EMBO Molecular Medicine

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	327
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	212
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	144
uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils	133
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	130
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	125
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	123
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	115
Elongator and the role of its subcomplexes in human diseases	109
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	100
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis	87
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	84
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	81
The state of the art of bispecific antibodies for treating human malignancies	68
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	65
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	64
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	63
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	61
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	60
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	55
Bi‐allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis‐like disease	54
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	54
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	54
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	53
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	53

Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	53
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	51
Systemic inflammation after stroke: implications for post‐stroke comorbidities	50
Nerve regeneration by interferon intervention in aging brain	48
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	48
Diagnostic biomarkers for active tuberculosis: progress and challenges	48
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	47
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	47
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation	46
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	46
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	45
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	44
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	44
Identification of TAPBPL as a novel negative regulator of T‐cell function	43
Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects	43
Optimizing the Cas13 antiviral train: cargo and delivery	42
Looking at a baby's heart through the lens of the mother's blood	41
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	40
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	40
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	40
Mining the bacterial genome to discover new antimicrobial molecules	39
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	39
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	38
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	38
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	38
Advances in high‐throughput mass spectrometry in drug discovery	37
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	37
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	37
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component	36
Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity	36
Sex differences and risk factors for bleeding in Alagille syndrome	35
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	35
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	35
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches	34
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	34
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	34
Deconstructing progressive inflammatory fibrosis in recessive dystrophic epidermolysis bullosa	34
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	33
Immuno(T)herapy for age‐related diseases	33
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	33
The human host response to monkeypox infection: a proteomic case series study	33
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	32
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau	32
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	32
The molecular biology of peritoneal metastatic disease	32
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	32
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	32
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	31
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	31
CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma	31

Nanobody‐mediated complement activation to kill HIV‐infected cells	31
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	31
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	30
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	30
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	29
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	29
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	29
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)	29
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	29
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	28
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	28
Dual IRE1 RNase functions dictate glioblastoma development	28
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	28
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	28
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	27
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	27
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	27
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	27
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	27
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	27
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	27
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	26
microRNAs trip down memory lane	26
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	26
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	26
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	26
Development of allogeneic iPS cell‐based therapy: from bench to bedside	26
RNAi to treat SARS‐CoV‐2—variant proofing the next generation of therapies	26
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	25
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	25
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation	25
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy	25
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	25
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease	24
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	24
COVID‐19 vaccination, time for a second breath?	24
Targeting the liver to treat the eye	24
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma	24
SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapies	24
MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	23
Repurposing immunosuppressants for antileukemia therapy	22
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	22
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	22
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation	22
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	22
Individual COVID‐19 disease trajectories revealed by plasma proteomics	22
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	22
Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy	22
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer	22
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	22
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	21
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	21
Functional genomics approaches to improve pre‐clinical drug screening and biomarker discovery	21
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	21
Intestinal Apc‐inactivation induces HSP25 dependency	21
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	21
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	20
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	20
Early 5‐HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	20
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent	20
Maternal diet and gut microbiome composition modulate early‐life immune development	20
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	20
Antagonizing microRNA ‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice	20
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	20
Machine learning algorithms reveal the secrets of mitochondrial dynamics	20
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	20
Liver‐directed gene therapy for ornithine aminotransferase deficiency	20
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	20
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	20
Seasonality of influenza and other respiratory viruses	20
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	20
A catalog of numerical centrosome defects in epithelial ovarian cancers	20
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	19
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	19
Immunological barriers to immunotherapy in primary and metastatic breast cancer	19
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	19
PI3Kα targeting, nipping pancreatic cancer evolution in the bud	19
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	18
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	18
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	18

Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	18
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	18
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	18
Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer	18
Dependence receptors: new targets for cancer therapy	18
Can THEM6 targeting stop resistance to prostate cancer treatment?	17
Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	17
Sensitivity towards HDAC inhibition is associated with RTK / MAPK pathway activation in gastric	17
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	17
The global emergence of a novel Streptococcus suis clade associated with human infections	17
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria	17
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	17
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation	16
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma	16
NAD + homeostasis in human health and disease	16
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	16
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	15
Fuse your mitochondria, lose appetite: an anorexic, anti‐obesity sphingolipid	15
Dual IRE1 RNase functions dictate glioblastoma development	15
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	15
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	15
Emerging roles of ATG7 in human health and disease	15
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary	15
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis	15
Targeting CRAC channels in inflammatory bowel disease	15
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	15
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies	15
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	14
Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host	14
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	14
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	14
Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2	14
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	14
Genetically modified macrophages accelerate myelin repair	14
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	14
Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS ‐mutant cancer	14
Modeling genetic epileptic encephalopathies using brain organoids	14
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	14
Acquired immunity against SARS‐CoV‐2 infection and vaccination	13
Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	13
Microbial metabolites in chronic heart failure and its common comorbidities	13
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	13
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	13
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	13
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome	13
Lifting the iron curtain of vision	13
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder	13
Nanog maintains stemness of Lkb1 ‐deficient lung adenocarcinoma and prevents gastric differentiation	13
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2	13
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	13
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	13