EMBO Molecular Medicine

Article	Citations
The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019	224
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID ‐19 patients	213
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	197
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology ar	193
Delivery of oligonucleotide‐based therapeutics: challenges and opportunities	178
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads	160
SARS ‐CoV‐2, bacterial co‐infections, and AMR : the deadly trio in COVID ‐19?	156
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region	151
Sarcoma treatment in the era of molecular medicine	147
Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke	143
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia	125
SARS‐CoV‐2 outbreak investigation in a German meat processing plant	120
Why does Japan have so few cases of COVID‐19?	120
The rapidly evolving view of lysosomal storage diseases	117
Blood‐based biomarkers for Alzheimer's disease	115
COVID ‐19: lambda interferon against viral load and hyperinflammation	107
Mechanisms of small cell lung cancer metastasis	100
Rationale for targeting complement in COVID‐19	98
Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?	97
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	97
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau	86
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases	85
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion	84
NAD + homeostasis in human health and disease	82
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease	81

Is BCG vaccination causally related to reduced COVID‐19 mortality?	80
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection	80
A Parkinson's disease Circ RNA s Resource reveals a link between circ SLC 8A1 and oxidative stress	80
Innovations, challenges, and minimal information for standardization of humanized mice	77
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity	75
Hydroxychloroquine in rheumatic autoimmune disorders and beyond	72
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application	71
Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice	71
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation	69
Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19	66
Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients	60
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection	59
A comparative analysis of remdesivir and other repurposed antivirals against SARS‐CoV‐2	59
Emerging roles of ATG7 in human health and disease	59
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer	57
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders	57
Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress	56
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	55
Improvement of islet transplantation by the fusion of islet cells with functional blood vessels	54
Pharmacological reversal of synaptic and network pathology in human MECP2 ‐KO neurons and cortical organoids	53
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers	52
Targeting the pregnane X receptor using microbial metabolite mimicry	51
FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer	51
Towards the optical cochlear implant: optogenetic approaches for hearing restoration	50
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control	50
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models	49
The state of the art of bispecific antibodies for treating human malignancies	48
Systemic inflammation after stroke: implications for post‐stroke comorbidities	47
Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis	47
Kaposiform lymphangiomatosis effectively treated with MEK inhibition	47
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis	47
MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?	46
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?	46
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	44
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming	43
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	43
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	42
Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients	41
Maintaining protein stability of ∆Np63 via USP 28 is required by squamous cancer cells	41
Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes	41
Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress	40
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea	40
Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells	40
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection	40
Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease	40
FBXL 4 deficiency increases mitochondrial removal by autophagy	40
Fate and propagation of endogenously formed Tau aggregates in neuronal cells	39
A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming	39
LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma	39
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness	37

Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors	37
Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child	37
Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7	36
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin	36
Disease‐specific phenotypes in iPSC ‐derived neural stem cells with POLG mutations	36
Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2	35
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors	34
Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ ALS / FTD is rescued by SV	34
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation	34
A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation	34
Micro RNA ‐483 amelioration of experimental pulmonary hypertension	34
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome	34
IL ‐10 producing type 2 innate lymphoid cells prolong islet allograft survival	34
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts	34
Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer	33
The global emergence of a novel Streptococcus suis clade associated with human infections	32
The prospects for the SARS ‐CoV‐2 pandemic in Africa	32
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma	32
Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads	32
SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells	31
Deletions in CWH43 cause idiopathic normal pressure hydrocephalus	31
Development of a small molecule that corrects misfolding and increases secretion of Z α 1 ‐antitrypsin	31
Dietary magnesium supplementation improves lifespan in a mouse model of progeria	31
‘All In’: a pragmatic framework for COVID‐19 testing and action on a global scale	31
COVID ‐19 pandemic‐related lockdown: response time is more important than its strictness	30
Attenuated CSF‐1R signalling drives cerebrovascular pathology	30
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection	29
PI 3‐kinase delta enhances axonal PIP 3 to support axon regeneration in the adult CNS	29
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples	29
Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress	29
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer	29
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	29
Biofabricating murine and human myo‐substitutes for rapid volumetric muscle loss restoration	29
The mutational landscape of the SCAN ‐B real‐world primary breast cancer transcriptome	29
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM 1 epilepsy	29
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype	28
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	28
Ketone body oxidation increases cardiac endothelial cell proliferation	28
BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?	28
Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages	28
P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease	28
Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein	28
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve	28
HER3 targeting with an antibody‐drug conjugate bypasses resistance to anti‐HER2 therapies	27
Seasonality of influenza and other respiratory viruses	27
Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis	27
Targeting prominin2 transcription to overcome ferroptosis resistance in cancer	27
A microRNA signature that correlates with cognition and is a target against cognitive decline	27
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	27
A Parkinson’s disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress	27
Biological foundations of successful bacteriophage therapy	27
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation	27
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death	26
The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells	26
Resolving mechanisms of immune‐mediated disease in primary CD 4 T cells	26
A combination of two human monoclonal antibodies cures symptomatic rabies	26
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression	26
Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies	26
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease	26
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	25
The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis	25
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer	25
Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation	25
An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer	25
SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapies	25
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	25
STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells	24
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function	24
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	24
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1	24
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice	24
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies	24
Modeling genetic epileptic encephalopathies using brain organoids	24
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	24
Adeno‐associated virus‐vectored influenza vaccine elicits neutralizing and Fcγ receptor‐activating antibodies	23
Modulation of intrinsic inhibitory checkpoints using nano‐carriers to unleash NK cell activity	23
MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders	23
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	22
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	22
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	22

A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant	21
Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis	21
RIPK1‐mediated immunogenic cell death promotes anti‐tumour immunity against soft‐tissue sarcoma	21
Synaptic disruption and CREB‐regulated transcription are restored by K + channel blockers in ALS	21
Non‐genetic heterogeneity, altered cell fate and differentiation therapy	21
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component	20
Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease	20
Aged lipid‐laden microglia display impaired responses to stroke	20
Autopsy registry can facilitate COVID ‐19 research	20
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway	20
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation	20
MicroRNA‐574 regulates FAM210A expression and influences pathological cardiac remodeling	20
Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential	20
Metronomic chemotherapy offsets HIFα induction upon maximum‐tolerated dose in metastatic cancers	19
Endothelial Notch signaling controls insulin transport in muscle	19
A high‐affinity, bivalent PDZ domain inhibitor complexes PICK 1 to alleviate neuropathic pain	19
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	19
Mannose receptor‐derived peptides neutralize pore‐forming toxins and reduce inflammation and development of pneumococcal disease	18
Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors	18
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	18
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	18
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes	18
Systemic CD4 immunity: A powerful clinical biomarker for PD‐L1/PD‐1 immunotherapy	18
Early 5‐ HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	17
Muscle‐directed gene therapy corrects Pompe disease and uncovers species‐specific GAA immunogenicity	17
Targeted genome editingin vivocorrects aDmdduplication restoring wild‐type dystrophin expression	17
MYH 3‐associated distal arthrogryposis zebrafish model is normalized with para‐aminoblebbistatin	17
SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity	17
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	17
Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity	17
Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species‐specific barrier	17
Mycobacterium tuberculosis Rv2626c‐derived peptide as a therapeutic agent for sepsis	17
TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1,	17
Loss of PIKfyve drives the spongiform degeneration in prion diseases	17
Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	17
Diagnostic biomarkers for active tuberculosis: progress and challenges	16
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	16
The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib	16
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria	16
Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients	16
Bi‐allelic pathogenic variants in NDUFC2 cause early‐onset Leigh syndrome and stalled biogenesis of complex I	16
Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling	16
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo	16
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches	16
Paneth cells as the cornerstones of intestinal and organismal health: a primer	15
Targeting netrin‐3 in small cell lung cancer and neuroblastoma	15
Protective anti‐prion antibodies in human immunoglobulin repertoires	15
Can artificial intelligence identify effective COVID ‐19 therapies?	15
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	15
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	15
Strengthening vaccines and medicines manufacturing capabilities in Africa: challenges and perspectives	15
ANGPTL 4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a	15
Bi‐allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis‐like disease	15
Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI 3K pathway inhibitors in	14
Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders	14
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	14
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis	14
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	14
Epigenetic gene expression links heart failure to memory impairment	14
CRISPR screens identify tumor‐promoting genes conferring melanoma cell plasticity and resistance	14
Dependence receptors: new targets for cancer therapy	14
Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis	13
The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors	13
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	13
Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells	13
SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytes	13
Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS	13
Pro‐inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang‐(1‐7)	13
Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium	13
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	13
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	13
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent	13
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia	13
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models	13
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	13
Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis	13
ALX 1‐ related frontonasal dysplasia results from defective neural crest cell development and migration	13
PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway	12
Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling	12
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	12
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein	12
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes	12
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype	12
Targeted stabilization of Munc18‐1 function via pharmacological chaperones	12
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	12
Preclinical validation of a novel metastasis‐inhibiting Tie1 function‐blocking antibody	12
Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease	12
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	12
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	12
Unexpected PD‐L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies	12
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease	12
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism	12
Malaria parasites differentially sense environmental elasticity during transmission	12
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	12
Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy	12