OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	353
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	239
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	144
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	142
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	132
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	116
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	96
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	79
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	70
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	68
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	67
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	66
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis	63
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	60
The state of the art of bispecific antibodies for treating human malignancies	60
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	57
Elongator and the role of its subcomplexes in human diseases	56
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	54
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	53
Systemic inflammation after stroke: implications for post‐stroke comorbidities	51
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	51
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	49
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	49
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	49
Diagnostic biomarkers for active tuberculosis: progress and challenges	48

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	47
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	46
Nerve regeneration by interferon intervention in aging brain	45
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	45
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	44
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	44
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	44
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	42
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	41
Advances in high‐throughput mass spectrometry in drug discovery	40
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	40
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	40
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	39
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	39
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	37
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	37
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	36
Mining the bacterial genome to discover new antimicrobial molecules	36
Looking at a baby's heart through the lens of the mother's blood	36
Optimizing the Cas13 antiviral train: cargo and delivery	36
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	35
Sex differences and risk factors for bleeding in Alagille syndrome	35
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	35
The molecular biology of peritoneal metastatic disease	35
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	35
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	34
Deconstructing progressive inflammatory fibrosis in recessive dystrophic epidermolysis bullosa	34
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	34
The human host response to monkeypox infection: a proteomic case series study	33
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	33
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	33
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	32
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	32
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	32
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	32
Immuno(T)herapy for age‐related diseases	32
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	32
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	32
Nanobody‐mediated complement activation to kill HIV‐infected cells	31
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	31
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4⁺ T cells	31
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	30
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	29
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	29
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	29
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)	29
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	29
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	29
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	29
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	28

Dual IRE1 RNase functions dictate glioblastoma development	28
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	28
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	27
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	27
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	27
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα⁺ breast cancer	27
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	27
Development of allogeneic iPS cell‐based therapy: from bench to bedside	27
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	26
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	26
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation	26
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	26
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	26
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	26
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	26