Chemical Biology & Drug Design

Article	Citations
Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review	145
Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy	87
Application of molecular dynamics simulation in biomedicine	63
Chromones: Privileged scaffold in anticancer drug discovery	55
Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt/GSK‐3β/β‐catenin signaling pathway	46
Preparation, structure, and properties of tea polysaccharide	44
Therapeutic potential and pharmacological activities of β‐eudesmol	41
Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review	40
SARS‐CoV‐2 and its variants of concern including Omicron: A never ending pandemic	39
Deciphering the detailed structure–activity relationship of coumarins as Monoamine oxidase enzyme inhibitors—An updated review	38
Computational design and modeling of nanobodies toward SARS‐CoV‐2 receptor binding domain	38
Repurposing potential of FDA‐approved and investigational drugs for COVID‐19 targeting SARS‐CoV‐2 spike and main protease and validation by machine learning algorithm	37
Discovery of two novel ALKBH5 selective inhibitors that exhibit uncompetitive or competitive type and suppress the growth activity of glioblastoma multiforme	33
Pyrimidine: An elite heterocyclic leitmotif in drug discovery‐synthesis and biological activity	32
Machine learning approaches and their applications in drug discovery and design	31
Extraction, derivatization, and antioxidant activity of Morinda citrifolia polysaccharide	31
Specific delivering of RNAi using Spike's aptamer‐functionalized lipid nanoparticles for targeting SARS‐CoV‐2: A strong anti‐Covid drug in a clinical case study	30
Focal adhesion kinase—An emerging viable target in cancer and development of focal adhesion kinase inhibitors	29
Evolution of peptide nucleic acid with modifications of its backbone and application in biotechnology	28
Alantolactone: A sesquiterpene lactone with diverse pharmacological effects	28
Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition	27
A minireview of 1,2,3‐triazole hybrids with O‐heterocycles as leads in medicinal chemistry	27
Silicon switch: Carbon–silicon Bioisosteric replacement as a strategy to modulate the selectivity, physicochemical, and drug‐like properties in anticancer pharmacophores	25
Recent progress in materials development and biological properties of GTR membranes for periodontal regeneration	25
Novel imidazo[2,1‐b]thiazole‐based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis, in silico and in vitro evaluation	25

A review on computer‐aided chemogenomics and drug repositioning for rationalCOVID‐19 drug discovery	24
Extraction and deproteinization process of polysaccharide from purple sweet potato	24
Anticancer properties and pharmaceutical applications of ginsenoside compound K: A review	23
Antibiotic–cell‐penetrating peptide conjugates targeting challenging drug‐resistant and intracellular pathogenic bacteria	23
Tetrazole: A privileged scaffold for the discovery of anticancer agents	22
The flavonoid Astragalin shows anti‐tumor activity and inhibits PI3K/AKT signaling in gastric cancer	22
A new insight into the treatment of diabetes by means of pan PPAR agonists	22
DNA intercalators as anticancer agents	22
Emerging quinoline‐ and quinolone‐based antibiotics in the light of epidemics	22
Pinoresinol diglucoside alleviates ischemia/reperfusion‐induced brain injury by modulating neuroinflammation and oxidative stress	21
Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry	21
Design and synthesis of isothiocyanate‐containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH–Deficient prostate cancer cells	20
Recent advances of benzimidazole as anticancer agents	19
Recent progress of research on anti‐tumor agents using benzimidazole as the structure unit	19
Benzimidazole‐based protein kinase inhibitors: Current perspectives in targeted cancer therapy	19
Synergistic antifungal effects of curcumin derivatives as fungal biofilm inhibitors with fluconazole	18
Therapeutic potential of ferulic acid and its derivatives in Alzheimer’s disease—A systematic review	18
Comprehensive review on natural pharmacophore tethered 1,2,3‐triazoles as active pharmaceuticals	18
A comprehensive review on glucokinase activators: Promising agents for the treatment of Type 2 diabetes	18
In silico prediction of drug‐induced ototoxicity using machine learning and deep learning methods	18
Molecular mechanisms of anticancer activities of polyphyllin VII	17
Alginate oligosaccharide alleviates senile osteoporosis via the RANKL–RANK pathway in D‐galactose‐induced C57BL/6J mice	17
Extraction, structural analysis, and activities of rice bran polysaccharide	17
An insight into therapeutic efficacy of heterocycles as histone‐modifying enzyme inhibitors that targets cancer epigenetic pathways	17
Ginkgetin alleviates high glucose‐evoked mesangial cell oxidative stress injury, inflammation, and extracellular matrix (ECM) deposition in an AMPK/mTOR‐mediated autophagy axis	17
Multiple function of lncRNA MALAT1 in cancer occurrence and progression	17
Development and radiosterilization of new hydrazono‐quinoline hybrids as DNA gyrase and topoisomerase IV inhibitors: Antimicrobial and hemolytic activities against uropathogenic	17
Preparation and antioxidant activity of phosphorylated polysaccharide from purple sweet potato	17
Design, synthesis, and molecular modeling of quinoline‐based derivatives as anti‐breast cancer agents targeting EGFR/AKT signaling pathway	16
Designing of kinase hinge binders: A medicinal chemistry perspective	16
Frontiers in G‐Quadruplex therapeutics in cancer: Selection of small molecules, peptides and aptamers	15
A novel peptide isolated from garlic shows anticancer effect against leukemic cell lines via interaction with Bcl‐2 family proteins	15
Design strategies, SAR, and mechanistic insight of Aurora kinase inhibitors in cancer	15
Extraction, structural characterization, and physicochemical properties of polysaccharide from purple sweet potato	15
A review of the effects and molecular mechanisms of dimethylcurcumin (ASC‐J9) on androgen receptor‐related diseases	15
Explainability and white box in drug discovery	14
The importance of co‐delivery of nanoparticle‐siRNA and anticancer agents in cancer therapy	14
Extraction, chemical modification, and antioxidant activities of Daucus carota polysaccharide	14
Review on marine sponge alkaloid, aaptamine: A potential antibacterial and anticancer drug	14
Current status of quinoxaline and quinoxaline 1,4‐di‐N‐oxides derivatives as potential antiparasitic agents	14
Design, synthesis and biological evaluation of N‐substituted indole‐thiazolidinedione analogues as potential pancreatic lipase inhibitors	14
99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress	14
Evaluation of small molecule kinase inhibitors as novel antimicrobial and antibiofilm agents	14
Multiple interactions between melatonin and non‐coding RNAs in cancer biology	14
Perspectives on cutting‐edge nanoparticulate drug delivery technologies based on lipids and their applications	14
Discovery of novel antibacterial agents: Recent developments in D‐alanyl‐D‐alanine ligase inhibitors	14
Elucidating specificity of an allosteric inhibitor WNK476 among With‐No‐Lysine kinase isoforms using molecular dynamic simulations	14
Emerging chemical scaffolds with potential SHP2 phosphatase inhibitory capabilities – A comprehensive review	13
Natural naphthoquinones and their derivatives as potential drug molecules against trypanosome parasites	13
Synthetic heterocyclic derivatives as promising xanthine oxidase inhibitors: An overview	13

Role of exosomal miRNA in chemotherapy resistance of Colorectal cancer: A systematic review	13
Secondary structure dependence of amyloid‐β(1–40) on simulation techniques and force field parameters	13
Radiosynthesis and in silico bioevaluation of 131I‐Sulfasalazine as a highly selective radiotracer for imaging of ulcerative colitis	13
A comprehensive review of recent advances in the biological activities of quinazolines	13
Epigallocatechin‐3‐O‐gallate ameliorates oxidative stress‐induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway	13
Baicalin mitigated IL‐1β‐Induced osteoarthritis chondrocytes damage through activating mitophagy	12
Synthesis and biological activity profile of novel triazole/quinoline hybrids	12
Integrated molecular modeling techniques to reveal selective mechanisms of inhibitors to PI3Kδ with marketed Idelalisib	12
Development of potent inhibitors by fragment‐linking strategies	12
Structure‐based derivation and optimization of YAP‐like coactivator‐derived peptides to selectively target TEAD family transcription factors by hydrocarbon stapling and cyclization	12
Discovery of potent α‐glucosidase inhibitors through structure‐based virtual screening of an in‐house azole collection	12
Pyrazolopyridine: An efficient pharmacophore in recent drug design and development	12
Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands	12
Role of calcium dysregulation in Alzheimer's disease and its therapeutic implications	11
1,3,4‐oxadiazole derivatives as potential antimicrobial agents	11
RNA: The most attractive target in recent viral diseases	11
Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application	11
Green synthesis and characterization of Solanum xanthocarpum capped silver nanoparticles and its antimicrobial effect on multidrug‐resistant bacterial (MDR) isolates	11
Synergy between machine learning and natural products cheminformatics: Application to the lead discovery of anthraquinone derivatives	11
Synthesis andin vitroanticancer activities of seleniumN‐heterocyclic carbene compounds	11
Facile synthesis and antimycobacterial activity of isoniazid, pyrazinamide and ciprofloxacin derivatives	11
Antiaggregant effects of (1,2,5‐oxadiazolyl)azasydnone ring assemblies as novel antiplatelet agents	11
Recent advances in antifungal drug development targeting lanosterol 14α‐demethylase (CYP51): A comprehensive review with structural and molecular insights	11
Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR)	11
Hydroxysafflor yellow A protects against ulcerative colitis via suppressing TLR4/NF‐κB signaling pathway	11
Current understanding and future prospects on Berberine for anticancer therapy	11
Rational design of novel N‐alkyl amine analogues of noscapine, their chemical synthesis and cellular activity as potent anticancer agents	10
Leishmania species: A narrative review on surface proteins with structural aspects involved in host–pathogen interaction	10
Classification of beta‐site amyloid precursor protein cleaving enzyme 1 inhibitors by using machine learning methods	10
Synthesis of new coumarin[1,3]oxazine derivatives of 7‐hydroxy‐6‐isobornyl‐4‐methylcoumarin and their antioxidant activity	10
Design, synthesis and antifungal evaluation of novel mandelic acid derivatives containing a 1,3,4‐oxadiazothioether moiety	10
Therapeutic efficacy of caffeic acid phenethyl ester in cancer therapy: An updated review	10
ELIOT: A platform to navigate the E3 pocketome and aid the design of new PROTACs	10
Review on target domains and natural compound‐based inhibitors of fatty acid synthase for anticancer drug discovery	10
A comprehensive review on the research progress of PTP1B inhibitors as antidiabetics	10
Tachyplesin induces apoptosis in non‐small cell lung cancer cells and enhances the chemosensitivity of A549/DDP cells to cisplatin by activating Fas and necroptosis pathway	10
Cyanidin as potential anticancer agent targeting various proliferative pathways	10
Therapeutic implications of crocin in Parkinson's disease: A review of preclinical research	9
Some important inhibitors and mechanisms of rheumatoid arthritis	9
Polysaccharide‐modified liposomes and their application in cancer research	9
Chemical composition analysis and antioxidant activity of black rice pigment	9
Glucosyl‐1,2,3‐triazoles derived from eugenol and analogues: Synthesis, anti‐Candida activity, and molecular modeling studies in CYP‐51	9
Sesamin exerts anti‐tumor activity in esophageal squamous cell carcinoma via inhibition of TRIM44 and NF‐κB signaling	9
Synthesis and discovery of potential tyrosinase inhibitor of new coumarin‐based thiophenyl‐pyrazolylthiazole nuclei: In vitro evaluation, cytotoxicity, kinetic, and computational studies	9
Pyronaridine induces apoptosis in non‐small cell lung cancer cells by upregulating death receptor 5 expression and inhibiting epidermal growth factor receptor	9
Discussion on structure classification and regulation function of histone deacetylase and their inhibitor	9
Synthetic molecules targeting yes associated protein activity as chemotherapeutics against cancer	9
LncRNA SNHG15: A potential therapeutic target in the treatment of colorectal cancer	9
Novel quantitative structure–activity relationship model to predict activities of natural products against COVID‐19	9
Dithiocarbamate derivatives inhibit α‐glucosidase through an apparent allosteric site on the enzyme	9
1H‐1,2,3‐triazole embedded Isatin‐Benzaldehyde‐bis(heteronuclearhydrazones): design, synthesis, antimycobacterial, and cytotoxic evaluation	8
Theoretical study of myriocin‐binding mechanism targeting serine palmitoyltransferase	8
An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1,4‐di‐N‐oxide scaffold	8
Role of miRNA in pathogenesis, diagnosis, and prognosis in hepatocellular carcinoma	8
[99mTc‐HYNIC/EDDA]‐MccJ25 antimicrobial peptide analog as a potential radiotracer for detection of infection	8
The rise of deep learning and transformations in bioactivity prediction power of molecular modeling tools	8
The role of FoxO1 and its modulation with small molecules in the development of diabetes mellitus: A review	8
Molecular docking‐guided synthesis of NSAID–glucosamine bioconjugates and their evaluation as COX‐1/COX‐2 inhibitors with potentially reduced gastric toxicity	8
Gossypin: A flavonoid with diverse pharmacological effects	8
Biological evaluation the 2‐aryl‐2,3‐dihydrobenzodiazaborinin‐4(1H)‐ones as potential dual α‐glucosidase and α‐amylase inhibitors with antioxidant properties	8
Synthesis and antiviral activity of diverse heterocyclic scaffolds	8
Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen	8
Structure‐based discovery of Licoflavone B and Ginkgetin targeting c‐Myc G‐quadruplex to suppress c‐Myc transcription and myeloma growth	8
Cell‐penetrating peptide conjugates of indole‐3‐acetic acid‐based DNA primase/Gyrase inhibitors as potent anti‐tubercular agents against planktonic and biofilm culture of Mycobacterium smegmatis	8
Rhodanine derivatives: An insight into the synthetic and medicinal perspectives as antimicrobial and antiviral agents	8
Fragment‐based in silico design of SARS‐CoV‐2 main protease inhibitors	8
3‐O‐trans‐caffeoyloleanolic acid improves acute lung injury via anti‐inflammation and antioxidative stress‐involved PI3K/AKT pathway	8
Recent updates in the development of small molecules as potential clinical candidates for Alzheimer's disease: A review	7
Identification of miR‐3182 and miR‐3143 target genes involved in the cell cycle as a novel approach in TNBC treatment: A systems biology approach	7
The salivary exosomal microRNA as a potential biomarker in patients with periodontitis and oral cancers	7
Ligustilide induces apoptosis and reduces proliferation in human bladder cancer cells by NFκB1 and mitochondria pathway	7
Thymoquinone potentiates anti‐cancer effects of cisplatin in oral squamous cell carcinoma via targeting oxidative stress	7
MiR‐27a‐3p targets USP46 to inhibit the cell proliferation of hepatocellular carcinoma	7
Current insights and molecular docking studies of HIV‐1 reverse transcriptase inhibitors	7
N‐pyridinylbenzamides: an isosteric approach towards new antimycobacterial compounds	7
Synthesis, biological evaluation, and molecular modeling studies of acetophenones‐tethered 1,2,4‐triazoles and their oximes as epidermal growth factor receptor inhibitors	7
Sulfonated non‐saccharide molecules and human factor XIa: Enzyme inhibition and computational studies	7
A novel alpha‐amylase inhibitor‐based spirooxindole‐pyrrolidine‐clubbed thiochromene‐pyrzaole pharmacophores: Unveiling the [3+2] cycloaddition reaction by molecular electron den	7
Design, synthesis, and biological evaluation of benzo[b]thiophene 1,1‐dioxide derivatives as potent STAT3 inhibitors	7
MiR‐22‐3p in exosomes increases the risk of heart failure after down‐regulation of FURIN	7

A systematic literature review for the prediction of anticancer drug response using various machine‐learning and deep‐learning techniques	7
Identification of selective mtbDHFR inhibitors by virtual screening and experimental approaches	7
Downregulation of NRARP exerts anti‐tumor activities in the breast tumor cells depending on Wnt/β‐catenin‐mediated signals: The role of miR‐130a‐3p	7
Isoquinolines alkaloids and cancer metabolism: Pathways and targets to novel chemotherapy	7
Synergistic interaction of N‐3‐Br‐benzyl‐noscapine and docetaxel abrogates oncogenic potential of breast cancer cells	7
Pyrimidine derivatives as EGFR tyrosine kinase inhibitors in non‐small‐cell lung cancer: A comprehensive review	7
High therapeutic efficacy of 5‐Fluorouracil‐loaded exosomes against colon cancer cells	7
Association of sigma‐1 receptor with dopamine transporter attenuates the binding of methamphetamine via distinct helix–helix interactions	6
Synthesis and inhibitory activities of inhibitors for the treatment of Alzheimer’s disease	6
Synthesis and structure–activity relationship of L‐methionine‐coupled 1,3,4‐thiadiazole derivatives with activity against influenza virus	6
Identification of novel P2X7R antagonists by using structure‐based virtual screening and cell‐based assays	6
Design, synthesis and biological evaluation of benz‐fused five‐membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities	6
Natural anthraquinone compound emodin as a novel inhibitor of aurora A kinase: A pilot study	6
Synthesis, molecular docking, and biological evaluation of novel 1,2,4‐triazole‐isatin derivatives as potential Mycobacterium tuberculosis shikimate kinase inhibitors	6
Exendin‐4: A potential therapeutic strategy for Alzheimer's disease and Parkinson's disease	6
Amentoflavone attenuates cell proliferation and induces ferroptosis in human gastric cancer by miR‐496/ATF2 axis	6
Synthesis, in silico docking studies, and antiplasmodial activity of hybrid molecules bearing 7‐substituted 4‐aminoquinoline moiety and cinnamic acid derivatives	6
Pharmacophore screening, denovo designing, retrosynthetic analysis, and combinatorial synthesis of a novel lead VTRA1.1 against RecA protein of Acinetobacter baumannii	6
Synthesis and activities of acetylcholinesterase inhibitors	6
Identification of an AXL kinase inhibitor in triple‐negative breast cancer by structure‐based virtual screening and bioactivity test	6
Upregulation of miR‐144‐3p alleviates Doxorubicin‐induced heart failure and cardiomyocytes apoptosis via SOCS2/PI3K/AKT axis	6
Molecular target interactions of quinoline derivatives as anticancer agents: A review	6
Design, synthesis, and molecular modeling of coumarin derivatives as MDM2 inhibitors targeting breast cancer	6
Synthesis, in vitro and in silico anti‐bacterial analysis of piperine and piperic ester analogues	6
Hydroxycinnamic acid‐spermidine amides from Tetragonisca angustula honey as anti‐Neospora caninum: In vitro and in silico studies	6
Identification of tripeptides against tyrosine kinase domain of EGFR for lung cancer cell inhibition by in silico and in vitro studies	6
Intrinsic drug potential of oxazolo[5,4‐d]pyrimidines and oxazolo[4,5‐d]pyrimidines	6
Synthesis of 2‐Chloro‐3‐amino indenone derivatives and their evaluation as inhibitors of DNA dealkylation repair	6
Breast cancer and its therapeutic targets: A comprehensive review	6
Ginsenoside Rg3 alleviates the migration, invasion, and angiogenesis of lung cancer cells by inhibiting the expressions of cyclooxygenase‐2 and vascular endothelial growth factor	6
Design, synthesis, and modelling study of new 1,2,3‐triazole/chalcone hybrids with antiproliferative action as epidermal growth factor receptor inhibitors	6
Delineating binding potential, stability of Sulforaphane‐N‐acetyl‐cysteine in the active site of histone deacetylase 2 and testing its cytotoxicity against distinct cancer lines through stringent mol	6
Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe	6
Synthesis, and antimalarial and antibacterial activities of marine alkaloids	5
Study the mechanism of peimisine derivatives on NF‐κB inflammation pathway on mice with acute lung injury induced by lipopolysaccharide	5
Anticancer and apoptotic activity in neuroblastoma SK‐N‐SH using phospholipid extract from bone of Scomberomorus niphonius	5
A consequence of drug targeting of aminoacyl‐tRNA synthetases in Mycobacteriumtuberculosis	5
Benzo[a]phenazine derivatives: Promising scaffolds to combat resistant Mycobacteriumtuberculosis	5
Anti‐Candida, docking studies, and in vitro metabolism‐mediated cytotoxicity evaluation of Eugenol derivatives	5
Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats	5
Stat5 inhibits NLRP3‐mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR‐182 transcription	5
Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system	5
N‐methylpiperazinyl and piperdinylalkyl‐O‐chalcone derivatives as potential polyfunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation	5
2‐Aminothiophene derivatives as a new class of positive allosteric modulators of glucagon‐like peptide 1 receptor	5
Evaluation of the performance of various machine learning methods on the discrimination of the active compounds	5
Investigating the active components of Huatan Tongjing decoction for the treatment of polycystic ovary syndrome via network pharmacology	5
Indole‐3‐carbinol induces apoptosis in AGS cancer cells via mitochondrial pathway	5
Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N‐formyl peptide receptors agonists	5
SARS‐CoV‐2 first contact: Spike–ACE2 interactions in COVID‐19	5
Lariciresinol protects rats from complete Freund's adjuvant induced arthritis in rats via modulation of transforming growth factor‐β and nuclear factor kappa B pathway: An in vivo and in silico study	5
Anticancer activities of Brachydin C in human prostate tumor cells (DU145) grown in 2D and 3D models: Stimulation of cell death and downregulation of metalloproteinases in spheroids	5
Isoginkgetin inhibits inflammatory response in the fibroblast‐like synoviocytes of rheumatoid arthritis by suppressing matrix metallopeptidase 9 expression	5
Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers	5
In silico design, chemical synthesis and biological screening of novel 4‐(1H)‐pyridone‐based antimalarial agents	5
Hydrogen bonding penalty used for virtual screening to discover potent inhibitors for Papain‐Like cysteine proteases of SARS‐CoV‐2	5
Orthogonal threading‐through‐β‐sheet design of lung cancer EGFR extracellular domain‐derived peptidic mimotopes binding to anti‐EGFR antibody	5
Synthetic peptides bioinspired in temporin‐PTa with antibacterial and antibiofilm activity	5
Synthesis, structural investigations, and in vitro biological activity of Co(II) and Fe(III) mixed ligand complexes of 1,10‐phenanthroline and 2,2′‐bipyridine	5
2‐Aroyl quinazolinone: Synthesis and in vitro anti‐parasitic activity	5
Toll‐like receptor 4 antagonist FP7 alleviates lipopolysaccharide‐induced septic shock via NF‐kB signaling pathway	5
1,3‐diarylpyrazolones as potential anticancer agents for non‐small cell lung cancer: Synthesis and antiproliferative activity evaluation	5
Sulfasalazine inhibits esophageal cancer cell proliferation by mediating ferroptosis	5
Interleukin‐25 recognition by its unique receptor IL‐17Rb via two discrete linear and cyclic epitopes	5
Chemotherapeutic potentials of β‐ionone against Trypanosoma congolense infection: Inhibition of parasite proliferation, anemia development, trans‐sialidase (TconTS3 and TconTS4) g	5
Novel candidates in the clinical development pipeline for TB drug development and their synthetic approaches	5
W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319	5
Peptide‐based diagnostic and therapeutic agents: Where we are and where we are heading?	5
In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines	5
KIF4A knockdown inhibits tumor progression and promotes chemo‐sensitivity via induction of P21 in lung cancer cells	4
Chemistry and biological evaluation of pyrido[4,3‐d]pyrimidines: A review	4
The expression of miR‐181b, CYLD, CBX‐7, BCL2, and p53 in osteosarcoma patients and correlation with clinicopathological factors	4
Pyrrole‐based EGFR inhibitors for the treatment of NCSLC: Binding modes and SARs investigations	4
HIV‐1 integrase inhibitor raltegravir promotes DNA damage‐induced apoptosis in multiple myeloma	4
Curcumin affects apoptosis of colorectal cancer cells through ATF6‐mediated endoplasmic reticulum stress	4
A comprehensive review on potential candidates for the treatment of chagas disease	4
Analysis of bioactive compounds using LC–ESI–MS/MS, cytotoxic, antimicrobial effects, and enzyme activities from Cyclotrichium origanifolium	4
Arylnitro monocarbonyl curcumin analogues: Synthesis and in vitro antitubercular evaluation	4
Aptamer‐siRNA chimeras: Promising tools for targeting HER2 signaling in cancer	4
Active site‐based analysis of structural proteins for drug targets in different human Coronaviruses	4
2, 4, 5‐Trideoxyhexopyranosides derivatives of diphyllin: Synthesis and anticancer activity	4
Glabridin inhibits urothelial bladder carcinoma cell growth in vitro and in vivo by inducing cell apoptosis and cell cycle arrest	4
Design, synthesis, and biological evaluation of urea‐based ROCK2 inhibitors	4
Why are heterocycles so special in medicinal chemistry?	4
Discovery of novel inhibitors of CDK2 using docking and physics‐based binding free energy calculation	4
Ursolic and betulinic semisynthetic derivatives show activity against CQ‐resistant Plasmodium falciparum isolated from Amazonia	4
Design, synthesis, and anticancer evaluation of N6‐hydrazone purine derivatives with potential antiplatelet aggregation activity	4
Hederagenin inhibits high glucose‐induced fibrosis in human renal cells by suppression of NLRP3 inflammasome activation through reducing cathepsin B expression	4
Progress of SARS‐CoV‐2 Main protease peptide‐like inhibitors	4
Discovery of drug‐like acetylcholinesterase inhibitors by rapid virtual screening of a 6.9 million compound database	4
In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors	4
Molecular docking‐based virtual screening and dynamics simulation study of novel and potential SIRT7 inhibitors	4
Synthesis of ring opening of evodiamine derivatives and evaluation on their biological activity	4
Long noncoding RNA SNHG7‐miRNA‐mRNA axes crosstalk with oncogenic signaling pathways in human cancers	4
Compounds from diverse natural origin against triple‐negative breast cancer: A comprehensive review	4
Evaluation of the histamine H3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies	4