Expert Review of Gastroenterology & Hepatology

Article	Citations
Current epidemiology in hepatocellular carcinoma	103
Recent advances of immunotherapy for biliary tract cancer	78
First-line immune checkpoint inhibitor-based combinations in unresectable hepatocellular carcinoma: current management and future challenges	73
Which role for predictors of response to immune checkpoint inhibitors in hepatocellular carcinoma?	65
Pitfalls, challenges, and updates in adjuvant systemic treatment for resected biliary tract cancer	50
Liver injury in severe COVID-19 infection: current insights and challenges	44
Contrast-enhanced harmonic endoscopic ultrasound-guided fine-needle aspiration versus standard fine-needle aspiration in pancreatic masses: a meta-analysis	40
Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia	38
Capsule endoscopy – Recent developments and future directions	38
Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota	38
A single-letter change in an acronym: signals, reasons, promises, challenges, and steps ahead for moving from NAFLD to MAFLD	35
Angiogenesis in the progression from liver fibrosis to cirrhosis and hepatocelluar carcinoma	34
BILCAP trial and adjuvant capecitabine in resectable biliary tract cancer: reflections on a standard of care	34
Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review	34
Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways	33
Chronic liver disease and oxidative stress – a narrative review	32
Obeticholic acid for the treatment of nonalcoholic steatohepatitis	29
Epidemiology and risk factors for eosinophilic esophagitis: lessons for clinicians	26
Gastrointestinal coronavirus disease 2019: epidemiology, clinical features, pathogenesis, prevention, and management	25
Is there a causal link between psychological disorders and functional gastrointestinal disorders?	25
ALBI versus child-pugh in predicting outcome of patients with HCC: A systematic review	25
Advances in understanding the potential therapeutic applications of gut microbiota and probiotic mediated therapies in celiac disease	25
Ranson score to stratify severity in Acute Pancreatitis remains valid – Old is gold	24
Cross-talk between immune system and microbiota in COVID-19	24
Evaluation of gallbladder wall thickening: a multimodality imaging approach	24

Clinical application of hepatocyte transplantation: current status, applicability, limitations, and future outlook	22
Utilizing artificial intelligence in endoscopy: a clinician’s guide	22
Recurrence of hepatocellular carcinoma following liver transplantation	20
MAFLD in COVID-19 patients: an insidious enemy	20
Endoscopic instruments and techniques in endoscopic submucosal dissection for early gastric cancer	20
Insights and updates on endoscopic papillectomy	20
Gut microbiota and obesity: causally linked?	19
A comprehensive review of the diagnosis and treatment of Parkinson’s disease dysphagia and aspiration	19
Data sharing during COVID-19 pandemic: what to take away	18
Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity	18
An overview of cannabis based treatment in Crohn’s disease	18
Updates in the field of hereditary nonpolyposis colorectal cancer	18
The high-dose amoxicillin-proton pump inhibitor dual therapy in eradication ofHelicobacter pyloriinfection	18
A comprehensive update on early gastric cancer: defining terms, etiology, and alarming risk factors	17
Treat to target or ‘treat to clear’ in inflammatory bowel diseases: one step further?	17
Prevention and Treatment of Stricturing Crohn’s Disease – Perspectives and Challenges	17
Treatment of childhood constipation: a synthesis of systematic reviews and meta-analyses	17
An update on the use of immunotherapy in patients with colorectal cancer	17
Dietary therapy for eosinophilic esophagitis: chances and limitations in the clinical practice	16
Maternal and infant factors that shape neonatal gut colonization by bacteria	16
Nivolumab + Ipilimumab for patients with hepatocellular carcinoma previously treated with Sorafenib	16
Liver fibrosis with two-dimensional shear-wave elastography in patients with autoimmune hepatitis	15
Clinical impact of sarcopenia assessment in patients with liver cirrhosis	15
PK, PD, and interactions: the new scenario with JAK inhibitors and S1P receptor modulators, two classes of small molecule drugs, in IBD	15
Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis	15
An overview of interventions for constipation in adults	14
Noninvasive diagnostic tools for pediatric NAFLD: where are we now?	14
Hepatitis B reactivation: diagnosis and management	14
The clinical application of camrelizumab on advanced hepatocellular carcinoma	14
The cellular and molecular components involved in pre-metastatic niche formation in colorectal cancer liver metastasis	14
Nonalcoholic fatty liver disease and sarcopenia: pathophysiological connections and therapeutic implications	14
Prognostic value of vascular endothelial growth factor in both conventional and drug eluting beads transarterial chemoembolization for treatment of unresectable hepatocellular carcinoma in HCV patient	14
Defining the current role of immune checkpoint inhibitors in the treatment of mismatch repair-deficient/microsatellite stability-high colorectal cancer and shedding light on future approaches	14
Epigenetics factors in nonalcoholic fatty liver disease	14
Darvadstrocel for the treatment of perianal fistulas in Crohn’s disease	14
Cholangiocarcinoma: new perspectives for new horizons	13
JAK selectivity: more precision less troubles	13
Comparison of two-dimensional shear wave elastography, magnetic resonance elastography, and three serum markers for diagnosing fibrosis in patients with chronic hepatitis B: a meta-analysis	13
Effects of probiotics on nonalcoholic fatty liver disease: a systematic review and meta-analysis	13
Feasibility of telehealth in the management of autoimmune hepatitis before and during the COVID-19 pandemic	13
The effect of medical cannabis in inflammatory bowel disease: analysis from the UK Medical Cannabis Registry	13
Updates in association of gastroesophageal reflux disease and dental erosion: systematic review	13
Patients with inflammatory bowel disease (IBD) prefer oral tablets over other modes of medicine administration	13
Acute-on-chronic liver failure (ACLF) in 2022: have novel treatment paradigms already arrived?	13
A 2020 update on liver transplant for hepatocellular carcinoma	13
Dietary interventions for functional abdominal pain disorders in children: a systematic review and meta-analysis	13
Mucosal healing in Crohn’s disease: new insights	13
Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease	12
The role of vitamin D in inflammatory bowel disease: a guide for clinical practice	12
Helicobacter pylori infection treatment in the United States: clinical consequences and costs of eradication treatment failure	12

Curcumin therapy for ulcerative colitis remission: systematic review and meta-analysis	12
Irritable bowel syndrome and migraine: evidence from Mendelian randomization analysis in the UK Biobank	12
The role of dietary patterns in colorectal cancer: a 2019 update	12
Iron deficiency anemia in IBD: an overlooked comorbidity	12
Liver-spleen axis in nonalcoholic fatty liver disease	12
Gastroduodenal tuberculosis: a case series and a management focused systematic review	12
Targeting the gut layers in Crohn’s disease: mucosal or transmural healing?	12
The effects of epigenetic modification on the occurrence and progression of liver diseases and the involved mechanism	11
Diagnostic yield of endoscopic ultrasound-guided liver biopsy in comparison to percutaneous liver biopsy: a systematic review and meta-analysis	11
Patient’s profiling for therapeutic management of inflammatory bowel disease: a tailored approach	11
Efficacy of rifaximin in treating with small intestine bacterial overgrowth: a systematic review and meta-analysis	11
Combined ablation-chemotherapy versus chemotherapy alone for pancreatic cancer with liver metastasis: a propensity score matching study	11
The vascular endothelial growth factor signaling pathway regulates liver sinusoidal endothelial cells during liver regeneration after partial hepatectomy	11
The Integrative Human microbiome project: a mile stone in the understanding of the gut microbiome	11
Long-term effects of appendectomy in humans: is it the optimal management of appendicitis?	11
Gut microbiota: a target for intervention in obesity	11
Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis	11
Managing cognitive symptoms and fatigue in cholestatic liver disease	11
Genetics and epigenetics purpose in nonalcoholic fatty liver disease	10
Implementing psychological therapies for gastrointestinal disorders in pediatrics	10
Human intestinal parasitic infection: a narrative review on global prevalence and epidemiological insights on preventive, therapeutic and diagnostic strategies for future perspectives	10
Is histological healing a feasible endpoint in ulcerative colitis?	10
Risk of selected gastrointestinal toxicities in metastatic renal cell carcinoma patients treated with immuno-TKI combinations: a meta-analysis	10
Endoscopic imaging in inflammatory bowel disease: current developments and emerging strategies	10
A consensus integrated care pathway for patients with primary biliary cholangitis: a guideline-based approach to clinical care of patients	10
Prognostic biomarkers for cholangiocarcinoma (CCA): state of the art	9
COVID-19 in patients with inflammatory bowel disease	9
Clinical heterogeneity in patients with non-alcoholic fatty liver disease-associated hepatocellular carcinoma	9
Telemedicine in gastroenterology in the wake of COVID-19	9
Non-alcoholic fatty liver disease: molecular and cellular interplays of the lipid metabolism in a steatotic liver	9
Teduglutide for pediatric short bowel syndrome patients	9
High platelet count predicts poor prognosis in HCC patients undergoing TACE: a propensity score-matched analysis	9
Metabolic disorders and the risk of cholangiocarcinoma	9
The impact of L-branched-chain amino acids and L-leucine on malnutrition, sarcopenia, and other outcomes in patients with chronic liver disease	9
Liver transplant for alcoholic hepatitis: a current clinical overview	9
The influence of the gastrointestinal microbiome on infant colic	9
Use of antibiotic prophylaxis is not needed for endoscopic ultrasound-guided fine-needle aspiration of pancreatic cysts: a meta-analysis	9
The use of peripheral blood mononuclear cells in celiac disease diagnosis and treatment	9
Survival nomogram for patients with metastatic siewert type II adenocarcinoma of the esophagogastric junction: a population-based study	9
Identification and validation of a new gene signature predicting prognosis of hepatocellular carcinoma patients by network analysis of stemness indices	9
Current role of cyanoacrylate glue transcatheter embolization in the treatment of acute nonvariceal gastrointestinal bleeding	8
Perioperative antiviral therapy improves the prognosis of HBV DNA-negative patients with HBV-related hepatocellular carcinoma	8
Efficiency of ursodeoxycholic acid for the treatment of nonalcoholic steatohepatitis: A systematic review and meta-analysis	8
Single center analysis of therapy and outcomes of hepatocellular carcinoma in Sub-Saharan Africa	8
Current perspectives on the pathophysiology of metabolic associated fatty liver disease: are macrophages a viable target for therapy?	8
Endoscopic drainage versus percutaneous drainage for the management of infected walled-off necrosis: a comparative analysis	8
Positioning of tofacitinib in treatment of ulcerative colitis: a global perspective	8
CT assessment of preoperative nutritional status in gastric cancer: severe low skeletal muscle mass and obesity-related low skeletal muscle mass are unfavorable factors of postoperative complications	8
Research progress on the relationship between TM6SF2 rs58542926 polymorphism and non-alcoholic fatty liver disease	8
Recent updates in diagnosis of abdominal tuberculosis with emphasis on nucleic acid amplification tests	8
Liver transplantation for perihilar cholangiocarcinoma: patient selection and outcomes	8
Next generation sequencing for biliary tract cancers	8
Periodontal and dental health in inflammatory bowel diseases: a systematic review	8
Synergistic impact of resection margin and microscopic vascular invasion for patients with HBV-related intrahepatic cholangiocarcinoma	8
Cytomegalovirus in ulcerative colitis: an evidence-based approach to diagnosis and treatment	8
Survival analysis of colorectal cancer patients in a Thai hospital-based cancer registry	8
Metabolome and microbiome alterations in tongue coating of gastric precancerous lesion patients	8
Different prognostic significance of signet ring cell histology for early and advanced gastric cancer patients: a systematic review and meta-analysis	8
Differences between current clinical guidelines for screening, diagnosis and management of nonalcoholic fatty liver disease and real-world practice: a targeted literature review	8
Integrating efficacy and safety of vedolizumab compared with other advanced therapies to assess net clinical benefit of ulcerative colitis treatments: a network meta-analysis	8
Hepatitis c virus and chronic kidney disease	8
NAFLD and renal function in children: is there a genetic link?	8
Transhiatal versus transthoracic surgical approach for Siewert type Ⅱ adenocarcinoma of the esophagogastric junction: a meta-analysis	7
The role and function of CD4+ T cells in hepatic ischemia-reperfusion injury	7
Biomarkers for hepatitis B virus replication: an overview and a look to the future	7
Dilemma in post-IBD patients with IBS-D symptoms: A 2020 overview	7
Statins decrease overall mortality and cancer related mortality but are underutilized in NAFLD: a longitudinal analysis of 12,538 individuals	7
Recent advances in the treatment of primary sclerosing cholangitis	7
Role of noninvasive imaging in the evaluation of intrahepatic cholangiocarcinoma: from diagnosis and prognosis to treatment response	7
A modern multidisciplinary approach to the treatment of enterocutaneous fistulas in Crohn’s disease patients	7
Grayscale ultrasonography findings for characterization of gallbladder wall thickening in non-acute setting: a systematic review and meta-analysis	7
Role of adjuvant and neoadjuvant therapy for resectable biliary tract cancer	7
An overview of stereotactic body radiation therapy for hepatocellular carcinoma	7
Anemia and iron deficiency in Crohn’s disease	7
Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran	7
PSC associated inflammatory bowel disease: a distinct entity	7
Radiation-induced liver disease in the era of SBRT: a review	7
The efficacy, safety, and predictors of outcomes of transarterial radioembolization for hepatocellular carcinoma: a retrospective study	6
Safety and efficacy of indocyanine green fluorescence imaging-guided radical gastrectomy: a systematic review and meta-analysis	6
Comparative efficacy of glucagon-like peptide 1 (GLP-1) receptor agonists, pioglitazone and vitamin E for liver histology among patients with nonalcoholic fatty liver disease: systematic review and pi	6

Key factors for improving adenoma detection rate	6
Dientamoeba fragilis in children: a systematic review on diagnostic considerations and efficacy of treatment	6
T-tube or no T-tube for biliary tract reconstruction in orthotopic liver transplantation: an updated systematic review and meta-analysis	6
Perioperative management of ileocecal Crohn’s disease in the current era	6
Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases	6
Effect of the SARS-CoV2 Pandemic on Endoscopy Provision – The Impact of Compliance with National Guidance	6
Sarcopenia in chronic liver diseases: a translational overview	6
FGFR inhibitors in elderly patients with advanced biliary tract cancer: an unsolved issue	6
A 2020 update of anal cancer: the increasing problem in women and expanding treatment landscape	6
Gallbladder carcinosarcoma: current perspectives and new development	6
Sites of distant metastases and the cancer-specific survival of metastatic Siewert type II esophagogastric junction adenocarcinoma: a population-based study	6
Targeting neutrophils in inflammatory bowel disease: revisiting the role of adsorptive granulocyte and monocyte apheresis	6
Microwave ablation determines similar survival outcomes as compared to radiofrequency ablation for the treatment of hepatocellular carcinoma	6
Diagnosis of peritoneal tuberculosis by real-time immuno-PCR assay based on detection of a cocktail of Mycobacterium tuberculosis CFP-10 and HspX proteins	6
Systematic review of sarcopenia in chronic pancreatitis: prevalence, impact on surgical outcomes, and survival	6
Changes in clinical scenarios, management, and perspectives of patients with chronic hepatitis C after viral clearance by direct-acting antivirals	6
Skills over pills? A clinical gastroenterologist’s primer in cognitive behavioral therapy for irritable bowel syndrome	6
Combining the serum lactic acid level and the lactate clearance rate into the CLIF-SOFA score for evaluating the short-term prognosis of HBV-related ACLF patients	6
Contemporary role of liver transplantation for the treatment of cholangiocarcinoma	6
Efficacy and safety of preoperative biliary drainage in patients undergoing pancreaticoduodenectomy: an updated systematic review and meta-analysis	5
Patients’ perception of colonoscopy and acceptance of colonoscopy based IBD related colorectal cancer surveillance	5
Randomized, placebo-controlled trial of xyloglucan and gelose for the treatment of acute diarrhea in children	5
Evaluating the potential of artificial intelligence in ulcerative colitis	5
Hepatitis b infection: progress in identifying patients most likely to respond to peginterferon alfa	5
Impact of pancreatic enzyme replacement therapy on short- and long-term outcomes in advanced pancreatic cancer: meta-analysis of randomized controlled trials	5
Negative role of sleep disturbance in the recovery of gastrointestinal postoperative patients	5
Clinical utility of clonal origin determination in managing recurrent hepatocellular carcinoma	5
Training in endoscopic retrograde cholangio-pancreatography: a critical assessment of the broad scenario of training programs and models	5
Might helicobacter pylori play a role in allergic or cross-reaction related disorders?	5
Paraneoplastic syndromes in hepatocellular carcinoma: a review	5
Which patients benefit from preoperative biliary drainage in resectable pancreatic cancer?	5
Impact of diabetes mellitus on the long-term prognosis of patients with hepatocellular carcinoma after hepatectomy	5
Anorexia nervosa and gut microbiome: implications for weight change and novel treatments	5
Radiological criteria for disconnected pancreatic duct syndrome: a targeted literature review	5
Identification of a ferroptosis-related gene signature for predicting the prognosis of cholangiocarcinoma	5
Efficacy of anti-TNFα drugs in patients with stricturing Crohn’s disease	5
Nomograms for predicting survival in early-onset esophageal cancer	5
Development and validation of a risk score for prediction of clinical success after duodenal stenting for malignant gastric outlet obstruction	5
Tumor burden score as a new prognostic surrogate in patients with hepatocellular carcinoma undergoing radiofrequency ablation: role of albumin-bilirubin (ALBI) grade vs easy ALBI grade	5
Recent insights on the use of topical steroids in eosinophilic esophagitis	5
Role of histone deacetylase on nonalcoholic fatty liver disease	5
Current perspectives on the safety and efficacy of robot-assisted surgery for gastric cancer	4
An essential technique for modern hepato-pancreato-biliary surgery: minimally invasive biliary reconstruction	4
Biliary diversion in progressive familial intrahepatic cholestasis: a systematic review and meta-analysis	4
Endoscopy after surgery in inflammatory bowel disease: Crohn’s disease recurrence and pouch surveillance	4
Hepatitis C: looking into the future	4
Prevention of pancreatitis after stent implantation for distal malignant biliary strictures: systematic review and meta-analysis	4
Current practice and contrasting views on discontinuation of nucleos(t)ide analog therapy in chronic hepatitis B	4
Appendiceal neoplasm incidence and mortality rates are on the rise in Australia	4
Endoscopic incision for treatment of benign gastrointestinal strictures	4
Evaluating the role of endoscopic ultrasound in pancreatitis	4
Medical professional liability in gastroenterology: definitions, trends, risk factors, provider behaviors, and implications	4
Clinical features and management issues of NAFLD-related HCC: what we know so far	4
Role of vitamin D in ulcerative colitis: an update on basic research and therapeutic applications	4
Ripretinib for the treatment of adult patients with advanced gastrointestinal stromal tumors	4
Antibiotics in pediatric inflammatory bowel diseases: a systematic review	4
How widespread and convenient H. pylori susceptibility testing will result in pharmacological opportunities	4
Hospice care for end stage liver disease in the United States	4
Sofosbuvir/velpatasvir for the treatment of hepatitis C in pediatric patients	4
Addition of thermal ablation to systemic chemotherapy for the treatment of unresectable intrahepatic cholangiocarcinoma: a propensity score matching analysis	4
Achilles’heel of laparoscopic pancreatectomy: reconstruction of the remnant pancreas	4
New advances in the clinical management of RAS and BRAF mutant colorectal cancer patients	4
Comparative efficacy and safety of local palliative therapeutics for unresectable malignant biliary obstruction: a Bayesian network meta-analysis	4
Hepatic encephalopathy – recent advances in treatment and diagnosis	4
The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors	3
Impact of biologic therapies and small molecules on the risk of major adverse cardiovascular events in patients with inflammatory bowel diseases: systematic review and meta-analysis of randomized cont	3
Altered gut microbiota is associated with sleep disturbances in patients with minimal hepatic encephalopathy caused by hepatitis B-related liver cirrhosis	3
New progress with calcium-binding protein S100A16 in digestive system disease	3
Does adjuvant chemotherapy improve outcomes in elderly patients with colorectal cancer? A systematic review and meta-analysis of real-world studies	3
Capsule endoscopy - a non-invasive modality to investigate the GI tract: out with the old and in with the new?	3
Post-endoscopic submucosal dissection electrocoagulation syndrome: a clinical overview	3
Advances in our understanding of the molecular heterogeneity of fatty liver disease: toward informed treatment decision making	3
Roles of nuclear receptors in hepatic stellate cells	3
Do sleep quality and psychological factors link precancerous conditions of colorectal cancer? A retrospective case-control study	3
An update of pharmacology, efficacy, and safety of vonoprazan in acid-related disorders	3
Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?	3
The clinical impact of cirrhosis on the postoperative outcomes of patients undergoing bariatric surgery: propensity score-matched analysis of 2011-2017 US hospitals	3
Small intestinal bacterial overgrowth and Celiac disease – coincidence or causation?	3
Hepatobiliary disease after bone marrow transplant	3
Combination systemic therapies with immune checkpoint inhibitors in biliary tract cancer: effective but not enough?	3
Highlighting novel targets in immunotherapy for liver cancer	3
Dual energy computed tomography in Crohn’s disease: a targeted review	3
Understanding the relationship between esophageal motor disorders and reflux disease	3
Differentiated/undifferentiated mixed type is a prognostic factor for T2/T3 gastric cancer patients	3
Research progress in the role of gut microbiota and its metabolites in intrahepatic cholestasis of pregnancy	3
Metabolic endoscopy by duodenal mucosal resurfacing: expert review with critical appraisal of the current technique and results	3
Magnetic endoscopic imaging as a rational investment for specific colonoscopies: a systematic review and meta-analysis	3
Induction and maintenance of healing in erosive esophagitis in the United States	3
Application and prospect of artificial intelligence in digestive endoscopy	3
Early alpha-fetoprotein response predicts prognosis of immune checkpoint inhibitor and targeted therapy for hepatocellular carcinoma: a systematic review with meta-analysis	3
COVID-19 and hygiene hypothesis: increment of the inflammatory bowel diseases in next generation?	3
Screening for pancreatic cancer has the potential to save lives, but is it practical?	3
Medical care of liver transplant patients	3
Filgotinib for moderately to severely active ulcerative colitis	3
Venous thromboembolism in chronic gastrointestinal disorders	3