Radiation Oncology

Article	Citations
Efficacy and safety of tyrosine kinase inhibitors with thoracic radiotherapy for patients with oncogene-mutated non-small cell lung cancer: a meta-analysis	76
Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer	69
125I seed brachytherapy for non-central pelvic recurrence of cervical cancer after external beam radiotherapy	68
A multifunctional targeted nano-delivery system with radiosensitization and immune activation in glioblastoma	62
Ventilation and perfusion MRI at a 0.35 T MR-Linac: feasibility and reproducibility study	59
Direct comparison of low-dose-rate brachytherapy versus radical prostatectomy using the surgical definition of biochemical recurrence for patients with intermediate-risk prostate cancer	50
Injection of hydrogel spacer increased maximal intrafractional prostate motion in anterior and superior directions during volumetric modulated arc therapy-stereotactic body radiation therapy for prost	45
Treatment outcomes and radiotherapy deintensification strategies in human papillomavirus-associated tonsil cancer	45
CT-based auto-segmentation of multiple target volumes for all-in-one radiotherapy in rectal cancer patients	42
Radiotherapy refusal in breast cancer with breast-conserving surgery	37
CircRNA_101491 regulated the radiation sensitivity of esophageal squamous cell carcinomas via sponging miR-125a-5p	34
A retrospective study comparing definitive chemoradiotherapy vs. chemoradiotherapy followed by surgery in T4 esophageal squamous cell carcinoma patients who were downstaged after neochemoradiotherapy	33
Current status and perspectives of interventional clinical trials for brain metastases: analysis of ClinicalTrials.gov	32
Whole lung radiomic features are associated with overall survival in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy	32
Pamiparib as consolidation treatment after concurrent chemoradiotherapy of limited-stage small cell lung cancer: a single-arm, open-label phase 2 trial	31
Outcome of patients with soft tissue sarcomas of the extremities and trunk treated by (neo)adjuvant intensity modulated radiation therapy with curative intent	31
Estimating cancer risks due to whole lungs low dose radiotherapy with different techniques for treating COVID-19 pneumonia	31
Preoperative short-course radiotherapy followed by consolidation chemotherapy for treatment with locally advanced rectal cancer: a meta-analysis	30
The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma	30
Extensive clinical target volume in postoperative chemoradiotherapy for esophageal squamous cell carcinoma: a phase II clinical trial (ESO-Shanghai 9)	29
Compliance of volunteers in a fully-enclosed patient rotation system for MR-guided radiation therapy: a prospective study	29
Knowledge-based DVH estimation and optimization for breast VMAT plans with and without avoidance sectors	27
Comparison of deep learning networks for fully automated head and neck tumor delineation on multi-centric PET/CT images	27
Using meta-analysis and CNN-NLP to review and classify the medical literature for normal tissue complication probability in head and neck cancer	27
Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis	25

Establishment of prognostic models for adenocarcinoma of oesophagogastric junction patients with neoadjuvant chemoradiotherapy: a real-world study	24
Impact of radiation response on survival in pediatric medulloblastoma with residual or disseminated disease	23
Carbon ion irradiation mobilizes antitumor immunity: from concept to the clinic	23
Biological target volume based on fluorine-18-fluorode-oxyglucose positron emission tomography/computed tomography imaging: a spurious proposition?	23
Online adaptive stereotactic body radiotherapy for localized prostate cancer in patients with lower urinary tract symptoms and/or prostate hyperplasia (X-SMILE)	23
Simulation CT-based radiomics for prediction of response after neoadjuvant chemo-radiotherapy in patients with locally advanced rectal cancer	22
A survey of cancer patients’ interest in undertaking exercise to promote relaxation during radiotherapy for breast cancer and metastatic cancer	22
Risk of temporal lobe necrosis between proton beam and volumetric modulated arc therapies in patients with different head and neck cancers	21
Real world clinical experience using daily intelligence-assisted online adaptive radiotherapy for head and neck cancer	21
Prospective phase II trial of preoperative hypofractionated proton therapy for extremity and truncal soft tissue sarcoma: the PRONTO study rationale and design	21
Hypofractionated versus standard fractionation radiotherapy for merkel cell carcinoma	21
Dosimetric parameters and absolute monocyte count can predict the prognosis of acute hematologic toxicity in cervical cancer patients undergoing concurrent chemotherapy and volumetric-modulated arc th	21
Effects of whole-brain radiation therapy on the blood–brain barrier in immunocompetent and immunocompromised mouse models	20
Clinical features and risk factors for interstitial lung disease spreading in low-dose irradiated areas after definitive radiotherapy with or without durvalumab consolidation therapy for patients with	20
Dosimetric evaluation of photons versus protons in postmastectomy planning for ultrahypofractionated breast radiotherapy	20
Efficacy of concurrent chemoradiotherapy alone for loco-regionally advanced nasopharyngeal carcinoma: long-term follow-up analysis	19
Characteristics of locoregional extension of unilateral nasopharyngeal carcinoma and suggestions for clinical target volume delineation	19
A deep learning-informed interpretation of why and when dose metrics outside the PTV can affect the risk of distant metastasis in SBRT NSCLC patients	19
The roles of CC chemokines in response to radiation	19
Protective ileostomy increased the incidence of rectal stenosis after anterior resection for rectal cancer	19
Review of cone beam computed tomography based online adaptive radiotherapy: current trend and future direction	19
Preliminary study of feasibility of surface-guided radiotherapy with concurrent tumor treating fields for glioblastoma: region of interest	19
Correction: Artificial intelligence contouring in radiotherapy for organs-at-risk and lymph node areas	19
Assessing intra- and interfraction motion and its dosimetric impacts on cervical cancer adaptive radiotherapy based on 1.5T MR-Linac	18
Early recovery of leukocyte subsets is associated with favorable progression-free survival in patients with inoperable stage II/III NSCLC after multimodal treatment: a prospective explorative study	17
Effects of EGFR-TKIs combined with intracranial radiotherapy in EGFR-mutant non-small cell lung cancer patients with brain metastases: a retrospective multi-institutional analysis	17
Dose-escalated radiotherapy to 82 Gy for prostate cancer following insertion of a peri-rectal hydrogel spacer: 3-year outcomes from a phase II trial	17
Criteria-calibration approaches to deep learning-based cervical cancer radiation treatment auto-planning	17
Intrafraction organ movement in adaptive MR-guided radiotherapy of abdominal lesions – dosimetric impact and how to detect its extent in advance	16
Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation	16
Radio-opaque contrast agents for liver cancer targeting with KIM during radiation therapy (ROCK-RT): an observational feasibility study	16
Comparison of the distribution of lymph node metastases compared to healthy lymph nodes in breast cancer	16
Evaluating the impact of possible interobserver variability in CBCT-based soft-tissue matching using TCP/NTCP models for prostate cancer radiotherapy	16
Influence and optimization strategy of the magnetic field in 1.5 T MR-linac liver stereotactic radiotherapy	16
Treatment plan comparison for irradiation of multiple brain metastases with hippocampal avoidance whole brain radiotherapy and simultaneous integrated boost using the Varian Halcyon and the Elekta Syn	16
Magnetic resonance imaging-guided radiotherapy for portal vein tumor thrombus in hepatocellular carcinoma: outcomes and prognostic factors	16
Deformable registration for nasopharyngeal carcinoma using adaptive mask and weight allocation strategy based CycleFCNs model	15
Radiotherapy with S-1 for the treatment of esophageal squamous cell carcinoma 75 years or older	15
Implementing ocular treatment with pencil beam scanning: the FHCC experience	15
Improving total bone marrow and lymphoid irradiation: feasibility of intensity-modulated proton therapy (IMPT) and dosimetric comparison with helical tomotherapy (HT)	15
Prognostic value of tumour-stroma ratio in nasopharyngeal carcinoma: a two-center retrospective study	15
High buttocks supine position to reduce small bowel exposure in gynecological radiotherapy	15
Clinical practice in stereotactic radiotherapy delivery at treatment unit: a practitioner survey and consensus-based recommendations for multidisciplinary professional development	15
Multiple brain metastases: resection with IORT versus adjuvant radiotherapy and concurrent irradiation of unresected lesions	15
Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm	14
Timing matters: diurnal spine length variation in pediatric patients during radiotherapy	14
Prognostic value of baseline 18F-FDG PET/CT in patients with esophageal squamous cell carcinoma treated with definitive (chemo)radiotherapy	14
Functional outcome after Brachytherapy with bi-nuclide (Ru-106/Iodine-125) plaques in large uveal melanomas	14
Prostate radiotherapy may cause fertility issues: a retrospective analysis of testicular dose following modern radiotherapy techniques	14
Use of focal radiotherapy boost for prostate cancer: radiation oncologists’ perspectives and perceived barriers to implementation	14

Integration of X-Ray and γ-Ray technologies in lattice radiotherapy: a novel approach for optimizing dose delivery in large-volume non-small cell lung cancer	14
The safety of an MRI simulation-guided boost after short-course preoperative radiotherapy for unresectable rectal cancer (SUNRISE): interim analysis of a randomized phase II trial	14
Outcomes of definitive radiotherapy vs. laryngectomy followed by adjuvant radiotherapy in patients with locally advanced laryngeal squamous cell carcinoma: real-world experience in a referral cancer c	14
Dosimetric effect of respiratory motion on planned dose in whole-breast volumetric modulated arc therapy using moderate and ultra-hypofractionation	14
Optimizing stereotactic ablative body radiotherapy for ultra-central lung lesions: a comparative dosimetric analysis	13
Dose prediction for cervical cancer VMAT patients with a full-scale 3D-cGAN-based model and the comparison of different input data on the prediction results	13
Dosimetric evaluation of VMAT and helical tomotherapy techniques comparing conventional volumes with clinical target volumes based on new ESTRO ACROP post-mastectomy with immediate implant reconstruct	13
The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis	13
Radiation therapy for retroperitoneal sarcoma: practice patterns in North America	13
Generation of tissues outside the field of view (FOV) of radiation therapy simulation imaging based on machine learning and patient body outline (PBO)	13
Identification of variables and development of a prediction model for DIBH eligibility in left-sided breast cancer radiotherapy: a prospective cohort study with temporal validation	13
Magnetic resonance-guided online adaptive stereotactic body radiotherapy for advanced inoperable pancreatic cancer: a prospective study	13
Impact of high dose radiotherapy for breast tumor in locoregionally uncontrolled stage IV breast cancer: a need for a risk-stratified approach	13
Chemoradiation for oesophageal cancer: the choice of treatment modality	13
Clinical outcomes and lung toxicities after lung SABR using dynamic conformal arc therapy: a single-institution cohort study	13
The MRI-guided two adaptive brachytherapy fractions versus one adaptive brachytherapy fraction in one application for the cervical cancer: a retrospective study	13
Deep learning-powered radiotherapy dose prediction: clinical insights from 622 patients across multiple sites tumor at a single institution	13
The role of the soft palate dose regarding normal tissue toxicities in older adults with head and neck cancer undergoing definitive radiotherapy	12
Efficacy and safety of induction immunochemotherapy followed by radiotherapy for patients with unresectable locally advanced non-small cell lung cancer: A retrospective study	12
Localized fine-tuning and clinical evaluation of deep-learning based auto-segmentation (DLAS) model for clinical target volume (CTV) and organs-at-risk (OAR) in rectal cancer radiotherapy	12
Evaluation of CNN-based deep learning models for auto-contouring in glioblastoma radiotherapy: a review	12
Impact of chronic graft-versus-host disease on quality of life and cognitive function of long-term transplant survivors after allogeneic hematopoietic stem cell transplantation with total body irradia	12
Evaluation of PTV margins with daily iterative online adaptive radiotherapy for postoperative treatment of endometrial and cervical cancer: a prospective single-arm phase 2 study	12
Multi-institutional evaluation of a Pareto navigation guided automated radiotherapy planning solution for prostate cancer	12
Automatic IMRT treatment planning through fluence prediction and plan fine-tuning for nasopharyngeal carcinoma	12
A PET/CT radiomics model for predicting distant metastasis in early-stage non–small cell lung cancer patients treated with stereotactic body radiotherapy: a multicentric study	12
Dosimetric evaluation of LINAC-based single-isocenter multi-target multi-fraction stereotactic radiosurgery with more than 20 targets: comparing MME, HyperArc, and RapidArc	12
Pneumonitis after normofractionated radioimmunotherapy: a method for dosimetric evaluation	11
Simultaneous integrated boost (SIB) to dominant intra-prostatic lesions during extreme hypofractionation for prostate cancer: the impact of rectal spacers	11
Postoperative recurrent patterns of gallbladder cancer: possible implications for adjuvant therapy	11
Interfractional variation in whole-breast VMAT irradiation: a dosimetric study with complementary SGRT and CBCT patient setup	11
Radiation-induced senescence: therapeutic opportunities	11
Correction: Real world clinical experience using daily intelligence-assisted online adaptive radiotherapy for head and neck cancer	11
The role of deep hyperthermia in IMRT in elderly patients with esophageal cancer: a retrospective cohort study	11
Deep learning tools for the cancer clinic: an open-source framework with head and neck contour validation	11
Hypofractionated radiation leads to more rapid bleeding cessation in women with vaginal bleeding secondary to gynecologic malignancy	11
Therapeutic and prognostic impact of target volume delineation in postoperative radiotherapy for high-grade glioma patients with subventricular zone involvement	11
Generation of ozone during irradiation using medical linear accelerators: an experimental study	11
CT radiomics-based long-term survival prediction for locally advanced non-small cell lung cancer patients treated with concurrent chemoradiotherapy using features from tumor and tumor organismal envir	11
Lymphocyte recovery from radiation-induced lymphopenia in locally advanced esophageal squamous cell carcinoma: correlations with prognosis and lymphocyte-related organs	11
FAPI-PET/CT guided radiotherapy for patients with esophageal cancer	11
Risk-adapted intensification therapy in high-risk prostate cancer: how relevant is the role of radiation dose	11
Dose-dependent taste dysfunction in head and neck cancer patients receiving radiotherapy	11
Research trends and hot spots in the prevention and management of radiation dermatitis: a bibliometric analysis based on CiteSpace	11
High-dose stereotactic radiotherapy boost in the treatment of squamous cell carcinoma of the head and neck region	11
Application of four-dimensional cone beam computed tomography in lung cancer radiotherapy	11
Cardiac substructure dose distributions in node-positive and node-negative breast cancer patients undergoing 3D-CRT: comparing the predictive accuracy of mean heart dose and mean left ventricular dose	11
Dummy run quality assurance study in the Korean Radiation Oncology Group 19 − 09 multi-institutional prospective cohort study of breast cancer	11
Risk factors for severity of breast cancer-related lymphedema	11
Boost modalities in cervical cancer: dosimetric comparison between intracavitary BT vs. intracavitary + interstitial BT vs. SBRT.	11
Management of critically located brain metastases in patients with precluded survival using customised double-dose prescription-based, adaptive accelerated staged radiosurgery: a long-term retrospecti	10
A deep learning-based dose calculation method for volumetric modulated arc therapy	10
Efficacy and safety of particle therapy for inoperable stage II-III non-small cell lung cancer: a systematic review and meta-analysis	10
A novel knowledge-based prediction model for estimating an initial equivalent uniform dose in semi-auto-planning for cervical cancer	10
Impact of random outliers in auto-segmented targets on radiotherapy treatment plans for glioblastoma	10
Single-cell transcriptional analysis of irradiated skin reveals changes in fibroblast subpopulations and variability in caveolin expression	10
The relationship between the radiation dose of pelvic-bone marrow and lymphocytic toxicity in concurrent chemoradiotherapy for cervical cancer	10
Proton therapy for adult type IDH-mutated glioma: Proglio-1, a multicenter retrospective study	10
Focal HDR brachytherapy boost to stereotactic radiotherapy (fBTsRT) for prostate cancer: a phase II randomized controlled trial	10
Paclitaxel and cisplatin combined with concurrent involved-field irradiation in definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: a phase II clinical trial	10
HLA-DQA1 expression is associated with prognosis and predictable with radiomics in breast cancer	10
Beyond the ratio of tumor reduction: residual volume after induction chemotherapy emerges as the optimal biomarker in advanced nasopharyngeal cancer	10
MR-guided SBRT boost for patients with locally advanced or recurrent gynecological cancers ineligible for brachytherapy: feasibility and early clinical experience	10
The role of hyperthermia in modern radiation treatment- state of art	10
Pulmonary magnetic resonance-guided online adaptive radiotherapy of locally advanced non-small-cell lung cancer: the PUMA trial	10
Stereotactic radiotherapy with Gamma Master System® for palliation of hepatocellular carcinoma in patients with liver cirrhosis	10
Predicting local control of brain metastases after stereotactic radiotherapy with clinical, radiomics and deep learning features	10
Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study	10
Radiobiological and dosimetric comparison of 60Co versus 192Ir high-dose-rate intracavitary-interstitial brachytherapy for cervical cancer	10
Measuring out-of-field dose to the hippocampus in common radiotherapy indications	9
Outcomes of proton therapy for non-small cell lung cancer in patients with interstitial pneumonia	9
Correction: Evolution of radiation-induced temporal lobe injury after intensity-modulated radiation therapy in nasopharyngeal carcinoma: a large cohort retrospective study	9
Local control and recurrence patterns after stereotactic irradiation delivered in more than 4 fractions for hepatocellular carcinomas and liver metastases: a retrospective study	9
High-volume prostate biopsy core involvement is not associated with an increased risk of cancer recurrence following 5-fraction stereotactic body radiation therapy monotherapy	9
Dosimetric impact of deep learning-based CT auto-segmentation on radiation therapy treatment planning for prostate cancer	9
Monte Carlo simulation of linac using PRIMO	9
Towards deep-learning (DL) based fully automated target delineation for rectal cancer neoadjuvant radiotherapy using a divide-and-conquer strategy: a study with multicenter blind and randomized valida	9
Practical recommendations for the management of radiodermatitis: on behalf of the ESTRO RTT committee	9
Influence of brain metastases on the classification, treatment, and outcome of patients with extracranial oligometastasis: a single-center cross-sectional analysis	9
Prognostic value of neutrophil to lymphocyte ratio and lymphocyte counts before durvalumab consolidation after radio-chemotherapy in locally advanced non-small cell lung cancer	9

Technical aspects of SBRT for therapy-refractory ventricular tachycardia: a systematic review for radiation oncologists	9
Comparison of outcome after stereotactic ablative radiotherapy of patients with metachronous lung versus primary lung cancer	9
Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation	9
Clinical application of MR-Linac in tumor radiotherapy: a systematic review	9
Dosimetric benefits of adaptive radiation therapy for patients with stage III non-small cell lung cancer	9
Radiotherapy plus anti-PD1 versus radiotherapy for hepatic toxicity in patients with hepatocellular carcinoma	9
Bone matching versus tumor matching in image-guided carbon ion radiotherapy for locally advanced non-small cell lung cancer	9
Neurocognitive impact of different irradiation modalities for patients with grade I-II skull base meningioma: a prospective multi-arm cohort study (CANCER COG)	9
Regularity and correlation analysis of regional lymph node metastasis in nonoperative patients with non-small cell lung cancer based on positron emission tomography/computed tomography images	9
Prognostic implications of tumor volume reduction during radiotherapy in locally advanced cervical cancer: a risk-stratified analysis	9
A review of diffusion-weighted magnetic resonance imaging in head and neck cancer patients for treatment evaluation and prediction of radiation-induced xerostomia	9
Functional imaging guided stereotactic ablative body radiotherapy (SABR) with focal dose escalation and bladder trigone sparing for intermediate and high-risk prostate cancer: study protocol for phase	9
Photobiomodulation as a treatment for dermatitis caused by chemoradiotherapy for squamous cell anal carcinoma: case report and literature review	9
Assessing organ at risk position variation and its impact on delivered dose in kidney SABR	9
Stereotactic MRI-guided radiation therapy for localized prostate cancer (SMILE): a prospective, multicentric phase-II-trial	9
Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases	9
Prognostic nomogram for synchronous metastatic nasopharyngeal carcinoma: a retrospective multicentre study	9
Response assessment after stereotactic body radiation therapy for spine and non-spine bone metastases: results from a single institutional study	8
Synthetic CT generation from CBCT and MRI using StarGAN in the Pelvic Region	8
Deep learning for segmentation of the cervical cancer gross tumor volume on magnetic resonance imaging for brachytherapy	8
MOREOVER: multiomics MR-guided radiotherapy optimization in locally advanced rectal cancer	8
PLK4 as a potential target to enhance radiosensitivity in triple-negative breast cancer	8
A cycle generative adversarial network for improving the quality of four-dimensional cone-beam computed tomography images	8
Outcomes of carbon ion radiotherapy compared with segmentectomy for ground glass opacity-dominant early-stage lung cancer	8
A nomogram model based on pre-treatment and post-treatment MR imaging radiomics signatures: application to predict progression-free survival for nasopharyngeal carcinoma	8
ALA-RDT in GBM: protocol of the phase I/II dose escalation trial of radiodynamic therapy with 5-Aminolevulinic acid in patients with recurrent glioblastoma	8
Predicting the survival of patients with painful tumours treated with palliative radiotherapy: a secondary analysis using the 3-variable number-of-risk-factors model	8
Comparison of data fusion strategies for automated prostate lesion detection using mpMRI correlated with whole mount histology	8
A focused review of statistical practices for relating radiation dose-volume exposure and toxicity	8
Cancer care at the time of the fourth industrial revolution: an insight to healthcare professionals’ perspectives on cancer care and artificial intelligence	8
Quantification of biological range uncertainties in patients treated at the Krakow proton therapy centre	8
Predictive value of delta radiomics in xerostomia after chemoradiotherapy in patients with stage III-IV nasopharyngeal carcinoma	8
Radiotherapy outcomes and risk factors for young patients with head-and-neck squamous cell carcinomas: a matched-pair analysis	8
Advancements of radiotherapy for recurrent head and neck cancer in modern era	8
Treatment outcomes of stereotactic body radiation therapy for primary and metastatic sarcoma of the spine	8
Prognostic value of tumor measurement parameters and SCC-Ag changes in patients with locally-advanced cervical cancer	8
Protocol of a phase II study to evaluate the efficacy and safety of deep-inspiration breath-hold daily online adaptive radiotherapy for centrally located lung tumours (PUDDING study)	8
Minimizing human interference in an online fully automated daily adaptive radiotherapy workflow for bladder cancer	8
Development and validation of a machine learning-based model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma	8
Treatment results for patients with squamous-cell carcinoma of the anus, a single institution retrospective analysis	8
A nomogram based on circulating CD8+ T cell and platelet-to-lymphocyte ratio to predict overall survival of patients with locally advanced nasopharyngeal carcinoma	8
Palliative radiotherapy for tumor bleeding in patients with unresectable pancreatic cancer: a single-center retrospective study	8
Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challenges	8
Partial abdominal carbon-ion FLASH irradiation spares lethality compared to conventional irradiation: impact of LET and dose rate	8
Molecular features of glioblastomas in long-term survivors compared to short-term survivors—a matched-pair analysis	8
Gastric side effects and the stomach dosimetric analysis in left-sided breast cancer radiotherapy in free-breathing and deep inspiration breath-hold technique	8
Evaluating ECM stiffness and liver cancer radiation response via shear-wave elasticity in 3D culture models	8
Developing an automatic treatment record review system for quality assurance of patient treatment delivery in radiation therapy	8
Smoking increases breast toxicity despite adjuvant hypofractionated IMRT in early breast cancer	8
Chemoradiotherapy is an alternative choice for patients with primary mediastinal seminoma	8
Functional brain imaging interventions for radiation therapy planning in patients with glioblastoma: a systematic review	8