Nature Chemistry

(The TQCC of Nature Chemistry is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-06-01 to 2024-06-01.)
Coupling N2 and CO2 in H2O to synthesize urea under ambient conditions532
Iridium single-atom catalyst on nitrogen-doped carbon for formic acid oxidation synthesized using a general host–guest strategy479
α-Synuclein aggregation nucleates through liquid–liquid phase separation470
General synthesis of single-atom catalysts with high metal loading using graphene quantum dots390
Deep-neural-network solution of the electronic Schrödinger equation287
Ethylene/ethane separation in a stable hydrogen-bonded organic framework through a gating mechanism268
Best practices in machine learning for chemistry257
A glycan gate controls opening of the SARS-CoV-2 spike protein254
Single-molecule visualization of DNA G-quadruplex formation in live cells240
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains236
Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes187
Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time185
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome184
Metal–organic frameworks embedded in a liposome facilitate overall photocatalytic water splitting176
De novo engineering of intracellular condensates using artificial disordered proteins171
Mechanochemical bond scission for the activation of drugs170
The complex chemical effects of COVID-19 shutdowns on air quality151
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics144
CD44 regulates epigenetic plasticity by mediating iron endocytosis139
Enantioselective radical C–H amination for the synthesis of β-amino alcohols139
Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures135
Improving the efficiency of CO2 electrolysis by using a bipolar membrane with a weak-acid cation exchange layer133
Tunable exciton binding energy in 2D hybrid layered perovskites through donor–acceptor interactions within the organic layer132
Oxidative cleavage of C–C bonds in lignin126
Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis126
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses125
Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditions125
Olefin metathesis-based chemically recyclable polymers enabled by fused-ring monomers124
A biologically stable DNAzyme that efficiently silences gene expression in cells123
Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates121
Quantum machine learning using atom-in-molecule-based fragments selected on the fly118
Synthesis of bilayer borophene118
A proteome-wide atlas of lysine-reactive chemistry117
Predator–prey interactions between droplets driven by non-reciprocal oil exchange117
Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells113
Aromatic hydrocarbon belts112
Challenges to developing materials for the transport and storage of hydrogen109
Large magnetic exchange coupling in rhombus-shaped nanographenes with zigzag periphery108
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates108
Manganese-catalysed divergent silylation of alkenes106
Charge transfer driven by ultrafast spin transition in a CoFe Prussian blue analogue106
Tailored self-assembled photocatalytic nanofibres for visible-light-driven hydrogen production105
Meta-DNA structures105
A short peptide synthon for liquid–liquid phase separation103
Metabolic glycan labelling for cancer-targeted therapy103
Synthesis of a zigzag carbon nanobelt102
A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60102
Manganese(i) complexes with metal-to-ligand charge transfer luminescence and photoreactivity102
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination102
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications101
Switching on prodrugs using radiotherapy97
Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres96
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives95
Competition between chiral solvents and chiral monomers in the helical bias of supramolecular polymers94
The photochemical reaction of phenol becomes ultrafast at the air–water interface93
Partitioning the interlayer space of covalent organic frameworks by embedding pseudorotaxanes in their backbones92
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery90
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids90
One-pot, room-temperature conversion of dinitrogen to ammonium chloride at a main-group element89
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells89
Single crystals of mechanically entwined helical covalent polymers88
Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones88
A molecular endless (74) knot87
Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions86
Crowdsourcing drug discovery for pandemics85
SuFExable polymers with helical structures derived from thionyl tetrafluoride85
Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins84
Dissipative DNA nanotechnology83
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells83
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides83
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization83
Fast motion of molecular rotors in metal–organic framework struts at very low temperatures82
Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform81
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation80
Correlating ligand-to-metal charge transfer with voltage hysteresis in a Li-rich rock-salt compound exhibiting anionic redox79
Reagentless biomolecular analysis using a molecular pendulum78
Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores78
A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids78
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates77
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles77
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages76
On-surface photopolymerization of two-dimensional polymers ordered on the mesoscale76
Tunable acetylene sorption by flexible catenated metal–organic frameworks75
A platinum(ii) metallonitrene with a triplet ground state75
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides75
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes75
A general arene C–H functionalization strategy via electron donor–acceptor complex photoactivation74
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes73
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation72
Modulation of porosity in a solid material enabled by bulk photoisomerization of an overcrowded alkene72
Evolution of dynamical networks enhances catalysis in a designer enzyme72
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells72
Aromaticity rules71
A metal–organic framework that exhibits CO2-induced transitions between paramagnetism and ferrimagnetism71
Substantial π-aromaticity in the anionic heavy-metal cluster [Th@Bi12]4−70
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production70
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity69
Melting of hybrid organic–inorganic perovskites69
Time-dependent enantiodivergent synthesis via sequential kinetic resolution69
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions69
Chemical fuels for molecular machinery69
Switching the magnetic hysteresis of an [Feii–NC–Wv]-based coordination polymer by photoinduced reversible spin crossover68
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles68
Low-temperature liquid platinum catalyst68
A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres68
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides67
Nickel-catalysed asymmetric hydrogenation of oximes67
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation67
Post-translational formation of strained cyclophanes in bacteria67
Mechanochemical synthesis of an elusive fluorinated polyacetylene67
Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping67
Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer66
A site-selective amination catalyst discriminates between nearly identical C–H bonds of unsymmetrical disubstituted alkenes66
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds65
A circular polyester platform based on simple gem-disubstituted valerolactones65
Synthesis of monophosphines directly from white phosphorus65
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime65
A dissipative pathway for the structural evolution of DNA fibres64
Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides64
Constructing ion channels from water-soluble α-helical barrels62
In situ multiscale probing of the synthesis of a Ni-rich layered oxide cathode reveals reaction heterogeneity driven by competing kinetic pathways62
Water oxidation electrocatalysis using ruthenium coordination oligomers adsorbed on multiwalled carbon nanotubes62
In situ electrochemical recomposition of decomposed redox-active species in aqueous organic flow batteries61
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine61
Scalable and selective deuteration of (hetero)arenes61
Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube61
Concurrent control over sequence and dispersity in multiblock copolymers60
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane60
Silylated silicon–carbonyl complexes as mimics of ubiquitous transition-metal carbonyls59
Insights from an information thermodynamics analysis of a synthetic molecular motor59
Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands59
Accelerating symmetry-breaking charge separation in a perylenediimide trimer through a vibronically coherent dimer intermediate59
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity59
Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator59
Functional DNA-based cytoskeletons for synthetic cells58
Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme58
Strategies for developing DNA-encoded libraries beyond binding assays58
Interplay of vibrational wavepackets during an ultrafast electron transfer reaction58
Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor58
Harnessing chemical energy for the activation and joining of prebiotic building blocks57
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature57
Isolation and reactivity of an elusive diazoalkene57
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes57
Organocatalyst-controlled site-selective arene C–H functionalization57
Spin-crossover nanoparticles anchored on MoS2 layers for heterostructures with tunable strain driven by thermal or light-induced spin switching57
Electron spin resonance of single iron phthalocyanine molecules and role of their non-localized spins in magnetic interactions57
Atomic control of active-site ensembles in ordered alloys to enhance hydrogenation selectivity56
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array56
Enzyme-free synthesis of natural phospholipids in water56
A bis(silylene)-stabilized diphosphorus compound and its reactivity as a monophosphorus anion transfer reagent55
Fast CO2 hydration kinetics impair heterogeneous but improve enzymatic CO2 reduction catalysis55
Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster55
Adaptive response of a metal–organic framework through reversible disorder–disorder transitions55
Cyclic polyacetylene54
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation54
Nuclear spin conservation enables state-to-state control of ultracold molecular reactions53
Supercrystal engineering of atomically precise gold nanoparticles promoted by surface dynamics53
An autonomously oscillating supramolecular self-replicator53
Immobilization of molecular catalysts on electrode surfaces using host–guest interactions53
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis53
Using waste poly(vinyl chloride) to synthesize chloroarenes by plasticizer-mediated electro(de)chlorination52
Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes51
A general design of caging-group-free photoactivatable fluorophores for live-cell nanoscopy51
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins51
Emissive spin-0 triplet-pairs are a direct product of triplet–triplet annihilation in pentacene single crystals and anthradithiophene films51
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold51
A 9.2-GHz clock transition in a Lu(II) molecular spin qubit arising from a 3,467-MHz hyperfine interaction51
Porous covalent organic nanotubes and their assembly in loops and toroids50
Free-triplet generation with improved efficiency in tetracene oligomers through spatially separated triplet pair states50
Atomistic dynamics of elimination and nucleophilic substitution disentangled for the F− + CH3CH2Cl reaction49
Tunable and recyclable polyesters from CO2 and butadiene49
Catalytic asymmetric C–C cross-couplings enabled by photoexcitation49
Tracking the ultraviolet-induced photochemistry of thiophenone during and after ultrafast ring opening49
Multilayer stacks of polycyclic aromatic hydrocarbons48
Electrochemically driven desaturation of carbonyl compounds48
Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins48
Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells48
Emergence of low-symmetry foldamers from single monomers48
Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids48
Merging molecular catalysts and metal–organic frameworks for photocatalytic fuel production47
Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties47
The loss of endgroup effects in long pyridyl-endcapped oligoynes on the way to carbyne46
Photoinduced inverse vulcanization46
A ring expansion strategy towards diverse azaheterocycles46
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons46
Machine learning overcomes human bias in the discovery of self-assembling peptides46
Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water46
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions45
Catalytic enantiocontrol over a non-classical carbocation45
Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning45
Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications45
Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities45
Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity44
C–C bond activation enabled by dyotropic rearrangement of Pd(iv) species44
σ–σ Stacked supramolecular junctions44
Mechanism of mediated alkali peroxide oxidation and triplet versus singlet oxygen formation44
Highly conducting single-molecule topological insulators based on mono- and di-radical cations44
Constructing covalent organic nanoarchitectures molecule by molecule via scanning probe manipulation44
NH3 formation from N2 and H2 mediated by molecular tri-iron complexes44
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction44
Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles44
Long-range ordered and atomic-scale control of graphene hybridization by photocycloaddition43
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria43
Audible sound-controlled spatiotemporal patterns in out-of-equilibrium systems43
Selective visible-light photocatalysis of acetylene to ethylene using a cobalt molecular catalyst and water as a proton source43
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors43
Isolation and electronic structures of derivatized manganocene, ferrocene and cobaltocene anions42
A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes42
Knotting a molecular strand can invert macroscopic effects of chirality42
Spontaneous N2 formation by a diruthenium complex enables electrocatalytic and aerobic oxidation of ammonia42
Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination41
Magnetic ordering through itinerant ferromagnetism in a metal–organic framework41
Isolation of a Ru(iv) side-on peroxo intermediate in the water oxidation reaction41
Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner41
Light-activated tetrazines enable precision live-cell bioorthogonal chemistry41
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design41
Active repair of a dinuclear photocatalyst for visible-light-driven hydrogen production40
Making the collective knowledge of chemistry open and machine actionable40
Palladium-catalysed selective oxidative amination of olefins with Lewis basic amines40
Using collective knowledge to assign oxidation states of metal cations in metal–organic frameworks39
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein39
A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes39
Controlled growth of ordered monolayers of N-heterocyclic carbenes on silicon39
Dimeric and trimeric catenation of giant chiral [8 + 12] imine cubes driven by weak supramolecular interactions38
Structure, reactivity and catalytic properties of manganese-hydride amidate complexes38
Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting38
Solutal Marangoni effect determines bubble dynamics during electrocatalytic hydrogen evolution38
Catalytic reductive desymmetrization of malonic esters38
Sustainable polyesters via direct functionalization of lignocellulosic sugars38
Determining the nature of quantum resonances by probing elastic and reactive scattering in cold collisions38
A two-directional vibrational probe reveals different electric field orientations in solution and an enzyme active site38
Targeted activation in localized protein environments via deep red photoredox catalysis38
An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination38
Stepwise on-demand functionalization of multihydrosilanes enabled by a hydrogen-atom-transfer photocatalyst based on eosin Y37
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation37
2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring37
Selectivity control in hydrogenation through adaptive catalysis using ruthenium nanoparticles on a CO2-responsive support37
Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides37
How synonymous mutations alter enzyme structure and function over long timescales37
Recyclable cyclic bio-based acrylic polymer via pairwise monomer enchainment by a trifunctional Lewis pair37
Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy36
Isolation and characterization of diazoolefins36
Complexes featuring a linear [N≡U≡N] core isoelectronic to the uranyl cation36
Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis36
Protein folding modulates the chemical reactivity of a Gram-positive adhesin36
Electrochemical synthesis of propylene from carbon dioxide on copper nanocrystals36
Photocatalytic nitrogen fixation under an ambient atmosphere using a porous coordination polymer with bridging dinitrogen anions35
Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides35
Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification34
Photocaged 5′ cap analogues for optical control of mRNA translation in cells34