OOIR: Observatory of International Research

Papers

(The median citation count of Biology Direct is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Pathophysiology of Crohn’s disease inflammation and recurrence	115
A link between mitotic defects and mitotic catastrophe: detection and cell fate	56
Inter-organelle membrane contact sites: implications for lipid metabolism	49
Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases?	46
The p53 family member p73 in the regulation of cell stress response	44
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	43
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis	37
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	34
Understanding p53 tumour suppressor network	32
Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection	32
Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure	32
Migrasomes, new vescicles as Hansel and Gretel white pebbles?	29
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis	29
Redressing the interactions between stem cells and immune system in tissue regeneration	25
Integrative analysis of the salt stress response in cyanobacteria	25
p53 regulates expression of nuclear envelope components in cancer cells	24
Lifestyle-dependent microglial plasticity: training the brain guardians	23
p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer	20
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis	20
The periosteum: a simple tissue with many faces, with special reference to the antler-lineage periostea	19
The immune system view of the coronavirus SARS-CoV-2	19
Unraveling city-specific signature and identifying sample origin locations for the data from CAMDA MetaSUB challenge	19
Circ_0067680 expedites the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells through miR-4429/CTNNB1/Wnt/β-catenin pathway	18
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	18
Mini-review: advances in 3D bioprinting of vascularized constructs	17

N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	17
Why call it developmental bias when it is just development?	17
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network	17
Total neoadjuvant therapy for the treatment of locally advanced rectal cancer: a systematic minireview	16
Long non-coding RNAs affecting cell metabolism in cancer	16
IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism	16
CXCL1 promotes colon cancer progression through activation of NF-κB/P300 signaling pathway	15
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer	15
Commensal microbes and p53 in cancer progression	14
TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC	14
Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites	14
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis	14
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	14
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis	13
Study on the mechanism of LOXL1-AS1/miR-3614-5p/YY1 signal axis in the malignant phenotype regulation of hepatocellular carcinoma	13
Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae	13
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	12
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	12
Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins	12
LncRNA RP11-620J15.3 promotes HCC cell proliferation and metastasis by targeting miR-326/GPI to enhance glycolysis	12
Biological roles of RNA m7G modification and its implications in cancer	12
A machine learning framework to determine geolocations from metagenomic profiling	11
An ensemble learning approach for modeling the systems biology of drug-induced injury	11
METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway	11
Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis	11
Systematic evaluation of supervised machine learning for sample origin prediction using metagenomic sequencing data	11
Principles and biological concepts of heredity before Mendel	10
About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature	10
Serological determinants of COVID-19	10
Phylogenomic analysis of the diversity of graspetides and proteins involved in their biosynthesis	10
A novel gene selection method for gene expression data for the task of cancer type classification	9
Small extracellular vesicles derived from Nrf2-overexpressing human amniotic mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting NLRP3	9
Alamandine alleviated heart failure and fibrosis in myocardial infarction mice	9
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	9
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	9
Host-mediated RNA editing in viruses	9
LINC00858 stabilizes RAN expression and promotes metastasis of gastric cancer	9
LncRNA NORAD facilitates oral squamous cell carcinoma progression by sponging miR-577 to enhance TPM4	8
H3K27ac-activated EGFR-AS1 promotes cell growth in cervical cancer through ACTN4-mediated WNT pathway	8
LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A	8
CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis	8
Identification and validation of a novel signature as a diagnostic and prognostic biomarker in colorectal cancer	7
Common pathways and functional profiles reveal underlying patterns in Breast, Kidney and Lung cancers	7
Pan-cancer analysis of cuproptosis regulation patterns and identification of mTOR-target responder in clear cell renal cell carcinoma	7
The current state of molecular profiling in gastrointestinal malignancies	7
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	7
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	6
Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches	6
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	6
circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway	6

Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions	6
Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque	6
Long noncoding RNA PSMA3-AS1 functions as a competing endogenous RNA to promote gastric cancer progression by regulating the miR-329-3p/ALDOA axis	6
Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis	6
LncRNA WAC-AS1 promotes osteosarcoma Metastasis and stemness by sponging miR-5047 to upregulate SOX2	5
Microglial exosomes alleviate intermittent hypoxia-induced cognitive deficits by suppressing NLRP3 inflammasome	5
A functional reference map of the RNF8 interactome in cancer	5
Gene expression in organoids: an expanding horizon	5
HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells	5
USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice	5
Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction	5
Pro-tumorigenic role of lnc-ZNF30-3 as a sponge counteracting miR-145-5p in prostate cancer	5
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	5
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	4
Opening of Cx43-formed hemichannels mediates the Ca2+ signaling associated with endothelial cell migration	4
A genome-wide search of Toll/Interleukin-1 receptor (TIR) domain-containing adapter molecule (TICAM) and their evolutionary divergence from other TIR domain containing proteins	4
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	4
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo	4
IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	4
Identification of fatty acid metabolism-related lncRNAs in the prognosis and immune microenvironment of colon adenocarcinoma	4
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	4
MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction	4
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	4
Intron losses and gains in the nematodes	4
Dendritic cell-based vaccine prolongs survival and time to next therapy independently of the vaccine cell number	4
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	4
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	4
N6-methyladenosine methyltransferase KIAA1429 promoted ovarian cancer aerobic glycolysis and progression through enhancing ENO1 expression	4
USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1	3
Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest	3
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity	3
An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy	3
Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models	3
Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis	3
LncRNA XIST facilitates hypertrophy of ligamentum flavum by activating VEGFA-mediated autophagy through sponging miR-302b-3p	3
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	3
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	3
The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors	3
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	3
Total network controllability analysis discovers explainable drugs for Covid-19 treatment	3
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	3
Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma	3
Bcl-B: an “unknown” protein of the Bcl-2 family	3
LncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer	2
Artificial genetic polymers against human pathologies	2
PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation	2
Plant hormones and phenolic acids response to UV-B stress in Rhododendron chrysanthum pall	2
The power of randomization by sex in multilocus genetic evolution	2
M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction	2
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	2
MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain	2
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	2
Trinity of G-tetrads and origin of translation	2
Correction: ILC1-derived IFN-γ regulates macrophage activation in colon cancer	2
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity	2
Intranasal human-recombinant NGF administration improves outcome in children with post-traumatic unresponsive wakefulness syndrome	2
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	2
MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression	2
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma	2
Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease	2
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity	2
p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer	2
Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease	2
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1	2
Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process	2
Are prime numbers special? Insights from the life sciences	2
ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway	2
PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation and migration	2
Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway	2