Nature Chemistry

Article	Citations
Coupling N2 and CO2 in H2O to synthesize urea under ambient conditions	497
Iridium single-atom catalyst on nitrogen-doped carbon for formic acid oxidation synthesized using a general host–guest strategy	457
α-Synuclein aggregation nucleates through liquid–liquid phase separation	440
General synthesis of single-atom catalysts with high metal loading using graphene quantum dots	367
Deep-neural-network solution of the electronic Schrödinger equation	270
The synthesis, properties and potential applications of cyclic polymers	245
Best practices in machine learning for chemistry	244
Ethylene/ethane separation in a stable hydrogen-bonded organic framework through a gating mechanism	239
A glycan gate controls opening of the SARS-CoV-2 spike protein	238
Single-molecule visualization of DNA G-quadruplex formation in live cells	234
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains	217
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide	213
Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes	176
Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time	175
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome	172
Metal–organic frameworks embedded in a liposome facilitate overall photocatalytic water splitting	169
Enhanced reactivity of twisted amides inside a molecular cage	169
De novo engineering of intracellular condensates using artificial disordered proteins	161
Mechanochemical bond scission for the activation of drugs	157
The complex chemical effects of COVID-19 shutdowns on air quality	147
Cobalt-catalysed C–H methylation for late-stage drug diversification	142
Enantioselective radical C–H amination for the synthesis of β-amino alcohols	136
CD44 regulates epigenetic plasticity by mediating iron endocytosis	130
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics	124
Electrostatic co-assembly of nanoparticles with oppositely charged small molecules into static and dynamic superstructures	121

Tunable exciton binding energy in 2D hybrid layered perovskites through donor–acceptor interactions within the organic layer	121
Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditions	121
Improving the efficiency of CO2 electrolysis by using a bipolar membrane with a weak-acid cation exchange layer	121
A biologically stable DNAzyme that efficiently silences gene expression in cells	119
Enantioselective C(sp3)–C(sp3) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis	118
Olefin metathesis-based chemically recyclable polymers enabled by fused-ring monomers	116
Oxidative cleavage of C–C bonds in lignin	114
Quantum machine learning using atom-in-molecule-based fragments selected on the fly	114
Exploiting attractive non-covalent interactions for the enantioselective catalysis of reactions involving radical intermediates	113
A proteome-wide atlas of lysine-reactive chemistry	111
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses	110
Predator–prey interactions between droplets driven by non-reciprocal oil exchange	106
Synthesis of bilayer borophene	106
Aromatic hydrocarbon belts	106
Large magnetic exchange coupling in rhombus-shaped nanographenes with zigzag periphery	103
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates	102
Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells	102
Metabolic glycan labelling for cancer-targeted therapy	100
Tailored self-assembled photocatalytic nanofibres for visible-light-driven hydrogen production	100
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination	97
Charge transfer driven by ultrafast spin transition in a CoFe Prussian blue analogue	97
Facile synthesis of precious-metal single-site catalysts using organic solvents	97
Manganese-catalysed divergent silylation of alkenes	97
Meta-DNA structures	97
FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis	95
A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60	95
Synthesis of a zigzag carbon nanobelt	95
Switching on prodrugs using radiotherapy	94
A short peptide synthon for liquid–liquid phase separation	94
Manganese(i) complexes with metal-to-ligand charge transfer luminescence and photoreactivity	93
Engineered triply orthogonal pyrrolysyl–tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids	93
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications	93
Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres	90
Enantioselective photoinduced cyclodimerization of a prochiral anthracene derivative adsorbed on helical metal nanostructures	89
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives	89
Competition between chiral solvents and chiral monomers in the helical bias of supramolecular polymers	89
The photochemical reaction of phenol becomes ultrafast at the air–water interface	87
Intra- and intermolecular self-assembly of a 20-nm-wide supramolecular hexagonal grid	87
Partitioning the interlayer space of covalent organic frameworks by embedding pseudorotaxanes in their backbones	87
Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids	86
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery	85
A molecular endless (74) knot	85
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells	85
A silicon–carbonyl complex stable at room temperature	84
Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions	83
Crowdsourcing drug discovery for pandemics	83
Single crystals of mechanically entwined helical covalent polymers	83
One-pot, room-temperature conversion of dinitrogen to ammonium chloride at a main-group element	81
Directional conformer exchange in dihydrofolate reductase revealed by single-molecule nanopore recordings	81
Challenges to developing materials for the transport and storage of hydrogen	80

Chemical profiling of DNA G-quadruplex-interacting proteins in live cells	80
Fast motion of molecular rotors in metal–organic framework struts at very low temperatures	80
Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides	79
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization	78
Bottom-up fabrication of a proteasome–nanopore that unravels and processes single proteins	78
Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones	78
SuFExable polymers with helical structures derived from thionyl tetrafluoride	76
Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores	75
Correlating ligand-to-metal charge transfer with voltage hysteresis in a Li-rich rock-salt compound exhibiting anionic redox	75
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation	74
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles	74
A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids	74
An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates	73
Dissipative DNA nanotechnology	73
A platinum(ii) metallonitrene with a triplet ground state	71
Reagentless biomolecular analysis using a molecular pendulum	71
On-surface photopolymerization of two-dimensional polymers ordered on the mesoscale	71
Integrating programmable DNAzymes with electrical readout for rapid and culture-free bacterial detection using a handheld platform	70
A metal–organic framework that exhibits CO2-induced transitions between paramagnetism and ferrimagnetism	70
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes	70
Distal conformational locks on ferrocene mechanophores guide reaction pathways for increased mechanochemical reactivity	69
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production	68
Photochemical single-step synthesis of β-amino acid derivatives from alkenes and (hetero)arenes	68
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides	68
A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation	68
Time-dependent enantiodivergent synthesis via sequential kinetic resolution	67
Melting of hybrid organic–inorganic perovskites	66
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells	65
Modulation of porosity in a solid material enabled by bulk photoisomerization of an overcrowded alkene	65
Mechanochemical synthesis of an elusive fluorinated polyacetylene	64
Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides	63
Metallacyclic actinide catalysts for dinitrogen conversion to ammonia and secondary amines	63
Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides	63
Evolution of dynamical networks enhances catalysis in a designer enzyme	63
Tunable acetylene sorption by flexible catenated metal–organic frameworks	63
Post-translational formation of strained cyclophanes in bacteria	63
Substantial π-aromaticity in the anionic heavy-metal cluster [Th@Bi12]4−	63
Nickel-catalysed asymmetric hydrogenation of oximes	63
Switching the magnetic hysteresis of an [Feii–NC–Wv]-based coordination polymer by photoinduced reversible spin crossover	62
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles	62
Synthesis of monophosphines directly from white phosphorus	62
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages	62
A site-selective amination catalyst discriminates between nearly identical C–H bonds of unsymmetrical disubstituted alkenes	62
Low-temperature liquid platinum catalyst	61
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation	61
A dissipative pathway for the structural evolution of DNA fibres	61
Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine	60
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds	60
Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer	60
Constructing ion channels from water-soluble α-helical barrels	60
A general arene C–H functionalization strategy via electron donor–acceptor complex photoactivation	59
Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube	58
Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor	58
Weakly hydrated anions bind to polymers but not monomers in aqueous solutions	58
Concurrent control over sequence and dispersity in multiblock copolymers	58
Scalable and selective deuteration of (hetero)arenes	57
Water oxidation electrocatalysis using ruthenium coordination oligomers adsorbed on multiwalled carbon nanotubes	57
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime	57
Unnatural biosynthesis by an engineered microorganism with heterologously expressed natural enzymes and an artificial metalloenzyme	56
Silylated silicon–carbonyl complexes as mimics of ubiquitous transition-metal carbonyls	56
In situ electrochemical recomposition of decomposed redox-active species in aqueous organic flow batteries	56
Aromaticity rules	55
Functional DNA-based cytoskeletons for synthetic cells	55
Aerobic radical polymerization mediated by microbial metabolism	55
Chemical fuels for molecular machinery	55
Isolation and reactivity of an elusive diazoalkene	55
Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane	54
Insights from an information thermodynamics analysis of a synthetic molecular motor	54
In situ multiscale probing of the synthesis of a Ni-rich layered oxide cathode reveals reaction heterogeneity driven by competing kinetic pathways	54
A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres	54
Enzyme-free synthesis of natural phospholipids in water	53
A circular polyester platform based on simple gem-disubstituted valerolactones	53
Spin-crossover nanoparticles anchored on MoS2 layers for heterostructures with tunable strain driven by thermal or light-induced spin switching	53
Strategies for developing DNA-encoded libraries beyond binding assays	53
Emergence of light-driven protometabolism on recruitment of a photocatalytic cofactor by a self-replicator	53
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity	53
Adaptive response of a metal–organic framework through reversible disorder–disorder transitions	53
Interplay of vibrational wavepackets during an ultrafast electron transfer reaction	52
Organocatalyst-controlled site-selective arene C–H functionalization	52
Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping	52

Atomic control of active-site ensembles in ordered alloys to enhance hydrogenation selectivity	52
Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands	52
Fast CO2 hydration kinetics impair heterogeneous but improve enzymatic CO2 reduction catalysis	52
Harnessing chemical energy for the activation and joining of prebiotic building blocks	52
A bis(silylene)-stabilized diphosphorus compound and its reactivity as a monophosphorus anion transfer reagent	52
In situ chromatin interactomics using a chemical bait and trap approach	52
Iron-catalysed synthesis and chemical recycling of telechelic 1,3-enchained oligocyclobutanes	51
Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis	51
Total synthesis of brevianamide A	51
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature	51
Electron spin resonance of single iron phthalocyanine molecules and role of their non-localized spins in magnetic interactions	51
Cyclic polyacetylene	51
Accelerating symmetry-breaking charge separation in a perylenediimide trimer through a vibronically coherent dimer intermediate	51
Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes	50
Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins	49
Immobilization of molecular catalysts on electrode surfaces using host–guest interactions	49
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array	49
Dinitrogen binding and activation at a molybdenum–iron–sulfur cluster	48
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation	48
Porous covalent organic nanotubes and their assembly in loops and toroids	47
Emergence of low-symmetry foldamers from single monomers	47
Free-triplet generation with improved efficiency in tetracene oligomers through spatially separated triplet pair states	47
Catalytic asymmetric C–C cross-couplings enabled by photoexcitation	47
Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins	47
Nuclear spin conservation enables state-to-state control of ultracold molecular reactions	47
Spontaneous drying of non-polar deep-cavity cavitand pockets in aqueous solution	46
A 9.2-GHz clock transition in a Lu(II) molecular spin qubit arising from a 3,467-MHz hyperfine interaction	45
Multilayer stacks of polycyclic aromatic hydrocarbons	45
Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities	45
Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids	45
A general design of caging-group-free photoactivatable fluorophores for live-cell nanoscopy	45
Emissive spin-0 triplet-pairs are a direct product of triplet–triplet annihilation in pentacene single crystals and anthradithiophene films	45
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold	45
Supercrystal engineering of atomically precise gold nanoparticles promoted by surface dynamics	45
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons	45
Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells	44
Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties	44
Tracking the ultraviolet-induced photochemistry of thiophenone during and after ultrafast ring opening	44
Electrochemically driven desaturation of carbonyl compounds	44
Atomistic dynamics of elimination and nucleophilic substitution disentangled for the F− + CH3CH2Cl reaction	43
Using waste poly(vinyl chloride) to synthesize chloroarenes by plasticizer-mediated electro(de)chlorination	43
Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions	43
The loss of endgroup effects in long pyridyl-endcapped oligoynes on the way to carbyne	43
Mechanism of mediated alkali peroxide oxidation and triplet versus singlet oxygen formation	42
Long-range ordered and atomic-scale control of graphene hybridization by photocycloaddition	42
Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning	42
Catalytic enantiocontrol over a non-classical carbocation	42
Constructing covalent organic nanoarchitectures molecule by molecule via scanning probe manipulation	42
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria	42
A ring expansion strategy towards diverse azaheterocycles	42
Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications	42
Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity	41
Magnetic ordering through itinerant ferromagnetism in a metal–organic framework	41
NH3 formation from N2 and H2 mediated by molecular tri-iron complexes	40
Knotting a molecular strand can invert macroscopic effects of chirality	40
Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water	40
Isolation and electronic structures of derivatized manganocene, ferrocene and cobaltocene anions	40
C–C bond activation enabled by dyotropic rearrangement of Pd(iv) species	40
Merging molecular catalysts and metal–organic frameworks for photocatalytic fuel production	40
Spontaneous N2 formation by a diruthenium complex enables electrocatalytic and aerobic oxidation of ammonia	40
An autonomously oscillating supramolecular self-replicator	39
Audible sound-controlled spatiotemporal patterns in out-of-equilibrium systems	39
Light-activated tetrazines enable precision live-cell bioorthogonal chemistry	39
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein	39
Tunable and recyclable polyesters from CO2 and butadiene	39
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors	39
Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides	38
Selective visible-light photocatalysis of acetylene to ethylene using a cobalt molecular catalyst and water as a proton source	38
A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes	38
Highly conducting single-molecule topological insulators based on mono- and di-radical cations	38
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design	38
σ–σ Stacked supramolecular junctions	37
A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes	37
Isolation of a Ru(iv) side-on peroxo intermediate in the water oxidation reaction	37
Machine learning overcomes human bias in the discovery of self-assembling peptides	37
Photoinduced inverse vulcanization	37
Catalytic reductive desymmetrization of malonic esters	37
Isolation and characterization of diazoolefins	36
Structure, reactivity and catalytic properties of manganese-hydride amidate complexes	36
Phase-specific RNA accumulation and duplex thermodynamics in multiphase coacervate models for membraneless organelles	36
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation	36
Using collective knowledge to assign oxidation states of metal cations in metal–organic frameworks	36
Determining the nature of quantum resonances by probing elastic and reactive scattering in cold collisions	36
Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy	35
Palladium-catalysed selective oxidative amination of olefins with Lewis basic amines	35
An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination	35
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction	35
Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis	35
How synonymous mutations alter enzyme structure and function over long timescales	35
Making the collective knowledge of chemistry open and machine actionable	35
Wittig reagents for chemoselective sulfenic acid ligation enables global site stoichiometry analysis and redox-controlled mitochondrial targeting	35
Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner	35
Complexes featuring a linear [N≡U≡N] core isoelectronic to the uranyl cation	34
Selectivity control in hydrogenation through adaptive catalysis using ruthenium nanoparticles on a CO2-responsive support	34
Controlled growth of ordered monolayers of N-heterocyclic carbenes on silicon	34