OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pain is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway	126
Neural adaptation of the reward system in primary dysmenorrhea	75
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	42
Viral vector-mediated interleukin 10 for gene therapy on chronic pain	36
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	36
Long-term effects on functional brain networks in adolescents treated for lumbar disc herniation	29
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	27
RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain	27
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	26
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	24
Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	22
Amino acid transporter SLC38A3 mediates bone cancer pain in rats via the PI3K/AKT/TRPV1 signaling pathway	20
In memory of Dr. Howard Fields	19
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	17
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	16
EXPRESS: Evaluation of Stress Biomarkers in individuals with Migraine or Tension-Type headached before and after Botulinum Toxin Injection	15
Caffeic acid phenethyl ester attenuates inflammatory pain through promoting spinal microglial M1-to-M2 polarization by suppressing the PI3K/Akt/NF-κB pathway and attenuating peripheral inflammation	15
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	14
CGRP expression and signaling sensitization in a mouse model of chronic oxaliplatin-induced peripheral neuropathy	14
miRNA-let7b5p alleviates visceral hypersensitivity by inhibiting the activation of spinal microglial in male IBS-like rats	14
Unraveling the PVN ^Glu -PrL ^Glu circuit: A new frontier in chronic pain management for lumbar disc	14
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	13
A note on estimating absolute cytosolic Ca ²⁺ concentration in sensory neurons using a single wavelength Ca ²⁺	12
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	12
Electroacupuncture at Zusanli (ST36) alleviates paclitaxel-induced neuropathic pain in rats via regulating TLR4 signaling pathway in the spinal cord	12

Piezo1-mediated neuroexcitation via collaboration with KCa1.1 and Nav1.9 currents in myelinated Ah-type of trigeminal ganglion neurons in rats: Mechanistic insights with sex-specific effects	12
T cells modulate the development and maintenance of painful paclitaxel-induced peripheral neuropathy in RNU rats	12
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	11
Inflammation in pathogenesis of chronic pain: Foe and friend	11
Pain and aging: A unique challenge in neuroinflammation and behavior	11
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	10
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	10
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p , and 15q13.3 hotspot CNVs in migraineurs	10
Effects of cooling on the excitability of trigeminal Aβ-afferent nociceptors in mice: Involvement of temperature-sensitive K2P channels	10
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	10
Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients	10
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	10
Meningeal macrophages mask incision pain sensitization in male rats	10
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	10
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	9
Contribution of immune cells to cancer-related neuropathic pain: An updated review	9
Identification of acetylation-related molecular signatures in knee osteoarthritis patients with significant response to warm-needle acupuncture using machine-learning approaches	9
Spinal overexpression of CAPN1 in CaMKII neurons mediates paclitaxel-induced neuropathic pain via NCS-1-TRPV4 signaling	8
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	8
Serum miR-145-5p as a predictive biomarker for postoperative pain after percutaneous kyphoplasty	8
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	8
Circadian gene NPAS2 modulates pain sensitization in CFA-induced inflammatory pain model	8
Mechanism of asiatic acid in relieving psoriasis by modulating the PI3K/Akt/NF-κB pathway and NLRP3 inflammasome	8
Redox-associated gene and microRNA signatures in degenerative intervertebral disc disease	8
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
Analgesia and silymarin: What are the opportunities and challenges?	7
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	7
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	7
EXPRESS: A Road to Recovery: Transient Receptor Potential (TRP) Channels as Therapeutic Avenues for Spinal Cord Injury	7
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	7
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	7
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	7
Exploring novel non-opioid pathways and therapeutics for pain modulation	7
Exploring frequency-dependent and dynamic changes in brain connectivity of chronic back pain patients using degree centrality analysis	7
Dezocine alleviates cancer-induced bone pain and suppresses intraosseous tumor growth in renal cell carcinoma via the NAMPT/NAD+ axis	6
AMPAkines have site-specific analgesic effects in the cortex	6
Corrigendum to “Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress”	6
Lithium prevents the neurotoxic effects of paclitaxel mediated through TRPA1 channels	6
Pain and Inflammatory Biomarkers: Phytoactive Therapeutics and Drug Delivery Advances	6
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	6
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus	6
Silent synapses in pain-related anterior cingulate cortex	6
Transcriptome profiling and experimental validation identify FOS, RAC2, and TYROBP as potential biomarkers for Fu’s subcutaneous needling in neuropathic pain treatment	6
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	6
Therapeutic modulation of pain-related affective disorders by acupuncture: Mechanistic review	6