OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
T-type Ca²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	49
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	27
Neural Adaptation of the Reward System in Primary Dysmenorrhea	24
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	23
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	21
Analgesic effect of gastrin-releasing peptide in the dorsal horn	21
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	19
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	17
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain	15
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	13
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone	12
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	12
A note on estimating absolute cytosolic Ca²⁺ concentration in sensory neurons using a single wavelength Ca²⁺ indicator	12
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients	12
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	12
Inflammation in pathogenesis of chronic pain: Foe and friend	11
Pain and aging: A unique challenge in neuroinflammation and behavior	11
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	11
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	11
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	11
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	11
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	10
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	10
The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study	10
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	10

miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	10
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	9
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	9
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	9
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	9
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	9
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	8
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	8
Contribution of immune cells to cancer-related neuropathic pain: An updated review	8
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	8
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	8
Epigenetic age predictors in community-dwelling adults with high impact knee pain	8
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	7
Exploring novel non-opioid pathways and therapeutics for pain modulation	7
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	7
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	7
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	7
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	7
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	7
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	7
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	6
AMPAkines have site-specific analgesic effects in the cortex	6
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	6
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	6
Silent synapses in pain-related anterior cingulate cortex	6
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	6
Curcumin relieves CFA-induced inflammatory pain by inhibiting the AP-1/c-Jun-CCL2-CCR2 pathway in the spinal dorsal horn	6
Sudan Black B treatment uncovers the distribution of angiotensin-converting enzyme2 in nociceptors	6
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus	6
Corrigendum to “Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress”	5
Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats	5
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity	5
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part 2. Biophysics and gene expr	5
Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent	5
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis	5
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	5
Urolithin A alleviates neuropathic pain and activates mitophagy	4
Cholinergic modulation is independent of T lymphocytes in a mouse model of neuropathic pain	4
Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice	4
Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats	4
Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats	4
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis	4
Gut microbiota-derived short-chain fatty acid suppresses the excitability of rat nociceptive secondary neurons via G-protein-coupled receptor 41 signaling	4
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	4
Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain	4
Concomitant use of pre-emptive analgesia with local and general anesthesia in rat uterine pain surgical model	4
Neurotropin^® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response	4
Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain	4
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y₁₂ receptor expression in the spinal cord	4

microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression	4
Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions	4
Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation	4
Vascular endothelial growth factor-A/vascular endothelial growth factor2 signaling in spinal neurons contributes to bone cancer pain	4
Polysorbate 80 blocked a peripheral sodium channel, Na_v1.7, and reduced neuronal excitability	4
Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord	4
Mitochondrial dysfunction and disulfidptosis co-regulate neuronal cell in neuropathic pain based on bioinformatics analysis	3
Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse	3
Low-frequency electroacupuncture exerts antinociceptive effects through activation of POMC neural circuit induced endorphinergic input to the periaqueductal gray from the arcuate nucleus	3
Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)	3
Identification of genetic variations in μ opioid receptor in cats	3
The pace of biological aging helps explain the association between insomnia and chronic low back pain	3
Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross	3
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	3
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	3
Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity	3
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part. 1: Behavior and single-cel	3
Puerarin improves the comorbidity of chronic pain and depression by binding with Bax and reducing mitochondrial dysfunction	3
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	3
Melatonin attenuated chronic visceral pain by reducing Na_v1.8 expression and nociceptive neuronal sensitization	3
Association between migraine and mitochondria: A Mendelian randomization study	3
Systematic analysis of inflammation and pain pathways in a mouse model of gout	3
NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin	3
Sound-induced analgesia cannot always be observed in adult mice	3
Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund’s adjuvant	2
Causal associations of immune cell phenotypes with migraine: A mendelian randomization study	2
Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress	2
Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain	2
Adverse effects of methylene blue in peripheral neurons: An in vitro electrophysiology and cell culture study	2
In silico exploration of bioactive secondary metabolites with anesthetic effects on sodium channels Nav 1.7, 1.8, and 1.9 in painful human dental pulp	2
Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA	2
Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice	2
Newly discovered functions of miRNAs in neuropathic pain: Transitioning from recent discoveries to innovative underlying mechanisms	2
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia	2
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs	2
Effects of systemic oxytocin administration on ultraviolet B-induced nociceptive hypersensitivity and tactile hyposensitivity in mice	2
Temporal alterations of pituitary adenylate cyclase activating polypeptide and its receptors in a rat model induced by recurrent chemical stimulations: Relevant to chronic migraine	2
Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors	2
Effects of administration of α₂ adrenergic receptor agonist into psoas major muscle on inflammatory pain induced by injection of complete Freund’s adjuvant in rats	2
Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia	2
Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain	2
Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: Preliminary observations	2
Toll-like receptor 4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via transient receptor potential ankyrin 1	2