Molecular Brain

Article	Citations
Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson’s disease pathogenesis	131
mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons	100
Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway	73
Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice	53
FMRP binds Per1 mRNA and downregulates its protein expression in mice	52
Correction to: Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease	45
Correction to: Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity	43
Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility	37
Spatiotemporal Pavlovian head-fixed reversal learning task for mice	33
New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue	33
Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates	32
A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy	31
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice	30
Recent developments in peptide vaccines against Glioblastoma, a review and update	29
Impact of volume and expression time in an AAV-delivered channelrhodopsin	28
Chronic oral administration of ibrutinib prevents long-term memory deficits and reduces AD pathology and neuroinflammatory responses in a mouse model of AD	28
Role of autophagy in neurotoxic protein’s clearance following post-ischemic stroke: where we are and what we know?	26
Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging	26
Upregulation of TRPV2 exacerbates age-related hearing loss by promoting oxidative stress in spiral ganglion neurons	26
Correction: The deficiency of Maged1 attenuates Parkinson’s disease progression in mice	25
Correction to: Synergistic actions of corticosterone and BDNF on rat hippocampal LTP	23
AKAP6 controls NFATc4 activity for BDNF-mediated neuroprotection	22
Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia	22
The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology	21
A simple and reliable method for claustrum localization across age in mice	21

Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice	20
m6A RNA methylation in neural plasticity, brain aging, and neurodegenerative vulnerability	20
Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H	19
Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications	19
Involvement of posterior hypothalamic CaMKII-positive neurons in ADHD-like behaviors in mice	19
Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis	18
Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction	18
Chemogenetic activation of histamine neurons promotes retrieval of apparently lost memories	18
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study	18
The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels	17
Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice	17
Reduced activity of parvalbumin-positive interneurons in the posterior parietal cortex causes visually dominant multisensory decisions in freely navigating mice	17
Subacute and chronic proteomic and phosphoproteomic analyses of a mouse model of traumatic brain injury at two timepoints and comparison with chronic traumatic encephalopathy in human samples	16
MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning	16
Pathophysiology of ion channels in amyotrophic lateral sclerosis	16
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export	16
Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study	15
A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice	15
The gut microbiota and metabolite profiles are altered in patients with spinal cord injury	15
Increased social interaction in Shank2-deficient mice following acute social isolation	15
Sonication dissociates the synaptic cleft and allows purification of postsynaptic densities with associated postsynaptic membrane	14
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD	14
Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake	14
Intravitreal injection of the Galectin-3 inhibitor TD139 provides neuroprotection in a rat model of ocular hypertensive glaucoma	14
Spermidine treatment: induction of autophagy but also apoptosis?	14
Changes in oligodendroglial subpopulations in Parkinson’s disease	13
mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination	13
Toll-like receptors and their role in neuropathic pain and migraine	13
Mycophenolate mofetil reduces the branching of microglial processes	13
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry	13
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression	12
Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice – a model-free multivariate analysis	12
Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity	12
Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus	12
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway	12
Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer’s disease	12
Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson’s disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy	12
Unaltered empathy-related behaviors in Williams–Beuren syndrome mouse models	12
Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord barrier integrity in mice	12
Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice	12
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus	11
NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells	11
Artificial intelligence-based biomarkers for the diagnosis and treatment of neurological conditions: a narrative review	11
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state	11
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease	10
A new AAV tool for highly preferentially targeting hippocampal CA2	10
Correction: Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles	10
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice	10
Correction: Extinction of contextual fear memory is facilitated in TRPM2 knockout mice	10
Aging-independent decrease of complex multi-spine boutons in hippocampal area CA1 after contextual fear conditioning	10

Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism	9
Crucial role of TFAP2B in the nervous system for regulating NREM sleep	9
Nek6 regulates autophagy through the mTOR signaling pathway to alleviate cerebral ischemia–reperfusion injury	9
Experience-dependent changes in affective valence of taste in male mice	9
Astrocytic activation increases blood flow in the adult olfactory bulb	9
Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice	9
Neurexin-1-dependent circuit activity is required for the maintenance of photoreceptor subtype identity in Drosophila	9
Hypothalamic protein profiling from mice subjected to social defeat stress	9
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism	9
AldoC BAC-GFP transgenic mice as a reliable model for astrocyte identification and functional studies in the brain	9
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway	9
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation	9
Synergistic actions of corticosterone and BDNF on rat hippocampal LTP	9
Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification	9
Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors	8
Regulation of dendritic spine length in corticopontine layer V pyramidal neurons by autism risk gene β3 integrin	8
Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability	8
PV-IRES-Cre mouse line targets excitatory granule neurons in the cerebellum	8
The absence of Neuroligin-1 shapes wake/sleep architecture, rhythmic and arrhythmic activities of the electrocorticogram in female mice	8
Targeted NMDA receptor knockdown in recall‐activated neuronal ensembles impairs remote fear extinction	8
Changes in the pH value of the human brain in Alzheimer’s disease pathology correlated with CD68-positive microglia: a community-based autopsy study in Beijing, China	8
Human midbrain organoids reveal the characteristics of axonal mitochondria specific to dopaminergic neurons	8
Central nervous system pericytes express soluble ST2 in inflammation and injury	8
Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke	8
The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics	7
Platelet proteomic signatures of amyloid β-positive mild cognitive impairment and Alzheimer’s disease	7
Proteasome inhibition suppresses the induction of lipocalin-2 upon systemic lipopolysaccharide challenge in mice	7
Circadian cilia transcriptome in mouse brain across physiological and pathological states	7
Inhibitory insula-ACC projections modulate affective but not sensory aspects of neuropathic pain	7
Septin5 deficiency impairs both recent and remote contextual fear memory	7
Astrocyte-derived dominance winning reverses chronic stress-induced depressive behaviors	7
Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration	7
Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala	7
Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice	7
Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex	7
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats	7
Hes5+ astrocytes potentiate primary afferent Aδ and C fiber-mediated excitatory synaptic transmission to spinal lamina I neurons	7
Quercetin carbon quantum dots: dual-target therapy for intracerebral hemorrhage in mice	7
Neural stem cell-specific deletion of Atg7 alleviates hippocampal dysfunction and neuronal alterations induced by chronic restraint stress	6
Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis	6
CSF Amyloid-β42 associates with neuropsychiatric and cognitive outcomes via cerebral glucose metabolism	6
Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025	6
Insights into the interplay between stroke and depression through lipid metabolism-related diagnostic genes	6
Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels	6
BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons	6
Distribution of five clinically important neuroglial proteins in the human brain	6
PKMζ-KIBRA interactions, molecular turnover, and memory	6
Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders	6
Mechanisms of glutamate receptors hypofunction dependent synaptic transmission impairment in the hippocampus of schizophrenia susceptibility gene Opcml-deficient mouse model	6
Prior episode of colitis impairs contextual fear memory	6
Shank3B deficiency disrupts GABAergic synaptic transmission in pyramidal neurons of the medial prefrontal cortex region in autism spectrum disorder	6
14-3-3γ haploinsufficiency leads to altered dopamine pathway and Parkinson’s disease-like motor incoordination in mice	6
Correction: The properties of TREM1 and its emerging role in pain-related diseases	6
The cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 inhibits neurite outgrowth and synapse formation	6
Postmortem gene expression profiles in the habenulae of suicides: implication of endothelial dysfunction in the neurovascular system	6
Modulating and monitoring the functionality of corticostriatal circuits using an electrostimulable microfluidic device	6
Knockdown of myorg leads to brain calcification in zebrafish	6
Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases	6
Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology	6
Adenylate kinase 5, a novel genetic risk factor for Alzheimer’s disease, regulates microglial inflammatory activation	6
Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction	6
Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens	5
Genome-wide translation control analysis of developing human neurons	5
Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay	5
Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder	5
Felodipine attenuates neuroinflammatory responses and tau hyperphosphorylation through JNK/P38 signaling in tau-overexpressing AD mice	5
Globus pallidus is not independent from striatal direct pathway neurons: an up-to-date review	5
Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions	5
Early hypoxia-induced secretome remodeling reveals adaptive mechanisms and biomarkers of blood-brain barrier dysfunction in ischemic stroke	5
Development of Cre-dependent retrograde trans-multisynaptic tracer based on pseudorabies virus bartha strain	5
A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism	5
Olfactory marker protein is unlikely to be cleaved by calpain 5	5
Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice	5
FCHO1 fine-tunes synaptic vesicle endocytosis in an activity-dependent manner	5
DYRK1A modulates fear memory formation via epigenetic modification	5
Characterization of exosome-mediated propagation of systemic inflammatory responses into the central nervous system	5
Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model	4
Analgesia by intrathecal delta-9-tetrahydrocannabinol is dependent on Cav3.2 calcium channels	4
Intranasal administration of human mesenchymal stromal cell-derived small extracellular vesicles delays disease progression in the SOD1(G93A) mouse model	4
Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping	4

Antihyperalgesic effect of joint mobilization requires Cav3.2 calcium channels	4
Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo	4
Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective	4
Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia	4
Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses	4
Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency	4
Integrated molecular data analysis confirms PDK1 as a candidate risk factor in ALS pathophysiology	4
Virally mediated expression of a biologically active peptide to restrain the nuclear functions of ERK1/2 attenuates learning extinction but not acquisition	4
Altered ECM deposition and cell adhesion signaling in a human cortical organoid model of fragile X syndrome	4
Cell-line dependency in cerebral organoid induction: cautionary observations in Alzheimer’s disease patient-derived induced pluripotent stem cells	4
Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice	4
A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Cav2.1 P/Q-type channel gating	4
Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)	4
Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy	4
Paraventricular hypothalamic vasopressin neurons induce self-grooming in mice	4
Cerebellar damage with inflammation upregulates oxytocin receptor expression in Bergmann Glia	4
Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection	4
Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study	4
Early autism detection: a review of emerging technologies, biomarkers, and explainable AI approaches	4
Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning	4
Identification and validation of microglia-associated genes in ischemic stroke using single-cell and bulk RNA-seq	4
Functional characterization of a novel de novo CACNA1C pathogenic variant in a patient with neurodevelopmental disorder	4
Involvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice	4
Impaired phrenic nerve axon development and diaphragm neuromuscular junction formation in embryonic Cyfip2-null mice	4
Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons	4
Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses	3
Surgery impairs glymphatic activity and cognitive function in aged mice	3
Roles of mediodorsal thalamus in observational fear-related neural activity in mouse anterior cingulate cortex	3
Extinction of contextual fear memory is facilitated in TRPM2 knockout mice	3
Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation	3
Ankyrin2 is essential for neuronal morphogenesis and long-term courtship memory in Drosophila	3
Absence of ATG9A and synaptophysin demixing on Rab5 mutation-induced giant endosomes	3
Systemic injection of nicotinic acetylcholine receptor antagonist mecamylamine affects licking, eyelid size, and locomotor and autonomic activities but not temporal prediction in male mice	3
Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex development	3
Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory	3
Transcriptome atlases of rat brain regions and their adaptation to diabetes resolution following gastrectomy in the Goto-Kakizaki rat	3
C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity	3
Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum	3
Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice	3
Improving working memory by electrical stimulation and cross-frequency coupling	3
CaVβ-subunit dependence of forward and reverse trafficking of CaV1.2 calcium channels	3
Simulated weightlessness procedure, head-down bed rest has reversible effects on the metabolism of rhesus macaque	3
GAS reduced inflammatory responses in activated microglia by regulating the Ccr2/Akt/Gsk-3β pathway	3
Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood–brain barrier model	3
Identification of VGLUT3-expressing LTMRs-recruited spinal circuits for itch inhibition	3
Electroacupuncture reduces inflammatory damage following cerebral ischemia–reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia	3
Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics	3
The deficiency of Maged1 attenuates Parkinson's disease progression in mice	3
β-hydroxybutyrate and ischemic stroke: roles and mechanisms	3
In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation	3
Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease	3
Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury	3
Moderate effect of early-life experience on dentate gyrus function	3
Ablation of microglia does not alter circadian rhythm of locomotor activity	3
Hippocampal transcriptome profiling in a 22q11.2 deletion syndrome mouse model: comparison with human schizophrenia	3
Stimulation of protein synthesis by optogenetic and chemical induction of excitatory synaptic plasticity in hippocampal somatostatin interneurons	3