Nature Chemistry

Article	Citations
General synthesis of single-atom catalysts with high metal loading using graphene quantum dots	397
Deep-neural-network solution of the electronic Schrödinger equation	295
Ethylene/ethane separation in a stable hydrogen-bonded organic framework through a gating mechanism	275
Best practices in machine learning for chemistry	264
A glycan gate controls opening of the SARS-CoV-2 spike protein	260
Single-molecule visualization of DNA G-quadruplex formation in live cells	247
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains	243
Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time	188
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome	188
Metal–organic frameworks embedded in a liposome facilitate overall photocatalytic water splitting	179
Mechanochemical bond scission for the activation of drugs	176
De novo engineering of intracellular condensates using artificial disordered proteins	172
The complex chemical effects of COVID-19 shutdowns on air quality	151
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics	146
CD44 regulates epigenetic plasticity by mediating iron endocytosis	142
Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures	142
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses	135
Improving the efficiency of CO2 electrolysis by using a bipolar membrane with a weak-acid cation exchange layer	135
Tunable exciton binding energy in 2D hybrid layered perovskites through donor–acceptor interactions within the organic layer	135
Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis	133
Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates	132
Olefin metathesis-based chemically recyclable polymers enabled by fused-ring monomers	130
Oxidative cleavage of C–C bonds in lignin	130
Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditions	128
A biologically stable DNAzyme that efficiently silences gene expression in cells	126

Synthesis of bilayer borophene	122
Predator–prey interactions between droplets driven by non-reciprocal oil exchange	121
A proteome-wide atlas of lysine-reactive chemistry	120
Quantum machine learning using atom-in-molecule-based fragments selected on the fly	119
Aromatic hydrocarbon belts	117
Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells	116
Challenges to developing materials for the transport and storage of hydrogen	112
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates	111
Large magnetic exchange coupling in rhombus-shaped nanographenes with zigzag periphery	110
Metabolic glycan labelling for cancer-targeted therapy	108
Manganese-catalysed divergent silylation of alkenes	107
Tailored self-assembled photocatalytic nanofibres for visible-light-driven hydrogen production	107
Charge transfer driven by ultrafast spin transition in a CoFe Prussian blue analogue	107
A short peptide synthon for liquid–liquid phase separation	107
Synthesis of a zigzag carbon nanobelt	106
Meta-DNA structures	105
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications	105
Manganese(i) complexes with metal-to-ligand charge transfer luminescence and photoreactivity	105
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination	104
A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60	103
Switching on prodrugs using radiotherapy	102
Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres	100
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives	99
Competition between chiral solvents and chiral monomers in the helical bias of supramolecular polymers	97
Partitioning the interlayer space of covalent organic frameworks by embedding pseudorotaxanes in their backbones	95
The photochemical reaction of phenol becomes ultrafast at the air–water interface	94
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids	93
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery	93
Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones	90
One-pot, room-temperature conversion of dinitrogen to ammonium chloride at a main-group element	90
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells	90
Dissipative DNA nanotechnology	89
Single crystals of mechanically entwined helical covalent polymers	89
A molecular endless (74) knot	89
Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions	88
SuFExable polymers with helical structures derived from thionyl tetrafluoride	87
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells	86
Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores	84
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides	84
Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform	84
Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins	84
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization	83
Fast motion of molecular rotors in metal–organic framework struts at very low temperatures	82
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation	82
Correlating ligand-to-metal charge transfer with voltage hysteresis in a Li-rich rock-salt compound exhibiting anionic redox	82
On-surface photopolymerization of two-dimensional polymers ordered on the mesoscale	80
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles	80
A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres	80
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages	80
A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids	79

Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes	78
Reagentless biomolecular analysis using a molecular pendulum	78
A general arene C–H functionalization strategy via electron donor–acceptor complex photoactivation	78
A platinum(ii) metallonitrene with a triplet ground state	78
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates	77
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes	77
Tunable acetylene sorption by flexible catenated metal–organic frameworks	76
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides	76
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells	76
Evolution of dynamical networks enhances catalysis in a designer enzyme	75
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation	75
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation	75
A metal–organic framework that exhibits CO2-induced transitions between paramagnetism and ferrimagnetism	74
Switching the magnetic hysteresis of an [Feii–NC–Wv]-based coordination polymer by photoinduced reversible spin crossover	72
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions	72
Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping	72
Chemical fuels for molecular machinery	71
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity	71
Aromaticity rules	71
Substantial π-aromaticity in the anionic heavy-metal cluster [Th@Bi12]4−	71
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production	71
Melting of hybrid organic–inorganic perovskites	70
Nickel-catalysed asymmetric hydrogenation of oximes	70
In situ multiscale probing of the synthesis of a Ni-rich layered oxide cathode reveals reaction heterogeneity driven by competing kinetic pathways	70
Low-temperature liquid platinum catalyst	70
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides	69
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles	69
Post-translational formation of strained cyclophanes in bacteria	68
Constructing ion channels from water-soluble α-helical barrels	68
A circular polyester platform based on simple gem-disubstituted valerolactones	68
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds	68
Mechanochemical synthesis of an elusive fluorinated polyacetylene	67
Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer	67
Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides	67
A dissipative pathway for the structural evolution of DNA fibres	67
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime	65
Synthesis of monophosphines directly from white phosphorus	65
In situ electrochemical recomposition of decomposed redox-active species in aqueous organic flow batteries	65
Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands	64
Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube	63
Scalable and selective deuteration of (hetero)arenes	63
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature	62
Accelerating symmetry-breaking charge separation in a perylenediimide trimer through a vibronically coherent dimer intermediate	62
Functional DNA-based cytoskeletons for synthetic cells	62
Concurrent control over sequence and dispersity in multiblock copolymers	62
Water oxidation electrocatalysis using ruthenium coordination oligomers adsorbed on multiwalled carbon nanotubes	62
Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme	61
Supercrystal engineering of atomically precise gold nanoparticles promoted by surface dynamics	61
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine	61
Insights from an information thermodynamics analysis of a synthetic molecular motor	61
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane	61
Silylated silicon–carbonyl complexes as mimics of ubiquitous transition-metal carbonyls	60
Electron spin resonance of single iron phthalocyanine molecules and role of their non-localized spins in magnetic interactions	60
Harnessing chemical energy for the activation and joining of prebiotic building blocks	60
Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor	60
Strategies for developing DNA-encoded libraries beyond binding assays	59
Isolation and reactivity of an elusive diazoalkene	59
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity	59
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array	58
Atomic control of active-site ensembles in ordered alloys to enhance hydrogenation selectivity	58
An autonomously oscillating supramolecular self-replicator	58
Interplay of vibrational wavepackets during an ultrafast electron transfer reaction	58
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes	58
Fast CO2 hydration kinetics impair heterogeneous but improve enzymatic CO2 reduction catalysis	57
Organocatalyst-controlled site-selective arene C–H functionalization	57
Spin-crossover nanoparticles anchored on MoS2 layers for heterostructures with tunable strain driven by thermal or light-induced spin switching	57
Enzyme-free synthesis of natural phospholipids in water	56
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis	56
Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster	56
Cyclic polyacetylene	55
Adaptive response of a metal–organic framework through reversible disorder–disorder transitions	55
Porous covalent organic nanotubes and their assembly in loops and toroids	55
Nuclear spin conservation enables state-to-state control of ultracold molecular reactions	55
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation	55
Using waste poly(vinyl chloride) to synthesize chloroarenes by plasticizer-mediated electro(de)chlorination	55
A bis(silylene)-stabilized diphosphorus compound and its reactivity as a monophosphorus anion transfer reagent	55
A general design of caging-group-free photoactivatable fluorophores for live-cell nanoscopy	54
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins	54
Immobilization of molecular catalysts on electrode surfaces using host–guest interactions	54
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold	53

Electrochemically driven desaturation of carbonyl compounds	52
Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water	52
A 9.2-GHz clock transition in a Lu(II) molecular spin qubit arising from a 3,467-MHz hyperfine interaction	52
Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells	52
Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids	52
Emissive spin-0 triplet-pairs are a direct product of triplet–triplet annihilation in pentacene single crystals and anthradithiophene films	52
Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes	51
Tunable and recyclable polyesters from CO2 and butadiene	51
Free-triplet generation with improved efficiency in tetracene oligomers through spatially separated triplet pair states	51
Multilayer stacks of polycyclic aromatic hydrocarbons	50
Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins	49
Catalytic asymmetric C–C cross-couplings enabled by photoexcitation	49
Atomistic dynamics of elimination and nucleophilic substitution disentangled for the F− + CH3CH2Cl reaction	49
Tracking the ultraviolet-induced photochemistry of thiophenone during and after ultrafast ring opening	49
Merging molecular catalysts and metal–organic frameworks for photocatalytic fuel production	49
Photoinduced inverse vulcanization	49
Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties	49
A ring expansion strategy towards diverse azaheterocycles	48
Emergence of low-symmetry foldamers from single monomers	48
Machine learning overcomes human bias in the discovery of self-assembling peptides	47
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons	47
Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles	47
Selective visible-light photocatalysis of acetylene to ethylene using a cobalt molecular catalyst and water as a proton source	47
Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications	47
Catalytic enantiocontrol over a non-classical carbocation	46
Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning	46
The loss of endgroup effects in long pyridyl-endcapped oligoynes on the way to carbyne	46
Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities	46
Mechanism of mediated alkali peroxide oxidation and triplet versus singlet oxygen formation	46
σ–σ Stacked supramolecular junctions	46
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions	45
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction	45
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria	45
C–C bond activation enabled by dyotropic rearrangement of Pd(iv) species	45
Solutal Marangoni effect determines bubble dynamics during electrocatalytic hydrogen evolution	44
Highly conducting single-molecule topological insulators based on mono- and di-radical cations	44
Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination	44
Constructing covalent organic nanoarchitectures molecule by molecule via scanning probe manipulation	44
Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity	44
Audible sound-controlled spatiotemporal patterns in out-of-equilibrium systems	44
Long-range ordered and atomic-scale control of graphene hybridization by photocycloaddition	43
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors	43
Spontaneous N2 formation by a diruthenium complex enables electrocatalytic and aerobic oxidation of ammonia	43
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design	43
Knotting a molecular strand can invert macroscopic effects of chirality	43
A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes	43
Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner	43
Isolation of a Ru(iv) side-on peroxo intermediate in the water oxidation reaction	42
Light-activated tetrazines enable precision live-cell bioorthogonal chemistry	42
Targeted activation in localized protein environments via deep red photoredox catalysis	42
Sustainable polyesters via direct functionalization of lignocellulosic sugars	42
Isolation and electronic structures of derivatized manganocene, ferrocene and cobaltocene anions	42
Magnetic ordering through itinerant ferromagnetism in a metal–organic framework	42
Active repair of a dinuclear photocatalyst for visible-light-driven hydrogen production	41
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein	41
2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring	41
Palladium-catalysed selective oxidative amination of olefins with Lewis basic amines	41
Making the collective knowledge of chemistry open and machine actionable	41
Catalytic reductive desymmetrization of malonic esters	40
Photocatalytic nitrogen fixation under an ambient atmosphere using a porous coordination polymer with bridging dinitrogen anions	40
Using collective knowledge to assign oxidation states of metal cations in metal–organic frameworks	40
Dimeric and trimeric catenation of giant chiral [8 + 12] imine cubes driven by weak supramolecular interactions	40
Controlled growth of ordered monolayers of N-heterocyclic carbenes on silicon	40
Determining the nature of quantum resonances by probing elastic and reactive scattering in cold collisions	39
Inverse kinetic isotope effects in the oxygen reduction reaction at platinum single crystals	39
Isolation and characterization of diazoolefins	39
A two-directional vibrational probe reveals different electric field orientations in solution and an enzyme active site	39
Stepwise on-demand functionalization of multihydrosilanes enabled by a hydrogen-atom-transfer photocatalyst based on eosin Y	39
A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes	39
Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides	38
Selectivity control in hydrogenation through adaptive catalysis using ruthenium nanoparticles on a CO2-responsive support	38
Recyclable cyclic bio-based acrylic polymer via pairwise monomer enchainment by a trifunctional Lewis pair	38
Structure, reactivity and catalytic properties of manganese-hydride amidate complexes	38
Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting	38
Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy	38
An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination	38
How synonymous mutations alter enzyme structure and function over long timescales	38
Protein folding modulates the chemical reactivity of a Gram-positive adhesin	37
Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides	37
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation	37
Surface-exposed silver nanoclusters inside molecular metal oxide cavities	37
Electrochemical synthesis of propylene from carbon dioxide on copper nanocrystals	37
Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data	37
Deep learning to design nuclear-targeting abiotic miniproteins	37
Bifunctional sulfilimines enable synthesis of multiple N-heterocycles from alkenes	36
In vivo metallophilic self-assembly of a light-activated anticancer drug	36
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors	36
Metalloradical approach for concurrent control in intermolecular radical allylic C−H amination	36
Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis	36
Complexes featuring a linear [N≡U≡N] core isoelectronic to the uranyl cation	36
Quantum nanomagnets in on-surface metal-free porphyrin chains	36
Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses	36
Photocaged 5′ cap analogues for optical control of mRNA translation in cells	35
Condensates in RNA repeat sequences are heterogeneously organized and exhibit reptation dynamics	35
Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification	35