OOIR: Observatory of International Research

Papers

(The median citation count of Cardiovascular Therapeutics is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Left Bundle Branch Area Pacing versus Right Ventricular Pacing in Patients with Atrioventricular Block: An Observational Cohort Study	89
Fibroblast Activation Protein‐Targeted CAR‐T Cells Induce Apoptosis in Murine Cardiac Myofibroblasts	53
Statin Eligibility according to 2013 ACC/AHA and USPSTF Guidelines among Jordanian Patients with Acute Myocardial Infarction: The Impact of Gender	42
L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway	37
A Novel Intracardiac Echocardiography–Guided Approach for Vein of Marshall Ethanol Infusion in Persistent Atrial Fibrillation Ablation	36
Thrombospondin‐1 Silencing Ameliorates Osteoblastic Differentiation of Aortic Valve Interstitial Cells via Inhibiting Nuclear Factor‐ κ B Pathway	32
Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC Modulation and Matrix Remodeling in Mice and Humans	25
Effect of Adiponectin Variant on Lipid Profile and Plasma Adiponectin Levels: A Multicenter Systematic Review and Meta-Analysis	24
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome‐Wide Mendelian Randomization and Colocalization Analysis	20
Role of K+ and Ca2+ Channels in the Vasodilator Effects of Plectranthus barbatus (Brazilian Boldo) in Hypertensive Rats	19
The Application Value of Brain Natriuretic Peptide in the Prognostic Evaluation of Patients With Chronic Left Heart Failure	17
Assessment of Angiography‐Based Renal Quantitative Flow Ratio Measurement in Patients with Atherosclerotic Renal Artery Stenosis	17
Efficacy and Safety of Olezarsen in Patients With Hypertriglyceridemia: A Meta‐Analysis of Randomized Controlled Trials	16
Characteristics of Cardiac Ketone Body Metabolism Throughout the Life Cycle	15
Cysteine‐Rich Protein 61 (CCN1) Deficiency Alleviated Cardiac Remodeling in 5/6 Nephrectomized Mice by Suppressing the MAPK Signaling Pathway	15
The Impact of the Metal Mixture Inflammation Index on All‐Cause Mortality in Patients With Cardiovascular‐Kidney‐Metabolic Syndrome Stages 0–3: A Study Based on NHANES 1999–2010	15
The Alteration of HDL in Patients with AMI Inhibited Angiogenesis by Blocking ERK1/2 Activation	15
A Multicohort Machine Learning Framework to Predict Mortality in Elderly Patients With Heart Disease: Insights From HARLS, SHARE, and HRS	14
Angiotensin Receptor–Neprilysin Inhibitor in Heart Failure Patients With Renal Dysfunction	13
Recent Advances in Renal Denervation Therapy and Novel Applications of High‐Intensity Focused Ultrasound	13
MIR22HG Aggravates Oxygen-Glucose Deprivation and Reoxygenation-Induced Cardiomyocyte Injury through the miR-9-3p/SH2B3 Axis	13
The Efficacy and Safety of Four Novel PCSK9 Monoclonal Antibodies in Patients With Hypercholesterolemia: A Systematic Review With Network Meta‐Analysis and Trial Sequential Analysis	12
Subclinical Hypothyroidism as a Risk for Coronary Artery Bypass Grafting	12
The Bioprotective Effects of Marigold Tea Polyphenols on Obesity and Oxidative Stress Biomarkers in High‐Fat‐Sugar Diet‐Fed Rats	11
Inhibitory Effect of Lactobacillus delbrueckii subsp. bulgaricus KSFY07 on Kappa-Carrageenan-Induced Thrombosis in Mice and the Regulation of Oxidative Damage	11

Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction	11
Metformin Attenuates Myocardial Ischemia–Reperfusion Injury in Rats by Modulating JNK Pathway and Inhibiting PANoptosis Mechanisms	11
Effect of Thrombolysis on Circulating Microparticles in Patients with ST-Segment Elevation Myocardial Infarction	11
Effect of TRIB1 Variant on Lipid Profile and Coronary Artery Disease: A Systematic Review and Meta-Analysis	11
The Effect of Clinically Indicated Liraglutide on Pericoronary Adipose Tissue in Type 2 Diabetic Patients	11
The Effect of Vasopressin on 90‐Day Mortality in Patients With Cardiogenic Shock: A Retrospective Cohort Study Using Propensity Score‐Weighted Analysis	10
IL6/IL10/TLR4 Govern Immunogenic Cell Death in Aortic Dissection	10
Knockdown of lncRNA XIST Ameliorates IL-1β-Induced Apoptosis of HUVECs and Change of Tissue Factor Level via miR-103a-3p/HMGB1 Axis in Deep Venous Thrombosis by Regulating the ROS/NF-κB Signaling Path	10
A Retrospective Cross‐Sectional Study on the Clinicopathologic Features of Essential Hypertension at High Altitude in China	9
Liquid Embolization of Peripheral Arteriovenous Malformations with Ethylene-Vinyl Alcohol Copolymer in Neonates and Infants	9
“RotaTripsy” as State‐of‐the‐Art Strategy for Coronary Artery Calcification: A Scoping Review	9
DT-010 Exerts Cardioprotective Effects by Regulating the Crosstalk between the AMPK/PGC-1α Pathway and ERp57	9
Antiatherogenic and Cardioprotective Effects of a Xanthine Derivative KMUP‐1 in ApoE Knockout Mice	9
Knockdown of LncRNA CCAT1 Attenuates ox‐LDL‐Induced Inflammation in THP1‐Derived Macrophages via the miR‐296‐3p/FOSL1 Axis	9
Electrocardiogram Parameters That Affect the Success Rate of Radiofrequency Ablation in Patients with Outflow Tract Ventricular Premature Complexes	9
The Regulation Network of Glycerolipid Metabolism as Coregulators of Immunotherapy-Related Myocarditis	8
Identification of Potential Biomarkers for Coronary Artery Disease Based on Cuproptosis	8
Association Between Albumin‐Corrected Anion Gap and Mortality in ICU Patients With Acute Heart Failure: A MIMIC‐IV Cohort Study	8
Integrating Traditional Wisdom With Modern Science: Ginsenosides as Antiheart Failure Agents	8
Benzoylaconine: Potential Therapeutic Agent for Cardiovascular Diseases From Fuzi	7
Water-Based Exercises on Peak Oxygen Consumption, Exercise Time, and Muscle Strength in Patients with Coronary Artery Disease: A Systematic Review with Meta-Analysis	7
Hemodynamic Variability in Aortic Stenosis and Regurgitation During Transcatheter Aortic Valve Replacement With Self‐Expanding Valves	7
Verteporfin Mitigates Isoproterenol‐Induced Myocardial Hypertrophy by Attenuating IL‐6/STAT3 in Cardiac Fibroblasts	7
The Impact of SGLT2 Inhibitors on Pulmonary Artery Pressures and Pulmonary Hemodynamics in Patients With Heart Failure: A Systematic Review	7
The Effect of Stress Ball on Anxiety and Pain Levels in Angiography: A Randomized Controlled Trial	7
Association of Choline Intake with Blood Pressure and Effects of Its Microbiota-Dependent Metabolite Trimethylamine-N-Oxide on Hypertension	6
Role of Macrophage Phagocytosis as Predictive Marker of the Prevalence of Coronary Heart Disease and Acute Coronary Syndromes	6
Analysis of the Efficacy and Safety of Coronary Catheterization through Distal Transradial Access: A Single-Center Data	6
NHANES‐Derived Machine Learning Model for Early Identification of Frailty Risk in CKM: Optimizing Resource Allocation Through Predictive Analytics	6
Low‐Dose Mavacamten Initiation in Obstructive Hypertrophic Cardiomyopathy: A Real‐World Study in China	6
Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage Closure	6
Metabolic Profiling Reveals Diagnostic Biomarkers for Distinguishing Myocarditis From Acute Myocardial Infarction	6
Effectiveness and Safety of Shengmai San for Viral Myocarditis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials	6
Safety and Feasibility of a Novel Split Design Left Atrial Appendage Occluder: From Preclinical Investigations to First‐in‐Human Application	6
Atrial Fibrillation Termination as a Predictor for Persistent Atrial Fibrillation Ablation: A Systemic Review and Meta‐Analysis of Prospective Studies	6
P2Y12 Inhibitor or Aspirin Monotherapy for Chronic Coronary Disease: A Nationwide Cohort Study	5
Association Between the Naples Score and Recurrence in Patients With Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation	5
Application of the Left Ventricular Pressure–Strain Loop Technique in Monitoring Improvement Factors of Patients With Heart Failure Reduced Ejection Fraction	5
DJ‐1 as a Novel Therapeutic Target for Mitigating Myocardial Ischemia–Reperfusion Injury	5
	5
Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats	5
Impacts of CD36 Variants on Plasma Lipid Levels and the Risk of Early‐Onset Coronary Artery Disease: A Systematic Review and Meta‐Analysis	5
Positive Association of Plasma Trimethylamine-N-Oxide and Atherosclerosis in Patient with Acute Coronary Syndrome	4
Heparin and Bivalirudin in Percutaneous Coronary Intervention for Acute Coronary Syndromes: A Review Article	4
Atorvastatin Attenuates Endothelial Cell Injury in Atherosclerosis Through Inhibiting ACSL4‐Mediated Ferroptosis	4
Frontiers and Hotspot Evolution of NLRP3 Inflammasome in Myocardial Infarction Research: A Bibliometric Analysis From 2013 to 2024	4
A Study on Weight Loss Cause as per the Side Effect of Liraglutide	4
Discovery and Validation of Potential Serum Biomarkers for Heart Failure by Untargeted Metabolomics	4
Hypermetabolism and Lipid Alterations Postburn: A Cardiovascular Perspective	4
Role of Traditional Cardiovascular Risk Factors after Initiation of Statin Therapy: A PharmLines Inception Cohort Study	4

Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells	4
Silencing RNA for MMPs May Be Utilized for Cardioprotection	4
An Updated Meta-Analysis for Safety Evaluation of Alirocumab and Evolocumab as PCSK9 Inhibitors	4
Social App to Improve Warfarin Therapy in Post-MHVR Chinese Patients: A Randomized Controlled Trial	4
From the Liver to Heart in Nonalcoholic Fatty Liver Disease: Single‐Cell and Serum Evidence for Cytokeratin 18 in Predicting Cardiovascular Risk	3
Drug‐Coated Balloons Versus Other Percutaneous Coronary Intervention Strategies in De Novo Coronary Artery Disease: A Systematic Review, Meta‐Analysis With Trial Sequential Analysis	3
Clinical and Echocardiographic Risk Factors of Adverse Outcomes in Young Patients With Dilated Cardiomyopathy	3
Does Spontaneous Echo Contrast in the Left Atrial Appendage Increase Thromboembolism Risk After Left Atrial Appendage Closure? A Retrospective Study on Its Impact on Device‐Related Thrombosis and Arte	3
Eplerenone Inhibits Atrial Autonomic Nerve Remodeling in Atrial Fibrillation Through ERK1/2 MAPK Pathway	3
Cardiopulmonary Protection of Modified Remote Ischemic Preconditioning in Mitral Valve Replacement Surgery: A Randomized Controlled Trial	3
The Relationship Between C‐Reactive Protein–Triacylglycerol–Glucose Index and All‐Cause Mortality in Patients With Cardiovascular Disease: A Retrospective Cohort Study and Development of a Machine Lea	3
Application of Transesophageal Echocardiography in Amplatzer Atrial Septal Defect Occluder for Percutaneous Closure of Large Patent Foramen Ovale	3
Efficacy and Safety of Stellate Ganglion Block for Treating Angina Pectoris: A Systematic Review and Meta‐Analysis	3
Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats	3
miR-135a Regulates Atrial Fibrillation by Targeting Smad3	3
Colchicine Does Not Reduce Abdominal Aortic Aneurysm Growth in a Mouse Model	3
HSPB1 Regulates Autophagy and Apoptosis in Vascular Smooth Muscle Cells in Arteriosclerosis Obliterans	3
Association of Initial Laxative Strategy With Clinical Outcomes in Critically Ill Patients With Acute Myocardial Infarction: A Retrospective Cohort Study	2
A Positive Feedback Loop Between CXCL16 and the Inflammatory Factors IL‐17A and TGF‐ β Promotes Large Artery Atherosclerosis by Activating the STAT3/NF‐	2
Vasoactive–Inotropic Score Reduction Rate Is Highly Associated With Prognosis for Critically Ill Patients With Cardiogenic Shock: Insights From the Real‐World Dynamic Data	2
The Impact of COVID‐19 Infection on Abdominal Aortic Aneurysms: Mechanisms and Clinical Implications	2
Impact of Prolonged Cycle Length Resulting From Conversion of Atrial Fibrillation to Atrial Tachycardia on Ablation Outcome in Persistent Atrial Fibrillation Ablation	2
Efficacy of Acupuncture in the Treatment of Essential Hypertension: An Overview of Systematic Reviews and Meta-Analyses	2
Improved Risk Prediction of Acute Myocardial Infarction in Patients With Stable Coronary Artery Disease Using an Amino Acid‐Assisted Model	2
DUSP22 Ameliorates Endothelial‐to‐Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways	2
Optimization of Clinical Trial Design and Decision‐Making for Heart Failure with Preserved Ejection Fraction (HFpEF): A Meta‐Analysis Based on a Placebo Response Model	2
Antagonizing CCR2 With Propagermanium Leads to Altered Distribution of Macrophage Subsets and Favorable Tissue Remodeling After Myocardial Infarction in Mice	2
Asprosin Protects H9C2 Cells From Ferroptosis Following Hypoxia/Reoxygenation by Promoting Mitophagy	2
Development and Validation of a Nomogram Model for Predicting the Risk of Readmission in Patients with Heart Failure with Reduced Ejection Fraction within 1 Year	2
Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway	2
Ginsenoside Rb1 Mitigates Myocardial Fibrosis Through Inhibiting Exosomal‐Derived miRNA‐21–Associated Inflammation and Cardiac Signaling	2
Improving Health Outcomes in Coronary Artery Disease Patients with Short-Term Protocols of High-Intensity Interval Training and Moderate-Intensity Continuous Training: A Community-Based Randomized Con	2
Rivaroxaban Ameliorates Sunitinib‐Induced Injury of Cardiomyocytes via Repressing MAPK Signaling Pathway	2
HTR2B‐Mediated Endothelial Protection: Modulating Ferroptosis via the PI3K/AKT Signaling Pathway in Atherosclerosis	2
The Acute Effects of Motor Imagery Combined With Action Observation Breathing Exercise on Cardiorespiratory Responses, Brain Activity, and Cognition: A Randomized, Controlled Trial	2
Interpretable Machine Learning Model for Predicting 30‐Day Readmission in Advanced Heart Failure Patients: Synergistic Assessment of Inflammatory and Metabolic Biomarkers	2
Designing, Validation, and Feasibility of Integrated Approach of Heartfulness Meditation and Yoga Protocol (IAHFNM & YP) for Hypertensive Participants	2
A Meta‐Analysis of the Incidence of Adverse Reactions of Statins in Various Diseases	2
Safety and Efficacy of Bivalirudin versus Unfractionated Heparin Monotherapy in Patients with CAD and DM Undergoing PCI: A Retrospective Observational Study	2
Corrigendum to “Wogonin Inhibits Cardiac Hypertrophy by Activating Nrf‐2‐Mediated Antioxidant Responses”	2