OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Neurodegeneration is 57. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis	689
Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5– implications for dementia with lewy bodies	402
Regulation of the hippocampal translatome by Apoer2-ICD release	298
Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in amyloid-β pathology	269
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease	253
Synaptic control of retinal ganglion cell survival and axon regeneration	203
Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer’s pathogenesis	175
LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome	168
Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions	154
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits	152
Tau interactome and RNA binding proteins in neurodegenerative diseases	141
TREM2 dependent and independent functions of microglia in Alzheimer’s disease	137
Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer’s disease genetic pathways	125
Microglia sensing of peripheral signals that bridge the brain and body	120
Early binding of anti-amyloid antibodies to CAA drives complement activation, inflammation and ARIA in mice	119
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores	116
Cautions on utilizing plasma GFAP level as a biomarker for reactive astrocytes in neurodegenerative diseases	115
Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases	112
Death-associated protein kinase 1-dependent SENP1 degradation increases tau SUMOylation and leads to cognitive dysfunction in a mouse model for tauopathy	107
Understanding the genetic imperfections of Lewy body dementia	99
Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model	97
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease	96
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons	94
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress	92
Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition	89

ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders	86
Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement	84
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB	83
Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice	80
Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism	78
Single-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort	77
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology	76
A ‘Tangled Web’ in the CNS: unraveling neutrophil extracellular traps in neurological disorders	75
The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap	74
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases	74
Multi-omics insights into GBA1-associated Parkinson’s disease: interplay of genomics, transcriptomics, proteomics, and lipidomics	74
Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution	73
In Memoriam of Edward H. Koo, MD 1954–2025	72
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants	72
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner	72
Autophagic impairment in sleep–wake circuitry is linked to sleep loss at the early stages of Alzheimer’s disease	71
Impaired nucleocytoplasmic transport in SOD1-mediated ALS	68
Standardized protocol to detect phosphorylated α-synuclein in skin biopsies: recommendations from an expert panel	68
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6	66
Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration	65
Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease	65
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease	64
Parkinson’s disease LRRK2 mutations dysregulate iron homeostasis and promote oxidative stress and ferroptosis in human neurons and astrocytes	62
A randomized, placebo-controlled, double blind Phase 1 trial of the Aβ vaccine, AV-1959R, in non-clinically impaired participants: prelude for secondary preventive therapy in preclinical AD	62
Entering the era of precision medicine to treat amyotrophic lateral sclerosis	62
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps	61
Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus	60
Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease	60
A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics	59
Plasma platelet-derived growth factor receptor-β decrease correlates with blood-brain barrier damage in Alzheimer’s disease	58
TMEM106B aggregation in neurodegenerative diseases: linking genetics to function	58
Using mass spectrometry to validate mouse models of tauopathy	57
The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease	57
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation	57
Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s disease	57
ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses	57