OOIR: Observatory of International Research

Papers

(The H4-Index of Expert Opinion on Drug Discovery is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Lessons learned from phenotypic drug discovery efforts	159
Scaffold hopping approaches for dual-target antitumor drug discovery: opportunities and challenges	129
γ-Secretase: once and future drug target for Alzheimer’s disease	93
What is the plausibility that all drugs will be designed by computers by the end of the decade?	78
Advances in ion channel high throughput screening: where are we in 2023?	62
Reality check: lipid-oligonucleotide conjugates for therapeutic applications	54
Polypharmacology prediction: the long road toward comprehensively anticipating small-molecule selectivity to de-risk drug discovery	41
Discovery of novel cathepsin K inhibitors for osteoporosis treatment using a deep learning-based strategy	40
Advances in the discovery of drugs that treat pulmonary arterial hypertension	40
Strategies for targeting RNA with small molecule drugs	39
A comprehensive update on the use of molecular topology applications for anti-infective drug discovery	37
Tools and techniques for the discovery of therapeutic aptamers: recent advances	35
Bisquinoline as a promising scaffold in anti-infective drug discovery: the current state of the art and future prospects	34
Methods in marine natural product drug discovery: what’s new?	34
The preclinical discovery and development of gepirone hydrochloride extended-release tablets: the first oral selective 5-HT1A receptor agonist for the treatment of major depressive disorder	34
Understanding the impact of binding free energy and kinetics calculations in modern drug discovery	33
C. elegans : a prominent platform for modeling and drug screening in neurological disorders	32
Designing drugs against leishmaniasis: is targeting the sterol biosynthesis pathway the answer?	32
Acoustic ejection mass spectrometry: fundamentals and applications in high-throughput drug discovery	31
Novel insights into structure–activity relationships of kynurenine 3-monooxygenase inhibitors (KMOis) with emphasis on chemical space, activity landscape exploration	31
Virtual screening: hope, hype, and the fine line in between	29
The potential of microfluidic platforms for neuron differentiation and pain modeling in novel drug discovery	29
Phenotypic screening for new heart failure therapeutics: scalable animal modeling in zebrafish	28
The rules often neglected in current medicinal chemistry	27
A cautionary tale of paradox and false positives in cannabidiol research	27

Molecular hybridization: a powerful tool for multitarget drug discovery	27
An update on knowledge graphs and their current and potential applications in drug discovery	26
Calcium channel blockers’ contribution to overcoming Current drug discovery challenges in Alzheimer’s disease	26