OOIR: Observatory of International Research

Papers

(The TQCC of Epigenomics is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
DNMT3L Interacts with Piwi and Modulates the Expression of piRNAs in Transgenic Drosophila	68
Decoding the Year of 2023: Welcome to the 16th Volume of Epigenomics	66
Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study	64
Epigenetic Signature of Exposure to Maternal Trypanosoma Cruzi Infection in Cord Blood Cells from Uninfected Newborns	39
The epigenetic roles of pirfenidone - implication in liver disease management	35
Altered epigenetic landscape as infectious disease diagnostics	32
Precision Epigenetics Provides a Scalable Pathway for Improving Coronary Heart Disease Care Globally	31
Exosome-transmitted microRNA-323a-3p participated in the occurrence of Hirschsprung’s disease	29
The role of long non-coding RNA in the pathogenesis of aneurysms	28
Unlocking the Epigenetic Symphony: Histone Acetylation’s Impact on Neurobehavioral Change in Neurodegenerative Disorders	24
Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos	24
RNA modifications at the crossroads of inflammation: METTL1-mediated m ⁷ G methylation of Sarm1 mRNA	23
Epigenetic alterations in prostate cancer: the role of chromatin remodeling	23
Epigenetics in evolution and adaptation to environmental challenges: pathways for disease prevention and treatment	22
Targeting Tudor domains in leukemia: epigenetic insights for drug development	20
From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases	20
The Impact and Mechanism of TET3 Overexpression on the Progression of Hepatic Fibrosis	20
Epigenome-Wide Studies of Antipsychotics: A Systematic Review and Pathway Meta-Analysis	20
Phytochemicals in Cervical Cancer: An Epigenetic Overview	19
Decoding Mitochondrial–Nuclear (epi)genome Interactions: The Emerging Role of ncRNAs	19
The Study of HMOX1 DNA Methylation and Gene Expression and the Diagnostic Potential of miR-153-3p in Preeclampsia	19
Advancing epigenetic signatures as functional biomarkers in rare diseases	19
SET Protein as an Epigenetics Target	18
Ultra-sensitive urine DNA methylation test enables early and accurate detection of bladder cancer	18
Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma	18

Alteration of the N ⁶ -Methyladenosine Epitranscriptomic Profile in Synthetic Phthalate-Treated Human Induced Pluripotent Stem Cell-Derived Endothelial Cells	17
Long-term molecular embedding of early life adversity: leukocyte DNA methylation and gene expression associations from childhood to young adulthood	17
Age-Related Changes in Sperm DNA Methylation and their Forensic and Clinical Implications	17
Epigenetics and Cutaneous Neoplasms: From Mechanism to Therapy	17
Epigenetic rejuvenation: a journey backwards towards an epigenomic ground state	17
Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations	16
Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging	16
EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1	16
Combined therapy targeting AR and EZH2 curbs castration-resistant prostate cancer enhancing anti-tumor T-cell response	15
High methylation of the same promoter of lncRNA ZNF582-AS1 / ZNF582 promotes malignant progression of esophageal cancer	15
The eighth annual US DOHAD meeting: promising approaches in epigenetics research of early life exposures	14
Matched Analysis of Detailed Peripheral Blood and Tumor Immune Microenvironment Profiles in Bladder Cancer	14
POU2F2-mediated Upregulation of lncRNA PTPRG-AS1 Inhibits Ferroptosis in Breast Cancer Via miR-376c-3p/SLC7A11 Axis	14
Insights to aging prediction with AI based epigenetic clocks	14
DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment	13
Blood-based DNA methylation markers for autism spectrum disorder identification using machine learning	12
Dissecting the Nuances of Cancer Epigenomics in Liquid Biopsy	12
ncRNAs as Biomarkers and Therapeutic Targets for Bronchiectasis	12
Exploring the Molecular Targets for Type 2 Diabetes-Induced Alzheimer’s Disease Through Bioinformatics Analysis	12
Transposable element regulation in mammalian germ cells and other contexts: multilayered repression, fertility, and regulated activation	11
Impact of 14 weeks combined exercise on serum cadmium levels, DNA methylation, and epigenetic aging in older women	11
Three generations of epigenetic clocks in mediating the adverse effect of smoking on metabolic health	11
microRNAs and their Therapeutic Strategy in Phase I and Phase II Clinical Trials	11
Role Of Epigenetic Drugs In Sensitizing Cancers To Anticancer Therapies: Emerging Trends And Clinical Advancements	10
The epigenetics of frailty	10
Beadchip Technology to Detect DNA Methylation in Mouse Faithfully Recapitulates Whole-Genome Bisulfite Sequencing	10
Epigenetics and suicidal behavior in adolescents: a critical review	10
Integrated epigenomic exposure signature discovery	10
The epigenetic potential of vitamin K2 in brain health	10
Exploring Perinatal Biopsychosocial Factors and Epigenetic Age in 1-Year-Old Offspring	9
Combined replacement of lnc-MEG3 and miR-155 elicit tumor suppression in multiple myeloma	9
Mitochondrial D-loop Methylation Levels Inversely Correlate with Disease Duration in Amyotrophic Lateral Sclerosis	9
DNA methylation profile to aid in the diagnosis of pancreatic ductal adenocarcinoma and its role in disease progression	9
Epigenetic Memory in Breast Cancer: Electrochemical Biosensor-Based Tracing of Histone H3 Acetylation Inheritance	9
Transcription Factors: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma	9
Computational-based integrative methylome-transcriptome analysis reveals widespread enhancer hypomethylation in esophageal carcinoma	9
METTL3 promotes Non-Small-Cell Lung Cancer Growth and Metastasis by Inhibiting FDX1 Through Copper Death-Associated Pri-miR-21-5p Maturation	9
Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	9
Emerging roles of RNA modifications in normal development and congenital craniofacial malformations	9
LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac	9
Epigenome-Wide Association Study of Serum Folate in Maternal Peripheral Blood Leukocytes	9
The Role of N ⁶ -Methyladenosine RNA Modification in Platinum Resistance	8
Dna Methylation as a Powerful Tool to Investigate the Biology and Pathology of Aging	8
Paternal preconception exercise and sperm epigenetic mechanisms: a systematic review on offspring health	8
A father’s legacy: the sperm epigenome, preimplantation development, and paternal environment	8
Mom genes and dad genes: genomic imprinting in the regulation of social behaviors	8
Integrative analysis of a novel 5 methylated snoRNA genes prognostic signature in patients with glioma	8
Cell-free DNA methylation patterns in aging and their association with inflamm-aging	8
m ⁶ A Modification and its Role in Neural Development and Neurological Diseases	8
Constructed Competitive Endogenous RNA Network and Patterns of Immune Infiltration Revealing the Prognostic Signature for Cervical Cancer	8

Association between imprinting disorders and assisted reproductive technologies	8
EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data	8
cfDNA Methylation in Liquid Biopsies as Potential Testicular Seminoma Biomarker	8
MiR-4732-3p Prevents Lung Cancer Progression via Inhibition of the TBX15/TNFSF11 Axis	8
Psychiatry and sensation: the epigenetic links	7
PTEN Promoter Methylation And Expression In Endometrial Cancer Tissues	7
Dulaglutide as a Demethylating Agent to Improve the Outcome of Breast Cancer	7
Epigenetic landscape of intestinal cell line HT29 cocultured with Lacticaseibacillus	7
Overview of transcriptomics and epigenomics approaches in the diagnosis, prognosis, and therapeutics of primary brain cancers	7
DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients	7
Epigenetics: the missing link between environmental exposures and Parkinson's disease?	7
Dysregulation of epigenetic modifications in inborn errors of immunity	7
RASSF1A Promotes ATM Signaling and RASSF1A Methylation is a Synthetic Lethal Marker for ATR Inhibitors	7
Epigenetic Disruption of Histone Deacetylase-2 Accelerated Apoptotic Signaling and Retarded Malignancy in Gastric Cells	7
The Epigenetics Orchestra of Notch Signaling: A Symphony for Cancer Therapy	7
Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome	7
The Epigenetic Landscape: How Environmental Cues Shape Gene Expression	7
Non-coding RNAs regulation in breast cancer pathogenesis	7
Super-enhancers: drivers of cells’ identities and cells’ debacles	6
PEMT Variants are Associated with Nonsyndromic Cleft Lip with or without Cleft Palate in Chile	6
Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States	6
HOTAIR at the metabolic crossroads: lncRNA control of carbohydrate and lipid metabolism	6
Dual epigenetic targeting in neuroblastoma: a new paradigm from synergistic lethality to clinical translation	6
Dna Methylation Episignatures are Sensitive and Specific Biomarkers for Detection of Patients with Kat6A / Kat6B Variants	6
The regulation of microRNAs on chemoresistance in triple-negative breast cancer: a recent update	6
SIX4 , a Potential Therapeutic Target for Estrogen Receptor-Positive Breast Cancer Patients, is Associated with low Promoter Methylation Level	6
DNA methylation-based health predictors: advances, applications, and perspectives	6
tRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet	6
Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India	6
A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer	6
Epigenetic Regulation of Vitamin D Deficiency	6
Interplay of the 3D genome and epigenome in androgen-driven prostate cancer	6
Targeting TET enzymes in ovarian cancer: epigenetic regulation, chemoresistance, and therapeutic opportunities	6
MDM2 and DNMT1 inhibitors induce neuroblastoma cell death through p53-dependent and independent pathways	6
Methylation changes of liver DNA during the formation of gallstones	6
Transcriptome Profiling and ceRNA Network of Small Extracellular Vesicles from Resting and Degranulated Mast Cells	6
Epigenomic mechanisms of dietary prescriptions for obesity therapy	6
Methylation changes of gallbladder DNA during the formation of gallstones	6
Clinical Uses of Epigenetics in Cardiology and Cardiothoracic Surgery: An Update	6
Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases	6
Epigenetics of cerebrovascular diseases: an update review of clinical studies	6
Development and validation of a novel cell type estimation method for targeted bisulfite sequencing data	6
Epigenomic Impacts of Meditative Practices	6
Impact of prematurity on LINE-1 promoter methylation	6
Accurate interpretation of inosines in RNAs: recognized as G is more than basepairing with C	6