Nature Chemistry

Article	Citations
General synthesis of single-atom catalysts with high metal loading using graphene quantum dots	441
Ethylene/ethane separation in a stable hydrogen-bonded organic framework through a gating mechanism	327
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains	305
Best practices in machine learning for chemistry	300
A glycan gate controls opening of the SARS-CoV-2 spike protein	292
Metal–organic frameworks embedded in a liposome facilitate overall photocatalytic water splitting	208
Mechanochemical bond scission for the activation of drugs	198
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome	195
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics	180
Oxidative cleavage of C–C bonds in lignin	168
Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures	165
Challenges to developing materials for the transport and storage of hydrogen	164
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses	161
Improving the efficiency of CO2 electrolysis by using a bipolar membrane with a weak-acid cation exchange layer	160
Olefin metathesis-based chemically recyclable polymers enabled by fused-ring monomers	157
Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis	154
A proteome-wide atlas of lysine-reactive chemistry	143
A biologically stable DNAzyme that efficiently silences gene expression in cells	139
Predator–prey interactions between droplets driven by non-reciprocal oil exchange	139
Synthesis of bilayer borophene	139
Aromatic hydrocarbon belts	138
A short peptide synthon for liquid–liquid phase separation	137
A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres	130
Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells	127
Switching on prodrugs using radiotherapy	125

Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates	124
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination	121
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications	121
Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres	121
Charge transfer driven by ultrafast spin transition in a CoFe Prussian blue analogue	121
Tailored self-assembled photocatalytic nanofibres for visible-light-driven hydrogen production	118
Manganese-catalysed divergent silylation of alkenes	118
A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60	117
Manganese(i) complexes with metal-to-ligand charge transfer luminescence and photoreactivity	117
Metabolic glycan labelling for cancer-targeted therapy	117
The photochemical reaction of phenol becomes ultrafast at the air–water interface	115
Large magnetic exchange coupling in rhombus-shaped nanographenes with zigzag periphery	115
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives	114
Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping	111
Synthesis of a zigzag carbon nanobelt	110
Competition between chiral solvents and chiral monomers in the helical bias of supramolecular polymers	108
A general arene C–H functionalization strategy via electron donor–acceptor complex photoactivation	106
Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones	105
Dissipative DNA nanotechnology	105
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation	100
Single crystals of mechanically entwined helical covalent polymers	99
Partitioning the interlayer space of covalent organic frameworks by embedding pseudorotaxanes in their backbones	98
SuFExable polymers with helical structures derived from thionyl tetrafluoride	98
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells	97
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages	97
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides	96
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization	95
Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores	94
A molecular endless (74) knot	94
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells	94
Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform	94
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes	93
Tunable acetylene sorption by flexible catenated metal–organic frameworks	92
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production	91
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation	91
Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins	90
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides	90
On-surface photopolymerization of two-dimensional polymers ordered on the mesoscale	89
Low-temperature liquid platinum catalyst	89
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates	89
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles	89
Correlating ligand-to-metal charge transfer with voltage hysteresis in a Li-rich rock-salt compound exhibiting anionic redox	88
Reagentless biomolecular analysis using a molecular pendulum	87
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells	85
In situ multiscale probing of the synthesis of a Ni-rich layered oxide cathode reveals reaction heterogeneity driven by competing kinetic pathways	84
Supercrystal engineering of atomically precise gold nanoparticles promoted by surface dynamics	83
Melting of hybrid organic–inorganic perovskites	82
Evolution of dynamical networks enhances catalysis in a designer enzyme	82
In situ electrochemical recomposition of decomposed redox-active species in aqueous organic flow batteries	82
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation	81

Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes	81
Scalable and selective deuteration of (hetero)arenes	80
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides	80
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane	79
Chemical fuels for molecular machinery	79
Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands	78
Accelerating symmetry-breaking charge separation in a perylenediimide trimer through a vibronically coherent dimer intermediate	77
A circular polyester platform based on simple gem-disubstituted valerolactones	77
Aromaticity rules	77
A metal–organic framework that exhibits CO2-induced transitions between paramagnetism and ferrimagnetism	76
Nickel-catalysed asymmetric hydrogenation of oximes	76
Substantial π-aromaticity in the anionic heavy-metal cluster [Th@Bi12]4−	76
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds	75
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles	75
Using waste poly(vinyl chloride) to synthesize chloroarenes by plasticizer-mediated electro(de)chlorination	75
Functional DNA-based cytoskeletons for synthetic cells	75
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions	74
Switching the magnetic hysteresis of an [Feii–NC–Wv]-based coordination polymer by photoinduced reversible spin crossover	74
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity	74
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime	73
Porous covalent organic nanotubes and their assembly in loops and toroids	73
Constructing ion channels from water-soluble α-helical barrels	72
2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring	72
Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides	72
Solutal Marangoni effect determines bubble dynamics during electrocatalytic hydrogen evolution	72
A dissipative pathway for the structural evolution of DNA fibres	71
Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer	71
Concurrent control over sequence and dispersity in multiblock copolymers	70
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature	70
Atomic control of active-site ensembles in ordered alloys to enhance hydrogenation selectivity	70
An autonomously oscillating supramolecular self-replicator	69
Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster	69
Mechanochemical synthesis of an elusive fluorinated polyacetylene	69
Synthesis of monophosphines directly from white phosphorus	69
Fast CO2 hydration kinetics impair heterogeneous but improve enzymatic CO2 reduction catalysis	68
Isolation and reactivity of an elusive diazoalkene	68
A general design of caging-group-free photoactivatable fluorophores for live-cell nanoscopy	68
Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water	68
Insights from an information thermodynamics analysis of a synthetic molecular motor	67
Electron spin resonance of single iron phthalocyanine molecules and role of their non-localized spins in magnetic interactions	66
Photoinduced inverse vulcanization	66
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity	65
Surface-exposed silver nanoclusters inside molecular metal oxide cavities	65
Immobilization of molecular catalysts on electrode surfaces using host–guest interactions	65
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold	65
In vivo metallophilic self-assembly of a light-activated anticancer drug	64
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine	64
Interplay of vibrational wavepackets during an ultrafast electron transfer reaction	63
Spin-crossover nanoparticles anchored on MoS2 layers for heterostructures with tunable strain driven by thermal or light-induced spin switching	63
Free-triplet generation with improved efficiency in tetracene oligomers through spatially separated triplet pair states	63
Machine learning overcomes human bias in the discovery of self-assembling peptides	63
Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme	62
Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner	62
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array	62
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation	62
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins	61
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes	61
Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles	61
A ring expansion strategy towards diverse azaheterocycles	61
Strategies for developing DNA-encoded libraries beyond binding assays	61
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis	60
Electrochemical synthesis of propylene from carbon dioxide on copper nanocrystals	60
Adaptive response of a metal–organic framework through reversible disorder–disorder transitions	59
A 9.2-GHz clock transition in a Lu(II) molecular spin qubit arising from a 3,467-MHz hyperfine interaction	58
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria	58
Photocatalytic nitrogen fixation under an ambient atmosphere using a porous coordination polymer with bridging dinitrogen anions	58
Organocatalyst-controlled site-selective arene C–H functionalization	58
Merging molecular catalysts and metal–organic frameworks for photocatalytic fuel production	58
Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells	58
Emissive spin-0 triplet-pairs are a direct product of triplet–triplet annihilation in pentacene single crystals and anthradithiophene films	57
Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination	57
Multilayer stacks of polycyclic aromatic hydrocarbons	57
Cyclic polyacetylene	57
Tunable and recyclable polyesters from CO2 and butadiene	57
Palladium-catalysed selective oxidative amination of olefins with Lewis basic amines	57
Nuclear spin conservation enables state-to-state control of ultracold molecular reactions	56
Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids	55
Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning	55
Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data	55
Catalytic asymmetric C–C cross-couplings enabled by photoexcitation	54

Light-activated tetrazines enable precision live-cell bioorthogonal chemistry	54
Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes	54
Electrochemically driven desaturation of carbonyl compounds	54
The loss of endgroup effects in long pyridyl-endcapped oligoynes on the way to carbyne	54
Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties	53
Linkage conversions in single-crystalline covalent organic frameworks	53
Atomistic dynamics of elimination and nucleophilic substitution disentangled for the F− + CH3CH2Cl reaction	53
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction	53
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design	53
Dimeric and trimeric catenation of giant chiral [8 + 12] imine cubes driven by weak supramolecular interactions	52
Sustainable polyesters via direct functionalization of lignocellulosic sugars	52
Photocatalytic hydrofluoroalkylation of alkenes with carboxylic acids	52
Targeted activation in localized protein environments via deep red photoredox catalysis	52
Inverse kinetic isotope effects in the oxygen reduction reaction at platinum single crystals	51
Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications	51
Selective visible-light photocatalysis of acetylene to ethylene using a cobalt molecular catalyst and water as a proton source	50
Mass photometric detection and quantification of nanoscale α-synuclein phase separation	50
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons	50
σ–σ Stacked supramolecular junctions	50
Metalloradical approach for concurrent control in intermolecular radical allylic C−H amination	49
Magnetic ordering through itinerant ferromagnetism in a metal–organic framework	49
C–C bond activation enabled by dyotropic rearrangement of Pd(iv) species	49
Emergence of low-symmetry foldamers from single monomers	49
Structure, reactivity and catalytic properties of manganese-hydride amidate complexes	49
Isolation of a Ru(iv) side-on peroxo intermediate in the water oxidation reaction	48
A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes	48
Mechanism of mediated alkali peroxide oxidation and triplet versus singlet oxygen formation	48
Highly conducting single-molecule topological insulators based on mono- and di-radical cations	48
Stepwise on-demand functionalization of multihydrosilanes enabled by a hydrogen-atom-transfer photocatalyst based on eosin Y	48
Recyclable cyclic bio-based acrylic polymer via pairwise monomer enchainment by a trifunctional Lewis pair	48
Constructing covalent organic nanoarchitectures molecule by molecule via scanning probe manipulation	48
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors	48
Spontaneous N2 formation by a diruthenium complex enables electrocatalytic and aerobic oxidation of ammonia	47
Controlled growth of ordered monolayers of N-heterocyclic carbenes on silicon	47
Making the collective knowledge of chemistry open and machine actionable	47
Condensates in RNA repeat sequences are heterogeneously organized and exhibit reptation dynamics	47
Isolation and characterization of diazoolefins	47
Catalytic undirected borylation of tertiary C–H bonds in bicyclo[1.1.1]pentanes and bicyclo[2.1.1]hexanes	47
Isolation and electronic structures of derivatized manganocene, ferrocene and cobaltocene anions	46
Chemical upcycling of commodity thermoset polyurethane foams towards high-performance 3D photo-printing resins	46
Using collective knowledge to assign oxidation states of metal cations in metal–organic frameworks	46
Enantioselective fullerene functionalization through stereochemical information transfer from a self-assembled cage	46
Bifunctional sulfilimines enable synthesis of multiple N-heterocycles from alkenes	45
Selective scandium ion capture through coordination templating in a covalent organic framework	45
Uniform segmented platelet micelles with compositionally distinct and selectively degradable cores	44
Quantum nanomagnets in on-surface metal-free porphyrin chains	44
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors	44
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein	44
Active repair of a dinuclear photocatalyst for visible-light-driven hydrogen production	44
An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination	44
Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides	43
Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy	42
Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification	42
Catalytic reductive desymmetrization of malonic esters	42
Active template strategy for the preparation of π-conjugated interlocked nanocarbons	42
A two-directional vibrational probe reveals different electric field orientations in solution and an enzyme active site	42
Deep learning to design nuclear-targeting abiotic miniproteins	42
Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride	41
Selectivity control in hydrogenation through adaptive catalysis using ruthenium nanoparticles on a CO2-responsive support	41
Deaminative chlorination of aminoheterocycles	41
Photocaged 5′ cap analogues for optical control of mRNA translation in cells	41
A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes	41
Micrometre-scale single-crystalline borophene on a square-lattice Cu(100) surface	41
Stabilization of hexazine rings in potassium polynitride at high pressure	40
Non-statistical assembly of multicomponent [Pd2ABCD] cages	40
The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils	40
Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting	40
Illuminating the dark conformational space of macrocycles using dominant rotors	40
Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network	40
Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution	39
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation	39
A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing	39
Determining the nature of quantum resonances by probing elastic and reactive scattering in cold collisions	39
Genetically encoded chemical crosslinking of carbohydrate	39
Reversible transformations between the non-porous phases of a flexible coordination network enabled by transient porosity	38
Genetically encoded chemical crosslinking of RNA in vivo	38
How synonymous mutations alter enzyme structure and function over long timescales	38
Native mass spectrometry-based metabolomics identifies metal-binding compounds	38
Chemical-mediated translocation in protocell-based microactuators	37
Copper-catalysed difluorocarbene transfer enables modular synthesis	37
Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses	37
Protein folding modulates the chemical reactivity of a Gram-positive adhesin	37
On-surface synthesis of disilabenzene-bridged covalent organic frameworks	37
RNAs undergo phase transitions with lower critical solution temperatures	37
Direct conversion of white phosphorus to versatile phosphorus transfer reagents via oxidative onioation	37
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles	36
Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes	36
O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95	36
Single nucleotide translation without ribosomes	36
Time-resolved terahertz–Raman spectroscopy reveals that cations and anions distinctly modify intermolecular interactions of water	36
Ion-pair reorganization regulates reactivity in photoredox catalysts	36
A thiolate-bridged FeIVFeIV μ-nitrido complex and its hydrogenation reactivity toward ammonia formation	36
Prebiotic photoredox synthesis from carbon dioxide and sulfite	36
Energy funnelling within multichromophore architectures monitored with subnanometre resolution	36
Enantioselective synthesis of atropisomeric indoles via iron-catalysed oxidative cross-coupling	36