Nature Chemistry

(The TQCC of Nature Chemistry is 35. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 500 papers]. The publications cover those that have been published in the past four years, i.e., from 2019-09-01 to 2023-09-01.)
Towards the online computer-aided design of catalytic pockets590
Iridium single-atom catalyst on nitrogen-doped carbon for formic acid oxidation synthesized using a general host–guest strategy371
α-Synuclein aggregation nucleates through liquid–liquid phase separation352
Coupling N2 and CO2 in H2O to synthesize urea under ambient conditions344
General synthesis of single-atom catalysts with high metal loading using graphene quantum dots274
Molecular engineering of organic–inorganic hybrid perovskites quantum wells255
Targeted photoredox catalysis in cancer cells242
Deep-neural-network solution of the electronic Schrödinger equation228
On-water surface synthesis of crystalline, few-layer two-dimensional polymers assisted by surfactant monolayers222
A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy213
Single-molecule visualization of DNA G-quadruplex formation in live cells208
The synthesis, properties and potential applications of cyclic polymers206
The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation201
A glycan gate controls opening of the SARS-CoV-2 spike protein189
Covalent on-surface polymerization186
Best practices in machine learning for chemistry186
Efficient and tunable one-dimensional charge transport in layered lanthanide metal–organic frameworks185
Understanding metal synergy in heterodinuclear catalysts for the copolymerization of CO2 and epoxides184
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide177
Multihole water oxidation catalysis on haematite photoanodes revealed by operando spectroelectrochemistry and DFT169
Ethylene/ethane separation in a stable hydrogen-bonded organic framework through a gating mechanism167
Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition166
Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination163
A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling161
Regio- and diastereoselective intermolecular [2+2] cycloadditions photocatalysed by quantum dots159
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains154
Enhanced reactivity of twisted amides inside a molecular cage146
Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes145
Metal–organic frameworks embedded in a liposome facilitate overall photocatalytic water splitting144
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome144
Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time136
Coordination cages as permanently porous ionic liquids133
Multi-responsive hydrogel structures from patterned droplet networks132
The complex chemical effects of COVID-19 shutdowns on air quality131
An alkyl-substituted aluminium anion with strong basicity and nucleophilicity128
De novo engineering of intracellular condensates using artificial disordered proteins124
An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)–H bonds123
Cobalt-catalysed C–H methylation for late-stage drug diversification121
Delayed fluorescence from a zirconium(iv) photosensitizer with ligand-to-metal charge-transfer excited states120
Mechanochemical bond scission for the activation of drugs117
Principle and design of pseudo-natural products113
Enantioselective radical C–H amination for the synthesis of β-amino alcohols112
Global aromaticity at the nanoscale110
Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes110
Iron(ii) coordination complexes with panchromatic absorption and nanosecond charge-transfer excited state lifetimes108
Nickel-catalysed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions108
Identification of a Frank–Kasper Z phase from shape amphiphile self-assembly105
Tailored silyl ether monomers enable backbone-degradable polynorbornene-based linear, bottlebrush and star copolymers through ROMP104
Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditions103
Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases101
A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates101
Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis99
CD44 regulates epigenetic plasticity by mediating iron endocytosis97
Improving the efficiency of CO2 electrolysis by using a bipolar membrane with a weak-acid cation exchange layer96
A biologically stable DNAzyme that efficiently silences gene expression in cells96
Olefin metathesis-based chemically recyclable polymers enabled by fused-ring monomers95
Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures94
3D global aromaticity in a fully conjugated diradicaloid cage at different oxidation states93
A review and critique of academic lab safety research93
Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates93
Quantum machine learning using atom-in-molecule-based fragments selected on the fly92
Tunable exciton binding energy in 2D hybrid layered perovskites through donor–acceptor interactions within the organic layer92
Capture of nitrogen dioxide and conversion to nitric acid in a porous metal–organic framework90
A multiplexed, electrochemical interface for gene-circuit-based sensors86
Differentiation and functionalization of remote C–H bonds in adjacent positions85
A proteome-wide atlas of lysine-reactive chemistry83
Rapid desolvation-triggered domino lattice rearrangement in a metal–organic framework83
Engineered triply orthogonal pyrrolysyl–tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids83
Tailored self-assembled photocatalytic nanofibres for visible-light-driven hydrogen production82
Aromatic hydrocarbon belts82
Charge transfer driven by ultrafast spin transition in a CoFe Prussian blue analogue82
Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns81
Facile synthesis of precious-metal single-site catalysts using organic solvents81
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination81
Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells81
Large magnetic exchange coupling in rhombus-shaped nanographenes with zigzag periphery81
Synthesis of a zigzag carbon nanobelt80
Metabolic glycan labelling for cancer-targeted therapy80
Meta-DNA structures80
Achieving spin-triplet exciton transfer between silicon and molecular acceptors for photon upconversion79
Modular and regioselective synthesis of all-carbon tetrasubstituted olefins enabled by an alkenyl Catellani reaction78
Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs78
Oxidative cleavage of C–C bonds in lignin77
Synthesis of bilayer borophene77
FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis76
Crowdsourcing drug discovery for pandemics76
Predator–prey interactions between droplets driven by non-reciprocal oil exchange75
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates75
Switching on prodrugs using radiotherapy74
A silicon–carbonyl complex stable at room temperature74
Manganese(i) complexes with metal-to-ligand charge transfer luminescence and photoreactivity74
Single-atom gold oxo-clusters prepared in alkaline solutions catalyse the heterogeneous methanol self-coupling reactions74
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids73
Enantioselective photoinduced cyclodimerization of a prochiral anthracene derivative adsorbed on helical metal nanostructures73
One-pot, room-temperature conversion of dinitrogen to ammonium chloride at a main-group element73
Intra- and intermolecular self-assembly of a 20-nm-wide supramolecular hexagonal grid73
Manganese-catalysed divergent silylation of alkenes72
Competition between chiral solvents and chiral monomers in the helical bias of supramolecular polymers72
Spatial separation of triplet excitons drives endothermic singlet fission72
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells71
Directional conformer exchange in dihydrofolate reductase revealed by single-molecule nanopore recordings71
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses70
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics70
Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions69
Photodriven quantum teleportation of an electron spin state in a covalent donor–acceptor–radical system69
Partitioning the interlayer space of covalent organic frameworks by embedding pseudorotaxanes in their backbones69
Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres68
The cascade unzipping of ladderane reveals dynamic effects in mechanochemistry67
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery66
Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms66
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives65
The photochemical reaction of phenol becomes ultrafast at the air–water interface65
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications65
A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C6065
The role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA64
Interface-mediated noble metal deposition on transition metal dichalcogenide nanostructures64
A photoswitchable polar crystal that exhibits superionic conduction63
Fast motion of molecular rotors in metal–organic framework struts at very low temperatures63
A short peptide synthon for liquid–liquid phase separation63
A platinum(ii) metallonitrene with a triplet ground state62
Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins62
A molecular endless (74) knot62
A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids61
Electronic landscape of the P-cluster of nitrogenase as revealed through many-electron quantum wavefunction simulations61
A metal–organic framework that exhibits CO2-induced transitions between paramagnetism and ferrimagnetism60
On-surface synthesis and characterization of individual polyacetylene chains60
Catalytic C(sp3)–H bond activation in tertiary alkylamines60
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides60
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells59
Time-dependent enantiodivergent synthesis via sequential kinetic resolution59
A site-selective amination catalyst discriminates between nearly identical C–H bonds of unsymmetrical disubstituted alkenes59
Reagentless biomolecular analysis using a molecular pendulum59
On-surface photopolymerization of two-dimensional polymers ordered on the mesoscale59
A marine viral halogenase that iodinates diverse substrates59
Mechanochemical synthesis of an elusive fluorinated polyacetylene59
Modular bismacycles for the selective C–H arylation of phenols and naphthols57
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production57
Temperature-jump solution X-ray scattering reveals distinct motions in a dynamic enzyme57
Modulation of porosity in a solid material enabled by bulk photoisomerization of an overcrowded alkene56
SuFExable polymers with helical structures derived from thionyl tetrafluoride56
Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones56
Single-chromophore single-molecule photocatalyst for the production of dihydrogen using low-energy light55
Metallacyclic actinide catalysts for dinitrogen conversion to ammonia and secondary amines55
Rapid functionalization of multiple C–H bonds in unprotected alicyclic amines54
Chemoselective oxidative generation of ortho-quinone methides and tandem transformations54
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation54
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity54
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage54
Synthesis of monophosphines directly from white phosphorus53
Use of α-trifluoromethyl carbanions for palladium-catalysed asymmetric cycloadditions53
Correlating ligand-to-metal charge transfer with voltage hysteresis in a Li-rich rock-salt compound exhibiting anionic redox53
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation52
Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides52
Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids52
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides51
Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform51
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine51
Constructing ion channels from water-soluble α-helical barrels51
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization51
Melting of hybrid organic–inorganic perovskites50
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds50
Single crystals of mechanically entwined helical covalent polymers50
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides50
Substantial π-aromaticity in the anionic heavy-metal cluster [Th@Bi12]4−50
Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer49
Aerobic radical polymerization mediated by microbial metabolism48
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles48
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates48
Silylated silicon–carbonyl complexes as mimics of ubiquitous transition-metal carbonyls47
Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase47
Harnessing chemical energy for the activation and joining of prebiotic building blocks47
Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube46
Water oxidation electrocatalysis using ruthenium coordination oligomers adsorbed on multiwalled carbon nanotubes46
Enzyme-free synthesis of natural phospholipids in water46
Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor46
Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores46
Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster45
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes45
Nuclear spin conservation enables state-to-state control of ultracold molecular reactions45
A dissipative pathway for the structural evolution of DNA fibres45
Hofmeister’s curse45
Adaptive response of a metal–organic framework through reversible disorder–disorder transitions45
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles44
Catalytic asymmetric C–C cross-couplings enabled by photoexcitation44
A bis(silylene)-stabilized diphosphorus compound and its reactivity as a monophosphorus anion transfer reagent44
Total synthesis of brevianamide A44
Spin-crossover nanoparticles anchored on MoS2 layers for heterostructures with tunable strain driven by thermal or light-induced spin switching44
Interplay of vibrational wavepackets during an ultrafast electron transfer reaction44
Observation of the asphericity of 4f-electron density and its relation to the magnetic anisotropy axis in single-molecule magnets44
Post-translational formation of strained cyclophanes in bacteria44
Genome mining- and synthetic biology-enabled production of hypermodified peptides44
Scalable and selective deuteration of (hetero)arenes44
Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures43
In situ chromatin interactomics using a chemical bait and trap approach43
Isolation and reactivity of an elusive diazoalkene43
In situ visualization of loading-dependent water effects in a stable metal–organic framework43
Immobilization of molecular catalysts on electrode surfaces using host–guest interactions43
Evolution of dynamical networks enhances catalysis in a designer enzyme43
Emergence of low-symmetry foldamers from single monomers43
Isolation, characterization and reactivity of three-coordinate phosphorus dications isoelectronic to alanes and silylium cations43
Energy threshold for chiral symmetry breaking in molecular self-replication42
Tunable acetylene sorption by flexible catenated metal–organic frameworks42
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins42
Nickel-catalysed asymmetric hydrogenation of oximes41
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold41
Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins41
Demystifying the asymmetry-amplifying, autocatalytic behaviour of the Soai reaction through structural, mechanistic and computational studies41
Organocatalyst-controlled site-selective arene C–H functionalization40
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime40
Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator40
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes40
Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities40
Switching the magnetic hysteresis of an [Feii–NC–Wv]-based coordination polymer by photoinduced reversible spin crossover39
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity39
Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme39
Insights from an information thermodynamics analysis of a synthetic molecular motor39
Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity39
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells39
Long-range ordered and atomic-scale control of graphene hybridization by photocycloaddition38
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis38
Concurrent control over sequence and dispersity in multiblock copolymers38
Structural basis for chain release from the enacyloxin polyketide synthase38
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature38
Planar three-coordinate iron sulfide in a synthetic [4Fe-3S] cluster with biomimetic reactivity38
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array37
Tracking the ultraviolet-induced photochemistry of thiophenone during and after ultrafast ring opening37
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons37
Connecting remote C–H bond functionalization and decarboxylative coupling using simple amines37
In situ electrochemical recomposition of decomposed redox-active species in aqueous organic flow batteries37
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes36
Dissipative DNA nanotechnology36
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages36
NH3 formation from N2 and H2 mediated by molecular tri-iron complexes36
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions36
Electron spin resonance of single iron phthalocyanine molecules and role of their non-localized spins in magnetic interactions36
Determining the nature of quantum resonances by probing elastic and reactive scattering in cold collisions36
Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands36
Spontaneous drying of non-polar deep-cavity cavitand pockets in aqueous solution36
Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells36
The loss of endgroup effects in long pyridyl-endcapped oligoynes on the way to carbyne35
Strategies for developing DNA-encoded libraries beyond binding assays35
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation35
Emissive spin-0 triplet-pairs are a direct product of triplet–triplet annihilation in pentacene single crystals and anthradithiophene films35
Porous covalent organic nanotubes and their assembly in loops and toroids35
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane35
Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications35
Multilayer stacks of polycyclic aromatic hydrocarbons35
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions35
Impact of non-equilibrium molecular packings on singlet fission in microcrystals observed using 2D white-light microscopy35
A bright future for photosensitizers35
Free-triplet generation with improved efficiency in tetracene oligomers through spatially separated triplet pair states35