OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Neurodegeneration is 55. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome	630
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease	354
Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in amyloid-β pathology	268
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis	257
Synaptic control of retinal ganglion cell survival and axon regeneration	240
Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5– implications for dementia with lewy bodies	188
Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer’s pathogenesis	185
TREM2 dependent and independent functions of microglia in Alzheimer’s disease	168
Regulation of the hippocampal translatome by Apoer2-ICD release	161
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits	158
Tau interactome and RNA binding proteins in neurodegenerative diseases	143
Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions	139
Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases	133
Death-associated protein kinase 1-dependent SENP1 degradation increases tau SUMOylation and leads to cognitive dysfunction in a mouse model for tauopathy	125
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons	112
Cautions on utilizing plasma GFAP level as a biomarker for reactive astrocytes in neurodegenerative diseases	110
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores	108
Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model	107
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress	106
Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer’s disease genetic pathways	104
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease	104
Microglia sensing of peripheral signals that bridge the brain and body	103
Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism	97
The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap	93
Multi-omics insights into GBA1-associated Parkinson’s disease: interplay of genomics, transcriptomics, proteomics, and lipidomics	93

The role of NURR1 in metabolic abnormalities of Parkinson’s disease	86
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology	85
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases	78
Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition	78
Single-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort	76
Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB	74
Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement	73
Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution	73
In Memoriam of Edward H. Koo, MD 1954–2025	71
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner	70
Impaired nucleocytoplasmic transport in SOD1-mediated ALS	69
Combination therapy using GDNF and cell transplant in Parkinson’s disease	68
Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6	67
Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration	66
Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease	65
BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps	64
Autophagic impairment in sleep–wake circuitry is linked to sleep loss at the early stages of Alzheimer’s disease	63
Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease	62
Entering the era of precision medicine to treat amyotrophic lateral sclerosis	61
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease	61
APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants	61
Plasma platelet-derived growth factor receptor-β decrease correlates with blood-brain barrier damage in Alzheimer’s disease	60
Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus	60
A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics	59
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation	59
ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses	58
TMEM106B aggregation in neurodegenerative diseases: linking genetics to function	57
Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes	56
Using mass spectrometry to validate mouse models of tauopathy	56
The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression	55
Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis	55