Biology Direct

Article	Citations
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	69
Long-term longitudinal study on swine VML model	53
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	53
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	52
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	44
Moving biology direct towards a new dimension	39
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	35
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	34
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	34
Wandering about allostery	33
NID1 promotes laryngeal cancer stemness via activating WNT pathway	31
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	29
Deciphering the role of SAMHD1 in endometrial cancer progression	29
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	28
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	28
Dualistic role of ZEB1 and ZEB2 in tumor progression	28
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	26
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	25
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	24
The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	24
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	24
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	23
Conventional type 1 dendritic cells (cDC1) in cancer immunity	22
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	22
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	21

DTX2 promotes glioma development via regulation of HLTF	19
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	19
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	18
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	18
The p53 family member p73 in the regulation of cell stress response	18
p53 regulates expression of nuclear envelope components in cancer cells	16
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	16
Martin Karplus (1930–2024)	15
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	15
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	15
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	15
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	14
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	14
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	13
Lipidome atlas of p53 mutant variants in pancreatic cancer	13
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	12
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	12
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	12
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	12
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	12
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	11
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	11
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	11
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	11
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	11
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	10
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	10
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	10
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	10
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	10
Eraldo Antonini Lectures, 1983–2019	10
Artificial genetic polymers against human pathologies	10
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	10
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	9
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	9
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	9
A link between mitotic defects and mitotic catastrophe: detection and cell fate	9
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	9
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	9
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	9
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	9
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	9
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	9
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	8
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	8
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	8
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	8
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	8
Understanding p53 tumour suppressor network	8
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	8

RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	8
Biological roles of RNA m7G modification and its implications in cancer	8
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	7
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	7
A functional approach to homeostatic regulation	7
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	7
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	6
Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma	6
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway	6
Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process	6
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	6
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis	6
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	6
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis	6
cGAS-STING targeting offers therapy choice in lung diseases	6
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	6
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	6
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	6
Host-mediated RNA editing in viruses	6
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	6
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis	5
Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers	5
Identification of fatty acid metabolism-related lncRNAs in the prognosis and immune microenvironment of colon adenocarcinoma	5
Did the early full genome sequencing of yeast boost gene function discovery?	5
PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome	5
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	5
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn	5
Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease	5
Genomic characteristics and evolution of Multicentric Esophageal and gastric Cardiac Cancer	5
Ultrastructural studies distinguish skin diversities among Galápagos iguanas	5
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	5
Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation	5
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	5
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging	5
Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9	5
Redressing the interactions between stem cells and immune system in tissue regeneration	5
Unveiling the molecular profile of a prostate carcinoma: implications for personalized medicine	4
Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque	4
Exploring the association between osteoporosis and kidney stones: a clinical to mechanistic translational study based on big data and bioinformatics	4
GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy	4
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma	4
METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway	4
AQP5 trafficking is regulated by its C-terminal tail and interaction with prolactin-inducible protein	4
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease	4
METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification	4
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways	4
p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer	4
Identifying the driver miRNAs with somatic copy number alterations driving dysregulated ceRNA networks in cancers	4
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo	4
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis	4
Lifestyle-dependent microglial plasticity: training the brain guardians	4
Proteomics and digital subtraction angiography approaches reveal CDH18 as a potential target for therapy of moyamoya disease	4
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway	4
Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasia	4
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis	4
Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle	4
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity	4
Integrating Circle-Seq with transcriptomics reveals genome-wide characterization of extrachromosomal circular DNA for dilated cardiomyopathy	4
Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles	3
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism	3
A glutamine metabolish-associated prognostic model to predict prognosis and therapeutic responses of hepatocellular carcinoma	3
Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway	3
CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis	3
Valentina Tassinari, the legacy of a young scientist	3
Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples	3
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network	3
Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy	3
Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins	3
PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1	3
miR-210 is essential to retinal homeostasis in fruit flies and mice	3
MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis	3
Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression	3
Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development	3
Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions	3
Efficient DNA-free co-targeting of nuclear genes in Chlamydomonas reinhardtii	3
Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma	3
BRD4 sustains p63 transcriptional program in keratinocytes	3
Coordinating energy metabolism and signaling pathways in epithelial self-renewal and differentiation	3
ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway	3
GALNT9 enrichment attenuates MPP+-induced cytotoxicity by ameliorating protein aggregations containing α-synuclein and mitochondrial dysfunction	2

Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest	2
Total network controllability analysis discovers explainable drugs for Covid-19 treatment	2
Machine learning model reveals the role of angiogenesis and EMT genes in glioma patient prognosis and immunotherapy	2
Are prime numbers special? Insights from the life sciences	2
Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma	2
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1	2
LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A	2
Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism	2
Overexpression of ZNF488 supports pancreatic cancer cell proliferation and tumorigenesis through inhibition of ferroptosis via regulating SCD1-mediated unsaturated fatty acid metabolism	2
Breaking barriers: improving time and space resolution of arbuscular mycorrhizal symbiosis with single-cell sequencing approaches	2
Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer	2
HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells	2
Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches	2
Extracellular vesicles derived from different tissues attenuate cardiac dysfunction in murine MI models	2
Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis	2
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer	2
C-MYC-activated lncRNA SNHG20 accelerates the proliferation of diffuse large B cell lymphoma via USP14-mediated deubiquitination of β-catenin	2
Ubiquitin recruiting chimera: more than just a PROTAC	2
Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression	2
Correction: ILC1-derived IFN-γ regulates macrophage activation in colon cancer	2
E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma	2
H3K27ac-activated EGFR-AS1 promotes cell growth in cervical cancer through ACTN4-mediated WNT pathway	2
Active enhancers: recent research advances and insights into disease	2
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity	2
Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor suppressor in clear cell renal cell carcinoma	2
Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma	2
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway	2
Evolution of retrocopies in the context of HUSH silencing	2
USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1	2
YTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6	2