OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	222
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	180
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	117
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	97
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	89
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	86
Elongator and the role of its subcomplexes in human diseases	78
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	74
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	73
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	64
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	63
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	63
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vi	62
Diagnostic biomarkers for active tuberculosis: progress and challenges	61
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	60
Systemic inflammation after stroke: implications for post‐stroke comorbidities	58
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	57
Nerve regeneration by interferon intervention in aging brain	53
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	51
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	51
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	50
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	49
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	49
Looking at a baby's heart through the lens of the mother's blood	48
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	48

Optimizing the Cas13 antiviral train: cargo and delivery	47
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	47
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	47
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using	46
Blocking STAT3 /5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	45
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV	45
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	44
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	43
Advances in high‐throughput mass spectrometry in drug discovery	42
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	41
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	41
Sex differences and risk factors for bleeding in Alagille syndrome	40
The human host response to monkeypox infection: a proteomic case series study	40
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	39
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	38
Immuno(T)herapy for age‐related diseases	38
The molecular biology of peritoneal metastatic disease	37
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	37
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	36
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	36
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	35
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	35
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ecto	35
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	33
Nanobody‐mediated complement activation to kill HIV ‐infected cells	33
IL ‐27 produced during acute malaria infection regulates Plasmodium ‐specific memory CD4	33
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	32
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	32
Answer to Gerber et al. “ Autosomal recessive pathogenic MSTO1	31
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV ‐2 mouse models of infection	31
TAPT1 —at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	31
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	31
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	30
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα ⁺ b	30
Development of allogeneic iPS cell‐based therapy: from bench to bedside	30