OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pain is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization	42
A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation	33
Electroacupuncture may alleviate neuropathic pain via suppressing P2X7R expression	30
Modulation of microglial activation states by spinal cord stimulation in an animal model of neuropathic pain: Comparing high rate, low rate, and differential target multiplexed programming	26
Epigenetic modifications in neuropathic pain	25
Inflammation in pathogenesis of chronic pain: Foe and friend	24
Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain	21
Transcriptome analysis reveals dysregulation of inflammatory and neuronal function in dorsal root ganglion of paclitaxel-induced peripheral neuropathy rats	19
Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice	17
Trigeminal neuralgia and genetics: A systematic review	17
Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia	16
SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury	13
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction	13
Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model	13
Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of neuropathic and inflammatory pain in adult female mice	12
P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models	12
Cellular and synaptic mechanisms for Parkinson’s disease-related chronic pain	12
MicroRNA-137-mediated inhibition of lysine-specific demethylase-1 prevents against rheumatoid arthritis in an association with the REST/mTOR axis	12
Characterisation of deep dorsal horn projection neurons in the spinal cord of the Phox2a::Cre mouse line	12
Tricyclic antidepressants and selective serotonin reuptake inhibitors but not anticonvulsants ameliorate pain, anxiety, and depression symptoms in an animal model of central post-stroke pain	12
Cortical mechanisms in migraine	12
Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain	11
Mechanisms of acupuncture–electroacupuncture on inflammatory pain	11
Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain	11
NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice	10

Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain	10
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels	10
Trigeminal neuropathic pain causes changes in affective processing of pain in rats	10
Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy	10
Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice	10
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	10
Inhibiting spinal secretory phospholipase A₂ after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling	10
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	9
Epigenetic age predictors in community-dwelling adults with high impact knee pain	9
The interaction between P2X3 and TRPV1 in the dorsal root ganglia of adult rats with different pathological pains	9
Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats via induction of Nrf2-mediated mitochondrial biogenesis	9
Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury	9
Ion channels and pain in Fabry disease	9
Cold pain sensitivity is associated with single-nucleotide polymorphisms of PAR2/F2RL1 and TRPM8	9
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	8
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	8
Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress	8
Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity	8
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	8
Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain	8
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	8
Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice	8
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs	8
Distinct roles of GT1b and CSF-1 in microglia activation in nerve injury-induced neuropathic pain	8
CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats	7
Voxel-based quantitative susceptibility mapping revealed increased cerebral iron over the whole brain in chronic migraine	7
Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study	7
Analgesic effect of gastrin-releasing peptide in the dorsal horn	7
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production	7
Review of complex regional pain syndrome and the role of the neuroimmune axis	7
A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat	7
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	7
Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis	7
BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury	7
Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects	7
Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model	7
Circulating sex steroids and bladder pain sensitivity in dysmenorrhea	7