Journal of the Mechanical Behavior of Biomedical Materials

Article	Citations
Bioinspired film-terminated ridges for enhancing friction force on lubricated soft surfaces	159
Mechanical properties of stromal striae, and their impact on corneal tissue behavior	133
Biomechanical evaluation of various internal fixation patterns for unilateral mandibular condylar base fractures: A three-dimensional finite element analysis	99
A linear systems model of the hydrothermal isometric tension test for assessing collagenous tissue quality	95
Effect of mold shape on the microstructure of gelatin sponges for tissue engineering applications	75
Performance of personalised prosthesis under static pressure: Numerical analysis and experimental validation	74
On the contribution of solid and fluid behavior to the modeling of the time-dependent mechanics of tendons under semi-confined compression	65
Emerging trends in multi-modal multi-dimensional biomechanical materials research	64
A statistical machine learning approach linking molecular conformational changes to altered mechanical characteristics of skin due to thermal injury	63
A comparative study of invariant-based hyperelastic models for silicone elastomers under biaxial deformation with the virtual fields method	63
Could light-curing time, post-space region and cyclic fatigue affect the nanomechanical behavior of a dual-curing cement for fiber post luting?	62
In situ and in vitro evaluation of the bioavailability of rumen-protected methionine with coating prototypes	58
Diatomaceous earth as a drug-loaded carrier in a glass-ionomer cement	57
Evaluation of the damping capacity of common CAD/CAM restorative materials	56
Quantitative in silico analysis for patient-specific annuloplasty in bicuspid aortic valve regurgitation	54
Sol-gel preparation of ZrO2–Li2Si2O5 ceramics and their sintering properties	51
Biomimetic crimped/aligned microstructure to optimize the mechanics of fibrous hybrid materials for compliant vascular grafts	50
Comparative study of hydroxyapatite synthesized using Schiff base and wet chemical precipitation methods	49
Improving accuracy in assessing osseointegration in small animal bone using specimen-specific additively-manufactured fixtures based on clinical CT imaging	49
Predicting osteosynthesis screw failure by peri-implant bone morphology in multiple loading conditions	48
Characterization of damage mechanisms in cortical bone: Quantification of fracture resistance, critical strains, and crack tortuosity	48
Comparison of simplified bone-screw interface models in materially nonlinear μFE simulations	47
Fabrication and characterisation of low-cost powder metallurgy Ti-xCu-2.5Al alloys produced for biomedical applications	47
Usability of the ECAP-Conform process for the production of dental implants material	47
Determination of elastic moduli of polymeric materials using microhardness indentation	47

Printing fidelity assessment and micro-mechanical characterization of FDM-printed PLA/HA composite for maxillofacial and oral applications	46
Saline-polyethylene glycol blends preserve in vitro annulus fibrosus hydration and mechanics: An experimental and finite-element analysis	45
Collagen hydrogels with similar polymer content but different microstructure — A comparative analysis of mechanical response	45
Empirical evidence that bone collagen molecules denature as a result of bone fracture	45
Elastic parameter identification of three-dimensional soft tissue based on deep neural network	45
Anisotropic elastic behavior of a hydrogel-coated electrospun polyurethane: Suitability for heart valve leaflets	44
SALS-ing is believing: Determining dominant fibre orientation in pericardium using visual inspection and Small Angle Light Scattering (SALS)	44
Prediction of osteoporotic degradation of tibia human bone at trabecular scale	44
Surface fractures in pre-crystallized and crystallized zirconia-containing lithium silicate glass-ceramics generated in ultrasonic vibration-assisted machining	44
Corrigendum to “Corrosion-fatigue of additively manufactured Ti6Al4V” [J. Mech. Behav. Biomed. Mater. 175 107289]	43
Effect of abutment screw-access hole on the fatigue performance of implant-supported lithium-disilicate luted simplified restorations	43
Time-dependent effects of ethanol-glycerin embalming on iliotibial band biomechanics	43
The effect of phase contents on the properties of yttria stabilized zirconia dental materials fabricated by stereolithography-based additive manufacturing	42
Indentation size effect in Knoop and Vickers hardness measurement of dental resin-based composites	41
Preparation of chitosan quaternary ammonium salt-sodium alginate/poly acrylic acid hydrogel and its application in flexible sensing	41
Processing and characterization of egg shell derived nano-hydroxyapatite synthetic bone for Orthopaedic and Arthroscopy implants and substitutes in dentistry	41
Effect of strain rate on the mechanical properties of human ribs: Insights from complete rib bending tests	40
Mechanical characterization of Xenopus laevis oocytes using atomic force microscopy	39
Gaussian random field-based characterization and reconstruction of cancellous bone microstructure considering the constraint of correlation structure	39
3D strain analysis of trabecular bone within the osteoarthritic humeral head subjected to stepwise compressive loads	38
Effect of air abrasion, acid etching, and aging on the shear bond strength with resin cement to 3Y-TZP zirconia	38
A new method for determining the ogden parameters of soft materials using indentation experiments	37
Biodegradable implant application: Electrodeposition of HA/TiO2/ZrO2 coating onto Zn-composite substrates	36
A plantar surface shear strain methodology utilising Digital Image Correlation	36
Durable PP/EPDM/GF/SiO2 nanocomposites with improved strength and toughness for orthotic applications	36
Melt electrowriting reinforced composite membrane for controlled drug release	36
Highly lubricious SPMK-g-PEEK implant surfaces to facilitate rehydration of articular cartilage	36
Screw preload loss under occlusal load as a predictor of loosening risk in varying dental implant designs	36
AFM advanced modes for dental and biomedical applications	35
Human collagen sequence polypeptides mediated biomineralization and its molecular mechanism	34
Augmentation of suture anchors with magnesium phosphate cement – Simple technique with striking effect	34
The current state of biomechanical analyses of the adult human femur: A systematic review	34
Editorial Board	33
Size effect in polymeric lattice materials with size-dependent Poisson's ratio caused by Cosserat elasticity	33
Cyclic fatigue tests on non-anatomic specimens of dental ceramic materials: A scoping review	33
Investigating simultaneous mineralization across layers during tooth development using atomic force microscopy and Raman spectroscopy	32
Cardiac mesh morphing method for finite element modeling of heart failure with preserved ejection fraction	32
Unravelling the mechanics of gastric tissue: A comparison of constitutive models, damage probability and microstructural insights	32
Impact of thrombus composition on virtual thrombectomy procedures using human clot analogues mechanical data	31
Subchondral bone plate thickness is associated with micromechanical and microstructural changes in the bovine patella osteochondral junction with different levels of cartilage degeneration	31
Thickness and internal adjustment of monolithic resin composite milled crowns: Effect on the load-bearing capacity under fatigue	30
Electrochemical behavior and surface stability of dental zirconia ceramics in acidic environments	30
Copper nanoparticles incorporated visible light-curing chitosan-based hydrogel membrane for enhancement of bone repair	30
Silk fibroin hydrogel membranes prepared by a sequential cross-linking strategy for guided bone regeneration	30
Age-dependent mechanical properties of tail tendons in wild-type and mimecan gene-knockout mice – A preliminary study	30
On the thermal impact during drilling operations in guided dental surgery: An experimental and numerical investigation	30
Fabrication of adhesive hydrogels based on poly (acrylic acid) and modified hyaluronic acid	30
Assessing the aneurysm occlusion efficacy of a shear-thinning biomaterial in a 3D-printed model	30
Improving early running-in wear characteristics for dental lithium disilicate glass-ceramics by ion-exchange	30
Material removal and surface damage in high-speed grinding of enamel	30

Fabrication of a gradient AZ91-bioactive glass composite with good biodegradability	29
Influence of core material and occlusal contact pattern on fatigue behavior of different monolithic ceramic crowns	29
Mechanical finite element analysis of needle tip shape to develop insertable polymer-based microneedle without plastic deformation	29
Development and characterisation of hybrid composite skin simulants based on short polyethylene fibre and bioactive glass particle-reinforced silicone	29
An analytical model describing the mechanics of erythrocyte membrane wrapping during active invasion of a plasmodium falciparum merozoite	29
Biomodification of eroded and abraded dentin with epigallocatechin-3-gallate (EGCG)	29
Biodegradable polyvinyl alcohol/nano-hydroxyapatite composite membrane enhanced by MXene nanosheets for guided bone regeneration	29
Both network architecture and micro cracks effects on lacuno-canalicular liquid flow efficiency within the context of multiphysics approach for bone remodeling	28
A finite element simulation study on the superficial collagen fibril network of knee cartilage under cyclic loading: Effects of fibril crosslink densities	28
Shear wave elastography characterizes passive and active mechanical properties of biceps brachii muscle in vivo	28
A novel device for investigating structure-function relationships and mechanoadaptation of biological tissues	28
Mechanical characterization of TiO2 nanowires flexible scaffold by nano-indentation/scratch	28
Designs and mechanical responses of 3D-printed Ti6Al4V porous structures based on triply periodic minimal surfaces with different iso-values	28
Measuring the density and viscosity of culture media for optimized computational fluid dynamics analysis of in vitro devices	28
Fabrication of Customized dental guide by stereolithography method and evaluation of dimensional accuracy with artificial neural networks	27
A review of strategies for improving the mechanical properties of 3D bioprinted skin grafts	27
Near-field electrospinning of polydioxanone small diameter vascular graft scaffolds	27
Mechanical response of human thoracic spine ligaments under quasi-static loading: An experimental study	27
Towards biomimetic, lattice-based, tendon and ligament metamaterial designs	27
Bio-inspired auto-adaptive framework for optimized movement of passive knee prosthesis	27
Structural parameters defining distribution of collagen fiber directions in human carotid arteries	27
Comparison of two contrast-enhancing staining agents for use in X-ray imaging and digital volume correlation measurements across the cartilage-bone interface	27
Predicting fracture in the proximal humerus using phase field models	27
Accelerated bruxism-simulating fatigue test of occlusal veneers	27
Soft tissue-like coupling materials for in vitro acoustic emission studies in total hip arthroplasty	26
Mechanical strength predictability of full factorial, Taguchi, and Box Behnken designs: Optimization of thermal settings and Cellulose Nanofibers content in PA12 for MEX AM	26
A noninvasive measurement technique for the initial stiffness of the radial artery	26
Dimensional changes of CAD/CAM polymer crowns after water aging – An in vitro experiment	26
A novel diffusion tensor based three-dimensional constitutive model for human breast tissue	26
Macrocrack propagation in a notched shaft segment of human long bone: Experimental results and mechanical aspects	26
The effect of varying monocalcium phosphate and polylysine levels on dental composite properties	26
The assessment of natural human skin tension orientation and its variation according to age for two body areas: Forearm and thigh	25
Do nanofillers provide better physicomechanical properties to resin-based pit and fissure sealants? A systematic review	25
Rigid flexible coupling contact mechanism for oral and maxillofacial skin and soft tissues	25
A specialized protocol for mechanical testing of isolated networks of type II collagen	25
Material design of soft biological tissue replicas using viscoelastic micromechanical modelling	25
Insights into cell classification based on combination of multiple cellular mechanical phenotypes by using machine learning algorithm	25
A neural network-assisted 3D theoretical thermoelastic solution for laminated liquid crystal elastomer plate used in restoring cardiac mechanical function	25
Patient-specific finite element analysis of human corneal lenticules: An experimental and numerical study	25
Finite element modeling framework for evaluating the efficacy of protective plates in minimizing organ and tissue damage resulting from a blast wave impact	25
A hazardous boundary of Poly(L-lactic acid) braided stent design: Limited elastic deformability of polymer materials	25
Original implementation of low-temperature SPS for bioactive glass used as a bone biomaterial	25
Preparation and characterizations of antibacterial iodine-containing coatings on pure Ti	25
Water flow elastography – A promising tool to measure tissue stiffness during minimally invasive surgery	25
Corrigendum to “Degradation resistance of PVDF mesh in vivo in comparison to PP mesh” [J. Mech. Behav. Biomed. Mater. 119 (2021) 104490]	25
Finite element analysis of esophageal atresia repair with biodegradable polymer sleeves	25
Electrochemical deposition multi-walled carbon nanotube coatings on the surface of Ti6Al4V alloy for enhancing its biotribological properties	24
Characterization of hardness and elastic modulus using nanoindentation and correlation with wear behavior of UHMWPE during uniaxial tension	24
In-vitro assessment of a novel intraocular lens made of crosslinked polyisobutylene	24
Mechanical loading of ex vivo bovine trabecular bone in 3D printed bioreactor chambers	24
Estimation of the mechanical properties of a transversely isotropic material from shear wave fields via artificial neural networks	24
Fracture strength of endocrown maxillary restorations using different preparation designs and materials	24
Controlled Microstructural Evolution of Hydroxyapatite–Bioglass® Nanocomposites via Two-Step Sintering	24
CyMAD bioreactor: A cyclic magnetic actuation device for magnetically mediated mechanical stimulation of 3D bioprinted hydrogel scaffolds	24
Force and energy transmission at the brain-skull interface of the minipig in vivo and post-mortem	24
Computational study of the mechanical influence of lacunae and perilacunar zones in cortical bone microcracking	24
Micromechanical characteristics of titanium alloy (Ti-6Al-4V) made by laser powder bed fusion using an in-situ SEM micropillar compression technique	24
Synthesis of chitosan based reduced graphene oxide-CeO2 nanocomposites for drug delivery and antibacterial applications	23
Dynamic finite element analysis of hip replacement edge loading: Balancing precision and run time in a challenging model	23
Review paper: The importance of consideration of collagen cross-links in computational models of collagen-based tissues	23
Developing failure criteria for laceration injury of dermal tissue	23
Impact of a prophylactic mesh on the biomechanics of abdominal wall closure: an animal study	23
Calibration of Drucker–Prager plasticity in prosthetic materials: From experimental characterization to reverse-engineering finite element analysis	23
Breaking points of human hamstring muscle–tendon complex: A cadaveric study	23
An improved parameter fitting approach of a planar biaxial test including the experimental prestretch	23
Time-dependent mechanical behavior of partially oxidized polyvinyl alcohol hydrogels for tissue engineering	23
Effects of post-curing duration on the mechanical properties of complex 3D printed geometrical parts	23
A dermal light sensor controls anisotropic biomechanical properties in insect cuticle	22
Elasticity of whole blood clots measured via Volume Controlled Cavity Expansion	22
In vitro assessment of dental erosion caused by clear aligners	22
Fatigue strength of bilayer yttria-stabilized zirconia after low-temperature degradation	22
Editorial Board	22
Edge chipping patterns in posterior teeth of hominins and apes	22
Rotational 3D shear wave elasticity imaging: Effect of knee flexion on 3D shear wave propagation in in vivo vastus lateralis	22
Study of the compression behavior of functionally graded lattice for customized cranial remodeling orthosis	22
Comparison of tendon attachment to 3D printed Ti6Al4V implant versus Trevira® implant: A paired experimental animal study	22
Kirchhoff's law-based velocity-controlled motion models to predict real-time cutting forces in minimally invasive surgeries	22
Effects of Streptococcus mutans and their metabolites on the wear behavior of dental restorative materials	22
Measurement of changes in muscle viscoelasticity during static stretching using stress-relaxation data	22
Enhanced injectability of aqueous β-tricalcium phosphate suspensions through PAA incorporation, gelling and preshearing	22

Cardiac valve scaffold design: Implications of material properties and geometric configuration on performance and mechanics	21
Quantifying how altered lacunar morphology and perilacunar tissue properties influence local mechanical environment of osteocyte lacunae using finite element modeling	21
An study on the influence of collagen fiber directions in TAVs performance using FEM	21
Comparative study of stress characteristics around the adjacent teeth tissues during insertion of mini-screws with different insertion angles: A three-dimensional finite element study	21
Distribution and propagation of stress and strain in cube honeycombs as trabecular bone substitutes: Finite element model analysis	21
Shore hardness of bulk polyurethane affects the properties of nanofibrous materials differently	21
Vinyl-modified silica nanoparticles for mSLA: Promoting photocurable PEGDA resin performance and print quality	21
Exploring a parallel rheological framework to capture the mechanical behaviour of a thin-strut polymeric bioresorbable coronary scaffold	21
Finite element simulations of a single type I collagen fibril, using a novel cross-linking system	21
Mechanical properties and machinability of lithium silicate glass-ceramics with varying MgO content	21
A hyper-viscoelastic uniaxial characterization of collagenous embolus analogs in acute ischemic stroke	21
Using Statistical Shape and Appearance Modelling to characterise the 3D shape and material properties of human lumbar vertebrae: A proof of concept study	21
Study on the adverse effect of acid-corrosion on the dentin in terms of degradation of fracture resistance	21
Towards predicting shear-banding instabilities in lipid monolayers	21
Explant analysis of a Discocerv cervical disc: A case study for a ceramic-on-ceramic cervical disc	21
Cerebral vascular strains in dynamic head impact using an upgraded model with brain material property heterogeneity	20
Mechanical characterisation of hand first dorsal interosseous muscle during gripping	20
Effect of the region of the CAD/CAM block on the flexural strength and structural reliability of restorative materials	20
Effect of tension and compression on dynamic alveolar histomorphometry	20
Application of modified aldehyde compounds in self-etching bonding of dentin	20
Effect of simulated brushing and disinfection on the surface roughness and color stability of CAD-CAM denture base materials	20
Printability for additive manufacturing with machine learning: Hybrid intelligent Gaussian process surrogate-based neural network model for Co-Cr alloy	20
Preparation and evaluation of (R)-(−)-carvone-doped polymeric resins as potential antibacterial dental materials	20
Tribological behaviour of 3D printed materials for small joint implants: A pilot study	20
Si3N4-TiN rotary EDM optimization by Mo-Jaya algorithm with Pareto optimal solution, analysis of micro-structural and geometrical tolerances	20
An advanced method to design graded cylindrical scaffolds with versatile effective cross-sectional mechanical properties	20
Tailoring the mechanical properties of macro-porous PVA hydrogels for biomedical applications	20
Immediate dentin sealing influences the fracture strength of ultrathin occlusal veneers made of a polymer-infiltrated ceramic network	20
Mechanical and bioactive properties of PVD TiO2 coating modified PEEK for biomedical applications	20
Critical size of kidney stone through ureter: A mechanical analysis	20
Nacre-like block lattice metamaterials with targeted phononic band gap and mechanical properties	20
Evolution of degradation mechanism and fixation strength of biodegradable Zn–Cu wire as sternum closure suture: An in vitro study	19
Tuning the mechanical properties of alginate dialdehyde–gelatin (ADA–GEL) bioinks for bioprinting approaches by varying the degree of oxidation	19
Editorial Board	19
Relationship between magnetization transfer ratio and axial compressive strain in tibiofemoral articular cartilage	19
Fatigue performance of 4YSZ: Effect of finishing/polishing protocol and surface treatments of the bonding surface	19
An investigation on the effects of in vitro induced advanced glycation end-products on cortical bone fracture mechanics at fall-related loading rates	19
Effects of orientation of myocardial fibers on the contractility of left ventricle	19
Profiling oocytes with neural networks from images and mechanical data	19
Fitting mechanical properties of the aortic wall and individual layers to experimental tensile tests including residual stresses	19
An interferometric-based tensile tester to resolve damage events within reconstituted multi-filaments collagen bundles	19
Experimental & numerical investigations of ultra-high-speed dynamics of optically induced droplet cavitation in soft materials	19
Zirconia fixed dental prostheses fabricated by 3D gel deposition show higher fracture strength than conventionally milled counterparts	19
Development and validation of a parametric human mandible model to determine internal stresses for the future design optimization of maxillofacial implants	19
Hierarchical porous PLLA/ACP fibrous membrane towards bone tissue scaffold	19
Influence of strut-size and cell-size variations on porous Ti6Al4V structures for load-bearing implants	19
Skeletal impacts of dual in vivo compressive axial tibial and ulnar loading in mice	19
In-silico simulation of nanoindentation on bone using a 2D cohesive finite element model	19
Strain-based biomarkers at the skin surface differentiate asymmetries in soft tissue mobility associated with myofascial pain	19
Effects of an orthodontic primer containing amorphous fluorinated calcium phosphate nanoparticles on enamel white spot lesions	19
Preparation and mechanical behavior of the acellular porcine common bile duct and its immunogenicity in vivo	18
Insight on the in vivo wear characteristics of goat artificial cervical disc implanted for 6 months	18
Study on mechanical behavior of Cu-bearing antibacterial titanium alloy implant	18
Wear investigation based on a novel, anatomic shoulder prosthesis with bearing materials inversion	18
Bacterial nanocellulose: Reinforcement of compressive strength using an adapted Mobile Matrix Reservoir Technology and suitable post-modification strategies	18
Design of thermally programmable 3D shape memory polymer-based devices tailored for endovascular treatment of intracranial aneurysms	18
Experimental investigation on mechanical properties of aged bamboo fiber-reinforced composites under quasi-static loading	18
3D porous PCL-PEG-PCL / strontium, magnesium and boron multi-doped hydroxyapatite composite scaffolds for bone tissue engineering	18
Fabrication of a positional brain shift phantom through the utilization of the frozen intermediate hydrogel state	18
Accuracy of additively manufactured and steam sterilized surgical guides by means of continuous liquid interface production, stereolithography, digital light processing, and fused filament fabrication	18
Effect of thermocycling on the mechanical properties, inorganic particle release and low temperature degradation of glazed high translucent monolithic 3Y-TZP dental restorations	18
Aging of non-implanted Natrelle™ gel breast implants	18
Treatment affects load to failure and microdamage accumulation in healthy and osteolytic rat vertebrae	18
Increasing the fatigue strength of laser-powder bed fusion manufactured Ti6Al4V hip stems by means of appropriate post-treatments	18
Experimental analysis and numerical simulations of the mechanical properties of a (Ce,Y)-TZP/Al2O3/H6A ceramic composite containing coupled toughening mechanisms	18
Impact of multiple firings on fracture load of veneered zirconia restorations	18
Mechanical properties and osteointegration of the mesh structure of a lumbar fusion cage made by 3D printing	18
Probing nanoscale structural response of collagen fibril in human Achilles tendon during loading using in situ SAXS	18
On the fracture behavior of cortical bone microstructure: The effects of morphology and material characteristics of bone structural components	18
Is the fluid volume fraction equal to the water content in tendons? Insights on biphasic modeling	18
An investigation on osteoporosis based on guided wave propagation in multi-layered bone plates	18
Influence of pia-arachnoid complex on the indentation response of porcine brain at different length scales	17
Mechanical behavior and failure mode of body-centered cubic, gyroid, diamond, and Voronoi functionally graded additively manufactured biomedical lattice structures	17
Conceptual design of compliant bone scaffolds by full-scale topology optimization	17
Effects of hybrid inorganic-organic nanofibers on the properties of enamel resin infiltrants – An in vitro study	17
Comparative retrieval analysis of contemporary mobile and fixed unicompartmental knee bearing designs	17
A combined experimental and numerical method to estimate the elastic modulus of single trabeculae	17
Optimisation of the additive manufacturing parameters of polylactic acid (PLA) cellular structures for biomedical applications	17
Macroscopic creep behavior of spheroids derived from mesenchymal stem cells under compression	17
Biomineralization of calcium phosphates functionalized with hydroxyapatite-binding peptide	17
Effects of surface morphology and chemical composition on friction properties of Xenopeltis hainanensis scales	17
Fatigue and wear of human tooth enamel: A review	17
Development of a bioactive dentin adhesive resin modified with magnesium-doped synthetic hydroxyapatite crystals	17
3D-printed polyether-ether ketone/carboxymethyl cellulose scaffolds coated with Zn–Mn doped mesoporous bioactive glass nanoparticles	17
Post-printing processing and aging effects on Polyjet materials intended for the fabrication of advanced surgical simulators	17
Development of a continuum-based, meshless, finite element modeling approach for representation of trabecular bone indentation	17
Effect of butylated hydroxytoluene (BHT) concentrations on polymerization shrinkage stress and other physicochemical properties of experimental resin composites	17
Revealing the composite fretting-corrosion mechanisms of Ti6Al4V alloy against zirconia-toughened alumina ceramic in simulated body fluid	17
Biomechanical analysis of peri-prosthetic bone response to hybrid threaded zirconia dental implants: An in silico model	17
Electrodeposited Biodegradable Zn-Fe Alloy Foams: Synergistic Control of Degradation Kinetics and Biomechanical Properties for Cranial Bone Implants	17
Numerical simulation of mechanical tests on a living skin using anisotropic hyperelastic law	17
One-step synthesis of a piezoelectric hybrid BNNT/BaTiO3 composite and its application in bone tissue engineering	17
Influence of different surface finishing procedures of strength-gradient multilayered zirconia crowns on two-body wear and fracture load: Lithium silicate or leucite glazing versus polishing?	16
Effect of porcelain veneering technique in bilayered zirconia on bond strength and residual stress distribution	16
Synthesis of bioactive heat cured PMMA/PEKK blend reinforced by nano titanium dioxide for bone scaffold applications	16