OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization	33
Electroacupuncture may alleviate neuropathic pain via suppressing P2X7R expression	25
Modulation of microglial activation states by spinal cord stimulation in an animal model of neuropathic pain: Comparing high rate, low rate, and differential target multiplexed programming	23
A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation	22
Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain	16
Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia	15
Trigeminal neuralgia and genetics: A systematic review	14
Epigenetic modifications in neuropathic pain	14
SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury	12
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction	11
MicroRNA-137-mediated inhibition of lysine-specific demethylase-1 prevents against rheumatoid arthritis in an association with the REST/mTOR axis	11
Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model	10
Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of neuropathic and inflammatory pain in adult female mice	10
Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy	9
Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain	9
Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain	9
Transcriptome analysis reveals dysregulation of inflammatory and neuronal function in dorsal root ganglion of paclitaxel-induced peripheral neuropathy rats	9
The interaction between P2X3 and TRPV1 in the dorsal root ganglia of adult rats with different pathological pains	9
Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain	8
Distinct roles of GT1b and CSF-1 in microglia activation in nerve injury-induced neuropathic pain	8
Inhibiting spinal secretory phospholipase A₂ after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling	8
Tricyclic antidepressants and selective serotonin reuptake inhibitors but not anticonvulsants ameliorate pain, anxiety, and depression symptoms in an animal model of central post-stroke pain	8
Inflammation in pathogenesis of chronic pain: Foe and friend	8
Characterisation of deep dorsal horn projection neurons in the spinal cord of the Phox2a::Cre mouse line	8
Cold pain sensitivity is associated with single-nucleotide polymorphisms of PAR2/F2RL1 and TRPM8	8

NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice	8
Cortical mechanisms in migraine	8
Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice	8
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	7
Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats via induction of Nrf2-mediated mitochondrial biogenesis	7
Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice	7
Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity	7
Cellular and synaptic mechanisms for Parkinson’s disease-related chronic pain	7
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	7
P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models	7
Ion channels and pain in Fabry disease	7
Epigenetic age predictors in community-dwelling adults with high impact knee pain	6
Neuropeptide W, an endogenous NPBW1 and NPBW2 ligand, produced an analgesic effect via activation of the descending pain modulatory system during a rat formalin test	6
Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice	6
Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects	6
Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model	6
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia	6
Trigeminal neuropathic pain causes changes in affective processing of pain in rats	6
Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain	6
Analgesic effect of gastrin-releasing peptide in the dorsal horn	6
Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis	6
Review of complex regional pain syndrome and the role of the neuroimmune axis	6
Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study	5
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	5
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	5
The brinker repressor system regulates injury-induced nociceptive sensitization in Drosophila melanogaster	5
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	5
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	5
Analgesic characteristics of a newly developed α₂δ ligand, mirogabalin, on inflammatory pain	5
Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain	5
Spinal GABAergic neurons are under feed-forward inhibitory control driven by Aδ and C fibers in Gad2 td-Tomato mice	5
Lack of correlation between spinal microgliosis and long-term development of tactile hypersensitivity in two different sciatic nerve crush injury	4
Abnormal neurometabolites in fibromyalgia patients: Magnetic resonance spectroscopy study	4
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	4
Vascular endothelial growth factor-A/vascular endothelial growth factor2 signaling in spinal neurons contributes to bone cancer pain	4
A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat	4
Circulating sex steroids and bladder pain sensitivity in dysmenorrhea	4
Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: An	4
L-Acetylcarnitine causes analgesia in mice modeling Fabry disease by up-regulating type-2 metabotropic glutamate receptors	4
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	4
Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross	4
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels	4
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	4
CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats	4
Pain and aging: A unique challenge in neuroinflammation and behavior	4
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis	4
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	4
Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress	4
Interferon-β suppresses inflammatory pain through activating µ-opioid receptor	4
Increased nerve growth factor expression in the synovial tissues of patients with rotator cuff tears	3

Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity	3
Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress	3
Systematic analysis of inflammation and pain pathways in a mouse model of gout	3
Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury	3
Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats	3
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	3
The increased iron deposition of the gray matter over the whole brain in chronic migraine: An exploratory quantitative susceptibility mapping study	3
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	3
Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief	3
An operant temperature sensory assay provides a means to assess thermal discrimination	3
Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord	3
Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation	3
Voxel-based quantitative susceptibility mapping revealed increased cerebral iron over the whole brain in chronic migraine	3
Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner	3
Seeding of breast cancer cell line (MDA-MB-231^LUC+) to the mandible induces overexpression of substance P and CGRP throughout the trigeminal ganglion and widespread peripheral sensory neuro	3
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	3
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs	3
The emerging role of kainate receptor functional dysregulation in pain	3
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis	3
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	3
BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury	3
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	3
Sexual dimorphic role of the glucocorticoid receptor in chronic muscle pain produced by early-life stress	3
The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion	3
LncRNA MEG3-TRPV1 signaling regulates chronic inflammatory pain in rats	2
Effects of GABA_B receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation	2
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	2
Offset analgesia is associated with opposing modulation of medial versus dorsolateral prefrontal cortex activations: A functional near-infrared spectroscopy study	2
Severities in persistent mild traumatic brain injury related headache is associated with changes in supraspinal pain modulatory functions	2
microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression	2
Chemokine CCL7 mediates trigeminal neuropathic pain via CCR2/CCR3-ERK pathway in the trigeminal ganglion of mice	2
Electrophysiological properties of maxillary trigeminal Aβ-afferent neurons of rats	2
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	2
Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)	2
Melatonin attenuated chronic visceral pain by reducing Na_v1.8 expression and nociceptive neuronal sensitization	2
Differential modulation of thermal preference after sensitization by optogenetic or pharmacological activation of heat-sensitive nociceptors	2
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	2
Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats	2
Heparan sulfate 3-O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus–mediated fusogenic activity	2
Epitranscriptomic profiling of N4-acetylcytidine-related RNA acetylation in the spinal dorsal horn of rat with cancer-induced bone pain	2
Inhibition of NKCC1 in spinal dorsal horn and dorsal root ganglion results in alleviation of neuropathic pain in rats with spinal cord contusion	2
Extracellular signal-regulated kinase phosphorylation enhancement and Na_V1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic	2
Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats	2
Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: Preliminary observations	2
Association of serotonin transporter-linked polymorphic region (5-HTTLPR) with heat pain stimulation and postoperative pain in gastric cancer patients	2
Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury	2
Enhancement of morphine-induced antinociception after electroconvulsive shock in mice	2
Effects of administration of α₂ adrenergic receptor agonist into psoas major muscle on inflammatory pain induced by injection of complete Freund’s adjuvant in rats	2
Expression of Piezo mRNA is unaffected in a rat model of knee osteoarthritis	2
The holistic approach to theCHRNA7gene,hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	2
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production	2
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain	2