Nature Chemistry

Article	Citations
Not all catenanes with oriented rings are topologically chiral	453
The origin of translation	334
Finding the sweet spot for chaperone activity	316
Engineering yeast to produce plant-derived anti-obesity agent	300
Expanding the effectiveness of screening	292
Ultimate control in chemistry	213
Bite-size science	195
Analysing allostery	180
Ethics education for chemists	177
Chemical testing	168
Dissipative DNA fibres	165
A circular polyester platform based on simple gem-disubstituted valerolactones	162
Charting the ligandable proteome for stereoselective interactions	161
Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding	153
Enantioselective synthesis of atropisomeric indoles via iron-catalysed oxidative cross-coupling	146
Postdoc progression	139
Sulfone cross-coupling outcompetes proton transfer	138
Enantiospecific cross-coupling of cyclic alkyl sulfones	137
Repurposing of halogenated organic pollutants via alkyl bromide-catalysed transfer chlorination	130
Expanding the diversity of lithium electrolytes	125
Giving the green light	124
Facing the fluctuations	121
How many roads must a woman walk down?	121
Sweet as sucrose	119
Biosynthesis and characterization of fuscimiditide, an aspartimidylated graspetide	118

Playing Lego with perylene dyes	117
Synthesis of a glycan hairpin	117
From feedstock to pharmaceuticals	115
Aluminium analogue of oxirane	115
Pop-up rings to rule reactivity	113
Doing away with radium’s proxies	106
Signal transduction with a swing	105
Ion-pair reorganization regulates reactivity in photoredox catalysts	101
A handle on charge reorganization	100
Reversing the charge of lysine by genetic code expansion	99
Rings of power	98
Baird’s rules at the tipping point	97
How synonymous mutations alter enzyme structure and function over long timescales	96
Phase-separation behaviour of RNAs	96
Using symmetry to drive new protein assemblies	96
Plot twist in the iron spin saga	95
Stereoretentive enantioconvergent reactions	94
Fast track to structural biology	94
Nanomachines built from multiple components can have functional advantages	93
A near-linear lanthanide complex that displays magnet-like behaviour	92
Fullerenes promote transition-metal-catalysed ammonia synthesis	91
Chemoproteomic profiling unveils binding and functional diversity of endogenous proteins that interact with endogenous triplex DNA	90
Looking into the future of hybrid glasses	90
Fullerene on non-iron cluster-matrix co-catalysts promotes collaborative H2 and N2 activation for ammonia synthesis	90
C–H···π interactions disrupt electrostatic interactions between non-aqueous electrolytes to increase solubility	89
Spatiotemporal functional assembly of split protein pairs through a light-activated SpyLigation	89
Ultrafast proton-coupled isomerization in the phototransformation of phytochrome	89
Building enzymes from scratch	89
A 21-electron cobalt sandwich	87
An interfacial role for NO2	86
Hydrogen splitting at a single phosphorus centre and its use for hydrogenation	85
Single-electron transfer between sulfonium and tryptophan enables site-selective photo crosslinking of methyllysine reader proteins	83
Copper-catalysed asymmetric hydroboration of alkenes with 1,2-benzazaborines to access chiral naphthalene isosteres	82
Keeping COFs in the loop	82
Formylation boosts the performance of light-driven overcrowded alkene-derived rotary molecular motors	82
Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation	82
Probing precipitation properties	81
Decentring the central science	81
Comparing notes	80
A para- to meta-isomerization of phenols	80
An air- and moisture-stable ruthenium precatalyst for diverse reactivity	80
A molecular sandwich with a lithium–aluminium filling	79
Alkynes fuel free carbene formation	79
Back-to-back cycloadditions in nature	78
Tectonic shifts in framework chemistry	78
Colouring by force	77
Different timescales during ultrafast stilbene isomerization in the gas and liquid phases revealed using time-resolved photoelectron spectroscopy	77
Activity-based directed evolution of a membrane editor in mammalian cells	77
Heteromultivalency enables enhanced detection of nucleic acid mutations	76
Stabilizing Au2+ in a mixed-valence 3D halide perovskite	75

Tunable valence tautomerism in lanthanide–organic alloys	75
Co-precipitation behaviour of single atoms of rutherfordium in basic solutions	75
Accounts of academic ableism	74
Ribozyme for stabilized SAM analogue modifies RNA in cells	74
Radiotherapy activates picolinium prodrugs in tumours	73
Isolation and reactivity of an elusive diazoalkene	73
Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites	72
Glycine-derived nitronates bifurcate to O-methylation or denitrification in bacteria	72
Selection of a promiscuous minimalist cAMP phosphodiesterase from a library of de novo designed proteins	72
Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates	71
A locally activatable sensor for robust quantification of organellar glutathione	71
Bringing amines back into aziridination	70
Li–O2 battery redox mediators go positive	70
Intersystem crossing in the entrance channel of the reaction of O(3P) with pyridine	70
Hydrogenative double-bond deuteration	69
φ-Aromaticity in prismatic {Bi6}-based clusters	69
Thiophosphate photochemistry enables prebiotic access to sugars and terpenoid precursors	69
Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer	68
Energy-transfer-induced [3+2] cycloadditions of N–N pyridinium ylides	67
Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency	66
Isolation and characterization of a two-coordinate phosphinidene oxide	66
Corrole and squeezed coordination	66
Single crystals of purely organic free-standing two-dimensional woven polymer networks	66
Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses	65
Interweaving different metal–organic frameworks	65
Digital skills in chemical education	65
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors	65
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery	65
The anti-aromatic dianion and aromatic tetraanion of [18]annulene	65
In situ nonlinear optical spectroscopy for probing buried oxide–water interfaces	64
O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95	63
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages	63
Surface stratification determines the interfacial water structure of simple electrolyte solutions	62
Reconfiguring hydrogel assemblies using a photocontrolled metallopolymer adhesive for multiple customized functions	62
Chemical upcycling of commodity thermoset polyurethane foams towards high-performance 3D photo-printing resins	62
Nanopore DNA sequencing technologies and their applications towards single-molecule proteomics	62
Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping	62
Accelerating stereoselective radical cross-couplings	61
Hydrophobic assembly of molecular catalysts at the gas–liquid–solid interface drives highly selective CO2 electromethanation	61
Entropy-driven charge-transfer complexation yields thermally activated delayed fluorescence and highly efficient OLEDs	61
De novo design of ribosomally synthesized and post-translationally modified peptides	60
Separating fiction from fact for photocatalytic CO2 reduction	59
Arene radiofluorination enabled by photoredox-mediated halide interconversion	58
Oxidation of sulfur dioxide by nitrogen dioxide accelerated at the interface of deliquesced aerosol particles	58
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates	58
Photocaged 5′ cap analogues for optical control of mRNA translation in cells	58
Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles	58
Direct conversion of white phosphorus to versatile phosphorus transfer reagents via oxidative onioation	58
Photoacoustic imaging of elevated glutathione in models of lung cancer for companion diagnostic applications	58
Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides	58
SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome	57
Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes	57
Photogearing as a concept for translation of precise motions at the nanoscale	57
Nickel-catalysed asymmetric hydrogenation of oximes	57
A soil-inspired dynamically responsive chemical system for microbial modulation	55
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design	55
Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides	55
Platinum incorporation into titanate perovskites to deliver emergent active and stable platinum nanoparticles	55
Selecting aptamers with programmed affinities	54
Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor	54
Fragmentation and [4 + 3] cycloaddition in sodorifen biosynthesis	54
Enantioselective fullerene functionalization through stereochemical information transfer from a self-assembled cage	53
Controlled growth of ordered monolayers of N-heterocyclic carbenes on silicon	53
Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner	53
Selective scandium ion capture through coordination templating in a covalent organic framework	53
Cobalt(II)–tetraphenylporphyrin-catalysed carbene transfer from acceptor–acceptor iodonium ylides via N-enolate–carbene radicals	52
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria	52
Accelerating symmetry-breaking charge separation in a perylenediimide trimer through a vibronically coherent dimer intermediate	52
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead	52
Tandem catalysis enables chlorine-containing waste as chlorination reagents	51
Isomerization of bioactive acylhydrazones triggered by light or thiols	51
Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser	51
A general alkene aminoarylation enabled by N-centred radical reactivity of sulfinamides	50
Cage escape governs photoredox reaction rates and quantum yields	50
The numerous paths of ferrocene	50
Near-atomic-resolution structure of J-aggregated helical light-harvesting nanotubes	50
Author Correction: The liberating force of ultrasound	49
Author Correction: Organogel delivery vehicles for the stabilization of organolithium reagents	49
Catalysis-enabled amine sorting	49
Few-femtosecond electron transfer dynamics in photoionized donor–π–acceptor molecules	48

A metalloenzyme platform for catalytic asymmetric radical dearomatization	48
Supramolecular crystals for hydrogen storage	48
DNA catch bonds demonstrate the art of getting stuck	48
Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion	48
Reaction-induced unsaturated Mo oxycarbides afford highly active CO2 conversion catalysts	48
Precision synthesis and closed-loop recycling of ultrahigh-molar-mass cyclic polymers	48
Protein prediction takes the prize	48
Active template strategy for the preparation of π-conjugated interlocked nanocarbons	47
Publisher Correction: Collisional alignment and molecular rotation control the chemi-ionization of individual conformers of hydroquinone with metastable neon	47
Aqueous interphase formed by CO2 brings electrolytes back to salt-in-water regime	47
Author Correction: The missing colours of chemistry	47
Stereodefined alkenes with a fluoro-chloro terminus as a uniquely enabling compound class	46
Total synthesis of structurally diverse pleuromutilin antibiotics	46
Visible light-driven conjunctive olefination	45
Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation	45
Author Correction: Direct observation of coherent femtosecond solvent reorganization coupled to intramolecular electron transfer	45
The twists and turns of chiral chemistry	44
Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo	44
Opportunities and challenges with hyperpolarized bioresponsive probes for functional imaging using magnetic resonance	44
Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification	44
Iron–sulfur clusters as inhibitors and catalysts of viral replication	44
Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes	44
A pseudo-cubic metal–organic cage with conformationally switchable faces for dynamically adaptive guest encapsulation	43
Self-assembly of chiroptical ionic co-crystals from silver nanoclusters and organic macrocycles	43
Author Correction: Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity	42
Protons undermine lithium-ion batteries with positively disastrous results	42
Phase separation and ageing of glycine-rich protein from tick adhesive	42
Double-walled design for tetrahedral cages	42
Author Correction: Discovery of the selenium-containing antioxidant ovoselenol derived from convergent evolution	42
Photophysical oxidation of atmospheric carbonyls	42
Radical ring formation	41
Photodriven nitrogen fixation by lithium hydride	41
ATP hydrolysis captured in atomic detail	41
Cellular decoding for non-natural peptides	41
Hydrogen atom collisions with a semiconductor efficiently promote electrons to the conduction band	41
Deconvoluting double layers	41
High-throughput phase elucidation of polycrystalline materials using serial rotation electron diffraction	41
Photophysical oxidation of HCHO produces HO2 radicals	41
Changing channels	41
Cabinet of curiosities	40
Three’s molecular company	40
A template for artificial life	40
Stabilized resonances are no less exciting	40
Phase by phase through a condensate researcher's career path	40
Running rings around rings	40
A discrete antimony(v) oxide	39
The search for Europan life	39
Molecular jackhammers eradicate cancer cells by vibronic-driven action	39
Trapping of a phenoxyl radical at a non-haem high-spin iron(II) centre	39
Combining biological and chemical diversity	38
A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production	38
Cellular uptake of large biomolecules enabled by cell-surface-reactive cell-penetrating peptide additives	38
Multilayer stacks of polycyclic aromatic hydrocarbons	38
Photoswitching neutral homoaromatic hydrocarbons	37
Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water	37
Triarylmethyl cation redox mediators enhance Li–O2 battery discharge capacities	37
Expanding the molecular language of protein liquid–liquid phase separation	37
A charge-neutral organic cage selectively binds strongly hydrated sulfate anions in water	37
Emulsion-oriented assembly for Janus double-spherical mesoporous nanoparticles as biological logic gates	37
Author Correction: Cyclic polyacetylene	36
The role of aromaticity in the cyclization and polymerization of alkyne-substituted porphyrins on Au(111)	36
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions	36
Polyoxometalates as ligands to synthesize, isolate and characterize compounds of rare isotopes on the microgram scale	36
Tunable and recyclable polyesters from CO2 and butadiene	36
Making a start on the tenure track	36
Constructing ion channels from water-soluble α-helical barrels	36
Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography	36
The blue hue of einsteinium	36
Beyond Hubble	36
Coherent photoexcitation of entangled triplet pair states	35
Optical sequencing of single synthetic polymers	35
Total synthesis of strychnan alkaloids	35
A dissipative pathway for the structural evolution of DNA fibres	35
Hopping protons in supramolecular catalysis	34
Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase	34
Low-valent tungsten redox catalysis enables controlled isomerization and carbonylative functionalization of alkenes	34
Ionic glue	34
More details on diazoolefins	33
WT19F	33
Molecular spins clock in	33
Drawing conclusions	33
Aryl ortho methoxylation	33
Altogether changed, and yet the same	33
How to search for Europan life	32
Heat flows in rock cracks naturally optimize salt compositions for ribozymes	32
Controlling anisotropic properties by manipulating the orientation of chiral small molecules	32
Uniform single-crystal mesoporous metal–organic frameworks	32
A living library concept to capture the dynamics and reactivity of mixed-metal clusters for catalysis	32
Repurposing a plant peptide cyclase for targeted lysine acylation	32
Mysterious energy losses	32
Get to Know NO	32
Publisher Correction: Dimeric and trimeric catenation of giant chiral [8 + 12] imine cubes driven by weak supramolecular interactions	32
Publisher Correction: Photocatalytic hydrofluoroalkylation of alkenes with carboxylic acids	32
Engineering a DNA polymerase for modifying large RNA at specific positions	32
Challenges to developing materials for the transport and storage of hydrogen	31