OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 24. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019	228
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID ‐19 patients	213
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	207
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology ar	200
Delivery of oligonucleotide‐based therapeutics: challenges and opportunities	180
SARS ‐CoV‐2, bacterial co‐infections, and AMR : the deadly trio in COVID ‐19?	158
Sarcoma treatment in the era of molecular medicine	149
Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke	147
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia	127
Blood‐based biomarkers for Alzheimer's disease	122
SARS‐CoV‐2 outbreak investigation in a German meat processing plant	121
Why does Japan have so few cases of COVID‐19?	121
The rapidly evolving view of lysosomal storage diseases	119
COVID ‐19: lambda interferon against viral load and hyperinflammation	107
Mechanisms of small cell lung cancer metastasis	101
Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?	100
Rationale for targeting complement in COVID‐19	98
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	97
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau	89
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases	88
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion	86
NAD ⁺ homeostasis in human health and disease	82
A Parkinson's disease Circ RNA s Resource reveals a link between circ SLC 8A1 and oxidative stress	82
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease	82
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection	81

Is BCG vaccination causally related to reduced COVID‐19 mortality?	81
Innovations, challenges, and minimal information for standardization of humanized mice	79
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application	78
Hydroxychloroquine in rheumatic autoimmune disorders and beyond	75
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity	74
Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice	72
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation	70
Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19	68
Emerging roles of ATG7 in human health and disease	63
Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients	62
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders	60
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection	60
A comparative analysis of remdesivir and other repurposed antivirals against SARS‐CoV‐2	59
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer	59
Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress	57
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	56
Improvement of islet transplantation by the fusion of islet cells with functional blood vessels	55
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers	54
Pharmacological reversal of synaptic and network pathology in human MECP2 ‐KO neurons and cortical organoids	53
FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer	52
Kaposiform lymphangiomatosis effectively treated with MEK inhibition	51
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models	51
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control	50
Systemic inflammation after stroke: implications for post‐stroke comorbidities	49
The state of the art of bispecific antibodies for treating human malignancies	49
Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis	48
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?	47
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis	47
MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?	47
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	46
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming	45
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	44
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	44
Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients	42
Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress	42
Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease	42
Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells	41
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea	41
Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes	41
FBXL 4 deficiency increases mitochondrial removal by autophagy	41
Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads	40
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection	40
Fate and propagation of endogenously formed Tau aggregates in neuronal cells	39
Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7	39
LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma	39
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness	39
Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors	38
Disease‐specific phenotypes in iPSC ‐derived neural stem cells with POLG mutations	37
Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child	37
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin	36

A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation	36
Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ ALS / FTD is rescued by SV	35
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors	35
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation	35
Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2	35
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts	35
Micro RNA ‐483 amelioration of experimental pulmonary hypertension	34
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome	34
IL ‐10 producing type 2 innate lymphoid cells prolong islet allograft survival	34
The global emergence of a novel Streptococcus suis clade associated with human infections	33
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma	33
SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells	32
Dietary magnesium supplementation improves lifespan in a mouse model of progeria	32
Development of a small molecule that corrects misfolding and increases secretion of Z α ₁ ‐antitrypsin	32
The prospects for the SARS ‐CoV‐2 pandemic in Africa	32
‘All In’: a pragmatic framework for COVID‐19 testing and action on a global scale	31
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	31
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples	31
Deletions in CWH43 cause idiopathic normal pressure hydrocephalus	31
COVID ‐19 pandemic‐related lockdown: response time is more important than its strictness	30
Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein	30
Attenuated CSF‐1R signalling drives cerebrovascular pathology	30
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM 1 epilepsy	30
Biofabricating murine and human myo‐substitutes for rapid volumetric muscle loss restoration	30
The mutational landscape of the SCAN ‐B real‐world primary breast cancer transcriptome	30
P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease	30
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	30
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection	29
Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages	29
Biological foundations of successful bacteriophage therapy	29
Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress	29
A microRNA signature that correlates with cognition and is a target against cognitive decline	29
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer	29
BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?	29
PI 3‐kinase delta enhances axonal PIP ₃ to support axon regeneration in the adult CNS	29
Ketone body oxidation increases cardiac endothelial cell proliferation	29
Targeting prominin2 transcription to overcome ferroptosis resistance in cancer	28
Seasonality of influenza and other respiratory viruses	28
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype	28
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve	28
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death	28
The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells	28
A Parkinson’s disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress	27
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	27
HER3 targeting with an antibody‐drug conjugate bypasses resistance to anti‐HER2 therapies	27
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	27
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	27
Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis	27
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation	27
A combination of two human monoclonal antibodies cures symptomatic rabies	26
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	26
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	26
Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies	26
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease	26
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression	26
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1	26
Resolving mechanisms of immune‐mediated disease in primary CD 4 T cells	26
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer	26
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function	26
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies	25
Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation	25
STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells	25
The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis	25
SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapies	25
An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer	25
Modeling genetic epileptic encephalopathies using brain organoids	24
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice	24