OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	281
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology ar	252
Delivery of oligonucleotide‐based therapeutics: challenges and opportunities	200
Blood‐based biomarkers for Alzheimer's disease	163
The rapidly evolving view of lysosomal storage diseases	147
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia	142
Mechanisms of small cell lung cancer metastasis	120
NAD ⁺ homeostasis in human health and disease	119
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	108
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau	106
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application	100
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease	97
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion	94
Emerging roles of ATG7 in human health and disease	93
Systemic inflammation after stroke: implications for post‐stroke comorbidities	92
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection	86
Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19	73
Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients	72
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	70
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders	68
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	68
Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads	67
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers	67
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer	67
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection	63

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels	63
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models	62
A comparative analysis of remdesivir and other repurposed antivirals against SARS‐CoV‐2	62
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	59
Pharmacological reversal of synaptic and network pathology in human MECP2 ‐KO neurons and cortical organoids	59
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea	59
The state of the art of bispecific antibodies for treating human malignancies	58
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	58
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis	54
Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients	53
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming	51
Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells	50
Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease	50
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?	49
Fate and propagation of endogenously formed Tau aggregates in neuronal cells	48
Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child	46
A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation	46
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection	44
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts	43
Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7	43
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	43
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness	43
The global emergence of a novel Streptococcus suis clade associated with human infections	42
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma	41
Seasonality of influenza and other respiratory viruses	40
Deletions in CWH43 cause idiopathic normal pressure hydrocephalus	39
Targeting prominin2 transcription to overcome ferroptosis resistance in cancer	39
Biological foundations of successful bacteriophage therapy	39
Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies	38
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation	38
A microRNA signature that correlates with cognition and is a target against cognitive decline	38
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	38
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome	38
Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2	37
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation	37
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin	37
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples	36
Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress	36
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	36
Modeling genetic epileptic encephalopathies using brain organoids	36
Development of a small molecule that corrects misfolding and increases secretion of Z α ₁ ‐antitrypsin	35
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	35
Attenuated CSF‐1R signalling drives cerebrovascular pathology	35
P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease	35
Advances in high‐throughput mass spectrometry in drug discovery	34
Diagnostic biomarkers for active tuberculosis: progress and challenges	34
Biofabricating murine and human myo‐substitutes for rapid volumetric muscle loss restoration	34
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1	33
Ketone body oxidation increases cardiac endothelial cell proliferation	33
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	33

Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	33
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	33
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer	32
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression	32
Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein	32
Aged lipid‐laden microglia display impaired responses to stroke	32
BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?	31
Paneth cells as the cornerstones of intestinal and organismal health: a primer	31
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	31
The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib	31
An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer	31
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection	31
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	31
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype	30
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	30
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease	30
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	30
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death	30
The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis	30
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function	30
Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation	30
Modulation of intrinsic inhibitory checkpoints using nano‐carriers to unleash NK cell activity	29
Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential	29
A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant	29
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	29
The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells	29
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer	29
Synaptic disruption and CREB‐regulated transcription are restored by K ⁺ channel blockers in ALS	28
A Parkinson’s disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress	27
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation	27
SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapies	26
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway	26
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice	26
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	25
Strengthening vaccines and medicines manufacturing capabilities in Africa: challenges and perspectives	25
Non‐genetic heterogeneity, altered cell fate and differentiation therapy	25
Muscle‐directed gene therapy corrects Pompe disease and uncovers species‐specific GAA immunogenicity	25
Dependence receptors: new targets for cancer therapy	25
Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	24
Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease	24
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes	24
Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis	23
PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway	23
MicroRNA‐574 regulates FAM210A expression and influences pathological cardiac remodeling	23
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component	23
Loss of PIKfyve drives the spongiform degeneration in prion diseases	23
TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1,	23
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis	23