OOIR: Observatory of International Research

Papers

(The TQCC of Biology Direct is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	95
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1	73
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	57
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	49
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	44
Moving biology direct towards a new dimension	42
Long-term longitudinal study on swine VML model	42
Wandering about allostery	39
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	37
Molecular mechanisms of efferocytosis imbalance in the idiopathic pulmonary fibrosis microenvironment: from gene screening to dynamic regulation analysis	35
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	33
Deciphering the role of SAMHD1 in endometrial cancer progression	32
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	31
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	29
Comparative analysis of human Mesenchymal Stromal Cells from Adipose Tissue and Dental Pulp: phenotypic characterization and secretome profiling	29
Dualistic role of ZEB1 and ZEB2 in tumor progression	28
NID1 promotes laryngeal cancer stemness via activating WNT pathway	26
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	25
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	24
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	23
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	23
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	23
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	22
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	22
The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	22

DTX2 promotes glioma development via regulation of HLTF	21
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	20
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	19
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	18
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	18
Lipidome atlas of p53 mutant variants in pancreatic cancer	18
Conventional type 1 dendritic cells (cDC1) in cancer immunity	18
Martin Karplus (1930–2024)	18
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	17
Correction: Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	17
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	17
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	16
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	16
p53 regulates expression of nuclear envelope components in cancer cells	16
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions	16
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	16
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination	15
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	15
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	15
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	14
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	14
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	14
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	14
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	13
Plasma membrane calcium ATPases and cerebellar pathology: what’s the role in the ataxia?	13
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	13
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	13
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	13
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	13
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	13
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	13
CLOCK-mediated acetylation of NF-κB p65 drives immune evasion in breast cancer	12
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	12
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	12
Eraldo Antonini Lectures, 1983–2019	12
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	12
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	12
A link between mitotic defects and mitotic catastrophe: detection and cell fate	12
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	12
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	12
In vitro synergistic effect of AXL, FAK and ErbB receptors inhibitors for head and neck cancer	12
Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells	12
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	12
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	12
Artificial genetic polymers against human pathologies	12
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	12
Indispensable role of AcrEF in modulating Salmonella virulence and disrupting host tight junctions to facilitate paracellular entry and invasion	12
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling	11
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	11
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	11

Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	11
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	11
Biological roles of RNA m7G modification and its implications in cancer	11
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	10
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	10
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	10
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	10
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	10
Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway	10
HMGA1 promotes the progression of lung adenocarcinoma through the STAT1-mediated transcriptional activation of DDAH1	9
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	9
A functional approach to homeostatic regulation	9
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	9
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	9
Estrogen receptor alpha dynamics and plasticity during endocrine resistance	9
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions	9
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	9
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	9
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	9
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	9
Necroptosis-driven T cell activation promotes IL-6-mediated PD-L1 upregulation in cholangiocarcinoma cells: IL-6 gene signature as a biomarker for chemo-immunotherapy response	9
Spleen granulopoiesis in psoriasis immune microenvironment aggravates psoriasis via IL-6/P-STAT3 signaling	8
m6A methylation-mediated lncRNA RNF144A-AS1 promotes hepatocellular carcinoma progression through the miR-1301-3p/RNF38 pathway	8
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	8
cGAS-STING targeting offers therapy choice in lung diseases	8
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis	8
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	8
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	8
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	8
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	8
Host-mediated RNA editing in viruses	8
Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma	8
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway	8
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	8
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	8
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	8
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	8
Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process	8
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis	8