OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	228
Elongator and the role of its subcomplexes in human diseases	183
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	120
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	94
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	90
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	80
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	78
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	76
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells	66
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	66
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	63
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	62
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	62
Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation	60
Diagnostic biomarkers for active tuberculosis: progress and challenges	59
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	58
Systemic inflammation after stroke: implications for post‐stroke comorbidities	58
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	54
Nerve regeneration by interferon intervention in aging brain	54
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	53
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	50
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	49
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	49
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	48
Optimizing the Cas13 antiviral train: cargo and delivery	48

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2	48
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	48
Advances in high‐throughput mass spectrometry in drug discovery	48
Looking at a baby's heart through the lens of the mother's blood	44
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	44
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	43
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	42
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	42
Erratum To: ALX1‐related frontonasal dysplasia results from defective neural crest cell development and migration	42
Sex differences and risk factors for bleeding in Alagille syndrome	41
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	41
Immuno(T)herapy for age‐related diseases	40
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	40
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	38
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	38
The human host response to monkeypox infection: a proteomic case series study	37
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	37
The molecular biology of peritoneal metastatic disease	37
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	37
miR‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	37
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	35
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	34
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	34
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	33
Development of allogeneic iPS cell‐based therapy: from bench to bedside	32
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	32
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	32
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	32
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	32
Nanobody‐mediated complement activation to kill HIV‐infected cells	32
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	31
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	31