OOIR: Observatory of International Research

Papers

(The median citation count of EMBO Molecular Medicine is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	247
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	195
Elongator and the role of its subcomplexes in human diseases	127
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	97
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	94
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	85
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	82
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	80
Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation	72
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	70
Diagnostic biomarkers for active tuberculosis: progress and challenges	68
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	68
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	65
Systemic inflammation after stroke: implications for post‐stroke comorbidities	61
Nerve regeneration by interferon intervention in aging brain	60
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	58
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	57
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	54
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	53
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2	53
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	53
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	52
Looking at a baby's heart through the lens of the mother's blood	51
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	51
Optimizing the Cas13 antiviral train: cargo and delivery	47

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	45
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	45
Sex differences and risk factors for bleeding in Alagille syndrome	44
Advances in high‐throughput mass spectrometry in drug discovery	44
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	44
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	43
Immuno(T)herapy for age‐related diseases	43
The human host response to monkeypox infection: a proteomic case series study	42
The molecular biology of peritoneal metastatic disease	42
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	39
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	38
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	38
Nanobody‐mediated complement activation to kill HIV‐infected cells	37
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	37
miR‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	36
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	36
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	35
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	34
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	34
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	33
Development of allogeneic iPS cell‐based therapy: from bench to bedside	33
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	33
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	32
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	32
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	32
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	32
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	31
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	31
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	30
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	29
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	28
Targeting the liver to treat the eye	28
Erratum To: MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	28
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	28
Antagonizing microRNA‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice	28
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	28
Intestinal Apc‐inactivation induces HSP25 dependency	27
Repurposing immunosuppressants for antileukemia therapy	27
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	27
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	26
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation	26
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	25
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	25
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	25
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	25
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	24
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	24
Erratum To: Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	24
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	24
Erratum To: Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	24

Liver‐directed gene therapy for ornithine aminotransferase deficiency	24
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	23
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	23
A catalog of numerical centrosome defects in epithelial ovarian cancers	23
Maternal diet and gut microbiome composition modulate early‐life immune development	23
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	22
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID‐19 lung lesions	22
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	22
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	22
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation	21
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma	21
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	21
Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer	21
Targeting CRAC channels in inflammatory bowel disease	21
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	20
Erratum To: Dual IRE1 RNase functions dictate glioblastoma development	20
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	19
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	19
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	19
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary	18
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	18
Microbial metabolites in chronic heart failure and its common comorbidities	18
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies	18
Neuropilin‐1 (NRP1) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	18
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	18
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	18
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	18
Acquired immunity against SARS‐CoV‐2 infection and vaccination	18