OOIR: Observatory of International Research

Papers

(The median citation count of Epigenetics & Chromatin is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation	104
The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review	74
An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide-conjugated antibodies	52
Epigenetic regulation of MED12: a key contributor to the leukemic chromatin landscape and transcriptional dysregulation	50
Detecting Protein-DNA binding in single molecules using antibody guided methylation	50
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation	38
From compartments to loops: understanding the unique chromatin organization in neuronal cells	37
Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation	36
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages	33
Evolutionary adaptation of the Polycomb repressive complex 2	32
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development	29
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas	28
Who’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data	27
Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression	27
One-pot universal NicE-seq: all enzymatic downstream processing of 4% formaldehyde crosslinked cells for chromatin accessibility genomics	23
Chromatin balances cell redox and energy homeostasis	22
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation	22
Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization	21
Development of super-specific epigenome editing by targeted allele-specific DNA methylation	21
CpG DNA methylation changes during epididymal sperm maturation in bulls	20
Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos	20
Roles of post-translational modifications of UHRF1 in cancer	20
Heterosis of growth trait regulated by DNA methylation and miRNA in allotriploid fish	18
Manipulating chromatin architecture in C. elegans	17
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers	17

Native and tagged CENP-A histones are functionally inequivalent	16
Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells	16
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome	16
TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer	15
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation	15
Impact of chromatin on HIV-1 latency: a multi-dimensional perspective	15
The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor	15
Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation	14
Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation	14
Structural and functional specificity of H3K36 methylation	14
Mechanism of non-coding RNA regulation of DNMT3A	14
Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts	14
The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability	14
Knockout tales: the versatile roles of histone H3.3 in development and disease	14
Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity	13
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation	13
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals	12
Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model	12
Identification of genetic and non-genetic modifiers of genomic imprinting through screening of imprinted DMR methylation in humans	12
Making sense of the linear genome, gene function and TADs	12
Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring	12
Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellum	12
Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations	11
Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG	11
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat	11
Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data	11
Drosophila architectural proteins M1BP and Opbp cooperatively form the active promoter of a ribosomal protein gene	10
TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation	10
Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers	10
Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice	10
Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression	10
Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age	10
Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers	10
Revealing RCOR2 as a regulatory component of nuclear speckles	9
The role of MORC3 in silencing transposable elements in mouse embryonic stem cells	9
Cohesin stabilization at promoters and enhancers by common transcription factors and chromatin regulators	9
PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter	9
The linker histone chaperone Prothymosin α (PTMA) is essential for efficient DNA damage repair and the recruitment of PARP1	9
H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development	9
Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites	9
Differential enrichment of H3K9me3 at annotated satellite DNA repeats in human cell lines and during fetal development in mouse	9
Functions of HP1 proteins in transcriptional regulation	9
The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period	9
Dissecting the Kaiso binding profile in clear renal cancer cells	8
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects	8
Functional characterization of transcriptional enhancers in an Anopheles genetic locus controlling natural resistance to the malaria parasite, Plasmodium falciparum	8
The solid and liquid states of chromatin	8
Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae	8
Correction: Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi‑C, Micro‑C, and promoter capture Micro‑C	8
DNA methylation may affect beef tenderness through signal transduction in Bos indicus	8

Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells	7
Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns	7
Expanding the list of sequence-agnostic enzymes for chromatin conformation capture assays with S1 nuclease	7
A standardized nomenclature for mammalian histone genes	7
The isoflavone genistein selectively stimulates major satellite repeat transcription in mouse heterochromatin	7
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso	7
Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C	7
Improved epigenetic age prediction models by combining sex chromosome and autosomal markers	7
Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome	7
The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin	6
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex	6
Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation	6
Transcriptional regulation mechanism of PARP1 and its application in disease treatment	5
H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts	5
DNA methylation correlates of chronological age in diverse human tissue types	5
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity	5
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes	5
Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis	5
Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena	5
Telomere-specific chromatin capture using a pyrrole–imidazole polyamide probe for the identification of proteins and non-coding RNAs	5
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells	5
Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function	4
3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk	4
LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy	4
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer	4
Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals	4
Correction: Dissecting the Kaiso binding profle in clear renal cancer cells	4
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin	4
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system	4
Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci	4
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression	4
Pan-cancer predictions of transcription factors mediating aberrant DNA methylation	4