OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Biological Engineering is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Nano-size tantalum particles suppress the osteogenic activity of osteoblasts and stimulate osteoclasts	338
Cerium-doped calcium carbonate microparticles combined with low-intensity ultrasound for efficient sonodynamic therapy in body sculpting	110
A detoxified exosome–ECM hydrogel depot for localized and sustained chemotherapy in prostate cancer	104
Gene syntaxes modulate gene expression and circuit behavior on plasmids	95
Self-healing PVA/PVP micelle–hydrogel composite system for potential phenytoin repositioning in wound healing	86
Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity	73
Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast	65
Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms	62
Verification and application of an automated real-time antimicrobial susceptibility testing system: for accelerated antibiotic susceptibility testing and high-throughput screening of antibiotic synerg	56
Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida	55
3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects	51
Osteogenic differentiation of adipose-derived stem cells on dihydroartemisinin electrospun nanofibers	50
New approach methodologies for in vitro toxicity screening of nanomaterial using a pulmonary three-dimensional floating extracellular matrix model	46
3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects	44
Core-shell nanofiber dressings with zinc oxide nanoparticles and cell-free fat extract: boosting fibroblast activity and antibacterial efficacy	42
Waste-to-sensor upcycling of polyethylene terephthalate over Ag/Zr-MOF photocatalyst for microplastic degradation and AI-assisted heavy metal detection	40
Cell-cultivated aquatic food products: emerging production systems for seafood	40
Integrated genomic and transcriptomic Insights into methanol tolerance mechanisms in Methylobacterium extorquens AM1, identifying key targets for strain engineering	38
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues	38
Comparison of different decellularization protocols for porcine centrum tendineum diaphragmatis and diaphragmatic muscle – a base for effective recellularization	36
A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy	35
Research progress of biomimetic materials in oral medicine	33
A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines	28
RN-Autoencoder: Reduced Noise Autoencoder for classifying imbalanced cancer genomic data	26
Integration of TLR7/8 agonists into lipid nanoparticles enhances antigen-specific immune responses to N1-methyl-Ψ-modified mRNA-LNP vaccines	25

Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformati	24
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array	24
Tissue engineering in age-related macular degeneration: a mini-review	23
Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration	23
Influence of shear force on ex vivo expansion of hematopoietic model cells in a stirred tank bioreactor	22
Automated classification of urine biomarkers to diagnose pancreatic cancer using 1-D convolutional neural networks	22
Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach	22
Efficient site-specific recombination by self-activating split-Dre recombinase in mammalian cells and E. coli	21
Fabricating a robust POSS-PCL nanofiber scaffold for nesting of mesenchymal stem cells: potential application in bone tissue regeneration	21
Harnessing plant chloroplasts for oral delivery of a multi-epitope HPV vaccine: toward cost-effective systemic and mucosal immunization	21
Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1	20
Exploring of therapeutic potential of indirubin-loaded nanofibrous scaffolds for localized melanoma treatment	20
The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles	19
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs	19
Rapid osteoinduction of human adipose-derived stem cells grown on bioactive surfaces and stimulated by chemically modified media flow	19
DC electrical stimulation enhances proliferation and differentiation on N2a and MC3T3 cell lines	19
Engineered Metal-Organic Frameworks (MOFs)-electrospun nanofibers for wound healing: a review	19
Microfluidics-based cell recognition through optimizing suspended cell staining techniques and artificial intelligence	19
Thiol release improvement in Saccharomyces cerevisiae oenological strains by CRISPR/Cas9-based IRC7 molecular cisgenesis	19
An in vitro culture platform for studying the effect of collective cell migration on spatial self-organization within induced pluripotent stem cell colonies	18
Smartphone-based multispectral autofluorescence analysis of bacteria mixtures of staphylococci using convolutional neural network	18
Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms	18
Biology-inspired engineering for circular bioeconomy systems	18
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy	18
Design and performance analysis of bionic trabecular bone scaffold structure based on Voronoi	17
Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling	17
Engineered chitosan/HP-β-CD hydrogel for targeted co-delivery of curcumin and berberine for the treatment of ulcerative colitis	17
Rapid remodeling observed at mid-term in-vivo study of a smart reinforced acellular vascular graft implanted on a rat model	17
Microfluidic chip and isothermal amplification technologies for the detection of pathogenic nucleic acid	16
Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation	16
Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology	15
Biomaterials for fetal membrane repair in preterm premature rupture of membranes: advances in tissue engineering strategies	15
CRISPRi-assisted metabolic engineering of cyanobacteria for photosynthetic hyaluronic acid from CO2	15
Effect of recombinant protein production and release on microalgal fitness and the impact of environmental conditions for localized therapeutic delivery	15
Tissue engineering RPE sheet derived from hiPSC-RPE cell spheroids supplemented with Y-27632 and RepSox	15
Biomaterial-based chitosan nanohydrogel films: combination of Bistorta officinalis and Ca-doped carbon dots for improved blood clotting	15
Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management	14
Eggshell waste bioprocessing for sustainable acid phosphatase production and minimizing environmental hazards	14
Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy	14
Beyond linearity: reimagining AI as a participant in circular bioeconomies	14
Quantitative impedance-based characterization of breast cancer cell migration and metastatic potential	14
Early introduction of 3D modeling modules promotes the development of simulation skills in downstream biomedical engineering curricula	13
Microfluidic device for enhancement and analysis of osteoblast differentiation in three-dimensional cell cultures	13
Efflux pump knockout minimizes crosstalk and boosts response in transcription factor-based biosensors	13
Codon usage modulates the relationship between the burden and yield of protein overexpression	12
Applications of carbon dots and its modified carbon dots in bone defect repair	12
Correction: Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo	12
High-titer 2-phenylethanol production in Escherichia coli via decarboxylation-step optimization and a vegetable-oil overlay for biocompatible in situ recovery	12
Customized biofilm device for antibiofilm and antibacterial screening of newly developed nanostructured silver and zinc coatings	12
Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways	12

Enhanced methanol tolerance and utilization in Pichia pastoris revealed by adaptive laboratory evolution	12
Cloning, expression, and one-step purification/immobilization of two carbohydrate-binding module-tagged alcohol dehydrogenases	12
Therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles combined with injectable hydrogels in bone defect repair: a systematic review and meta-analysis of preclinical studies	12
Two-color spheroid model for determining the O2-induced radiosensitivity of HNSCC	12
Engineering probiotic Escherichia coli for inflammation-responsive indoleacetic acid production using RiboJ-enhanced genetic circuits	12
Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112	11
A novel inductively coupled capacitor wireless sensor system for rapid antibiotic susceptibility testing	11
NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication	11
Enhancing osteogenic differentiation of dental pulp stem cells through rosuvastatin loaded niosomes optimized by Box-Behnken design and modified by hyaluronan: a novel strategy for improved efficiency	11
Combined drugs-loaded nano-lipodisk carrier for pH-responsive delivery for improved therapeutic potential on lung cancer model	11
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and revers	11
Fluorescent tools for the standardized work in Gram-negative bacteria	11
Bakuchiol-loaded amphiphilic polymeric nanoparticles: enhancing stability and multifunctionality through encapsulation	11
Correction to: Challenges and progress of neurodrug: bioactivities, production and delivery strategies of nerve growth factor protein	11
Exosome-functionalized collagen-coated 3D-printed PCL scaffold for enhanced osteogenic differentiation and bone regeneration: an in vitro and in vivo study	11
Seaweed-based alginate/hydroxyapatite composite for the effective removal of bacteria, cyanobacteria, algae, and crystal violet from water	10
3D printed zirconia used as dental materials: a critical review	10
Residual-hybrid dynamic response-surface/machine-learning framework for predicting malachite green removal and biodegradation by a bacterial consortium	10
A dual-inducible control system for multistep biosynthetic pathways	10
Anti-inflammatory activity of magnetic fields emitted by graphene devices on cultured human cells	10
Chitin nanowhiskers/octacalcium phosphate synergistically reinforced chitosan hydrogel for enhanced bone regeneration	10
Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3D-printed bioceramic and human adipose-derived stem cells laden biohydrogel	10
Application of extracellular vesicles in the CRISPR-based diagnosis and treatment: possibilities and challenges	10