EMBO Molecular Medicine

Article	Citations
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	358
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	242
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	152
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	147
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	137
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	124
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	82
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	70
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	70
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	69
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	67
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis	65
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	60
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	59
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	54
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	53
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	53
Elongator and the role of its subcomplexes in human diseases	53
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	51
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	51
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	50
Diagnostic biomarkers for active tuberculosis: progress and challenges	50
Systemic inflammation after stroke: implications for post‐stroke comorbidities	48
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	48
Nerve regeneration by interferon intervention in aging brain	45

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	45
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	45
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	44
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	44
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	44
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	43
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	42
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	40
Looking at a baby's heart through the lens of the mother's blood	39
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	39
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	39
Optimizing the Cas13 antiviral train: cargo and delivery	38
Mining the bacterial genome to discover new antimicrobial molecules	38
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	37
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	37
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	37
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	36
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	36
Advances in high‐throughput mass spectrometry in drug discovery	36
Sex differences and risk factors for bleeding in Alagille syndrome	35
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	35
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	35
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	35
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	34
The human host response to monkeypox infection: a proteomic case series study	34
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	34
Deconstructing progressive inflammatory fibrosis in recessive dystrophic epidermolysis bullosa	33
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	33
The molecular biology of peritoneal metastatic disease	33
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	33
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	33
Immuno(T)herapy for age‐related diseases	33
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	32
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	32
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	32
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	32
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	32
Nanobody‐mediated complement activation to kill HIV‐infected cells	32
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	31
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	31
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	31
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	29
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	29
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	29
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	29
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	29
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	29
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	28
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	28
Dual IRE1 RNase functions dictate glioblastoma development	28

Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	28
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	27
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	27
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	27
Development of allogeneic iPS cell‐based therapy: from bench to bedside	27
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	27
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	26
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	26
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	26
RNAi to treat SARS‐CoV‐2—variant proofing the next generation of therapies	25
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy	25
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	25
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	25
microRNAs trip down memory lane	25
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	25
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	24
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation	24
Targeting the liver to treat the eye	24
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease	24
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	24
MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	23
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	23
COVID‐19 vaccination, time for a second breath?	23
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma	23
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	23
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer	22
Repurposing immunosuppressants for antileukemia therapy	22
Antagonizing microRNA ‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice	22
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	22
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	22
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	21
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	21
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	21
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	21
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	21
Intestinal Apc‐inactivation induces HSP25 dependency	21
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation	21
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	21
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	20
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	20
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	20
Seasonality of influenza and other respiratory viruses	20
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	20
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent	20
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	20
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	20
A catalog of numerical centrosome defects in epithelial ovarian cancers	20
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	19
Maternal diet and gut microbiome composition modulate early‐life immune development	19
Early 5‐HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	19
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	19
Liver‐directed gene therapy for ornithine aminotransferase deficiency	19
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	19
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	19
Sensitivity towards HDAC inhibition is associated with RTK / MAPK pathway activation in gastric	18
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation	18
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	18
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma	18
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	18
Can THEM6 targeting stop resistance to prostate cancer treatment?	18
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	18
Targeting CRAC channels in inflammatory bowel disease	18
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	18
Dependence receptors: new targets for cancer therapy	18
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	17
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis	17
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	17
Dual IRE1 RNase functions dictate glioblastoma development	17
Genetically modified macrophages accelerate myelin repair	17
Emerging roles of ATG7 in human health and disease	17
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	17
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	17
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	16
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	16
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	16
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	16
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary	16
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	16
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies	16
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome	15

Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	15
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	15
Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host	15
Acquired immunity against SARS‐CoV‐2 infection and vaccination	15
Microbial metabolites in chronic heart failure and its common comorbidities	15
Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	15
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	15
Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics	15