OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 21. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-01-01 to 2025-01-01.)

Article	Citations
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4⁺ T cells	281
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	221
Liquid biopsy: blood‐based analyses of circulating cell‐free DNA in xenografts	163
Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer	147
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	119
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	108
Combinatorial activation of the WNT‐dependent fibrogenic program by distinct complement subunits in dystrophic muscle	106
Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy	100
Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients	98
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	97
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	94
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder	93
PI3Kα targeting, nipping pancreatic cancer evolution in the bud	76
Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics	72
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	72
Lifting the iron curtain of vision	71
The genetic regulation of protein expression in cerebrospinal fluid	68
SARS‐CoV ‐2 spike protein enhances MAP4K3 / GLK ‐induced ACE2 stability	67
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	63
Low immunogenicity of malaria pre‐erythrocytic stages can be overcome by vaccination	62
Targeting CD301⁺ macrophages inhibits endometrial fibrosis and improves pregnancy outcome	59
Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome	59
Dependence receptors: new targets for cancer therapy	58
Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors	58
Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells	55

Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	53
FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice	50
Immunological barriers to immunotherapy in primary and metastatic breast cancer	50
PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice	49
From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors	46
CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma	43
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype	43
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	43
M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation	42
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	41
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	41
Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response	39
Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity	39
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	39
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	39
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	38
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	38
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo	38
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	38
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	37
Nanobody‐mediated complement activation to kill HIV‐infected cells	37
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	37
Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide	37
uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils	36
Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency	36
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)	36
Axin2 coupled excessive Wnt‐glycolysis signaling mediates social defect in autism spectrum disorders	36
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation	35
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression	35
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	35
Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2	34
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	34
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer	34
Concurrent targeting of glycolysis in bacteria and host cell inflammation in septic arthritis	33
Conformational change of adenine nucleotide translocase‐1 mediates cisplatin resistance induced by EBV‐LMP1	33
HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations	33
Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species‐specific barrier	33
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	33
NF45/NF90‐mediated rDNA transcription provides a novel target for immunosuppressant development	33
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	32
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	32
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression	32
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	32
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2	31
Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients	31
Nanog maintains stemness of Lkb1 ‐deficient lung adenocarcinoma and prevents gastric differentiation	31
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea	31
Aged lipid‐laden microglia display impaired responses to stroke	30
Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity	30
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	30

Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	30
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	30
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts	29
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	29
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα⁺ breast cancer	29
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?	29
Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons	29
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	29
LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy	29
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	28
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice	27
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	26
Targeting rare tumors: new focus for clinical research in China	26
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming	26
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes	25
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	25
HMBA ameliorates obesity by MYH9‐ and ACTG1‐dependent regulation of hypothalamic neuropeptides	25
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	25
A new chapter of healthy indoor air: antiviral air treatments	25
Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses	24
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	24
Shiga toxin (Stx) type 2‐induced increase in O‐linked N‐acetyl glucosamine protein modification: a new therapeutic target?	24
Can THEM6 targeting stop resistance to prostate cancer treatment?	24
Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	23
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease	23
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	23
rs41291957 controls miR‐143 and miR‐145 expression and impacts coronary artery disease risk	23
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	23
Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential	22
The state of the art of bispecific antibodies for treating human malignancies	22
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	22
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma	22
Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis	21
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	21
The tumor cell‐derived matrix of lobular breast cancer: a new vulnerability	21
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	21
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance	21
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	21
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	21