Biomarkers in Medicine

Article	Citations
Role of hematological parameters in COVID-19 patients in the emergency room	68
Systemic immune-inflammation index is a novel marker to predict functionally significant coronary artery stenosis	66
Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19	45
The association between biomarkers and clinical outcomes in novel coronavirus pneumonia in a US cohort	42
Krebs von den Lungen-6 as a biomarker for disease severity assessment in interstitial lung disease: a comprehensive review	40
Methods for rapid diagnosis of meningitis etiology in adults	36
Serum-soluble ST2 as a novel biomarker reflecting inflammatory status and illness severity in patients with COVID-19	35
The diagnostic value of plasma exosomal hsa_circ_0070396 for hepatocellular carcinoma	32
Cardiovascular disease as a biomarker for an increased risk of COVID-19 infection and related poor prognosis	29
Systemic immune–inflammation index predicts new-onset atrial fibrillation after ST elevation myocardial infarction	24
Neutrophil to lymphocyte ratio as a predictive biomarker for computed tomography scan use in mild traumatic brain injury	20
The prognostic significance of hemoglobin-to-red cell distribution width ratio in muscle-invasive bladder cancer	19
Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this field	19
Identification of a four-microRNA panel in serum as promising biomarker for colorectal carcinoma detection	18
Monocyte to high-density lipoprotein cholesterol ratio is associated with the presence of carotid artery disease in acute ischemic stroke	17
Serum aberrant expression of miR-24-3p and its diagnostic value in Alzheimer’s disease	17
Novel biomarkers for acute respiratory distress syndrome: genetics, epigenetics and transcriptomics	17
Prospective selected biomarkers in COVID-19 diagnosis and treatment	16
Circular RNAs: new genetic tools in melanoma	16
Prognostic value of hemoglobin-to-red cell distribution width ratio in cancer: a systematic review and meta-analysis	15
Exosomes as mediators and biomarkers in fibrosis	14
Cell-free DNA as a solid-organ transplant biomarker: technologies and approaches	14
Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future perspectives	14
How biomarkers can improve pneumonia diagnosis and prognosis: procalcitonin and mid-regional-pro-adrenomedullin	14
Biomarkers in pediatric sepsis: a review of recent literature	14

Homocysteine as a marker for predicting disease severity in patients with COVID-19	14
Liquid biopsy and their application progress in head and neck cancer: focus on biomarkers CTCs, cfDNA, ctDNA and EVs	13
Lymphocyte-to-C-reactive protein ratio is a potential new prognostic biomarker for patients with lung cancer	13
HER2 in metastatic colorectal cancer: a new to target to remember	13
Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients	13
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of outcomes in inflammatory breast cancer	12
Liquid biopsy: the value of different bodily fluids	12
Construction prognosis model based on autophagy-related gene signatures in hepatocellular carcinoma	11
Red blood cell distribution width and atrial fibrillation	11
Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for the diagnosis and prognosis in patients with restenosis following CAS	11
FAM3C: an emerging biomarker and potential therapeutic target for cancer	11
MiR-9-5p promotes cell proliferation and migration of hepatocellular carcinoma by targeting CPEB3	11
Quantitative muscle MRI biomarkers in Duchenne muscular dystrophy: cross-sectional correlations with age and functional tests	11
Red blood cell distribution width as a prognostic biomarker for viral infections: prospects and challenges	10
Biomarkers of cholestasis	10
Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides	10
Sialic acid as a potential biomarker for cardiovascular disease, diabetes and cancer	10
C-reactive protein in saliva and dried blood spot as markers of stress reactivity in healthy African–Americans	10
Macromolecular biomarkers of chronic obstructive pulmonary disease in exhaled breath condensate	10
SLC2A4 expression and its epigenetic regulation as biomarkers for insulin resistance treatment in diabetes mellitus	10
Increased levels of circulating circular RNA (hsa_circ_0013587) may serve as a novel biomarker for pancreatic cancer	9
N-glycosylation profiling of Type 2 diabetes mellitus from baseline to follow-up: an observational study in a Ghanaian population	9
Neutrophil-to-lymphocyte ratio is prognostic in recurrent glioblastoma multiforme treated with bevacizumab plus irinotecan	9
Mean platelet volume/platelet count ratio predicts long-term mortality in patients with infective endocarditis	9
Inflammatory markers and incident heart failure in older men: the role of NT-proBNP	9
Prognostic nutritional index and systemic immune-inflammation index are prognostic biomarkers for non-small-cell lung cancer brain metastases	9
Role of collagen turnover biomarkers in the noninvasive assessment of myocardial fibrosis: an update	9
Prognostic value of serum albumin for long-term mortality in patients with dual-chamber permanent pacemakers	9
Breast invasive ductal carcinoma diagnosis with a three-miRNA panel in serum	9
The potential of miR-499 plasmatic level as a biomarker of obstructive sleep apnea syndrome	9
Prognostic value and dynamics of antithyroglobulin antibodies for differentiated thyroid carcinoma	9
Prognostic value of D-dimer/fibrinogen ratio in the adverse outcomes of patients hospitalized for heart failure	8
Basic knowledge on BCR-ABL1-positive extracellular vesicles	8
NCAPG is a prognostic biomarker of immune infiltration in non-small-cell lung cancer	8
Cardiovascular risk assessment and association with novel biomarkers in patients with Type 2 diabetes mellitus	8
ANXA2is a potential marker for the diagnosis of human cervical cancer	8
Association between admission blood fibrinogen-to-albumin ratio and clinical outcomes after acute lacunar stroke	8
HSP90α combined with AFP and TK1 improved the diagnostic value for hepatocellular carcinoma	8
Significance of tumor protein p53 mutation in cellular process and drug selection in brain lower grade (WHO grades II and III) glioma	8
Neutrophil to lymphocyte ratio in the prediction of coagulopathy in traumatic brain injury	8
miR-224 is an early-stage biomarker of hepatocellular carcinoma with miR-224 and miR-125b as prognostic biomarkers	8
Circular RNA hsa_circ_0001445 in plasma as a novel biomarker for osteoporosis in postmenopausal women	8
The aegis: platelets as biomarkers of tumor progression	8
Sex-biased DNA methylation in papillary thyroid cancer	8
Galectin-3 and acute heart failure: genetic polymorphisms, plasma level, myocardial fibrosis and 1-year outcomes	8
Screening for regenerative therapy responders in heart failure	7
Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer	7
Circulating chemerin level and risk of cancer: a systematic review and meta-analysis	7
Safety and disease monitoring biomarkers in Duchenne muscular dystrophy: results from a Phase II trial	7
Prognostic Nutritional Index and CRP, age, platelet count, albumin level score in predicting mortality and intensive care unit admission for COVID-19	7

COVID-19 and diffusing capacity of the lungs for carbon monoxide: a clinical biomarker in postacute care settings	7
Biomarkers of human gut microbiota diversity and dysbiosis	7
Role of ncRNA in multiple myeloma	7
Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals	7
Advances in the discovery of novel biomarkers for cancer: spotlight on protein N-glycosylation	7
Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer	7
Mean corpuscular hemoglobin concentration correlates with prognosis of resected hepatocellular carcinoma	7
Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies	7
Circular RNA as a potential diagnostic and/or therapeutic target for endometriosis	7
Long noncoding plasmacytoma variant translocation 1 facilitates the surveillance of acute respiratory distress syndrome and mortality prediction in sepsis	7
Perspectives on statistical strategies for the regulatory biomarker qualification process	7
The performance of the SHOX2/PTGER4 methylation assay is influenced by cancer stage, age, type and differentiation	7
Copeptin: a neuroendocrine biomarker of COVID-19 severity	7
Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea	7
Novel biomarker-based score (SAD-60) for predicting mortality in patients with COVID-19 pneumonia: a multicenter retrospective cohort of 1013 patients	6
Copy number alteration signatures as biomarkers in cancer: a review	6
Role of MMP-2 and its inhibitor TIMP-2 as biomarkers for susceptibility to systemic lupus erythematosus	6
Novel molecular biomarkers and diagnosis of acute appendicitis in children	6
miRNA 21: a novel biomarker in the treatment of bladder cancer	6
Significance of plasma free fatty acid level for assessing and diagnosing acute myocardial infarction	6
Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?	6
Can the systemic immune-inflammation index be used as a novel diagnostic tool in the diagnosis of subacute thyroiditis?	6
Predictive biomarkers for molecular pathology in lung cancer	6
Lower prognostic nutritional index is associated with poorer survival in patients receiving immune checkpoint inhibitors	6
High expression of DNAJA1 (HDJ2) predicts unfavorable survival outcomes in breast cancer	6
National Early Warning Score 2 and laboratory predictors correlate with clinical deterioration in hospitalized patients with COVID-19	6
Role of plasma angiotensin II and angiotensin-converting enzyme 2 levels on prognosis and mortality in hypertensive patients with COVID-19	6
Urinary tubular biomarkers as predictors of death in critically ill patients with COVID-19	6
Osteopontin and galectin-3 as biomarkers of maladaptive right ventricular remodeling in pulmonary hypertension	6
Association of fibrinogen/albumin ratio and coronary collateral circulation in stable coronary artery disease patients	6
Association between D-dimer levels and post-acute sequelae of SARS-CoV-2 in patients from a tertiary care center	6
Bioinformatic identification of prognostic indicators in bladder cancer	6
Osteopontin as novel biomarker for reversibility of pressure overload induced left ventricular hypertrophy	6
Urinary proteins detected using modern proteomics intervene in early type 2 diabetic kidney disease – a pilot study	6
Serum biomarkers for thyroid cancer	6
Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma	6
Prognostic value of OCT4 in colorectal cancer: analysis using immunohistochemistry and bioinformatics validation	6
Nomogram based on neutrophil-to-platelet ratio to predict in-hospital mortality in infective endocarditis	6
iTRAQ-based comparative proteomics analysis reveals specific urinary biomarkers for various kidney diseases	6
CD34+ cells and endothelial progenitor cell subpopulations are associated with cerebral small vessel disease burden	6
Elevated serum sortilin is related to carotid plaque concomitant with calcification	6
Utility of inflammatory biomarkers in patients with COVID-19 infections: Bahrain experience	5
Interaction analysis of miR-1275/IGF2BP1/IGF2BP3 with the susceptibility to hepatocellular carcinoma	5
Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer	5
Circulating PV-1 as a marker of celiac disease-associated liver injury	5
Serum HMGB1 and soluble urokinase plasminogen activator receptor levels aid diagnosis and prognosis prediction of sepsis with acute respiratory distress syndrome	5
STAT6 correlates with response to immune checkpoint blockade therapy and predicts worse survival in thyroid cancer	5
Elevated expression of FABP4 is associated with disease activity in rheumatoid arthritis patients	5
Usefulness of C-reactive protein/albumin ratio as a predictor of new-onset atrial fibrillation in SARS-COV-2	5
Clinical significance of miR-33b in glioma and its regulatory role in tumor cell proliferation, invasion and migration	5
Study of confounding factors influence on lung cancer diagnostics effectiveness using gas chromatography–mass spectrometry analysis of exhaled breath	5
Serum biomarker CA 15-3 as predictor of response to antifibrotic treatment and survival in idiopathic pulmonary fibrosis	5
Application of a machine learning-driven, multibiomarker panel for prediction of incident cardiovascular events in patients with suspected myocardial infarction	5
Evaluation of the relation between cardiac biomarkers and thorax computed tomography findings in COVID-19 patients	5
Using machine learning method to identify MYLK as a novel marker to predict biochemical recurrence in prostate cancer	5
De Ritis ratio: how effectively can we use in bladder cancer management?	5
Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)	5
LncRNA NEAT1 correlates with Th1 and Th17 and could serve as an assistant biomarker in sepsis	5
Predictive value of a novel lncRNA LINC02518 in evaluating the prognosis of patients with hepatocellular carcinoma	5
Urine headspace analysis with field asymmetric ion mobility spectrometry for detection of chronic kidney disease	5
Serum AMDL DR-70 levels: a new concept in the diagnosis and follow-up of colorectal carcinoma	5
Identification of prognosis-associated immune genes and exploration of immune cell infiltration in colorectal cancer	5
Significance of lncRNA MIR31HG in predicting the prognosis for Chinese patients with cancer: a meta-analysis	5
Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer	5
Prognostic value of triglyceride/glucose index in patients with ST-segment elevation myocardial infarction	5
Lp-PLA2 as a biomarker and its possible associations with SARS-CoV-2 infection	5
Vitamin D level predicts angiographic no-reflow phenomenon after percutaneous coronary intervention in patients with ST segment elevation myocardial infarction	5
Novel marker for predicting the severity and prognosis of acute pulmonary embolism: platelet-to-hemoglobin ratio	5
COX-2 promotes metastasis and predicts prognosis in gastric cancer via regulating mTOR	5
Identification of potential genomic biomarkers for Parkinson’s disease using data pooling of gene expression microarrays	4
Development and validation of a m6A-related gene signature for predicting the prognosis of hepatocellular carcinoma	4
Prognostic and clinicopathological role of long noncoding RNA NORAD in various cancers: a meta-analysis	4
The emerging role of carbohydrate antigen 125 in heart failure	4
Organ function biomarker abnormalities, associated factors and disease outcome among hospitalized patients with COVID-19	4
Identification of hub genes and discovery of promising compounds in gastric cancer based on bioinformatics analysis	4
Gene’s co-expression network and experimental validation of molecular markers associated with the drug resistance of gastric cancer	4
Novel biomarkers in cardiovascular surgery	4
Association ofCD14genetic variants and circulating level with systemic lupus erythematosus risk in Egyptian children and adolescents	4
Circulating cell-free DNA as a diagnostic and prognostic biomarker for non-small-cell lung cancer: a systematic review and meta-analysis	4
Importance of electrocardiographic markers in predicting cardiac events in children	4

AKP and GGT level can provide an early prediction of first-line treatment efficacy in colorectal cancer patients with hepatic metastases	4
A case–control study of microRNA polymorphisms in gastric cancer screening by SNP chip combined with time of flight mass spectrometry	4
Validation of a gene expression signature to measure immune quiescence in kidney transplant recipients in the CLIA setting	4
Translation of a circulating miRNA signature of melanoma into a solid tissue assay to improve diagnostic accuracy and precision	4
Initial neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as prognostic markers in patients with inoperable locally advanced non-small-cell lung cancer	4
Cholesterol derivatives and breast cancer: oxysterols driving tumor growth and metastasis	4
Prognostic value of AKAP13 methylation and expression in lung squamous cell carcinoma	4
Soluble urokinase plasminogen activator receptor levels are predictive of COVID-19 severity in Afro-Caribbean patients	4
microR-505/heterogeneous nuclear ribonucleoprotein M inhibits hepatocellular carcinoma cell proliferation and induces cell apoptosis through the Wnt/β-catenin signaling pathway	4
Clinical potential of long non-coding RNA LINC01133 as a promising biomarker and therapeutic target in cancers	4
Biomarkers in vesicoureteral reflux: an overview	4
Overexpression of miRNA 26a and 26b with MMP-9 are valuable diagnostic biomarkers for colorectal cancer patients	4
Prevention of cardiac surgery-associated acute kidney injury by risk stratification using (TIMP-2)*(IGFBP7)	4
Relationship between blood viscosity and no-reflow phenomenon in ST-segment elevation myocardial infarction performed in primary percutaneous coronary interventions	4
Current role of cardiac biomarkers in extra-cardiac diseases in children	4
HOXA9-methylated DNA as a diagnostic biomarker of ovarian malignancy	4
Accuracy of cytokeratin 19 fragment in the diagnosis of bladder cancer	4
Integrin subunit β1 and laminin γ1 chain expression: a potential prognostic biomarker in cervical cancer	4
Decreased DHRS1 expression is a novel predictor of poor survival in patients with hepatocellular carcinoma	4
Advanced glycation end products as biomarkers for cardiovascular disease: browning clarifying atherogenesis	4
Relation of a novel fibrosis marker and post-myocardial infarction left ventricular ejection fraction in revascularized patients	3
Multiple time-point assessment of lncRNA MEG3 shows potential to monitor treatment efficacy in rheumatoid arthritis patients	3
Effect of TLR-4 gene polymorphisms on sepsis susceptibility in neonates: a systematic review and meta-analysis	3
ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma	3
Clinical utility of serum biomarkers for hepatocellular carcinoma	3
SCCA-IgM in hepatocellular carcinoma patients treated with transarterial chemoembolization: gender-related differences	3
Biochemical, clinical, demographic and imaging biomarkers for disease progression in knee osteoarthritis	3
Relationship between CANLPH score and in-hospital mortality in patients undergoing coronary artery bypass grafting	3
WDR5 promotes the proliferation of lung adenocarcinoma by inducing SOX9 expression	3
N-acetyl-ß-D-glucosaminidase is predictive of mortality in chronic heart failure: a 10-year follow-up	3
Overexpression of RNF126 is associated with poor prognosis and contributes to the progression of lung adenocarcinoma	3
Clinical implications of placenta-derived angiogenic/anti-angiogenic biomarkers in pre-eclampsia	3
EMAST frequency in colorectal cancer: a meta-analysis and literature review	3
Integrative meta-analysis for the identification of hub genes in chemoresistant colorectal cancer	3
Association of serum elabela levels with carotid artery stenosis in patients with non-cardioembolic ischemic stroke	3
A sputum 6-gene signature predicts airway inflammation endotypes and exacerbation frequency in chronic obstructive pulmonary disease	3
Usefulness of the systemic immune-inflammation index in predicting atrial fibrillation recurrence after direct current cardioversion	3
Prognostic role of aberrant mTOR activation in patients with stage II and III colorectal cancer	3
LOC389641 promotes papillary thyroid cancer progression by regulating the EMT pathway	3
Serum ITIH4 in coronary heart disease: a potential anti-inflammatory biomarker related to stenosis degree and risk of major adverse cardiovascular events	3
Thymidine kinase-1 as a biomarker in breast cancer: estimating prognosis and early recognition of treatment resistance	3
Predicting long-term cardiovascular outcomes in myocardial infarction survivors using multiple biomarkers	3
Urine miRNAs as potential biomarkers for systemic reactions induced by exposure to embedded metal	3
Cancer genotypes prediction and associations analysis from imaging phenotypes: a survey on radiogenomics	3
Whole blood viscosity predicts nondipping circadian pattern in essential hypertension	3
Impact of Naples Prognostic Score on midterm all-cause mortality in patients with decompensated heart failure	3
Correlation of autophagy-related genes for predicting clinical prognosis in colorectal cancer	3
Prognostic value of STC1 in solid tumors: a meta-analysis	3
miR-197, miR-26a and miR-27a analysis in chronic lymphocytic leukemia	3
Examining variation and temporal dynamics of extracellular matrix biomarkers following acute myocardial infarction	3
Emerging role for the inflammatory biomarker osteopontin in adverse cardiac remodeling	3
The relationship between serum lactate dehydrogenase level and mortality in critically ill patients	3
Diagnostic value of RNA for hepatocellular carcinoma: a network meta-analysis	3
Galectin-3 plasma levels in adult congenital heart disease and the pressure overloaded right ventricle: reason matters	3
A novel three-long noncoding RNA risk score system for the prognostic prediction of triple-negative breast cancer	3
Targeting glioblastoma: from dream to reality	3
Plasma heat shock protein 90 levels in patients with spondyloarthritis and their relation to structural changes: a cross-sectional study	3
Biomarkers to safely discharge head trauma patients in the COVID-19 pandemic era	3
Association of neurogranin with delirium among critically ill patients	3
Imaging biomarkers for diagnosis and treatment response in patients with lymphedema	3
Wnt/β-catenin pathway proteins in end-stage renal disease	3
Association of vitamin B12/ferritin deficiency in cancer patients with methylomic changes at promotors of TET methylcytosine dioxygenases	3
Long-term stability and age-dependence of six regulatory serum proteins	3
Association between LDL/HDL ratio and in-stent restenosis in patients with acute coronary syndrome after stent implantation	3
Upregulation of glutaminase 2 and neutrophil cytosolic factor 2 is associated with the poor prognosis of glioblastoma	3
Reproducibility challenges for biomarker detection with uncertain but informative experimental data	3
Study of usefulness of low-dose IgG for patients with septic disseminated intravascular coagulation	3
Role of miRNA polymorphism in recurrent pregnancy loss: a systematic review and meta-analysis	3
Plasma endostatin correlates with hypoxia and mortality in COVID-19-associated acute respiratory failure	3
Machine-learning algorithms predict breast cancer patient survival from UK Biobank whole-exome sequencing data	3
Changes in lactate dehydrogenase on admission throughout the COVID-19 pandemic and possible impacts on prognostic capability	3
Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer	3
Evaluation of sarcopenia as a prognostic biomarker in locally advanced head and neck squamous cell carcinoma	2
Markers of rejection of a lung allograft: state of the art	2
Associations between TAB2 gene polymorphisms and dilated cardiomyopathy in a Chinese population	2
Computational analysis of MRIs predicts osteosarcoma chemoresponsiveness	2
Personalized prediction of human diseases with single-sample dynamic network biomarkers	2
Preoperative red cell distribution width to lymphocyte ratio as biomarkers for prolonged intensive care unit stay among older patients undergoing cardiac surgery: a retrospective longitudinal study	2
Blood biomarkers for predicting coagulopathy occurrence in patients with traumatic brain injury: a systematic review	2
Prognostic value of D-dimer/fibrinogen ratio on in-hospital outcomes of patients with heart failure and COVID-19	2
Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer	2
Relationship between in-hospital mortality and creatinine/albumin in patients with ST-elevation myocardial infarction without standard modifiable risk factors	2
Prognostic value of cripto-1 expression in non-small-cell lung cancer patients: a systematic review and meta-analysis	2
Downregulation of reelin predicts poor prognosis for glioma	2
Targeting PIK3CA in HER2-positive breast cancer: what are the opportunities and the challenges?	2
GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension	2
Effect of neoadjuvant chemoradiotherapy on p53 and SOX2 protein expression in esophageal adenocarcinoma	2
Serum hemato-immunological biomarkers associated with increased COVID-19 mortality in the Latino population	2
Common variants of RARRES2 and RETN contribute to susceptibility to hand osteoarthritis and related pain	2
Association between the copper/selenium ratio and the immune response to SARS-CoV-2 infection	2
Pretreatment red blood cell distribution width may be a potential biomarker of prognosis in urologic cancer: a systematic review and meta-analysis	2
Predictive biomarkers in bladder cancer	2
Dynamic monitoring of serum ferritin as an adverse prognostic biomarker in patients with multiple myeloma	2
CHEK1: a hub gene related to poor prognosis for lung adenocarcinoma	2
Ultrasensitive detection of blood biomarkers of Alzheimer's and Parkinson's diseases: a systematic review	2