OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Protocols is 66. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Design and application of the transformer base editor in mammalian cells and mice	1024
Author Correction: Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox respo	481
Author Correction: cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA	435
Cytosine and adenosine base editing in human pluripotent stem cells using transient reporters for editing enrichment	353
ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ	331
Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis	313
Open thoracic surgical implantation of cardiac pacemakers in rats	269
GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution	254
Isoform-specific RNA structure determination using Nano-DMS-MaP	227
Routine culture and study of adult human brain cells from neurosurgical specimens	226
Generating human bone marrow organoids for disease modeling and drug discovery	196
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline	193
Generation of heart-forming organoids from human pluripotent stem cells	190
Purification and functional characterization of novel human skeletal stem cell lineages	185
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling	179
Reproducible strategy for excisional skin-wound-healing studies in mice	175
Protocols for clinical use at Nature Protocols	171
Fabrication of thin-film electrodes and organic electrochemical transistors for neural implants	163
Implantation of Neuropixels probes for chronic recording of neuronal activity in freely behaving mice and rats	162
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells	160
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration	159
Quantitative molecular imaging using deep magnetic resonance fingerprinting	159
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry	152
High-throughput fabrication of antimicrobial phage microgels and example applications in food decontamination	145
Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue	144

Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing	134
Fabrication of electron tunneling probes for measuring single-protein conductance	131
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice	130
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input	129
Publisher Correction: Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	121
Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	119
How to isolate channel-forming membrane proteins using the E. coli expression system	117
Publisher Correction: In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag	113
Small RNA structural biochemistry in a post-sequencing era	113
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses	112
Tutorial: using nanoneedles for intracellular delivery	110
Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance	108
Stable isotope tracing to assess tumor metabolism in vivo	108
Precise tracking of nanoparticles in plant roots	108
Chromatin accessibility profiling by ATAC-seq	100
Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds	100
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia	96
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids	96
mRNA lipid nanoparticle formulation, characterization and evaluation	90
Large-scale growth of C. elegans and isolation of membrane protein complexes	87
Honey bee functional genomics using symbiont-mediated RNAi	87
Gene expression and chromatin state mapped in space	86
A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography	86
Collections from Nature Protocols	86
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells	85
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract	85
Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data	84
Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging	83
Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts	81
Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases	81
Preparation and quantitative analysis of multicenter luminescence materials for sensing function	78
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery	78
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility	77
Comprehensive synthesis of Ti3C2Tx from MAX phase to MXene	76
Publisher Correction: A reconstituted cell-free assay for the evaluation of the intrinsic activity of purified human ribosomes	75
Author Correction: Efficient and strand-specific profiling of replicating chromatin with enrichment and sequencing of protein-associated nascent DNA in mammalian cells	74
Divergent synthesis of amino acid-linked O-GalNAc glycan core structures	74
Integrating genome-wide CRISPR screens and in silico drug profiling for targeted antidote development	72
Inverse electron demand Diels–Alder click chemistry for pretargeted PET imaging and radioimmunotherapy	69
Plant sperm cell sequencing for genome phasing and determination of meiotic crossover points	69
High-throughput single-cell transcriptomics of bacteria using combinatorial barcoding	68
Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting	66