OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Protocols is 65. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Author Correction: Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox respo	1161
Author Correction: cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA	582
Isoform-specific RNA structure determination using Nano-DMS-MaP	512
Open thoracic surgical implantation of cardiac pacemakers in rats	485
Design and application of the transformer base editor in mammalian cells and mice	411
Generation of heart-forming organoids from human pluripotent stem cells	379
Reproducible strategy for excisional skin-wound-healing studies in mice	372
Generating human bone marrow organoids for disease modeling and drug discovery	355
Expansion of human pluripotent stem cell–induced nephron progenitor cells (iNPCs) and the generation of nephron organoids from iNPCs	288
Spontaneous and experimental models of lymph node metastasis	265
ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ	251
Routine culture and study of adult human brain cells from neurosurgical specimens	248
Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states	240
Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis	235
GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution	195
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling	189
Purification and functional characterization of novel human skeletal stem cell lineages	188
Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing	185
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice	177
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input	167
Publisher Correction: Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	167
How to isolate channel-forming membrane proteins using the E. coli expression system	166
Preparation and biomedical applications of single-metal atom catalysts	164
Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue	159
Expansion and fluctuations-enhanced microscopy for nanoscale molecular profiling of cells and tissues	139

Publisher Correction: In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag	138
Fabrication of thin-film electrodes and organic electrochemical transistors for neural implants	138
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry	136
Small RNA structural biochemistry in a post-sequencing era	129
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration	126
Fabrication of electron tunneling probes for measuring single-protein conductance	120
Precise tracking of nanoparticles in plant roots	118
Quantitative molecular imaging using deep magnetic resonance fingerprinting	116
Sonicated inks and focused-ultrasound writing enable deep-penetration acoustic volumetric printing	110
Metabolomics using anion-exchange chromatography mass spectrometry for the analysis of cells, tissues and biofluids	108
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses	107
Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance	103
Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds	103
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells	102
Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	101
High-throughput fabrication of antimicrobial phage microgels and example applications in food decontamination	100
Chromatin accessibility profiling by ATAC-seq	98
Large-scale growth of C. elegans and isolation of membrane protein complexes	93
Collections from Nature Protocols	89
A practical guide to identifying associations between tandem repeats and complex human traits using consensus genotypes from multiple tools	88
Gene expression and chromatin state mapped in space	87
Expansion of human hepatocytes and their application in three-dimensional culture and genetic manipulation	84
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids	82
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells	79
Sonoafterglow nanoprobes for deep-tissue imaging of peroxynitrite	79
Fibrous polyisocyanide hydrogels for 3D cell culture applications	78
mRNA lipid nanoparticle formulation, characterization and evaluation	77
Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging	75
Achieving transient and reversible optical transparency in live mice with tartrazine	74
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract	74
Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts	73
Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data	73
Scalable growth of vertical graphene nanosheets by thermal chemical vapor deposition	73
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia	71
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery	70
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility	70
Honey bee functional genomics using symbiont-mediated RNAi	68
Preparation and quantitative analysis of multicenter luminescence materials for sensing function	66
Comprehensive synthesis of Ti3C2Tx from MAX phase to MXene	66
A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography	66