Journal of Ovarian Research

Papers
(The TQCC of Journal of Ovarian Research is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
The efficacy and safety of angiogenesis inhibitors for recurrent ovarian cancer: a meta‑analysis133
The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome131
Ovarian tissue cryopreservation in a patient with breast cancer during pregnancy: a case report61
Causal relationship between inflammatory cytokines and polycystic ovary syndrome: a bidirectional mendelian randomization study57
Correction: Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance53
HOXB2 promotes cisplatin resistance by upregulating lncRNA DANCR in ovarian cancer53
Effects of vitrified cryopreservation duration on IVF and neonatal outcomes53
Fertility-sparing surgery in children and adolescents with borderline ovarian tumors: a retrospective study52
Prognostic significance and risk factors for pelvic and para-aortic lymph node metastasis in type I and type II ovarian cancer: a large population-based database analysis51
Evaluation of calcification distribution by CT-based textural analysis for discrimination of immature teratoma47
Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing45
Comparison of oocyte vitrification using a semi-automated or a manual closed system in human siblings: survival and transcriptomic analyses44
Targeted proteomics of plasma extracellular vesicles uncovers MUC1 as combinatorial biomarker for the early detection of high-grade serous ovarian cancer44
The presence of ovarian endometrioma adversely affect ovarian reserve and response to stimulation but not oocyte quality or IVF/ICSI outcomes: a retrospective cohort study43
BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy43
Protective effect of Luffa cylindrica fermentation liquid on cyclophosphamide-induced premature ovarian failure in female mice by attenuating oxidative stress, inflammation and apoptosis39
Long noncoding RNA SNHG25 promotes the malignancy of endometrial cancer by sponging microRNA-497-5p and increasing FASN expression38
In vitro drug testing using patient-derived ovarian cancer organoids35
Ginseng alleviates folliculogenesis disorders via induction of cell proliferation and downregulation of apoptotic markers in nicotine-treated mice35
Pre-operative plasma VEGF-C levels portend recurrence in epithelial ovarian cancer patients and is a bankable prognostic marker even in the initial assessment of a patient34
Differences of survival benefits brought by various treatments in ovarian cancer patients with different tumor stages32
Retrospective analysis of GnRH-a prolonged protocol for in vitro fertilization in 18,272 cycles in China31
Synaptotagmin-like protein 1 is a potential diagnostic and prognostic biomarker in endometrial cancer based on bioinformatics and experiments30
The long non-coding RNA NEAT1 promotes the progression of human ovarian cancer through targeting miR-214-3p and regulating angiogenesis30
LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC28
Premature ovarian insufficiency: a review on the role of tobacco smoke, its clinical harm, and treatment28
MiR-149-3p promotes the cisplatin resistance and EMT in ovarian cancer through downregulating TIMP2 and CDKN1A27
An integrated machine learning-based model for joint diagnosis of ovarian cancer with multiple test indicators27
Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model27
Prognostic marker C3AR1 is associated with ovarian cancer cell proliferation and immunosuppression in the tumor microenvironment26
The PAPSS1 gene is a modulator of response to cisplatin by regulating estrogen receptor alpha signaling activity in ovarian cancer cells25
Dose inhibin B or anti-Müllerian hormone relate to precocious puberty in girls? result of a systematic review and meta-analysis23
Comparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome23
Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network23
Analysis of prognostic value of lactate metabolism-related genes in ovarian cancer based on bioinformatics23
MicroRNAs as the critical regulators of Cisplatin resistance in ovarian cancer cells23
Comprehensive in silico analysis of prognostic and immune infiltrates for FGFs in human ovarian cancer22
Personalization of IVF-ICSI workflow based on patient characteristics improves IVF laboratory outcomes and embryo ploidy by PGT-A22
High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer22
Cocultured porcine granulosa cells respond to excess non-esterified fatty acids during in vitro maturation22
Comparison of the quality of ovarian tissue cryopreservation by conventional slow cryopreservation and vitrification—a systematic review and meta-analysis22
Dehydroepiandrosterone-induced polycystic ovary syndrome mouse model requires continous treatments to maintain reproductive phenotypes22
Detection of plasma exosomal miRNA-205 as a biomarker for early diagnosis and an adjuvant indicator of ovarian cancer staging21
Causal association between metabolic syndrome and ovarian dysfunction: a bidirectional two-sample mendelian randomization21
Plasma circRNA microarray profiling identifies novel circRNA biomarkers for the diagnosis of ovarian cancer21
The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities21
The utility of all-freeze IVF cycles depends on the composition of study populations20
The pregnancy and oncology outcome of fertility-sparing management for synchronous primary neoplasm of endometrium and ovary20
Roles of follicle stimulating hormone and sphingosine 1-phosphate co-administered in the process in mouse ovarian vitrification and transplantation20
Correction: Effects and mechanisms of mUCMSCs on ovarian structure and function in naturally ageing C57 mice20
Near-infrared fluorescent molecular probes with cetuximab in the in vivo fluorescence imaging for epithelial ovarian cancer20
Construction and evaluation of machine learning-based prediction model for live birth following fresh embryo transfer in IVF/ICSI patients with polycystic ovary syndrome20
CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate19
The live birth rate of vitrified oocyte accumulation for managing diminished ovarian reserve: a retrospective cohort study19
Effects of different treatment methods on clinical efficacy and fertility outcomes of patients with adenomyosis19
Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome19
The landscape of transcriptional profiles in human oocytes with different chromatin configurations19
Mesonephric-like adenocarcinoma of the ovary19
Polycystic ovary rat model exposure to 150 kHz intermediate frequency: hypothalamic-pituitary-ovarian axis at the receptor, cellular, tissue, and hormone levels19
Role of different non-coding RNAs as ovarian cancer biomarkers19
Sempervirine inhibits proliferation, invasion and metastasis of ovarian cancer cells and induces ultrastructural changes in vivo19
The application value of two-dimensional ultrasound combined with contrast-enhanced ultrasound in the differential diagnosis of benign, borderline, and malignant ovarian epithelial tumors18
Correction: A methylation‑ and immune‑related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance18
Identification and validation of senescence-related genes in polycystic ovary syndrome18
Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome18
Development and validation of an ultrasound‑based radiomics nomogram to predict lymph node status in patients with high-grade serous ovarian cancer: a retrospective analysis18
Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis17
Establishment of an ovarian cancer omentum metastasis-related prognostic model by integrated analysis of scRNA-seq and bulk RNA-seq17
Correction: Transcriptomics of cumulus cells – a window into oocyte maturation in humans17
Orexin antagonism and substance-P: Effects and interactions on polycystic ovary syndrome in the wistar rats17
High expression levels of centromere protein O participates in cell proliferation of human ovarian cancer17
Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation16
Retraction Note: Extremely active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testes16
NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells16
Downregulation of FASN in granulosa cells and its impact on ovulatory dysfunction in PCOS16
Rare variants in GPR3 in POI patients: a case series with review of literature16
miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway15
Clinical significance and biological roles of lncRNA CTBP1-AS in polycystic ovary syndrome15
N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome15
Unveiling the link: anti-protein disulfide isomerase A3 autoantibody expression and polycystic ovary syndrome risk in euthyroid autoimmune thyroiditis women15
Ultrasonographic and histopathological investigation of the effect of N-acetylcysteine on doxorubicin-induced ovarian and uterine toxicity in rats15
A methylation- and immune-related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance15
Correction to: Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP syntha15
Development of machine learning models for diagnostic biomarker identification and immune cell infiltration analysis in PCOS15
Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats15
Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome14
Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review14
Ovarian endometrioid carcinoma and clear cell carcinoma: A 21-year retrospective study14
Extracellular vesicle-microRNAs mediated response of bovine ovaries to seasonal environmental changes14
Anti-Müllerian hormone independently affect mtDNA copy number in human granulosa cells14
Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells14
RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis14
A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model14
LncRNA-MSC-AS1 inhibits the ovarian cancer progression by targeting miR-425-5p14
Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer14
High visceral fat-to-muscle ratio is an independent factor that predicts worse overall survival in patients with primary epithelial ovarian, fallopian tube, and peritoneal cancer14
Baicalin improves the functions of granulosa cells and the ovary in aged mice through the mTOR signaling pathway13
Ovarian microcystic stromal tumor with omental metastasis: the first case report and literature review13
Acetylation model predicts prognosis of patients and affects immune microenvironment infiltration in epithelial ovarian carcinoma13
Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR13
Galectin-1 as a predictive biomarker in ovarian cancer13
Association of HOMA-IR with unexpected poor ovarian response in non-obese women in poseidon 1: a retrospective cohort study13
Simultaneous expression of steroid sulfatase and androgen receptor reduced overall survival of patients with epithelial ovarian tumors13
The impact of clinical and laboratory parameters on clinical pregnancy and live birth rates in fresh cycles: a retrospective study of 9608 high-quality cleavage-stage embryos13
Correction: Pivotal role of High-Mobility Group Box 2 in ovarian folliculogenesis and fertility13
Genome wide identification and characterization of fertility associated novel CircRNAs as ceRNA reveal their regulatory roles in sheep fecundity13
Causal association between telomere length and female reproductive endocrine diseases: a univariable and multivariable Mendelian randomization analysis13
Clinical significance for combined coagulation indexes in epithelial ovarian cancer prognosis13
CAPN2 correlates with insulin resistance states in PCOS as evidenced by multi-dataset analysis13
Retraction Note: SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer12
Identification of three subtypes of ovarian cancer and construction of prognostic models based on immune-related genes12
Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type12
Histidine buffered media maintains pH stabile during cooled transportation of human ovarian tissue12
Yijing Decoction improves premature ovarian failure in rats by activating VEGF/VEGFR-2/FAK pathway12
Does Anti-Müllerian hormone vary during a menstrual cycle? A systematic review and meta-analysis12
The cumulative live birth rate of recombinant follicle-stimulating hormone alfa verse urinary human follicle-stimulating hormone for ovarian stimulation in assisted reproductive technology cycles12
Linkage and association of variants in the dopamine receptor 2 gene (DRD2) with polycystic ovary syndrome12
Neutrophil-to-lymphocyte ratio and chemotherapy response score as prognostic markers in ovarian cancer patients treated with neoadjuvant chemotherapy12
Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome12
Minimal residual disease detection by multicolor flow cytometry in cryopreserved ovarian tissue from leukemia patients12
The LINC00922 aggravates ovarian cancer progression via sponging miR-361-3p12
Causal pathways linking polycystic ovary syndrome to distinct breast cancer subtypes through mediator factors: a multivariable mendelian randomization analysis12
Stage Ia squamous cell carcinoma as the malignant transformation of giant and unusual mature teratoma of the ovary in an elderly patient12
Exosomal biomarkers in the differential diagnosis of ovarian tumors: the emerging roles of CA125, HE4, and C5a12
The role of MMP-14 in ovarian cancer: a systematic review12
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice12
Androgen increases klotho expression via the androgen receptor-mediated pathway to induce GCs apoptosis12
Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis11
Cai’s prescription inhibits granulosa cell apoptosis through ARHGAP4 on poor ovarian responders11
PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis11
The intratumoral microbiota biomarkers for predicting survival and efficacy of immunotherapy in patients with ovarian serous cystadenocarcinoma11
Loss of Calponin 2 causes premature ovarian insufficiency in mice11
Initiation and elongation factor co-expression correlates with recurrence and survival in epithelial ovarian cancer11
Effects of n-3 PUFA supplementation on oocyte in vitro maturation in mice with polycystic ovary syndrome11
Efficacy and safety of follitropin delta for ovarian stimulation in vitro fertilization/ intracytoplasmic sperm injection cycles: a systematic review with meta-analysis11
Association between the food security status and dietary patterns with polycystic ovary syndrome (PCOS) in overweight and obese Iranian women: a case-control study11
ATF3 mediates PM2.5-induced apoptosis and inflammation in ovarian granulosa cells11
Pretreatment with or without GnRH-agonist before frozen–thawed embryo transfer in patients with PCOS: a systematic review and meta-analysis11
O-RADS combined with contrast-enhanced ultrasound in risk stratification of adnexal masses11
A case of synchronous serous ovarian cancer and uterine serous endometrial intraepithelial carcinoma11
CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer11
Identification and validation of m5c-related lncRNA risk model for ovarian cancer11
Past and present: a bibliometric study on polycystic ovary syndrome11
Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects11
Extracellular vesicles-derived MicroRNA-145-5p is upregulated in the uterine fluid of women with endometriosis and impedes mouse and human blastocyst development11
In-vitro generation of follicle-like structures from human germ cell-like cells derived from theca stem cell combined with ovarian somatic cells11
Intra-ovarian platelet-rich plasma administration plus successive accumulated embryo transfer could be a promising strategy for poor ovarian response management: a before-after study11
High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma11
CXCL2-mediated ATR/CHK1 signaling pathway and platinum resistance in epithelial ovarian cancer11
Can expelled cells/debris from a developing embryo be used for PGT?11
Effect of Nigella sativa-L supplementation on glycemia in adolescent polycystic ovarian syndrome: secondary analysis of a randomized controlled trial study10
Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer10
Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and10
LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis10
Baicalein improves the chemoresistance of ovarian cancer through regulation of CirSLC7A610
Potential use of DNA methylation in cervical swabs for early ovarian cancer diagnosis10
Clinical characteristics and risk factors of ovarian reserve decreases in women with Crohn’s disease: a case-control study10
Uterine involvement in epithelial ovarian cancer and its risk factors10
A real-world study of treatment patterns following disease progression in epithelial ovarian cancer patients undergoing poly-ADP-ribose polymerase inhibitor maintenance therapy10
Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth?10
Correction: Bone marrow mesenchymal stem cells expressing Neat-1, Hotair-1, miR-21, miR-644, and miR-144 subsided cyclophosphamide-induced ovarian insufficiency by remodeling the IGF-1–kisspeptin syst10
Diagnostic utility of a conventional MRI-based analysis and texture analysis for discriminating between ovarian thecoma-fibroma groups and ovarian granulosa cell tumors9
CACNA1C is a prognostic predictor for patients with ovarian cancer9
Fertility preservation after gonadotoxic treatments for cancer and autoimmune diseases9
Curcumin and its formulations for the treatment of polycystic ovary syndrome: current insights and future prospects9
Multi-omics reveal the metabolic patterns in mouse cumulus cells during oocyte maturation9
The molecular prognostic score, a classifier for risk stratification of high-grade serous ovarian cancer9
Metformin modifies plasma microbial-derived extracellular vesicles in polycystic ovary syndrome with insulin resistance9
Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis9
MSCs–derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis9
Investigation of androgen receptor CAG repeats length in polycystic ovary syndrome diagnosed using the new international evidence-based guideline9
The effect of paclitaxel- and fisetin-loaded PBM nanoparticles on apoptosis and reversal of drug resistance gene ABCG2 in ovarian cancer9
ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in patients with ovarian cancer: a systematic review and meta-analysis9
Maintenance therapy for newly diagnosed epithelial ovarian cancer– a review9
Epitranscriptome marks detection and localization of RNA modifying proteins in mammalian ovarian follicles9
Long non-coding RNA OIP5-AS1 suppresses microRNA-92a to augment proliferation and metastasis of ovarian cancer cells through upregulating ITGA69
Preparation of triangular silver nanoparticles and their biological effects in the treatment of ovarian cancer9
Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis9
Interlukin-22 improves ovarian function in polycystic ovary syndrome independent of metabolic regulation: a mouse-based experimental study9
Targeted next-generation sequencing of 21 candidate genes in hereditary ovarian cancer patients from the Republic of Bashkortostan9
UBE2T regulates epithelial–mesenchymal transition through the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer9
Successful in vitro fertilization following conservative surgery for synchronous endometrioid tumor of ovary and uterus9
Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice9
Correlation between the follicular fluid extracellular-vesicle-derived microRNAs and signaling disturbance in the oocytes of women with polycystic ovary syndrome9
Differences between complex epithelial neoplasms of the ovary and high-grade serous ovarian cancer: a retrospective observational cohort study9
LH level on ovulation trigger day has a different impact on the outcomes of agonist and antagonist regimens during in vitro fertilization9
The role of vitamin D3 in follicle development9
Machine learning models in evaluating the malignancy risk of ovarian tumors: a comparative study9
Platelet-rich plasma activation: are there differential effects in reproductive medicine?9
Paternal genetic effects of cadmium exposure during pregnancy on hormone synthesis disorders in ovarian granulosa cells of offspring9
Application of comprehensive unit-based safety program model to improve chemotherapy-induced nausea and vomiting in patients with ovarian cancer: a retrospective study9
Serum vascular endothelial growth factor associated with the progression of granulosa cell tumor: a report of two cases9
Targeting mitochondrial metabolism with CPI-613 in chemoresistant ovarian tumors9
ApoC3 is expressed in oocytes and increased expression is associated with PCOS progression8
RETRACTED ARTICLE: Extremely Active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testes8
Effects of single and multiple transplantations of human umbilical cord mesenchymal stem cells on the recovery of ovarian function in the treatment of premature ovarian failure in mice8
Establishment of a novel CNV-related prognostic signature predicting prognosis in patients with breast cancer8
Comparison of anti-Müllerian hormone and antral follicle count in the prediction of ovarian response: a systematic review and meta-analysis8
Characteristics of the vaginal microbiome in women with premature ovarian insufficiency8
Comprehensive analysis of hub genes associated with cisplatin-resistance in ovarian cancer and screening of therapeutic drugs through bioinformatics and experimental validation8
Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary – a review8
Stearoyl-CoA desaturase 1 inhibition induces ER stress-mediated apoptosis in ovarian cancer cells8
Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies8
MiR-425-5p accelerated the proliferation, migration, and invasion of ovarian cancer cells via targeting AFF48
A risk score system based on a six-microRNA signature predicts the overall survival of patients with ovarian cancer8
Predicting CD27 expression and clinical prognosis in serous ovarian cancer using CT-based radiomics8
Oxidative stress and inflammatory markers in ovarian follicular fluid of women with diminished ovarian reserve during in vitro fertilization8
Oligogenic basis of premature ovarian insufficiency: an observational study8
The association between systemic immune-inflammation index and in vitro fertilization outcomes in women with polycystic ovary syndrome: a cohort study8
Gengnianchun formula ameliorates insulin resistance-induced diminished ovarian reserve via the estrogen signaling pathway: evidence from network pharmacology and experimental validation8
hUMSC transplantation restores follicle development in ovary damaged mice via re-establish extracellular matrix (ECM) components8
Preovulatory progesterone levels are the top indicator for ovulation prediction based on machine learning model evaluation: a retrospective study8
Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX18
Extracellular vesicles and their content in the context of polycystic ovarian syndrome and endometriosis: a review8
Dynamic and functional analyses of exosomal miRNAs regulating cellular microenvironment of ovarian cancer cells8
Predictive factors of endometriosis progression into ovarian cancer8
EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells8
Letrozole increases preantral follicle growth and decreases estradiol production without impairing follicle survival8
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