OOIR: Observatory of International Research

Papers

(The TQCC of Epigenomics is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
DNMT3L Interacts with Piwi and Modulates the Expression of piRNAs in Transgenic Drosophila	60
Decoding the Year of 2023: Welcome to the 16th Volume of Epigenomics	53
Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study	53
Epigenetic Signature of Exposure to Maternal Trypanosoma Cruzi Infection in Cord Blood Cells from Uninfected Newborns	36
Unlocking the Epigenetic Symphony: Histone Acetylation’s Impact on Neurobehavioral Change in Neurodegenerative Disorders	33
The epigenetic roles of pirfenidone - implication in liver disease management	31
Altered epigenetic landscape as infectious disease diagnostics	28
Precision Epigenetics Provides a Scalable Pathway for Improving Coronary Heart Disease Care Globally	27
Epigenetic alterations in prostate cancer: the role of chromatin remodeling	26
Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos	24
The role of long non-coding RNA in the pathogenesis of aneurysms	23
Epigenetics in evolution and adaptation to environmental challenges: pathways for disease prevention and treatment	23
Exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschsprung’s disease	20
From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases	20
Association between Alcohol Consumption and DNA Methylation in Blood: A Systematic Review of Observational Studies	20
Epigenetics and Cutaneous Neoplasms: From Mechanism to Therapy	19
Epigenome-Wide Studies of Antipsychotics: A Systematic Review and Pathway Meta-Analysis	19
Comparison of Methylation Episignatures in KMT2B - and KMT2D -Related Human Disorders	19
The Impact and Mechanism of TET3 Overexpression on the Progression of Hepatic Fibrosis	19
Targeting Tudor domains in leukemia: epigenetic insights for drug development	18
Epigenetic rejuvenation: a journey backwards towards an epigenomic ground state	18
Advancing epigenetic signatures as functional biomarkers in rare diseases	17
The Study of HMOX1 DNA Methylation and Gene Expression and the Diagnostic Potential of miR-153-3p in Preeclampsia	16
Age-Related Changes in Sperm DNA Methylation and their Forensic and Clinical Implications	16
The hMeDIP-Seq Identified INPP4A as a Novel Biomarker for Eosinophilic Chronic Rhinosinusitis with Nasal Polyps	16

Alteration of the N ⁶ -Methyladenosine Epitranscriptomic Profile in Synthetic Phthalate-Treated Human Induced Pluripotent Stem Cell-Derived Endothelial Cells	16
Decoding Mitochondrial–Nuclear (epi)genome Interactions: The Emerging Role of ncRNAs	15
Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma	15
SET Protein as an Epigenetics Target	15
The eighth annual US DOHAD meeting: promising approaches in epigenetics research of early life exposures	14
Phytochemicals in Cervical Cancer: An Epigenetic Overview	14
Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations	14
High methylation of the same promoter of lncRNA ZNF582-AS1 / ZNF582 promotes malignant progression of esophageal cancer	13
Human RNA-Directed DNA Methylation Methylates High-Mobility Group Box 1 Protein-Produced DNA Gaps	13
Combined therapy targeting AR and EZH2 curbs castration-resistant prostate cancer enhancing anti-tumor T-cell response	13
Matched Analysis of Detailed Peripheral Blood and Tumor Immune Microenvironment Profiles in Bladder Cancer	13
EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1	13
Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging	13
DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment	13
Blood-based DNA methylation markers for autism spectrum disorder identification using machine learning	12
ncRNAs as Biomarkers and Therapeutic Targets for Bronchiectasis	12
POU2F2-mediated Upregulation of lncRNA PTPRG-AS1 Inhibits Ferroptosis in Breast Cancer Via miR-376c-3p/SLC7A11 Axis	12
Insights to aging prediction with AI based epigenetic clocks	12
Three generations of epigenetic clocks in mediating the adverse effect of smoking on metabolic health	12
Integrated epigenomic exposure signature discovery	11
Beadchip Technology to Detect DNA Methylation in Mouse Faithfully Recapitulates Whole-Genome Bisulfite Sequencing	11
Dissecting the Nuances of Cancer Epigenomics in Liquid Biopsy	11
Epigenetics and suicidal behavior in adolescents: a critical review	10
Role Of Epigenetic Drugs In Sensitizing Cancers To Anticancer Therapies: Emerging Trends And Clinical Advancements	10
microRNAs and their Therapeutic Strategy in Phase I and Phase II Clinical Trials	10
Exploring the Molecular Targets for Type 2 Diabetes-Induced Alzheimer’s Disease Through Bioinformatics Analysis	10
The epigenetics of frailty	10
Transcription Factors: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma	9
Emerging roles of RNA modifications in normal development and congenital craniofacial malformations	9
Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	9
LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac	9
m ⁶ A Modification and its Role in Neural Development and Neurological Diseases	9
Epigenetic Memory in Breast Cancer: Electrochemical Biosensor-Based Tracing of Histone H3 Acetylation Inheritance	9
Exploring Perinatal Biopsychosocial Factors and Epigenetic Age in 1-Year-Old Offspring	9
Combined replacement of lnc-MEG3 and miR-155 elicit tumor suppression in multiple myeloma	9
MiR-4732-3p Prevents Lung Cancer Progression via Inhibition of the TBX15/TNFSF11 Axis	9
Computational-based integrative methylome-transcriptome analysis reveals widespread enhancer hypomethylation in esophageal carcinoma	8
DNA methylation profile to aid in the diagnosis of pancreatic ductal adenocarcinoma and its role in disease progression	8
Constructed Competitive Endogenous RNA Network and Patterns of Immune Infiltration Revealing the Prognostic Signature for Cervical Cancer	8
Mom genes and dad genes: genomic imprinting in the regulation of social behaviors	8
METTL3 promotes Non-Small-Cell Lung Cancer Growth and Metastasis by Inhibiting FDX1 Through Copper Death-Associated Pri-miR-21-5p Maturation	8
The epigenetic potential of vitamin K2 in brain health	8
The Role of N ⁶ -Methyladenosine RNA Modification in Platinum Resistance	8
A father’s legacy: the sperm epigenome, preimplantation development, and paternal environment	8
Epigenome-Wide Association Study of Serum Folate in Maternal Peripheral Blood Leukocytes	8
Mitochondrial D-loop Methylation Levels Inversely Correlate with Disease Duration in Amyotrophic Lateral Sclerosis	8
Integrative analysis of a novel 5 methylated snoRNA genes prognostic signature in patients with glioma	8
Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome	7
Dulaglutide as a Demethylating Agent to Improve the Outcome of Breast Cancer	7
Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health	7

Epigenetics: the missing link between environmental exposures and Parkinson's disease?	7
Dna Methylation as a Powerful Tool to Investigate the Biology and Pathology of Aging	7
The Epigenetic Landscape: How Environmental Cues Shape Gene Expression	7
Cell-free DNA methylation patterns in aging and their association with inflamm-aging	7
DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients	7
RASSF1A Promotes ATM Signaling and RASSF1A Methylation is a Synthetic Lethal Marker for ATR Inhibitors	7
EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data	7
PTEN Promoter Methylation And Expression In Endometrial Cancer Tissues	7
Non-coding RNAs regulation in breast cancer pathogenesis	6
A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer	6
The Role of H3K9 Acetylation and Gene Expression in Different Brain Regions of Alzheimer’s Disease Patients	6
Clinical Uses of Epigenetics in Cardiology and Cardiothoracic Surgery: An Update	6
Methylation changes of gallbladder DNA during the formation of gallstones	6
The regulation of microRNAs on chemoresistance in triple-negative breast cancer: a recent update	6
Dna Methylation Episignatures are Sensitive and Specific Biomarkers for Detection of Patients with Kat6A / Kat6B Variants	6
cfDNA Methylation in Liquid Biopsies as Potential Testicular Seminoma Biomarker	6
Dysregulation of epigenetic modifications in inborn errors of immunity	6
The Epigenetics Orchestra of Notch Signaling: A Symphony for Cancer Therapy	6
Accurate interpretation of inosines in RNAs: recognized as G is more than basepairing with C	6
Transcriptome Profiling and ceRNA Network of Small Extracellular Vesicles from Resting and Degranulated Mast Cells	6
Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India	6
Epigenetics of cerebrovascular diseases: an update review of clinical studies	6
Epigenetic Disruption of Histone Deacetylase-2 Accelerated Apoptotic Signaling and Retarded Malignancy in Gastric Cells	6
Association between imprinting disorders and assisted reproductive technologies	6
Epigenetic landscape of intestinal cell line HT29 cocultured with Lacticaseibacillus	6
Epigenetic Regulation of Vitamin D Deficiency	6
MDM2 and DNMT1 inhibitors induce neuroblastoma cell death through p53-dependent and independent pathways	6
Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States	6
Development and validation of a novel cell type estimation method for targeted bisulfite sequencing data	6
DNA methylation-based health predictors: advances, applications, and perspectives	6
Targeting TET enzymes in ovarian cancer: epigenetic regulation, chemoresistance, and therapeutic opportunities	6
Psychiatry and sensation: the epigenetic links	6
Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases	6
Epigenomic mechanisms of dietary prescriptions for obesity therapy	5
tRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet	5
Role of epigenetic markers in cardiovascular disease following hypertensive disorders of pregnancy	5
Environmental aging: through the prism of DNA methylation	5
DNA Methylation as a Window into Female Reproductive Aging	5
ALKBH5-mediated m6A demethylation of TXNDC5 drives malignant progression in gastric cancer	5
Epigenomic Impacts of Meditative Practices	5
Super-enhancers: drivers of cells’ identities and cells’ debacles	5
Methylation changes of liver DNA during the formation of gallstones	5
Epigenetic landscape of Leishmania-host interactions	5
Current trends in clinical trials and the development of small molecule epigenetic inhibitors as cancer therapeutics	5
Deciphering KDM8 dysregulation and CpG methylation in hepatocellular carcinoma using multi-omics and machine learning	5
Assessing the epigenetic consequences of ART in male infertility: what risks to embryo and offspring health?	5
Impact of prematurity on LINE-1 promoter methylation	5
PEMT Variants are Associated with Nonsyndromic Cleft Lip with or without Cleft Palate in Chile	5
SIX4 , a Potential Therapeutic Target for Estrogen Receptor-Positive Breast Cancer Patients, is Associated with low Promoter Methylation Level	5
Performance Comparisons of Methylation and Structural Variants From Low-Input Whole-Genome Methylation Sequencing	5
Combining EZH2 inhibitors with other therapies for solid tumors: more choices for better effects	5
Recent advances in methodologies of epigenomics	5
The mystique of epigenetic regulation: the remarkable case of a human noncoding RNA, nc886	5