OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4⁺ T cells	281
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	221
Liquid biopsy: blood‐based analyses of circulating cell‐free DNA in xenografts	163
Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer	119
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	108
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	106
Combinatorial activation of the WNT‐dependent fibrogenic program by distinct complement subunits in dystrophic muscle	100
Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy	98
Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients	94
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	93
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	76
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder	72
PI3Kα targeting, nipping pancreatic cancer evolution in the bud	72
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	71
Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics	68
Lifting the iron curtain of vision	67
The genetic regulation of protein expression in cerebrospinal fluid	63
SARS‐CoV ‐2 spike protein enhances MAP4K3 / GLK ‐induced ACE2 stability	62
Low immunogenicity of malaria pre‐erythrocytic stages can be overcome by vaccination	59
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	59
Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome	58
Targeting CD301⁺ macrophages inhibits endometrial fibrosis and improves pregnancy outcome	58
Dependence receptors: new targets for cancer therapy	55
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors	50
Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells	49

Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	46
PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice	43
Immunological barriers to immunotherapy in primary and metastatic breast cancer	43
FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice	43
From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors	42
CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma	41
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype	41
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	39
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	39
M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation	39
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	38
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	38
Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity	38
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo	37
Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response	37
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	37
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	37
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	36
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	36
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	36
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	36
Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide	35
Nanobody‐mediated complement activation to kill HIV‐infected cells	35
Axin2 coupled excessive Wnt‐glycolysis signaling mediates social defect in autism spectrum disorders	34
Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency	34
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)	34
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation	33
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	33
uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils	33
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression	33
Aged lipid‐laden microglia display impaired responses to stroke	33
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	33
Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2	32
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis	32
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	32
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer	32
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	31
NF45/NF90‐mediated rDNA transcription provides a novel target for immunosuppressant development	31
Conformational change of adenine nucleotide translocase‐1 mediates cisplatin resistance induced by EBV‐LMP1	31
Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species‐specific barrier	31
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	30
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression	30
HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations	30
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	30
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2	29
Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity	29
Nanog maintains stemness of Lkb1 ‐deficient lung adenocarcinoma and prevents gastric differentiation	29
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	29
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	29
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea	29

Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	29
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts	28
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?	27
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα⁺ breast cancer	26
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	26
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	26
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	25
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice	25
Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons	25
LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy	25
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	25
Targeting rare tumors: new focus for clinical research in China	24
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming	24
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	24
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	24
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	23
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes	23
A new chapter of healthy indoor air: antiviral air treatments	23
Can THEM6 targeting stop resistance to prostate cancer treatment?	23
HMBA ameliorates obesity by MYH9‐ and ACTG1‐dependent regulation of hypothalamic neuropeptides	23
Shiga toxin (Stx) type 2‐induced increase in O‐linked N‐acetyl glucosamine protein modification: a new therapeutic target?	22
Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses	22
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	22
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	22
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance	21
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	21
Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	21
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma	21
Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential	21
The state of the art of bispecific antibodies for treating human malignancies	21
rs41291957 controls miR‐143 and miR‐145 expression and impacts coronary artery disease risk	21
Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis	20
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	20
The tumor cell‐derived matrix of lobular breast cancer: a new vulnerability	20
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	20
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	20
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	20