OOIR: Observatory of International Research

Papers

(The TQCC of Biology Direct is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	86
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	63
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	60
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1	48
Organelle-specific regulation of ferroptosis	47
ELOVL1 promotes the progression of intrahepatic cholangiocarcinoma by enhancing endoplasmic reticulum stress and the PI3K/AKT/mTOR signaling pathway	46
Long-term longitudinal study on swine VML model	42
Single-cell transcriptomic analysis deciphers heterogeneity and transcriptional regulatory programs of sepsis with different prognosis	41
Moving biology direct towards a new dimension	38
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	38
Wandering about allostery	37
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	36
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	35
SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation	34
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	33
Deciphering the role of SAMHD1 in endometrial cancer progression	32
A hybrid ST-ViT–driven multimodal architecture combining spatiotemporal MRI patterns and radiomic features for enhanced prediction of pCR in neoadjuvant breast cancer therapy	29
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	28
Molecular mechanisms of efferocytosis imbalance in the idiopathic pulmonary fibrosis microenvironment: from gene screening to dynamic regulation analysis	28
Comparative analysis of human Mesenchymal Stromal Cells from Adipose Tissue and Dental Pulp: phenotypic characterization and secretome profiling	27
Dualistic role of ZEB1 and ZEB2 in tumor progression	27
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	27
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	26
Effect of pesticides on breast cancer tumor	25
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	25

NID1 promotes laryngeal cancer stemness via activating WNT pathway	25
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	23
Exploring fetal skeletal alterations induced by gold nanoparticles in mice confirmed by laser speckle imaging and LIBS approach	23
Radix Rehmanniae Preparata polysaccharide promoted zebrafish heart regeneration by activating the IFN-γ/NF-κB signaling axis	23
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	23
Attenuation of Wnt signaling by miR-27a-5p–GFPT2–HBP axis via metabolic reprogramming in colorectal cancer	22
The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	21
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	21
The MST4–14-3-3ζ complex promotes pancreatic cancer by activating YAP	20
Transcutaneous auricular vagus nerve stimulation alleviates chronic heart failure by targeting cathepsin K/p53-mediated ferroptosis	19
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	19
Single-cell analysis reveals that NRG1/3–ERBB4 signaling affects metabolic reprogramming and immune escape in Wilms tumor	19
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	19
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	19
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	18
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	18
Pyrroloquinoline quinone protects heat-stressed porcine oocytes and improves early embryonic development via maintaining mitochondrial integrity and redox homeostasis	18
DTX2 promotes glioma development via regulation of HLTF	18
Restriction-modification systems and prophages drive genomic diversification in Priestia megaterium	18
Conventional type 1 dendritic cells (cDC1) in cancer immunity	18
Activation of the TGR5/cAMP/PKA/CREB axis in cholangiocytes mediates epithelial-mesenchymal transition and fibrosis in hepatolithiasis	18
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	17
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination	17
Correction: Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	17
A novel synergistic action of phage vB_PaeP_GZMU_A1002 with allicin against carbapenem-resistant Pseudomonas aeruginosa	17
Lipidome atlas of p53 mutant variants in pancreatic cancer	17
Martin Karplus (1930–2024)	17
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	17
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	16
Spatiotemporal dynamics of neuronal subtypes and their interactions with glia following intracortical electrode implantation	16
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	16
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	16
Transcription factor IRF1 modulates HDAC1 and PANoptosis to regulate preeclampsia progression	15
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	15
S100A4 triggeres the pyroptosis of vsmcs: association with mitochondrial damage, impaired mitophagy, and Ca2+ dysregulation	15
Incomplete radiofrequency ablation may elicit pro-oncogenic effects in thyroid cancer cells in a xenograft mouse model	15
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	15
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	15
Integrative transcriptomic profiling reveals NK cell exhaustion–associated prognostic genes and identifies CSF1 as a key immunoregulatory target in hepatocellular carcinoma	15
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	15
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	15
PHGDH mediated serine biosynthesis metabolism suppresses vascular calcification	15
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions	14
Prenatal bisphenol A exposure perturbs sex-dependent transcriptomic regionalization of autism-associated genes in the developing brain	14
Dysregulated competitive splicing between circular and linear RNAs characterizes hepatocellular carcinoma tumorigenesis and recurrence	14
Plasma membrane calcium ATPases and cerebellar pathology: what’s the role in the ataxia?	14
p53 regulates expression of nuclear envelope components in cancer cells	14
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	14
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	14
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	14

MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	14
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	14
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	14
Artificial genetic polymers against human pathologies	13
In vitro synergistic effect of AXL, FAK and ErbB receptors inhibitors for head and neck cancer	13
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	13
CLOCK-mediated acetylation of NF-κB p65 drives immune evasion in breast cancer	13
Indispensable role of AcrEF in modulating Salmonella virulence and disrupting host tight junctions to facilitate paracellular entry and invasion	13
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	13
Eraldo Antonini Lectures, 1983–2019	13
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	13
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	12
CircPTP4A2 (hsa_circ_0007364) facilitates non-small cell lung cancer progression by regulating miR-127-5p/SMC3	12
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	12
ETV4 promotes colorectal cancer progression through SLC7A11-mediated ferroptosis inhibition	12
Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells	12
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	12
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	12
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	12
MEF2A activates the ZDHHC20/NF-κB pathway to inhibit doxorubicin sensitivity and promote the malignant progression of acute myeloid leukemia	12
Integrative satellitomics reveals distinct patterns of organization, transcription and evolution of satellite DNAs in Tenebrio molitor	11
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling	11
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	11
Inhibition of circZFX suppresses malignant phenotypes in cholangiocarcinoma via the miR-654-3p/HDGF and YAP1 signaling activation	11
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	11
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	11
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	11
Platelet-activating factor induces ferroptosis by binding to ATF3 and inhibiting the SLC7A11/GPX4 axis to suppress the progression of endometrial carcinoma	11
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	11
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	11
Biological roles of RNA m7G modification and its implications in cancer	11
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	10
A dopaminergic projection from the ventral tegmental area to the dorsal raphe nucleus critically regulates propofol anesthesia in mice	10
Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway	10
Necroptosis-driven T cell activation promotes IL-6-mediated PD-L1 upregulation in cholangiocarcinoma cells: IL-6 gene signature as a biomarker for chemo-immunotherapy response	10
Revealing FPR1 as a potential pathogenic biomarker for aortic dissection based on Mendelian randomization, single-cell transcriptome and clinical data analysis	10
HMGA1 promotes the progression of lung adenocarcinoma through the STAT1-mediated transcriptional activation of DDAH1	10
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	10
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	10
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	10
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	10
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	10
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	10
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	10
Estrogen receptor alpha dynamics and plasticity during endocrine resistance	10
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	10
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	10
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	10
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	10
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	9
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions	9
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	9
Decoding the Snail transcriptional network: its role in cancer progression and therapy	9
m6A methylation-mediated lncRNA RNF144A-AS1 promotes hepatocellular carcinoma progression through the miR-1301-3p/RNF38 pathway	9
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	9
Robust SH2 binding affinity indicates minimal SH3-to-SH2 communication in Grb2	9
Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma	9
ZNF750 suppresses esophageal squamous cell carcinoma by maintaining epithelial barrier–driven mucosal immune homeostasis	9
Impeding hypoxia-driven tumor progression in hepatocellular carcinoma: clinical and pre-clinical analyses using 2D and 3D in vitro models	9
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	9
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	9
JUNB transcriptional regulation of KRT20 via ITGB1 activates PI3K/AKT signaling pathway against fibrosis-induced by renal injury	9
A functional approach to homeostatic regulation	9
Naringin and hesperidin protect ovarian granulosa cells from cisplatin-induced mitochondrial dysfunction by enhancing bioenergetics and mitophagy	9
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	9
Single-cell analysis highlights the role of CD4+ IFN-I-related T cells in Behcet’s uveitis during Interferonα-2a therapy	9
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	9