Nature Chemistry

Article	Citations
Towards the online computer-aided design of catalytic pockets	590
Iridium single-atom catalyst on nitrogen-doped carbon for formic acid oxidation synthesized using a general host–guest strategy	371
α-Synuclein aggregation nucleates through liquid–liquid phase separation	352
Coupling N2 and CO2 in H2O to synthesize urea under ambient conditions	344
General synthesis of single-atom catalysts with high metal loading using graphene quantum dots	274
Molecular engineering of organic–inorganic hybrid perovskites quantum wells	255
Targeted photoredox catalysis in cancer cells	242
Deep-neural-network solution of the electronic Schrödinger equation	228
On-water surface synthesis of crystalline, few-layer two-dimensional polymers assisted by surfactant monolayers	222
A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy	213
Single-molecule visualization of DNA G-quadruplex formation in live cells	208
The synthesis, properties and potential applications of cyclic polymers	206
The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation	201
A glycan gate controls opening of the SARS-CoV-2 spike protein	189
Covalent on-surface polymerization	186
Best practices in machine learning for chemistry	186
Efficient and tunable one-dimensional charge transport in layered lanthanide metal–organic frameworks	185
Understanding metal synergy in heterodinuclear catalysts for the copolymerization of CO2 and epoxides	184
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide	177
Multihole water oxidation catalysis on haematite photoanodes revealed by operando spectroelectrochemistry and DFT	169
Ethylene/ethane separation in a stable hydrogen-bonded organic framework through a gating mechanism	167
Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition	166
Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination	163
A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling	161
Regio- and diastereoselective intermolecular [2+2] cycloadditions photocatalysed by quantum dots	159

Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains	154
Enhanced reactivity of twisted amides inside a molecular cage	146
Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes	145
Metal–organic frameworks embedded in a liposome facilitate overall photocatalytic water splitting	144
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome	144
Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time	136
Coordination cages as permanently porous ionic liquids	133
Multi-responsive hydrogel structures from patterned droplet networks	132
The complex chemical effects of COVID-19 shutdowns on air quality	131
An alkyl-substituted aluminium anion with strong basicity and nucleophilicity	128
De novo engineering of intracellular condensates using artificial disordered proteins	124
An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)–H bonds	123
Cobalt-catalysed C–H methylation for late-stage drug diversification	121
Delayed fluorescence from a zirconium(iv) photosensitizer with ligand-to-metal charge-transfer excited states	120
Mechanochemical bond scission for the activation of drugs	117
Principle and design of pseudo-natural products	113
Enantioselective radical C–H amination for the synthesis of β-amino alcohols	112
Global aromaticity at the nanoscale	110
Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes	110
Iron(ii) coordination complexes with panchromatic absorption and nanosecond charge-transfer excited state lifetimes	108
Nickel-catalysed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions	108
Identification of a Frank–Kasper Z phase from shape amphiphile self-assembly	105
Tailored silyl ether monomers enable backbone-degradable polynorbornene-based linear, bottlebrush and star copolymers through ROMP	104
Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditions	103
Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases	101
A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates	101
Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis	99
CD44 regulates epigenetic plasticity by mediating iron endocytosis	97
Improving the efficiency of CO2 electrolysis by using a bipolar membrane with a weak-acid cation exchange layer	96
A biologically stable DNAzyme that efficiently silences gene expression in cells	96
Olefin metathesis-based chemically recyclable polymers enabled by fused-ring monomers	95
Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures	94
3D global aromaticity in a fully conjugated diradicaloid cage at different oxidation states	93
A review and critique of academic lab safety research	93
Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates	93
Quantum machine learning using atom-in-molecule-based fragments selected on the fly	92
Tunable exciton binding energy in 2D hybrid layered perovskites through donor–acceptor interactions within the organic layer	92
Capture of nitrogen dioxide and conversion to nitric acid in a porous metal–organic framework	90
A multiplexed, electrochemical interface for gene-circuit-based sensors	86
Differentiation and functionalization of remote C–H bonds in adjacent positions	85
A proteome-wide atlas of lysine-reactive chemistry	83
Rapid desolvation-triggered domino lattice rearrangement in a metal–organic framework	83
Engineered triply orthogonal pyrrolysyl–tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids	83
Tailored self-assembled photocatalytic nanofibres for visible-light-driven hydrogen production	82
Aromatic hydrocarbon belts	82
Charge transfer driven by ultrafast spin transition in a CoFe Prussian blue analogue	82
Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns	81
Facile synthesis of precious-metal single-site catalysts using organic solvents	81
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination	81
Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells	81

Large magnetic exchange coupling in rhombus-shaped nanographenes with zigzag periphery	81
Synthesis of a zigzag carbon nanobelt	80
Metabolic glycan labelling for cancer-targeted therapy	80
Meta-DNA structures	80
Achieving spin-triplet exciton transfer between silicon and molecular acceptors for photon upconversion	79
Modular and regioselective synthesis of all-carbon tetrasubstituted olefins enabled by an alkenyl Catellani reaction	78
Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs	78
Oxidative cleavage of C–C bonds in lignin	77
Synthesis of bilayer borophene	77
FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis	76
Crowdsourcing drug discovery for pandemics	76
Predator–prey interactions between droplets driven by non-reciprocal oil exchange	75
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates	75
Switching on prodrugs using radiotherapy	74
A silicon–carbonyl complex stable at room temperature	74
Manganese(i) complexes with metal-to-ligand charge transfer luminescence and photoreactivity	74
Single-atom gold oxo-clusters prepared in alkaline solutions catalyse the heterogeneous methanol self-coupling reactions	74
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids	73
Enantioselective photoinduced cyclodimerization of a prochiral anthracene derivative adsorbed on helical metal nanostructures	73
One-pot, room-temperature conversion of dinitrogen to ammonium chloride at a main-group element	73
Intra- and intermolecular self-assembly of a 20-nm-wide supramolecular hexagonal grid	73
Manganese-catalysed divergent silylation of alkenes	72
Competition between chiral solvents and chiral monomers in the helical bias of supramolecular polymers	72
Spatial separation of triplet excitons drives endothermic singlet fission	72
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells	71
Directional conformer exchange in dihydrofolate reductase revealed by single-molecule nanopore recordings	71
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses	70
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics	70
Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions	69
Photodriven quantum teleportation of an electron spin state in a covalent donor–acceptor–radical system	69
Partitioning the interlayer space of covalent organic frameworks by embedding pseudorotaxanes in their backbones	69
Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres	68
The cascade unzipping of ladderane reveals dynamic effects in mechanochemistry	67
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery	66
Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms	66
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives	65
The photochemical reaction of phenol becomes ultrafast at the air–water interface	65
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications	65
A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60	65
The role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA	64
Interface-mediated noble metal deposition on transition metal dichalcogenide nanostructures	64
A photoswitchable polar crystal that exhibits superionic conduction	63
Fast motion of molecular rotors in metal–organic framework struts at very low temperatures	63
A short peptide synthon for liquid–liquid phase separation	63
A platinum(ii) metallonitrene with a triplet ground state	62
Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins	62
A molecular endless (74) knot	62
A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids	61
Electronic landscape of the P-cluster of nitrogenase as revealed through many-electron quantum wavefunction simulations	61
A metal–organic framework that exhibits CO2-induced transitions between paramagnetism and ferrimagnetism	60
On-surface synthesis and characterization of individual polyacetylene chains	60
Catalytic C(sp3)–H bond activation in tertiary alkylamines	60
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides	60
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells	59
Time-dependent enantiodivergent synthesis via sequential kinetic resolution	59
A site-selective amination catalyst discriminates between nearly identical C–H bonds of unsymmetrical disubstituted alkenes	59
Reagentless biomolecular analysis using a molecular pendulum	59
On-surface photopolymerization of two-dimensional polymers ordered on the mesoscale	59
A marine viral halogenase that iodinates diverse substrates	59
Mechanochemical synthesis of an elusive fluorinated polyacetylene	59
Modular bismacycles for the selective C–H arylation of phenols and naphthols	57
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production	57
Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme	57
Modulation of porosity in a solid material enabled by bulk photoisomerization of an overcrowded alkene	56
SuFExable polymers with helical structures derived from thionyl tetrafluoride	56
Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones	56
Single-chromophore single-molecule photocatalyst for the production of dihydrogen using low-energy light	55
Metallacyclic actinide catalysts for dinitrogen conversion to ammonia and secondary amines	55
Rapid functionalization of multiple C–H bonds in unprotected alicyclic amines	54
Chemoselective oxidative generation of ortho-quinone methides and tandem transformations	54
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation	54
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity	54
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage	54
Synthesis of monophosphines directly from white phosphorus	53
Use of α-trifluoromethyl carbanions for palladium-catalysed asymmetric cycloadditions	53
Correlating ligand-to-metal charge transfer with voltage hysteresis in a Li-rich rock-salt compound exhibiting anionic redox	53
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation	52
Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides	52
Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids	52
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides	51

Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform	51
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine	51
Constructing ion channels from water-soluble α-helical barrels	51
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization	51
Melting of hybrid organic–inorganic perovskites	50
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds	50
Single crystals of mechanically entwined helical covalent polymers	50
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides	50
Substantial π-aromaticity in the anionic heavy-metal cluster [Th@Bi12]4−	50
Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer	49
Aerobic radical polymerization mediated by microbial metabolism	48
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles	48
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates	48
Silylated silicon–carbonyl complexes as mimics of ubiquitous transition-metal carbonyls	47
Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase	47
Harnessing chemical energy for the activation and joining of prebiotic building blocks	47
Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube	46
Water oxidation electrocatalysis using ruthenium coordination oligomers adsorbed on multiwalled carbon nanotubes	46
Enzyme-free synthesis of natural phospholipids in water	46
Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor	46
Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores	46
Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster	45
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes	45
Nuclear spin conservation enables state-to-state control of ultracold molecular reactions	45
A dissipative pathway for the structural evolution of DNA fibres	45
Hofmeister’s curse	45
Adaptive response of a metal–organic framework through reversible disorder–disorder transitions	45
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles	44
Catalytic asymmetric C–C cross-couplings enabled by photoexcitation	44
A bis(silylene)-stabilized diphosphorus compound and its reactivity as a monophosphorus anion transfer reagent	44
Total synthesis of brevianamide A	44
Spin-crossover nanoparticles anchored on MoS2 layers for heterostructures with tunable strain driven by thermal or light-induced spin switching	44
Interplay of vibrational wavepackets during an ultrafast electron transfer reaction	44
Observation of the asphericity of 4f-electron density and its relation to the magnetic anisotropy axis in single-molecule magnets	44
Post-translational formation of strained cyclophanes in bacteria	44
Genome mining- and synthetic biology-enabled production of hypermodified peptides	44
Scalable and selective deuteration of (hetero)arenes	44
Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures	43
In situ chromatin interactomics using a chemical bait and trap approach	43
Isolation and reactivity of an elusive diazoalkene	43
In situ visualization of loading-dependent water effects in a stable metal–organic framework	43
Immobilization of molecular catalysts on electrode surfaces using host–guest interactions	43
Evolution of dynamical networks enhances catalysis in a designer enzyme	43
Emergence of low-symmetry foldamers from single monomers	43
Isolation, characterization and reactivity of three-coordinate phosphorus dications isoelectronic to alanes and silylium cations	43
Energy threshold for chiral symmetry breaking in molecular self-replication	42
Tunable acetylene sorption by flexible catenated metal–organic frameworks	42
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins	42
Nickel-catalysed asymmetric hydrogenation of oximes	41
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold	41
Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins	41
Demystifying the asymmetry-amplifying, autocatalytic behaviour of the Soai reaction through structural, mechanistic and computational studies	41
Organocatalyst-controlled site-selective arene C–H functionalization	40
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime	40
Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator	40
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes	40
Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities	40
Switching the magnetic hysteresis of an [Feii–NC–Wv]-based coordination polymer by photoinduced reversible spin crossover	39
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity	39
Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme	39
Insights from an information thermodynamics analysis of a synthetic molecular motor	39
Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity	39
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells	39
Long-range ordered and atomic-scale control of graphene hybridization by photocycloaddition	38
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis	38
Concurrent control over sequence and dispersity in multiblock copolymers	38
Structural basis for chain release from the enacyloxin polyketide synthase	38
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature	38
Planar three-coordinate iron sulfide in a synthetic [4Fe-3S] cluster with biomimetic reactivity	38
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array	37
Tracking the ultraviolet-induced photochemistry of thiophenone during and after ultrafast ring opening	37
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons	37
Connecting remote C–H bond functionalization and decarboxylative coupling using simple amines	37
In situ electrochemical recomposition of decomposed redox-active species in aqueous organic flow batteries	37
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes	36
Dissipative DNA nanotechnology	36
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages	36
NH3 formation from N2 and H2 mediated by molecular tri-iron complexes	36
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions	36
Electron spin resonance of single iron phthalocyanine molecules and role of their non-localized spins in magnetic interactions	36
Determining the nature of quantum resonances by probing elastic and reactive scattering in cold collisions	36
Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands	36
Spontaneous drying of non-polar deep-cavity cavitand pockets in aqueous solution	36
Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells	36
The loss of endgroup effects in long pyridyl-endcapped oligoynes on the way to carbyne	35
Strategies for developing DNA-encoded libraries beyond binding assays	35
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation	35
Emissive spin-0 triplet-pairs are a direct product of triplet–triplet annihilation in pentacene single crystals and anthradithiophene films	35
Porous covalent organic nanotubes and their assembly in loops and toroids	35
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane	35
Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications	35
Multilayer stacks of polycyclic aromatic hydrocarbons	35
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions	35
Impact of non-equilibrium molecular packings on singlet fission in microcrystals observed using 2D white-light microscopy	35
A bright future for photosensitizers	35
Free-triplet generation with improved efficiency in tetracene oligomers through spatially separated triplet pair states	35