Biology Direct

Article	Citations
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	95
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1	73
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	57
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	49
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	44
Long-term longitudinal study on swine VML model	42
Moving biology direct towards a new dimension	42
Wandering about allostery	39
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	37
Molecular mechanisms of efferocytosis imbalance in the idiopathic pulmonary fibrosis microenvironment: from gene screening to dynamic regulation analysis	35
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	33
Deciphering the role of SAMHD1 in endometrial cancer progression	32
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	31
Comparative analysis of human Mesenchymal Stromal Cells from Adipose Tissue and Dental Pulp: phenotypic characterization and secretome profiling	29
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	29
Dualistic role of ZEB1 and ZEB2 in tumor progression	28
NID1 promotes laryngeal cancer stemness via activating WNT pathway	26
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	25
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	24
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	23
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	23
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	23
The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	22
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	22
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	22

DTX2 promotes glioma development via regulation of HLTF	21
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	20
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	19
Lipidome atlas of p53 mutant variants in pancreatic cancer	18
Conventional type 1 dendritic cells (cDC1) in cancer immunity	18
Martin Karplus (1930–2024)	18
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	18
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	18
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	17
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	17
Correction: Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	17
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions	16
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	16
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	16
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	16
p53 regulates expression of nuclear envelope components in cancer cells	16
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	15
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination	15
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	15
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	14
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	14
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	14
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	14
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	13
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	13
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	13
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	13
Plasma membrane calcium ATPases and cerebellar pathology: what’s the role in the ataxia?	13
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	13
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	13
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	13
Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells	12
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	12
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	12
Artificial genetic polymers against human pathologies	12
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	12
Indispensable role of AcrEF in modulating Salmonella virulence and disrupting host tight junctions to facilitate paracellular entry and invasion	12
CLOCK-mediated acetylation of NF-κB p65 drives immune evasion in breast cancer	12
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	12
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	12
Eraldo Antonini Lectures, 1983–2019	12
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	12
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	12
A link between mitotic defects and mitotic catastrophe: detection and cell fate	12
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	12
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	12
In vitro synergistic effect of AXL, FAK and ErbB receptors inhibitors for head and neck cancer	12
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	11
Biological roles of RNA m7G modification and its implications in cancer	11
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling	11

Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	11
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	11
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	11
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	10
Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway	10
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	10
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	10
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	10
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	10
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	9
Necroptosis-driven T cell activation promotes IL-6-mediated PD-L1 upregulation in cholangiocarcinoma cells: IL-6 gene signature as a biomarker for chemo-immunotherapy response	9
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	9
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	9
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	9
A functional approach to homeostatic regulation	9
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	9
HMGA1 promotes the progression of lung adenocarcinoma through the STAT1-mediated transcriptional activation of DDAH1	9
Estrogen receptor alpha dynamics and plasticity during endocrine resistance	9
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions	9
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	9
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	9
Spleen granulopoiesis in psoriasis immune microenvironment aggravates psoriasis via IL-6/P-STAT3 signaling	8
m6A methylation-mediated lncRNA RNF144A-AS1 promotes hepatocellular carcinoma progression through the miR-1301-3p/RNF38 pathway	8
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	8
cGAS-STING targeting offers therapy choice in lung diseases	8
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis	8
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	8
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	8
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	8
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	8
Host-mediated RNA editing in viruses	8
Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma	8
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway	8
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	8
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	8
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	8
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	8
Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process	8
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis	8
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity	7
AQP5 trafficking is regulated by its C-terminal tail and interaction with prolactin-inducible protein	7
METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification	7
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma	7
Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	7
PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome	7
Identification of fatty acid metabolism-related lncRNAs in the prognosis and immune microenvironment of colon adenocarcinoma	7
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn	7
Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9	7
Ultrastructural studies distinguish skin diversities among Galápagos iguanas	7
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis	7
Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque	7
METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway	7
Did the early full genome sequencing of yeast boost gene function discovery?	7
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging	7
Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease	7
Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers	7
Proteomics and digital subtraction angiography approaches reveal CDH18 as a potential target for therapy of moyamoya disease	7
Unveiling the molecular profile of a prostate carcinoma: implications for personalized medicine	7
Genomic characteristics and evolution of Multicentric Esophageal and gastric Cardiac Cancer	7
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway	7
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease	7
Integrating Circle-Seq with transcriptomics reveals genome-wide characterization of extrachromosomal circular DNA for dilated cardiomyopathy	7
Prognostic model integrating histology, systemic inflammation, and recurrence status predicts immunotherapy response in advanced non-small-cell lung cancer patients	7
Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data	7
Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation	7
Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasia	6
TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer	6
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways	6
A glutamine metabolish-associated prognostic model to predict prognosis and therapeutic responses of hepatocellular carcinoma	6
Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway	6
ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway	6
GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy	6
Identifying the driver miRNAs with somatic copy number alterations driving dysregulated ceRNA networks in cancers	6
Autophagy is influenced by vitamin D3 level in people with HIV-1	6
p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer	6
Horizontal transfer of matrix metalloproteinase genes links early animal and microbial evolution	6
Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development	6
Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions	6
scE2EGAE: enhancing single-cell RNA-Seq data analysis through an end-to-end cell-graph-learnable graph autoencoder with differentiable edge sampling	6
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo	6

Exploring the association between osteoporosis and kidney stones: a clinical to mechanistic translational study based on big data and bioinformatics	6
Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy	6
Efficient DNA-free co-targeting of nuclear genes in Chlamydomonas reinhardtii	6
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism	6
Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle	6
Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples	5
Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis	5
MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis	5
Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans	5
Machine learning model reveals the role of angiogenesis and EMT genes in glioma patient prognosis and immunotherapy	5
Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles	5
BRD4 sustains p63 transcriptional program in keratinocytes	5
Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression	5
CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis	5
Extracellular vesicles derived from different tissues attenuate cardiac dysfunction in murine MI models	5
Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma	5
Coordinating energy metabolism and signaling pathways in epithelial self-renewal and differentiation	5
Valentina Tassinari, the legacy of a young scientist	5
Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma	5
miR-210 is essential to retinal homeostasis in fruit flies and mice	5
Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model	5
Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor suppressor in clear cell renal cell carcinoma	5
PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1	5
Breaking barriers: improving time and space resolution of arbuscular mycorrhizal symbiosis with single-cell sequencing approaches	4
HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells	4
Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma	4
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway	4
Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes	4
Topological determinants in protein folding dynamics: a comparative analysis of metamorphic proteins	4
Large-scale bulk and single-cell RNA sequencing combined with machine learning reveals glioblastoma-associated neutrophil heterogeneity and establishes a VEGFA+ neutrophil prognostic model	4
Ubiquitin recruiting chimera: more than just a PROTAC	4
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway	4
Correction: ILC1-derived IFN-γ regulates macrophage activation in colon cancer	4
Total network controllability analysis discovers explainable drugs for Covid-19 treatment	4
Active enhancers: recent research advances and insights into disease	4
Overexpression of ZNF488 supports pancreatic cancer cell proliferation and tumorigenesis through inhibition of ferroptosis via regulating SCD1-mediated unsaturated fatty acid metabolism	4
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1	4
H3K27ac-activated EGFR-AS1 promotes cell growth in cervical cancer through ACTN4-mediated WNT pathway	4
Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression	4
Evolution of retrocopies in the context of HUSH silencing	4
USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1	4
LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A	4
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity	4
GALNT9 enrichment attenuates MPP+-induced cytotoxicity by ameliorating protein aggregations containing α-synuclein and mitochondrial dysfunction	4
Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches	4
Are prime numbers special? Insights from the life sciences	4
Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest	4
Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism	4
Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells	4
Correction: METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway	4
YTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6	4
E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma	4
Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer	4