Nature Chemistry

Papers
(The TQCC of Nature Chemistry is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-12-01 to 2024-12-01.)
ArticleCitations
General synthesis of single-atom catalysts with high metal loading using graphene quantum dots441
Ethylene/ethane separation in a stable hydrogen-bonded organic framework through a gating mechanism327
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains305
Best practices in machine learning for chemistry300
A glycan gate controls opening of the SARS-CoV-2 spike protein292
Metal–organic frameworks embedded in a liposome facilitate overall photocatalytic water splitting208
Mechanochemical bond scission for the activation of drugs198
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome195
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics180
Oxidative cleavage of C–C bonds in lignin168
Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures165
Challenges to developing materials for the transport and storage of hydrogen164
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses161
Improving the efficiency of CO2 electrolysis by using a bipolar membrane with a weak-acid cation exchange layer160
Olefin metathesis-based chemically recyclable polymers enabled by fused-ring monomers157
Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis154
A proteome-wide atlas of lysine-reactive chemistry143
Synthesis of bilayer borophene139
A biologically stable DNAzyme that efficiently silences gene expression in cells139
Aromatic hydrocarbon belts138
A short peptide synthon for liquid–liquid phase separation137
A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres130
Switching on prodrugs using radiotherapy125
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates124
Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres121
Charge transfer driven by ultrafast spin transition in a CoFe Prussian blue analogue121
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination121
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications121
Manganese-catalysed divergent silylation of alkenes118
A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60117
Manganese(i) complexes with metal-to-ligand charge transfer luminescence and photoreactivity117
Large magnetic exchange coupling in rhombus-shaped nanographenes with zigzag periphery115
The photochemical reaction of phenol becomes ultrafast at the air–water interface115
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives114
Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping111
Synthesis of a zigzag carbon nanobelt110
A general arene C–H functionalization strategy via electron donor–acceptor complex photoactivation106
Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones105
Dissipative DNA nanotechnology105
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation100
Single crystals of mechanically entwined helical covalent polymers99
SuFExable polymers with helical structures derived from thionyl tetrafluoride98
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells97
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages97
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides96
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization95
Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores94
A molecular endless (74) knot94
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells94
Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform94
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes93
Tunable acetylene sorption by flexible catenated metal–organic frameworks92
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production91
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation91
Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins90
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides90
Low-temperature liquid platinum catalyst89
On-surface photopolymerization of two-dimensional polymers ordered on the mesoscale89
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates89
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles89
Correlating ligand-to-metal charge transfer with voltage hysteresis in a Li-rich rock-salt compound exhibiting anionic redox88
Reagentless biomolecular analysis using a molecular pendulum87
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells85
In situ multiscale probing of the synthesis of a Ni-rich layered oxide cathode reveals reaction heterogeneity driven by competing kinetic pathways84
Supercrystal engineering of atomically precise gold nanoparticles promoted by surface dynamics83
Melting of hybrid organic–inorganic perovskites82
Evolution of dynamical networks enhances catalysis in a designer enzyme82
In situ electrochemical recomposition of decomposed redox-active species in aqueous organic flow batteries82
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation81
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes81
Scalable and selective deuteration of (hetero)arenes80
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides80
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane79
Chemical fuels for molecular machinery79
Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands78
Accelerating symmetry-breaking charge separation in a perylenediimide trimer through a vibronically coherent dimer intermediate77
A circular polyester platform based on simple gem-disubstituted valerolactones77
Aromaticity rules77
Substantial π-aromaticity in the anionic heavy-metal cluster [Th@Bi12]4−76
Nickel-catalysed asymmetric hydrogenation of oximes76
Functional DNA-based cytoskeletons for synthetic cells75
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds75
Using waste poly(vinyl chloride) to synthesize chloroarenes by plasticizer-mediated electro(de)chlorination75
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles75
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions74
Switching the magnetic hysteresis of an [Feii–NC–Wv]-based coordination polymer by photoinduced reversible spin crossover74
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity74
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime73
Porous covalent organic nanotubes and their assembly in loops and toroids73
2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring72
Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides72
Solutal Marangoni effect determines bubble dynamics during electrocatalytic hydrogen evolution72
Constructing ion channels from water-soluble α-helical barrels72
Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer71
A dissipative pathway for the structural evolution of DNA fibres71
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature70
Atomic control of active-site ensembles in ordered alloys to enhance hydrogenation selectivity70
Concurrent control over sequence and dispersity in multiblock copolymers70
Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster69
Mechanochemical synthesis of an elusive fluorinated polyacetylene69
Synthesis of monophosphines directly from white phosphorus69
An autonomously oscillating supramolecular self-replicator69
Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water68
A general design of caging-group-free photoactivatable fluorophores for live-cell nanoscopy68
Fast CO2 hydration kinetics impair heterogeneous but improve enzymatic CO2 reduction catalysis68
Isolation and reactivity of an elusive diazoalkene68
Insights from an information thermodynamics analysis of a synthetic molecular motor67
Electron spin resonance of single iron phthalocyanine molecules and role of their non-localized spins in magnetic interactions66
Photoinduced inverse vulcanization66
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity65
Surface-exposed silver nanoclusters inside molecular metal oxide cavities65
Immobilization of molecular catalysts on electrode surfaces using host–guest interactions65
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold65
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine64
In vivo metallophilic self-assembly of a light-activated anticancer drug64
Spin-crossover nanoparticles anchored on MoS2 layers for heterostructures with tunable strain driven by thermal or light-induced spin switching63
Free-triplet generation with improved efficiency in tetracene oligomers through spatially separated triplet pair states63
Machine learning overcomes human bias in the discovery of self-assembling peptides63
Interplay of vibrational wavepackets during an ultrafast electron transfer reaction63
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array62
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation62
Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme62
Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner62
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes61
Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles61
A ring expansion strategy towards diverse azaheterocycles61
Strategies for developing DNA-encoded libraries beyond binding assays61
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins61
Electrochemical synthesis of propylene from carbon dioxide on copper nanocrystals60
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis60
Adaptive response of a metal–organic framework through reversible disorder–disorder transitions59
Photocatalytic nitrogen fixation under an ambient atmosphere using a porous coordination polymer with bridging dinitrogen anions58
A 9.2-GHz clock transition in a Lu(II) molecular spin qubit arising from a 3,467-MHz hyperfine interaction58
Merging molecular catalysts and metal–organic frameworks for photocatalytic fuel production58
Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells58
Organocatalyst-controlled site-selective arene C–H functionalization58
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria58
Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination57
Multilayer stacks of polycyclic aromatic hydrocarbons57
Cyclic polyacetylene57
Tunable and recyclable polyesters from CO2 and butadiene57
Palladium-catalysed selective oxidative amination of olefins with Lewis basic amines57
Emissive spin-0 triplet-pairs are a direct product of triplet–triplet annihilation in pentacene single crystals and anthradithiophene films57
Nuclear spin conservation enables state-to-state control of ultracold molecular reactions56
Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning55
Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data55
Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids55
Catalytic asymmetric C–C cross-couplings enabled by photoexcitation54
Electrochemically driven desaturation of carbonyl compounds54
Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes54
Light-activated tetrazines enable precision live-cell bioorthogonal chemistry54
Atomistic dynamics of elimination and nucleophilic substitution disentangled for the F− + CH3CH2Cl reaction53
Linkage conversions in single-crystalline covalent organic frameworks53
Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties53
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction53
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design53
Dimeric and trimeric catenation of giant chiral [8 + 12] imine cubes driven by weak supramolecular interactions52
Sustainable polyesters via direct functionalization of lignocellulosic sugars52
Photocatalytic hydrofluoroalkylation of alkenes with carboxylic acids52
Targeted activation in localized protein environments via deep red photoredox catalysis52
Inverse kinetic isotope effects in the oxygen reduction reaction at platinum single crystals51
Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications51
Selective visible-light photocatalysis of acetylene to ethylene using a cobalt molecular catalyst and water as a proton source50
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons50
Mass photometric detection and quantification of nanoscale α-synuclein phase separation50
σ–σ Stacked supramolecular junctions50
C–C bond activation enabled by dyotropic rearrangement of Pd(iv) species49
Structure, reactivity and catalytic properties of manganese-hydride amidate complexes49
Metalloradical approach for concurrent control in intermolecular radical allylic C−H amination49
Magnetic ordering through itinerant ferromagnetism in a metal–organic framework49
Highly conducting single-molecule topological insulators based on mono- and di-radical cations48
A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes48
Recyclable cyclic bio-based acrylic polymer via pairwise monomer enchainment by a trifunctional Lewis pair48
Constructing covalent organic nanoarchitectures molecule by molecule via scanning probe manipulation48
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors48
Isolation of a Ru(iv) side-on peroxo intermediate in the water oxidation reaction48
Stepwise on-demand functionalization of multihydrosilanes enabled by a hydrogen-atom-transfer photocatalyst based on eosin Y48
Mechanism of mediated alkali peroxide oxidation and triplet versus singlet oxygen formation48
Isolation and characterization of diazoolefins47
Condensates in RNA repeat sequences are heterogeneously organized and exhibit reptation dynamics47
Spontaneous N2 formation by a diruthenium complex enables electrocatalytic and aerobic oxidation of ammonia47
Controlled growth of ordered monolayers of N-heterocyclic carbenes on silicon47
Making the collective knowledge of chemistry open and machine actionable47
Catalytic undirected borylation of tertiary C–H bonds in bicyclo[1.1.1]pentanes and bicyclo[2.1.1]hexanes47
Enantioselective fullerene functionalization through stereochemical information transfer from a self-assembled cage46
Isolation and electronic structures of derivatized manganocene, ferrocene and cobaltocene anions46
Chemical upcycling of commodity thermoset polyurethane foams towards high-performance 3D photo-printing resins46
Using collective knowledge to assign oxidation states of metal cations in metal–organic frameworks46
Selective scandium ion capture through coordination templating in a covalent organic framework45
Bifunctional sulfilimines enable synthesis of multiple N-heterocycles from alkenes45
Active repair of a dinuclear photocatalyst for visible-light-driven hydrogen production44
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein44
Uniform segmented platelet micelles with compositionally distinct and selectively degradable cores44
Quantum nanomagnets in on-surface metal-free porphyrin chains44
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors44
An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination44
Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides43
A two-directional vibrational probe reveals different electric field orientations in solution and an enzyme active site42
Deep learning to design nuclear-targeting abiotic miniproteins42
Catalytic reductive desymmetrization of malonic esters42
Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification42
Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy42
Active template strategy for the preparation of π-conjugated interlocked nanocarbons42
A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes41
Micrometre-scale single-crystalline borophene on a square-lattice Cu(100) surface41
Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride41
Selectivity control in hydrogenation through adaptive catalysis using ruthenium nanoparticles on a CO2-responsive support41
Deaminative chlorination of aminoheterocycles41
Photocaged 5′ cap analogues for optical control of mRNA translation in cells41
Illuminating the dark conformational space of macrocycles using dominant rotors40
Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network40
Stabilization of hexazine rings in potassium polynitride at high pressure40
Non-statistical assembly of multicomponent [Pd2ABCD] cages40
The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils40
Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting40
A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing39
Genetically encoded chemical crosslinking of carbohydrate39
Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution39
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation39
Reversible transformations between the non-porous phases of a flexible coordination network enabled by transient porosity38
Genetically encoded chemical crosslinking of RNA in vivo38
How synonymous mutations alter enzyme structure and function over long timescales38
Native mass spectrometry-based metabolomics identifies metal-binding compounds38
Chemical-mediated translocation in protocell-based microactuators37
On-surface synthesis of disilabenzene-bridged covalent organic frameworks37
RNAs undergo phase transitions with lower critical solution temperatures37
Direct conversion of white phosphorus to versatile phosphorus transfer reagents via oxidative onioation37
Copper-catalysed difluorocarbene transfer enables modular synthesis37
Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses37
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles36
Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes36
O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-9536
Prebiotic photoredox synthesis from carbon dioxide and sulfite36
Energy funnelling within multichromophore architectures monitored with subnanometre resolution36
Ion-pair reorganization regulates reactivity in photoredox catalysts36
A thiolate-bridged FeIVFeIV μ-nitrido complex and its hydrogenation reactivity toward ammonia formation36
Single nucleotide translation without ribosomes36
Time-resolved terahertz–Raman spectroscopy reveals that cations and anions distinctly modify intermolecular interactions of water36
Enantioselective synthesis of atropisomeric indoles via iron-catalysed oxidative cross-coupling36
Single-particle combinatorial multiplexed liposome fusion mediated by DNA35
Emulsion-oriented assembly for Janus double-spherical mesoporous nanoparticles as biological logic gates35
Nature-inspired methylated polyhydroxybutyrates from C1 and C4 feedstocks35
Catalytic remote hydrohalogenation of internal alkenes35
Predicting the stability of homotrimeric and heterotrimeric collagen helices35
Metal-free reduction of CO2 to formate using a photochemical organohydride-catalyst recycling strategy34
Chiral control of spin-crossover dynamics in Fe(II) complexes34
Synthesis of planar chiral ferrocenes via enantioselective remote C–H activation34
Multistep, site-selective noncovalent synthesis of two-dimensional block supramolecular polymers33
Iron–sulfur clusters as inhibitors and catalysts of viral replication33
Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor33
0.043465852737427