Disease Models & Mechanisms

Papers
(The TQCC of Disease Models & Mechanisms is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Let's talk about sex… obesity and melanoma101
Pluripotent stem cell-derived neural progenitor cells can be used to model effects of IL-6 on human neurodevelopment93
Drop the MYC: An expansion of triple-negative breast cancer driver genes62
Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia51
A chance to turn HIV treatment up a Notch47
Molecular functions of ANKLE2 and its implications in human disease45
Biological and therapeutic insights from animal modeling of fusion-driven pediatric soft tissue sarcomas44
Optimized methods to image hepatic lipid droplets in zebrafish larvae44
RNA sequencing reveals molecular mechanisms of endometriosis lesion development in mice44
Vemurafenib improves muscle histopathology in a mouse model of LAMA2-related congenital muscular dystrophy41
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease Mouse Models41
The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice40
Prostatic Escherichia coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production39
CIB2 function is distinct from that of whirlin in the organization of sterocilia architecture39
Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury33
Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in Drosophila33
Cancer cachexia: lessons from Drosophila32
Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons32
Metabolism navigates neural cell fate in development, aging and neurodegeneration31
Human organoid model of pontocerebellar hypoplasia 2a recapitulates brain region-specific size differences30
Analysis of the H-Ras mobility pattern in vivo shows cellular heterogeneity inside epidermal tissue29
First person – Nichole Link29
Advancing lung organoids for COVID-19 research29
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants27
First person – Sheeza Mughal27
Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation27
Validity of Xiphophorus fish as models for human disease26
First person – Mayra Fernanda Martínez-López26
A Drosophila model for mechanistic investigation of tau protein spread25
The Company of Biologists: celebrating 100 years25
Joan Heath interviews Suzanne Cory and Joan Steitz: a female perspective of science in the swinging ‘60s24
Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma24
The shifting culture of the scientific workforce – a change for women and girls in science24
A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice24
Staphylococcus aureus lipid factors modulate melanoma cell clustering and invasion23
Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet23
Abnormalities in the migration of neural precursor cells in familial bipolar disorder23
Development and optimization of an in vivo electrocardiogram recording method and analysis program for adult zebrafish22
Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease22
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases22
New advances in CRISPR/Cas-mediated precise gene-editing techniques21
Immune function and dysfunction are determined by lymphoid tissue efficacy21
Drug-based mobilisation of mesenchymal stem/stromal cells improves cardiac function post myocardial infarction20
Modelling quiescence exit of neural stem cells reveals a FOXG1-FOXO6 axis19
First person – Rujuta Deshpande19
Stress in the metastatic journey – the role of cell communication and clustering in breast cancer progression and treatment resistance19
Reducing the aneuploid cell burden – cell competition and the ribosome connection19
Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis19
First person – Eli Matsell19
Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response18
Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish18
Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH18
RAS pathway regulation in melanoma18
Effectiveness of irinotecan plus trabectedin on a desmoplastic small round cell tumor patient-derived xenograft18
Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability18
Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina18
DMM Outstanding Paper Prize 2021 winner: Daniel Bronder17
Mechanistic studies in Drosophila and chicken give new insights into functions of DVL1 in dominant Robinow syndrome17
Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae17
Establishment and functional studies of a model of cardiomyopathy with cardiomyocyte-specific conditional knockout of Arhgef1817
Rapid assessment of the temporal function and phenotypic reversibility of neurodevelopmental disorder risk genes in Caenorhabditis elegans17
Contribution of model organism phenotypes to the computational identification of human disease genes16
HuR modulation counteracts lipopolysaccharide response in murine macrophages16
Defining the unknowns for cell therapies in Parkinson's disease16
First person – Rebeca Piñeiro-Sabarís16
Cardiac-specific Trim44 knockout in rat attenuates isoproterenol-induced cardiac remodeling via inhibition of AKT/mTOR pathway16
Correlative 3D imaging method for analysing lesion architecture in susceptible mice infected with Mycobacterium tuberculosis16
First person – Saba Naghipour16
First person – Michael Koch16
First person – Zongwang Zhang16
Activation of an actin signaling pathway in pre-malignant mammary epithelial cells by P-cadherin is essential for transformation16
A genetic labeling system to study dendritic spine development in zebrafish models of neurodevelopmental disorders15
An ALS-associated mutation dysregulates microglia-derived extracellular microRNAs in a sex-specific manner15
Localized heterochrony integrates overgrowth potential of oncogenic clones15
First person – Haimeng Lyu15
High-fat diet induces C-reactive protein secretion, promoting lung adenocarcinoma via immune microenvironment modulation15
Promoting validation and cross-phylogenetic integration in model organism research15
Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation15
A humanized Caenorhabditis elegans model of hereditary spastic paraplegia-associated variants in KLC415
Western lifestyle as a driver of dysbiosis in colorectal cancer15
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability15
Reducing the shock factor with new anti-epilepsy drugs15
Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish15
Stem cell modeling of nervous system tumors15
Genetic regulation of injury-induced heterotopic ossification in adult zebrafish15
Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy14
Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition14
A mouse model of brittle cornea syndrome caused by mutation in Zfp46914
Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease14
Genetically altered animal models forATP1A3-related disorders13
First person – Lorena Maili13
Pharmacological intervention of the FGF–PTH axis as a potential therapeutic for craniofacial ciliopathies13
Autophagy takes it all – autophagy inducers target immune aging13
A method for TAT-Cre recombinase-mediated floxed allele modification in ex vivo tissue slices13
First person – Jeanne Rakotopare13
Functional and in silico analysis of ATP8A2 and other P4-ATPase variants associated with human genetic diseases13
Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts13
Precise photopharmacological eradication of metastatic tumor cells13
First person – Matt Johansen13
Preclinical evaluation of targeted therapies for central nervous system metastases13
Supporting the evolution of infectious disease research13
First person – Lídia Faria12
Identification of genetic suppressors for a BSCL2 lipodystrophy pathogenic variant in Caenorhabditis elegans12
Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality12
Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice12
Reduced growth and biofilm formation at high temperatures contribute to Cryptococcus deneoformans dermatotropism12
First person – Yuka Kobayashi12
deCLUTTER2+ – a pipeline to analyze calcium traces in a stem cell model for ventral midbrain patterned astrocytes12
Correction: Cells expressing PAX8 are the main source of homeostatic regeneration of adult mouse endometrial epithelium and give rise to serous endometrial carcinoma12
What lies beyond 100 years of insulin12
Current approaches and advances in the imaging of stroke12
First person – Rebeka Popovic and Yizhou Yu12
Vangl2–environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension12
Transcriptional regulation of autophagy in skeletal muscle stem cells12
Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation12
First person – Kathrin Pfeifer11
First person – Pavitra Prakash11
Breaking the silos, stopping the spread: an interview with Jyoti Joshi11
The inflammasome adaptor pycard is essential for immunity against Mycobacterium marinum infection in adult zebrafish11
Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway11
Genetic variance in human disease – modelling the future of genomic medicine11
First person – Ariany Oliveira-Santos11
First person – Bernhard N. Bohnert11
Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice11
First person – Jiří Funda11
Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex11
Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth11
First person – Claire Montgomery and Lili Salinas11
Endometrial organoids derived from Mayer–Rokitansky–Küster–Hauser syndrome patients provide insights into disease-causing pathways11
First person – Jun-yi Zhu and Xiaohu Huang11
Nonlinear progression during the occult transition establishes cancer lethality11
NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome11
Cell competition from development to neurodegeneration11
Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in Caenorhabditis elegans11
First person – Li Wang11
First person – Toni Lemmetyinen11
Postnatal Zika virus infection leads to morphological and cellular alterations within the neurogenic niche10
Oral administration of aripiprazole to Drosophila causes intestinal toxicity10
Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation10
First person – Kaitly Woodard10
First person – Mohamadamin Forouzandehmehr10
Male germ cell-associated kinase is required for axoneme formation during ciliogenesis in zebrafish photoreceptors10
A BALB/c mouse model of Mycobacterium abscessus lung infection based on once-weekly cyclophosphamide administration10
Mouse models of fragile X-related disorders10
A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing10
Building a healthy mouse model ecosystem to interrogate cancer biology10
Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome10
First person – Casey Griffin10
Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency10
Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans10
eNOS in congenital to adult cardiovascular disease10
The Mouse Models of Human Cancer database (MMHCdb)10
Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice10
Improving bench-to-bedside translation for acute graft-versus-host disease models10
Patient advocacy in tuberculosis research and treatment: an interview with Zolelwa Sifumba10
Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion10
Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy10
Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol10
An arginase 2 promoter transgenic line illuminates immune cell polarisation in zebrafish9
Piglet cardiopulmonary bypass induces intestinal dysbiosis and barrier dysfunction associated with systemic inflammation9
Adult zebrafish as advanced models of human disease9
How metals fuel fungal virulence, yet promote anti-fungal immunity9
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans9
First person – Elin Schoultz and Ellen Johansson9
Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig9
Development of the aganglionic colon following surgical rescue in a cell therapy model of Hirschsprung disease in rat9
The loop-tail mouse model displays open and closed caudal neural tube defects9
RASopathies – what they reveal about RAS/MAPK signaling in skeletal muscle development9
First person – Sabrina Alam9
A systematic review of kidney-on-a-chip-based models to study human renal (patho-)physiology9
First person – Sarah Alghamdi9
Modeling Spitz melanoma in zebrafish using sequential mutagenesis9
In vivoquantitative high-throughput screening for drug discovery and comparative toxicology9
Contusions that reshape bone produce tidy conclusions9
An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation9
Transient, flexible gene editing in zebrafish neutrophils and macrophages for determination of cell-autonomous functions9
First person – Nefeli Skoufou-Papoutsaki9
Development and characterization of an animal model of Japanese encephalitis virus infection in adolescent C57BL/6 mouse9
A mouse model of hypoplastic left heart syndrome demonstrating left heart hypoplasia and retrograde aortic arch flow8
First person – Melissa Hinman8
Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival8
Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae8
Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death8
Purkinje cell dysfunction causes disrupted sleep in ataxic mice8
First person – Chang Sun8
Collagen (I) homotrimer potentiates the osteogenesis imperfecta (oim) mutant allele and reduces survival in male mice8
Functional cardiac consequences of β-adrenergic stress-induced injury in a model of Duchenne muscular dystrophy8
Disease Models & Mechanisms helps move heart failure to heart success8
Embracing complexity in Drosophila cancer models8
Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney8
Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes8
Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency8
An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome8
Stromal matrix directs corneal fibroblasts to re-express keratocan after injury and transplantation8
Genetically diverse mouse platform to xenograft cancer cells8
First person – Ilaria Gregorio8
Impactful disease research: a DMM year in review8
Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse8
Redefining tuberculosis: an interview with Lalita Ramakrishnan8
Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain8
DMM Outstanding Paper Prize 2022 winners: Tamihiro Kamata, Jennifer K. Sargent and Mark A. Warner8
Cross-species modeling of muscular dystrophy in Caenorhabditis elegans using patient-derived extracellular vesicles8
MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode7
Synergistic modelling of human disease7
First person – Katherine Robinson7
CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease7
First person – Jun-yi Zhu7
First person – Ionel Sandovici7
First person – Xuming Zhu7
Intrinsic and extrinsic regulation of rhabdomyolysis susceptibility by Tango27
Expanding the neuroimmune research toolkit with in vivo brain organoid technologies7
The behavioural consequences of dystrophinopathy7
Sox11 regulates mammary tumour-initiating and metastatic capacity in Brca1-deficient mouse mammary tumour cells7
A zebrafish model of diabetic nephropathy shows hyperglycemia, proteinuria and activation of the PI3K/Akt pathway7
Abca4, mutated in Stargardt disease, is required for structural integrity of cone outer segments7
Lateral thinking in syndromic congenital cardiovascular disease7
First person – Lauren Falkenberg7
First person – Amanda Miles7
Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila7
Treatment of age-related visual impairment with a peptide acting on mitochondria7
Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila7
First person – Jimena Monzón-Sandoval7
Innovating spinal muscular atrophy models in the therapeutic era7
First person – Mark Hanson7
The Michael J. Fox Foundation's quest for a cure for Parkinson's disease: an interview with Nicole Polinski7
Variable body and tissue weight reporting in preclinical cachexia literature may alter study outcomes and interpretation7
First person – Anaïs Kervadec and James Kezos7
Correction: Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling7
Patient-specific mutation of contact site protein Tomm70 causes neurodegeneration7
Sterol dysregulation in Smith–Lemli–Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk7
Evaluating protein prenylation of human and viral CaaX sequences using a humanized yeast system7
0.073705911636353