OOIR: Observatory of International Research

Papers

(The median citation count of EMBO Molecular Medicine is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	228
Elongator and the role of its subcomplexes in human diseases	183
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	120
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	94
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	90
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	80
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	78
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	76
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells	66
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	66
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	63
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	62
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	62
Eosinophil‐derived IL‐4 is necessary to establish the inflammatory structure in innate inflammation	60
Diagnostic biomarkers for active tuberculosis: progress and challenges	59
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	58
Systemic inflammation after stroke: implications for post‐stroke comorbidities	58
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	54
Nerve regeneration by interferon intervention in aging brain	54
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	53
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	50
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	49
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	49
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	48
Optimizing the Cas13 antiviral train: cargo and delivery	48

An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2	48
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	48
Advances in high‐throughput mass spectrometry in drug discovery	48
Looking at a baby's heart through the lens of the mother's blood	44
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	44
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	43
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	42
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	42
Erratum To: ALX1‐related frontonasal dysplasia results from defective neural crest cell development and migration	42
Sex differences and risk factors for bleeding in Alagille syndrome	41
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	41
Immuno(T)herapy for age‐related diseases	40
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	40
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	38
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	38
The human host response to monkeypox infection: a proteomic case series study	37
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	37
The molecular biology of peritoneal metastatic disease	37
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	37
miR‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	37
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	35
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	34
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	34
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	33
Development of allogeneic iPS cell‐based therapy: from bench to bedside	32
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	32
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	32
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	32
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	32
Nanobody‐mediated complement activation to kill HIV‐infected cells	32
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	31
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	31
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	30
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	30
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	30
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	29
Targeting the liver to treat the eye	27
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	27
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	27
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	27
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	27
Erratum To: MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	27
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	27
Intestinal Apc‐inactivation induces HSP25 dependency	26
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	26
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	26
Clinical grade ACE2 as a universal agent to block SARS‐CoV‐2 variants	26
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	25
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	25
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	25

Repurposing immunosuppressants for antileukemia therapy	25
Erratum To: Early 5‐HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	24
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	24
Erratum To: Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	24
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation	24
Antagonizing microRNA‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice	24
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	23
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	23
Maternal diet and gut microbiome composition modulate early‐life immune development	23
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	23
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	22
Liver‐directed gene therapy for ornithine aminotransferase deficiency	22
A catalog of numerical centrosome defects in epithelial ovarian cancers	22
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	21
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	21
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	21
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	21
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID‐19 lung lesions	21
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma	20
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation	20
Targeting CRAC channels in inflammatory bowel disease	20
Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer	20
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	19
Erratum To: Dual IRE1 RNase functions dictate glioblastoma development	19
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	19
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	19
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	19
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	18
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	18
Genetically modified macrophages accelerate myelin repair	18
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	18
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies	18
Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis	18
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary	18
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	18
Acquired immunity against SARS‐CoV‐2 infection and vaccination	17
Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer	17
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	17
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	17
Lifting the iron curtain of vision	17
Neuropilin‐1 (NRP1) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	17
Microbial metabolites in chronic heart failure and its common comorbidities	17
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	17