EMBO Molecular Medicine

Article	Citations
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	281
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology ar	252
Delivery of oligonucleotide‐based therapeutics: challenges and opportunities	200
Blood‐based biomarkers for Alzheimer's disease	163
The rapidly evolving view of lysosomal storage diseases	147
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia	142
Mechanisms of small cell lung cancer metastasis	120
NAD + homeostasis in human health and disease	119
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	108
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau	106
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application	100
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease	97
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion	94
Emerging roles of ATG7 in human health and disease	93
Systemic inflammation after stroke: implications for post‐stroke comorbidities	92
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection	86
Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19	73
Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients	72
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	70
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders	68
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	68
Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads	67
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers	67
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer	67
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection	63

Improvement of islet transplantation by the fusion of islet cells with functional blood vessels	63
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models	62
A comparative analysis of remdesivir and other repurposed antivirals against SARS‐CoV‐2	62
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	59
Pharmacological reversal of synaptic and network pathology in human MECP2 ‐KO neurons and cortical organoids	59
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea	59
The state of the art of bispecific antibodies for treating human malignancies	58
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	58
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis	54
Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients	53
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming	51
Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells	50
Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease	50
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?	49
Fate and propagation of endogenously formed Tau aggregates in neuronal cells	48
Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child	46
A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation	46
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection	44
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts	43
Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7	43
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	43
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness	43
The global emergence of a novel Streptococcus suis clade associated with human infections	42
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma	41
Seasonality of influenza and other respiratory viruses	40
Deletions in CWH43 cause idiopathic normal pressure hydrocephalus	39
Targeting prominin2 transcription to overcome ferroptosis resistance in cancer	39
Biological foundations of successful bacteriophage therapy	39
Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies	38
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation	38
A microRNA signature that correlates with cognition and is a target against cognitive decline	38
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	38
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome	38
Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2	37
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation	37
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin	37
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples	36
Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress	36
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	36
Modeling genetic epileptic encephalopathies using brain organoids	36
Development of a small molecule that corrects misfolding and increases secretion of Z α 1 ‐antitrypsin	35
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	35
Attenuated CSF‐1R signalling drives cerebrovascular pathology	35
P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease	35
Biofabricating murine and human myo‐substitutes for rapid volumetric muscle loss restoration	34
Advances in high‐throughput mass spectrometry in drug discovery	34
Diagnostic biomarkers for active tuberculosis: progress and challenges	34
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	33
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1	33
Ketone body oxidation increases cardiac endothelial cell proliferation	33

A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	33
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	33
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer	32
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression	32
Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein	32
Aged lipid‐laden microglia display impaired responses to stroke	32
BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?	31
Paneth cells as the cornerstones of intestinal and organismal health: a primer	31
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	31
The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib	31
An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer	31
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection	31
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	31
The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis	30
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function	30
Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation	30
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype	30
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	30
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease	30
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	30
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death	30
The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells	29
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer	29
Modulation of intrinsic inhibitory checkpoints using nano‐carriers to unleash NK cell activity	29
Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential	29
A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant	29
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	29
Synaptic disruption and CREB‐regulated transcription are restored by K + channel blockers in ALS	28
A Parkinson’s disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress	27
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation	27
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice	26
SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapies	26
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway	26
Muscle‐directed gene therapy corrects Pompe disease and uncovers species‐specific GAA immunogenicity	25
Dependence receptors: new targets for cancer therapy	25
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	25
Strengthening vaccines and medicines manufacturing capabilities in Africa: challenges and perspectives	25
Non‐genetic heterogeneity, altered cell fate and differentiation therapy	25
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes	24
Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	24
Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease	24
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component	23
Loss of PIKfyve drives the spongiform degeneration in prion diseases	23
TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1,	23
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis	23
Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis	23
PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway	23
MicroRNA‐574 regulates FAM210A expression and influences pathological cardiac remodeling	23
Targeting netrin‐3 in small cell lung cancer and neuroblastoma	22
Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species‐specific barrier	22
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	22
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo	22
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	22
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	22
Targeted genome editingin vivocorrects aDmdduplication restoring wild‐type dystrophin expression	21
LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma	21
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria	21
Pro‐inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang‐(1‐7)	21
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein	21
Is there an unmet medical need for improved hearing restoration?	20
Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS	20
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	20
SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity	20
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	20
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	20
Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease	20
SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytes	19
sTREM2 is associated with amyloid‐related p‐tau increases and glucose hypermetabolism in Alzheimer's disease	19
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression	19
Mycobacterium tuberculosis Rv2626c‐derived peptide as a therapeutic agent for sepsis	19
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	19
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	19
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	19
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches	19
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	19
The genetic regulation of protein expression in cerebrospinal fluid	19
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	18
Epigenetic gene expression links heart failure to memory impairment	18
Quantitative protein biomarker panels: a path to improved clinical practice through proteomics	18
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	18

Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis	18
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	18
Maternal diet and gut microbiome composition modulate early‐life immune development	18
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent	18
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	18
Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders	18
Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells	18
MiR ‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer	18
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	18
BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS	18
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	18
Bi‐allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis‐like disease	17
rs41291957 controls miR‐143 and miR‐145 expression and impacts coronary artery disease risk	17
Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients	17
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	17
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	17
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	17
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	17
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	17
Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity	17
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes	16
The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors	16
Malaria parasites differentially sense environmental elasticity during transmission	16
Targeted stabilization of Munc18‐1 function via pharmacological chaperones	16
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	16
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	16
A new ALK inhibitor overcomes resistance to first‐ and second‐generation inhibitors in NSCLC	16
Systemically targeted cancer immunotherapy and gene delivery using transmorphic particles	16
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome	15
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis	15
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia	15
Nirmatrelvir treatment of SARS‐CoV‐2‐infected mice blunts antiviral adaptive immune responses	15
SARS‐CoV ‐2 spike protein enhances MAP4K3 / GLK ‐induced ACE2 stability	15
The human host response to monkeypox infection: a proteomic case series study	15
CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity	15
Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury	15
CRISPR screens identify tumor‐promoting genes conferring melanoma cell plasticity and resistance	15
The molecular biology of peritoneal metastatic disease	15
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	15
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models	15
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	15
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	15
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	14
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	14
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	14
Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice	14
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	14
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	14
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	14
Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity	14
A universal SARS‐CoV DNA vaccine inducing highly cross‐reactive neutralizing antibodies and T cells	14
Conformational change of adenine nucleotide translocase‐1 mediates cisplatin resistance induced by EBV‐LMP1	14
A catalog of numerical centrosome defects in epithelial ovarian cancers	14
Macrophages inhibit Coxiella burnetii by the ACOD1 ‐itaconate pathway for containment of Q fever	14
Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis	14
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	14
Functional divergence of the two Elongator subcomplexes during neurodevelopment	13
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	13
LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy	13
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	13
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	13
KRAS signaling in malignant pleural mesothelioma	13
Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy	13
CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma	13
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease	13
Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth	13
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2	13
Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation	12
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism	12
Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses	12
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	12
Unexpected PD‐L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies	12
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	12
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype	12
Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects	12
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma	12
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance	12
From netrin‐1‐targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors	12
Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS ‐mutant cancer	11
SARS‐CoV‐2 Omicron emergence urges for reinforced One‐Health surveillance	11
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	11
Targeting shared molecular etiologies to accelerate drug development for rare diseases	11
Assessing and enhancing migration of human myogenic progenitors using directed iPS cell differentiation and advanced tissue modelling	11
Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy	11
The AhR‐SRC axis as a therapeutic vulnerability in BRAFi‐resistant melanoma	11
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	11
Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes	11
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	11
ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer	11
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy	11
HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations	11