OOIR: Observatory of International Research

Papers

(The TQCC of Regenerative Medicine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?	114
National human embryo and embryoid research policies: a survey of 22 top research-intensive countries	55
The use of innovative payment mechanisms for gene therapies in Europe and the USA	32
miR-19a/19b-loaded exosomes in combination with mesenchymal stem cell transplantation in a preclinical model of myocardial infarction	27
Breeding brains? Patients’ and laymen’s perspectives on cerebral organoids	27
Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells	27
Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice	25
Intra-articular injections of allogeneic human adipose-derived mesenchymal progenitor cells in patients with symptomatic bilateral knee osteoarthritis: a Phase I pilot study	23
Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration	22
The biological processes during wound healing	22
Corneal epithelium tissue engineering: recent advances in regeneration and replacement of corneal surface	18
Challenges in corneal endothelial cell culture	17
FGF2: a key regulator augmenting tendon-to-bone healing and cartilage repair	17
The effects of polydeoxyribonucleotide on wound healing and tissue regeneration: a systematic review of the literature	16
Platelet lysate: a promising candidate in regenerative medicine	16
Challenging misinformation and engaging patients: characterizing a regenerative medicine consult service	15
Clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide grafts for regeneration of periodontal defects: a systematic review and meta-analysis	14
In vitro potential of human mesenchymal stem cells for corneal epithelial regeneration	14
Biomimicry in 3D printing design: implications for peripheral nerve regeneration	14
Treatment of traumatic optic neuropathy using human placenta-derived mesenchymal stem cells in Asian patients	13
Regenerative engineering: a review of recent advances and future directions	13
Autologous fat grafting for nerve regeneration and neuropathic pain: current state from bench-to-bedside	13
Mechanisms underlying the therapeutic potential of mesenchymal stem cells in atherosclerosis	13
Human platelet lysate stimulated adipose stem cells exhibit strong neurotrophic potency for nerve tissue engineering applications	13
Modeling ALS using iPSCs: is it possible to reproduce the phenotypic variations observed in patients in vitro?	12

Regenerative medicine clinical readiness	12
Negative pressure wound therapy promotes wound healing by suppressing macrophage inflammation in diabetic ulcers	12
LncRNA MALAT1 from human adipose-derived stem cell exosomes accelerates wound healing via miR-378a/FGF2 axis	11
Development of a decellularized porcine bone matrix for potential applications in bone tissue regeneration	11
Combination of preconditioned adipose-derived mesenchymal stem cells and platelet-rich plasma improves the repair of osteoarthritis in rat	11
Real-world evidence of mesenchymal stem cell therapy in knee osteoarthritis: a large prospective two-year case series	10
Improved harmonization of critical characterization assays across cell therapies	10
Research progress on the regulatory role of microRNAs in spinal cord injury	10
Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration	10
Mesenchymal stem cell therapy combined with arthroscopic abrasion arthroplasty regenerates cartilage in patients with severe knee osteoarthritis: a case series	10
Cellular and biological factors involved in healing wounds and burns and treatment options in tissue engineering	10
Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium	10
Evaluation of autologous adipose-derived mesenchymal stem cell therapy in focal chondral defects of the knee: a pilot case series	10
Paracrine effect of human adipose-derived stem cells on lymphatic endothelial cells	10
Ultrasound-guided intra-articular injection of expanded umbilical cord mesenchymal stem cells in knee osteoarthritis: a safety/efficacy study with MRI data	9
Is right to try being tried? Using crowdfunding data to better understand usage of nontrial pre-approval access pathways	9
Platelet-rich plasma: are the obtaining methods, classification and clinical outcome always connected?	9
Adipose-derived mesenchymal stem cells ameliorate lung epithelial injury through mitigating of oxidative stress in mustard lung	9
Extracellular matrix extraction techniques and applications in biomedical engineering	9
Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis	9
Regenerative outlook: offering global solutions for equitable care	8
Vascularization strategies for tissue engineering for tracheal reconstruction	8
microRNA-148a-3p-targeting p300 protects against osteoblast differentiation and osteoporotic bone reconstruction	8
Digital regenerative medicine and surgery pedagogy for virtual learning in the time of COVID-19	8
Mesenchymal stem cell application for treatment of neuroinflammation-induced cognitive impairment in mice	7
Research progress in seed cells for cartilage tissue engineering	7
Evaluating the FDA regenerative medicine framework: opportunities for stakeholders	7
Sources, isolation strategies and therapeutic outcome of exosomes at a glance	7
Modeling policy development: examining national governance of stem cell-based embryo models	7
Toward next-generation advanced therapies: extracellular vesicles and cell therapy – partners or competitors?	7
Comparability: what we can learn from the review of advanced therapy medicinal products	7
Platelet-derived exosomes induce cell proliferation and wound healing in human endometrial cells	7
Understanding neural stem cell regulation in vivo and applying the insights to cell therapy for strokes	7
Adipose tissue versus stem cell-derived small extracellular vesicles to enhance the healing of acute burns	7
Digital readiness in 3D bioprinting: software, governance and hospitals’ proto-clinical interfaces	7
Comparative lessons in regenerative medicine readiness: learning from the UK and Japanese experience	7
Exosomes: the latest in regenerative aesthetics	7
Regulating advanced therapy medicinal products through the Hospital Exemption: an analysis of regulatory approaches in nine EU countries	7
Platelet-rich plasma for treatment of chronic proximal hamstring tendinopathy	7
LncRNA X inactive-specific transcript promotes osteoclast differentiation through Tgif2 by acting as a ceRNA of miR-590-3p in a murine model	7
Purified exosome product enhances chondrocyte survival and regeneration by modulating inflammation and promoting chondrogenesis	7
Recombinant human FGF-2 therapy for osteonecrosis of the femoral head: 5-year follow-up	7
Astragalus and human mesenchymal stem cells promote wound healing by mediating immunomodulatory effects through paracrine signaling	7
Novel assessment of leukocyte-rich platelet-rich plasma on functional and patient-reported outcomes in knee osteoarthritis: a pilot study	7
Characterization and bioassays of extracellular vesicles extracted by tangential flow filtration	7
Human umbilical cord-mesenchymal stem cells: a promising strategy for corneal epithelial regeneration	7
Decellularized bovine aorta as a promising 3D elastin scaffold for vascular tissue engineering applications	7
Neuroprotective effect of bone marrow-derived mesenchymal stem cell secretome in 6-OHDA-induced Parkinson's disease	6
The influence of sodium citrate on the characteristics and biological activity of plasma rich in growth factors	6
Mesenchymal stem cell-derived exosomes: therapeutic implications for rotator cuff injury	6

Human periodontal ligament stem cells with distinct osteogenic potential induce bone formation in rat calvaria defects	6
Regenerative medicine lexicon	6
Do knee injection portals affect clinical results of bone marrow aspirate concentrate injection in the treatment of osteoarthritis? A prospective randomized controlled study	6
The safety and effectiveness of bone marrow concentrate injection for knee and hip osteoarthritis: a Canadian cohort	6
Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies	6
Photoencapsulated-mesenchymal stromal cells in biodegradable thiol-acrylate hydrogels enhance regeneration of craniofacial bone tissue defects	6
Central versus peripheral nervous system regeneration: is there an exception for cranial nerves?	6
Online seminars as an information source for direct-to-consumer stem cell therapy	5
Treatment strategies for meniscal lesions: from past to prospective therapeutics	5
Evaluation of institutional readiness at sites within the UK NHS using a novel advanced therapy medicinal product assessment tool	5
Understanding the role of digital platforms in technology readiness	5
Delivery of hepatocyte growth factor mRNA from nanofibrillar scaffolds in a pig model of peripheral arterial disease	5
Reimbursement and pricing of regenerative medicine in South Korea: key factors for achieving reimbursement	5
Short-term outcomes after pure bone marrow aspirate injection for severe knee osteoarthritis: a case series	5
Challenges in the market access of regenerative medicines, and implications for manufacturers and decision-makers: a systematic review	5
Recombinant human FGF-2 for the treatment of early-stage osteonecrosis of the femoral head: TRION, a single-arm, multicenter, Phase II trial	5
The regulatory challenge of 3D bioprinting	5
Restoration of cartilage defects using a superparamagnetic iron oxide-labeled adipose-derived mesenchymal stem cell and TGF-β3-loaded bilayer PLGA construct	5
Effects of nicotine on the translation of stem cell therapy	5
Spatiotemporal readiness is key to preparing regenerative medicine for the clinic	5
Bibliometric analysis of the top 50 highly cited articles on platelet-rich plasma in osteoarthritis and tendinopathy	5
Monocytes recruitment blocking synergizes with mesenchymal stem cell transplantation for treating myocardial infarction	5
Adipose stem cell secretion combined with biomaterials facilitates large-area wound healing	5