud applications in bioanalytical laboratories	3
Nitrosamine Impurities: from Raw Materials to Final Drug Product	3
A Bioanalytical Screening Method for Enterococcus faecalis RNPP-type Quorum Sensing Peptides in Murine Feces	3
Detection of Sars-Cov-2At the Point of Care	3
Multi-residue analysis method based on QuEChERS followed by ultra-high performance liquid chromatography coupled with diode-array detector for pesticides in human serum and breast milk	3
Validated HPLC Method for Ceftriaxone from Dried Blood Spots for Pharmacokinetic Studies and Therapeutic Drug Monitoring in Neonatal Population	3
Re-thinking the current paradigm for clinical immunogenicity assessment: an update from the discussion in the European Bioanalysis Forum	3
High-Throughput MS for Intact Protein Analysis	3
2024 White paper on recent issues in bioanalysis: Impact of LDT in US and IVDR in EU; AI/ML for High Parameter Flow Cytometry; The rise of Olink Technology; CDx for AAV Gene Therapies; Integrative Bio	3
Analytical Considerations to Support Expeditious Formulation Development of Vaccines	3
Direct bioanalysis or indirect calculation of target engagement and free drug exposure: do we apply double standards?	3
Enantioselective electrochemical detection of a L-and D-serine at polyvinylpyrrolidone-modified platinum electrode	3
Measuring HSD17β13 protein turnover in mouse liver with D ₂ O metabolic labeling and hybrid LC-MS	3
Bioanalysis Rising Star Award 2023: announcing our finalists	3
Lessons Learned from the COVID-19 Pandemic and its Impact on Bioanalysis and Drug Development	3
BiSim Tool: a binding simulation tool to aid and simplify ligand-binding assay design and development	3
Research progress of N -nitrosamine detection methods: a review	3
Analytical Comparison of ELISA and Mass Spectrometry for Quantification of Serum Hepcidin in Critically Ill Patients	3
Large Molecule Bioanalysis by LC–MS: Beyond Simply Quantifying	3
Free serum concentrations of antibiotics determined by ultrafiltration: extensive evaluation of experimental variables	3
Development and Validation of Reversed-Phase-HPLC Method for Simultaneous Quantification of Fulvestrant and Disulfiram in Liposomes	3
Volumetric absorptive microsampling–LC–MS/MS assays for quantitation of giredestrant in dried human whole blood	3
Determination of Levofloxacin by HPLC with Fluorescence Detection in Human Breast Milk	3
Development of a validated novel bead extraction method for the detection of anti-PEG antibodies in human serum	3
Development and validation of an antidrug antibody assay for TRK-950 using Melon™ gel and SPEAD pretreatment	3
Green HPLC method for determination of paracetamol and ibuprofen in human plasma: applications to pharmacokinetics	3
A Validated Capillary Microsampling Liquid Chromatography–Tandem Mass Spectrometry Method for Quantification of Antisense Oligonucleotides in Mouse Serum	3
Blood Cell Quantification on Dry Blood Samples: Toward Patient-Centric Complete Blood Counts	3
China's NMPA Perspective on the Clinical Performance of SARS-CoV-2 Antigen Test Reagents	3
Welcome to Volume 14 of Bioanalysis	3
Singlicate analysis in ADA assays: comparing assay performance in duplicate and singlicate formats	3