Journal of Experimental & Clinical Cancer Research

Article	Citations
Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma	281
The role of microenvironment in tumor angiogenesis	272
Pyroptosis: a new paradigm of cell death for fighting against cancer	219
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer	198
Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)	197
CAR race to cancer immunotherapy: from CAR T, CAR NK to CAR macrophage therapy	168
Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy	158
Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways	153
TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer	141
Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer	140
Oral mucositis: the hidden side of cancer therapy	140
Statins: a repurposed drug to fight cancer	139
RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer	138
Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy	137
Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples	137
Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter”	136
Single‐cell RNA sequencing in cancer research	131
RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent	129
Pyroptosis at the forefront of anticancer immunity	126
Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies	119
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer	119
Exosomal miRNAs in tumor microenvironment	108
Emerging therapies for glioblastoma: current state and future directions	105
LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p/STAT1/PD-L1 axis	105
Advances in drug development for hepatocellular carcinoma: clinical trials and potential therapeutic targets	103

LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification	101
Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway	92
Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ	90
m6A modification in RNA: biogenesis, functions and roles in gliomas	90
microRNA-96 promotes occurrence and progression of colorectal cancer via regulation of the AMPKα2-FTO-m6A/MYC axis	87
Epigenetic regulation of ferroptosis via ETS1/miR-23a-3p/ACSL4 axis mediates sorafenib resistance in human hepatocellular carcinoma	86
Immunotherapy for glioblastoma: the promise of combination strategies	85
Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1	84
Cancer-associated adipocytes: emerging supporters in breast cancer	84
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion	83
Exosome-mediated transfer of miR-93-5p from cancer-associated fibroblasts confer radioresistance in colorectal cancer cells by downregulating FOXA1 and upregulating TGFB3	83
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer	82
Noncoding RNAs regulate alternative splicing in Cancer	80
Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas	78
Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling	77
RNA m6A demethylase FTO-mediated epigenetic up-regulation of LINC00022 promotes tumorigenesis in esophageal squamous cell carcinoma	76
LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond	76
Dexosomes as a cell-free vaccine for cancer immunotherapy	75
Alternative polyadenylation: methods, mechanism, function, and role in cancer	75
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors	75
Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies	74
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy	73
The role of extracelluar matrix in osteosarcoma progression and metastasis	72
CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis	72
Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages	72
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons	72
Determinants of resistance to VEGF-TKI and immune checkpoint inhibitors in metastatic renal cell carcinoma	71
Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma	70
LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma	69
RETRACTED ARTICLE: The circular RNA 001971/miR-29c-3p axis modulates colorectal cancer growth, metastasis, and angiogenesis through VEGFA	69
Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention	69
FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2	68
Gut microbiota influence tumor development and Alter interactions with the human immune system	68
Cancer-derived exosomal TRIM59 regulates macrophage NLRP3 inflammasome activation to promote lung cancer progression	68
Interfering with Tumor Hypoxia for Radiotherapy Optimization	68
Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma	68
Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response	68
The biomarkers related to immune related adverse events caused by immune checkpoint inhibitors	67
Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer	66
FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner	65
The U2AF2 /circRNA ARF1/miR-342–3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells	65
Disulfidptosis: a new target for metabolic cancer therapy	64
ALKBH5-HOXA10 loop-mediated JAK2 m6A demethylation and cisplatin resistance in epithelial ovarian cancer	64
Fibronectin as a multiregulatory molecule crucial in tumor matrisome: from structural and functional features to clinical practice in oncology	63
Human umbilical cord mesenchymal stem cells-derived exosomes deliver microRNA-375 to downregulate ENAH and thus retard esophageal squamous cell carcinoma progression	63
COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling	63
HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer	62
Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies	62
Long noncoding RNA: a dazzling dancer in tumor immune microenvironment	61
CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling	61

Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer	61
Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis	61
Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway	61
CPEB3 inhibits epithelial-mesenchymal transition by disrupting the crosstalk between colorectal cancer cells and tumor-associated macrophages via IL-6R/STAT3 signaling	60
Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression	60
Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis	59
TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity	58
The application of histone deacetylases inhibitors in glioblastoma	58
Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression	58
Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis	58
A specific tRNA half, 5’tiRNA-His-GTG, responds to hypoxia via the HIF1α/ANG axis and promotes colorectal cancer progression by regulating LATS2	58
Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1	57
SCD1, autophagy and cancer: implications for therapy	57
Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by regulating Kupffer cell secretion pattern and impeding MMP9 induced vascular leakiness	56
High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer	55
The CD70-CD27 axis in oncology: the new kids on the block	55
Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers	55
Induction of m6A methylation in adipocyte exosomal LncRNAs mediates myeloma drug resistance	53
CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway	53
Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models	53
Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis	52
Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10	52
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis	52
Long non-coding RNA DLEU2 drives EMT and glycolysis in endometrial cancer through HK2 by competitively binding with miR-455 and by modulating the EZH2/miR-181a pathway	52
Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma	51
CircCEMIP promotes anoikis-resistance by enhancing protective autophagy in prostate cancer cells	50
Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression	50
CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway	49
Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer	49
IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress	49
PKM2 inhibition may reverse therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma	49
Drug repurposing against COVID-19: focus on anticancer agents	49
Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation	48
Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumor regrowth	48
The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?	48
Recent advances in the developmental origin of neuroblastoma: an overview	48
PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages	48
RETRACTED ARTICLE: LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2	47
Long non-coding RNA MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop promotes hepatocellular carcinoma progression	47
Optimizing cisplatin delivery to triple-negative breast cancer through novel EGFR aptamer-conjugated polymeric nanovectors	47
Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma	47
KRAS wild-type pancreatic ductal adenocarcinoma: molecular pathology and therapeutic opportunities	47
Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth	46
Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway	46
miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis	46
Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer	46
Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis	46
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation	46
CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression	45
Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer	45
RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner	45
Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis	45
RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway	45
ROS and TGFβ: from pancreatic tumour growth to metastasis	45
Gut microbiota-mediated immunomodulation in tumor	45
Selective antagonism of cJun for cancer therapy	45
Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer	45
Hypoxia-dependent drivers of melanoma progression	44
Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma	44
Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation	44
RETRACTED ARTICLE: M2 macrophage-derived extracellular vesicles promote gastric cancer progression via a microRNA-130b-3p/MLL3/GRHL2 signaling cascade	44
HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis	44
Targeting WD repeat domain 5 enhances chemosensitivity and inhibits proliferation and programmed death-ligand 1 expression in bladder cancer	43
Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1	43
SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway	43
Mechanisms of hyperprogressive disease after immune checkpoint inhibitor therapy: what we (don’t) know	43
Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells	43
Circular RNA circNTRK2 facilitates the progression of esophageal squamous cell carcinoma through up-regulating NRIP1 expression via miR-140-3p	43
Blockade of novel immune checkpoints and new therapeutic combinations to boost antitumor immunity	43
Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer	43
Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC	42
POLE/POLD1 mutation and tumor immunotherapy	42
SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma	42
A systematic review on poly(I:C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy	42
Histone methyltransferase and drug resistance in cancers	42
The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)	42
Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway	41
Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway	41
NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer	40
The essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma	40

RETRACTED ARTICLE: Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17	40
CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization	40
A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling	40
Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer	40
Cancer: a mirrored room between tumor bulk and tumor microenvironment	40
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway	40
YAP promotes autophagy and progression of gliomas via upregulating HMGB1	39
M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop	39
Neutrophil extracellular traps in cancer: not only catching microbes	39
Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling	39
Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-κB activation	39
PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells	38
FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma	38
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling	38
PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells	38
Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression	38
Long noncoding RNA HOST2, working as a competitive endogenous RNA, promotes STAT3-mediated cell proliferation and migration via decoying of let-7b in triple-negative breast cancer	38
Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications	38
The role of tumor-infiltrating lymphocytes in cholangiocarcinoma	37
CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis	37
Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-J	37
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop	37
A reciprocal feedback between N6-methyladenosine reader YTHDF3 and lncRNA DICER1-AS1 promotes glycolysis of pancreatic cancer through inhibiting maturation of miR-5586-5p	37
Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer	37
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer	37
Lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids	37
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer	37
A 5′-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer	37
Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway	36
Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming	36
Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation	36
The role of TBK1 in cancer pathogenesis and anticancer immunity	36
Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression	36
METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis	36
BH3-mimetics: recent developments in cancer therapy	35
ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer	35
Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications	35
Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target	35
Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT	35
MicroRNA-30a-5pme: a novel diagnostic and prognostic biomarker for clear cell renal cell carcinoma in tissue and urine samples	35
CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapy	35
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer	35
Radiation induces NORAD expression to promote ESCC radiotherapy resistance via EEPD1/ATR/Chk1 signalling and by inhibiting pri-miR-199a1 processing and the exosomal transfer of miR-199a-5p	35
Disulfidptosis: a new form of programmed cell death	35
Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis	35
The immunomodulatory effects of endocrine therapy in breast cancer	35
CREB5 promotes invasiveness and metastasis in colorectal cancer by directly activating MET	34
Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer	34
The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex	34
Proteolysis targeting chimeras (PROTACs) in cancer therapy	34
Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma	34
CDK4/6 inhibitors: a novel strategy for tumor radiosensitization	34
PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells	34
The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived primary culture case series in tridimensional and zebrafish models	34
Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark	34
Aspartate β-hydroxylase as a target for cancer therapy	33
ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway	33
Long noncoding RNA MAPKAPK5-AS1 promotes colorectal cancer progression by cis-regulating the nearby gene MK5 and acting as a let-7f-1-3p sponge	33
Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing	33
Circ_0008532 promotes bladder cancer progression by regulation of the miR-155-5p/miR-330-5p/MTGR1 axis	33
Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion	33
TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer	33
METTL3-mediated m6A mRNA modification of FBXW7 suppresses lung adenocarcinoma	32
CircTADA2A suppresses the progression of colorectal cancer via miR-374a-3p/KLF14 axis	32
Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance	32
The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis	32
What are the applications of single-cell RNA sequencing in cancer research: a systematic review	32
Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system	32
An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile	32
Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer	31
Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy	31
A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer	31
TMPRSS4 promotes cancer stem–like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1	31
SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop	31
HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer	31
Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression	31
Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target	31
Nicotinamide inhibits melanoma in vitro and in vivo	31
ABCA8 is regulated by miR-374b-5p and inhibits proliferation and metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway	31
Super-enhancers: a new frontier for epigenetic modifiers in cancer chemoresistance	31
Long non-coding RNA NCK1-AS1 promotes the tumorigenesis of glioma through sponging microRNA-138-2-3p and activating the TRIM24/Wnt/β-catenin axis	31
Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway	31
EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability	31
Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma	31
Clinical implication of cellular vaccine in glioma: current advances and future prospects	31
NCAPD3 enhances Warburg effect through c-myc and E2F1 and promotes the occurrence and progression of colorectal cancer	31
Mir-20a-5p induced WTX deficiency promotes gastric cancer progressions through regulating PI3K/AKT signaling pathway	31
LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation	30
HMGA1-TRIP13 axis promotes stemness and epithelial mesenchymal transition of perihilar cholangiocarcinoma in a positive feedback loop dependent on c-Myc	30
USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc	30
The extracellular matrix alteration, implication in modulation of drug resistance mechanism: friends or foes?	30
CircRNA-DOPEY2 enhances the chemosensitivity of esophageal cancer cells by inhibiting CPEB4-mediated Mcl-1 translation	30
circHMGCS1–016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma	30
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway	30
LncRNA HOTAIR-mediated MTHFR methylation inhibits 5-fluorouracil sensitivity in esophageal cancer cells	30