OOIR: Observatory of International Research

Papers

(The H4-Index of Trials is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
The role of machine learning in clinical research: transforming the future of evidence generation	103
The reality of informed consent: empirical studies on patient comprehension—systematic review	92
Promoting inclusion in clinical trials—a rapid review of the literature and recommendations for action	85
Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects	70
COvid-19 and high-dose VITamin D supplementation TRIAL in high-risk older patients (COVIT-TRIAL): study protocol for a randomized controlled trial	69
Updated protocol of the SANO trial: a stepped-wedge cluster randomised trial comparing surgery with active surveillance after neoadjuvant chemoradiotherapy for oesophageal cancer	62
Reporting guidelines for clinical trials of artificial intelligence interventions: the SPIRIT-AI and CONSORT-AI guidelines	53
Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomiz	51
Developing the INCLUDE Ethnicity Framework—a tool to help trialists design trials that better reflect the communities they serve	47
The effect of the mobile “blood pressure management application” on hypertension self-management enhancement: a randomized controlled trial	46
Fidelity is not easy! Challenges and guidelines for assessing fidelity in complex interventions	46
MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a randomized controlled trial	44
Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospectiv	41
Managing clinical trials during COVID-19: experience from a clinical research facility	40
MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion—study protocol for a	40
Ethical care requires pragmatic care research to guide medical practice under uncertainty	39
The COVID-19 pandemic and new clinical trial activations	39
Underrepresentation of women in randomized controlled trials: a systematic review and meta-analysis	37
Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2	37
The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial	35
Attractive targeted sugar bait phase III trials in Kenya, Mali, and Zambia	35
Impact of a mobile phone-based interactive voice response software on tuberculosis treatment outcomes in Uganda (CFL-TB): a protocol for a randomized controlled trial	35
The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID-19: a randomized clinical trial	35
Clinical effectiveness and safety of baricitinib for the treatment of juvenile idiopathic arthritis-associated uveitis or chronic anterior antinuclear antibody-positive uveitis: study protocol for an	33
Efficacy and safety of secukinumab in patients with giant cell arteritis: study protocol for a randomized, parallel group, double-blind, placebo-controlled phase II trial	33

Planning a method for covariate adjustment in individually randomised trials: a practical guide	33
Exploring reasons for recruitment failure in clinical trials: a qualitative study with clinical trial stakeholders in Switzerland, Germany, and Canada	32
Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukae	32
Process evaluation within pragmatic randomised controlled trials: what is it, why is it done, and can we find it?—a systematic review	32
Active elderly and health—can moderate exercise improve health and wellbeing in older adults? Protocol for a randomized controlled trial	31
REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical multicentre trial	31