OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Neurodegeneration is 52. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
In Memoriam of John T. Trojanowski, MD, PhD 1946-2022	372
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis	230
Regulation of the hippocampal translatome by Apoer2-ICD release	221
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application	207
Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions	202
Tau interactome and RNA binding proteins in neurodegenerative diseases	194
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits	181
TREM2 dependent and independent functions of microglia in Alzheimer’s disease	169
Cautions on utilizing plasma GFAP level as a biomarker for reactive astrocytes in neurodegenerative diseases	169
Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model	168
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores	154
Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration	151
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease	142
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress	140
Circadian clocks, cognition, and Alzheimer’s disease: synaptic mechanisms, signaling effectors, and chronotherapeutics	139
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons	134
Single-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort	132
Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer’s disease brains	123
Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism	100
Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition	100
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases	98
Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement	91
Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution	90
The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap	89
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB	87

The role of NURR1 in metabolic abnormalities of Parkinson’s disease	85
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner	83
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy	79
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps	76
Combination therapy using GDNF and cell transplant in Parkinson’s disease	73
In Memoriam of Edward H. Koo, MD 1954–2025	72
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6	72
Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease	72
Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease	71
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis	71
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease	71
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants	70
Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus	68
TMEM106B aggregation in neurodegenerative diseases: linking genetics to function	67
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation	65
A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics	64
ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses	62
Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases	60
Using mass spectrometry to validate mouse models of tauopathy	58
Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis	55
Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer’s and Parkinson’s disease	55
Dementia with lewy bodies patients with high tau levels display unique proteome profiles	55
The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease	54
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease	53
RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD	53
Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes	53
The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression	52