OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway	126
Neural adaptation of the reward system in primary dysmenorrhea	75
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	42
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	36
Viral vector-mediated interleukin 10 for gene therapy on chronic pain	36
Long-term effects on functional brain networks in adolescents treated for lumbar disc herniation	29
RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain	27
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	27
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	26
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	24
Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	22
Amino acid transporter SLC38A3 mediates bone cancer pain in rats via the PI3K/AKT/TRPV1 signaling pathway	20
In memory of Dr. Howard Fields	19
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	17
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	16
Caffeic acid phenethyl ester attenuates inflammatory pain through promoting spinal microglial M1-to-M2 polarization by suppressing the PI3K/Akt/NF-κB pathway and attenuating peripheral inflammation	15
EXPRESS: Evaluation of Stress Biomarkers in individuals with Migraine or Tension-Type headached before and after Botulinum Toxin Injection	15
CGRP expression and signaling sensitization in a mouse model of chronic oxaliplatin-induced peripheral neuropathy	14
miRNA-let7b5p alleviates visceral hypersensitivity by inhibiting the activation of spinal microglial in male IBS-like rats	14
Unraveling the PVN ^Glu -PrL ^Glu circuit: A new frontier in chronic pain management for lumbar disc	14
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	14
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	13
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	12
Electroacupuncture at Zusanli (ST36) alleviates paclitaxel-induced neuropathic pain in rats via regulating TLR4 signaling pathway in the spinal cord	12
Piezo1-mediated neuroexcitation via collaboration with KCa1.1 and Nav1.9 currents in myelinated Ah-type of trigeminal ganglion neurons in rats: Mechanistic insights with sex-specific effects	12

T cells modulate the development and maintenance of painful paclitaxel-induced peripheral neuropathy in RNU rats	12
A note on estimating absolute cytosolic Ca ²⁺ concentration in sensory neurons using a single wavelength Ca ²⁺	12
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	11
Inflammation in pathogenesis of chronic pain: Foe and friend	11
Pain and aging: A unique challenge in neuroinflammation and behavior	11
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p , and 15q13.3 hotspot CNVs in migraineurs	10
Effects of cooling on the excitability of trigeminal Aβ-afferent nociceptors in mice: Involvement of temperature-sensitive K2P channels	10
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	10
Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients	10
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	10
Meningeal macrophages mask incision pain sensitization in male rats	10
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	10
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	10
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	10
Contribution of immune cells to cancer-related neuropathic pain: An updated review	9
Identification of acetylation-related molecular signatures in knee osteoarthritis patients with significant response to warm-needle acupuncture using machine-learning approaches	9
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	9
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	8
Circadian gene NPAS2 modulates pain sensitization in CFA-induced inflammatory pain model	8
Mechanism of asiatic acid in relieving psoriasis by modulating the PI3K/Akt/NF-κB pathway and NLRP3 inflammasome	8
Redox-associated gene and microRNA signatures in degenerative intervertebral disc disease	8
Spinal overexpression of CAPN1 in CaMKII neurons mediates paclitaxel-induced neuropathic pain via NCS-1-TRPV4 signaling	8
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	8
Serum miR-145-5p as a predictive biomarker for postoperative pain after percutaneous kyphoplasty	8
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	7
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	7
EXPRESS: A Road to Recovery: Transient Receptor Potential (TRP) Channels as Therapeutic Avenues for Spinal Cord Injury	7
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	7
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	7
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	7
Exploring novel non-opioid pathways and therapeutics for pain modulation	7
Exploring frequency-dependent and dynamic changes in brain connectivity of chronic back pain patients using degree centrality analysis	7
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
Analgesia and silymarin: What are the opportunities and challenges?	7
Corrigendum to “Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress”	6
Lithium prevents the neurotoxic effects of paclitaxel mediated through TRPA1 channels	6
Pain and Inflammatory Biomarkers: Phytoactive Therapeutics and Drug Delivery Advances	6
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	6
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus	6
Silent synapses in pain-related anterior cingulate cortex	6
Transcriptome profiling and experimental validation identify FOS, RAC2, and TYROBP as potential biomarkers for Fu’s subcutaneous needling in neuropathic pain treatment	6
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	6
Therapeutic modulation of pain-related affective disorders by acupuncture: Mechanistic review	6
Dezocine alleviates cancer-induced bone pain and suppresses intraosseous tumor growth in renal cell carcinoma via the NAMPT/NAD+ axis	6
AMPAkines have site-specific analgesic effects in the cortex	6
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis	5
Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats	5
Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions	5
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	5
Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent	5

Curcumin relieves CFA-induced inflammatory pain by inhibiting the AP-1/c-Jun-CCL2-CCR2 pathway in the spinal dorsal horn	5
Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain	5
Targeting sphingosine-1-phosphate receptor 1 alleviates neuropathic pain associated with pancreatic ductal adenocarcinoma in mice and inhibits tumor progression	5
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity	5
Interaction of chronic daily headache, dietary intake of iron, and FTO genotype	5
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part 2. Biophysics and gene expr	5
Gut microbiota-derived short-chain fatty acid suppresses the excitability of rat nociceptive secondary neurons via G-protein-coupled receptor 41 signaling	5
Urolithin A alleviates neuropathic pain and activates mitophagy	4
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y ₁₂ receptor	4
microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression	4
Gabapentin’s effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles	4
Characterisation of neurotensin-expressing interneurons in the mouse spinal dorsal horn	4
Mechanism of human umbilical cord mesenchymal stem cell-derived exosomes in alleviating neuropathic pain in CCI rats	4
Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation	4
The involvement of spinal lncRNA RT1-CE10 in chronic functional visceral pain	4
Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats	4
Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice	4
Concomitant use of pre-emptive analgesia with local and general anesthesia in rat uterine pain surgical model	4
Brain networking pain and anxiety: From basic mechanism to future treatment	4
Polysorbate 80 blocked a peripheral sodium channel, Na _v 1.7, and reduced neuronal excitability	4
Identification of genetic variations in μ opioid receptor in cats	3
Neurotropin ^® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response	3
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	3
Cortical mechanism of emotional pain	3
Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse	3
Mitochondrial dysfunction and disulfidptosis co-regulate neuronal cell in neuropathic pain based on bioinformatics analysis	3
Puerarin improves the comorbidity of chronic pain and depression by binding with Bax and reducing mitochondrial dysfunction	3
Melatonin attenuated chronic visceral pain by reducing Na _v 1.8 expression and nociceptive neuronal sensitization	3
The enhanced analgesic effects of electroacupuncture and repetitive transcranial magnetic stimulation on visceral pain via ventral lateral septal nucleus	3
Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain	3
Low-frequency electroacupuncture exerts antinociceptive effects through activation of POMC neural circuit induced endorphinergic input to the periaqueductal gray from the arcuate nucleus	3
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	3
Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity	3
Systemic curcumin administration mitigates neuropathic pain in a rat model of trigeminal neuralgia by suppressing TNF-α and pSTAT3 signaling	3
FK506 causes pain by upregulating Na _V 1.7 channels in the spinal dorsal root ganglia of Na _V 1.7–	3
Circulating microRNAs associated with acupuncture-induced Substance P reduction in chronic neck pain: Evidence for a neuroplasticity mechanism	3
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	3
The butterfly effect and its electrical mechanism: Non-linear non-reciprocate sawtooth subthreshold oscillations deactivate nociceptors	3
Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)	3
Association between migraine and mitochondria: A Mendelian randomization study	3
EXPRESS: Precursor signaling redefined: proneurotrophin-3, not neurotrophin-3, in primary sensory neurons as an instigator in neuropathic pain	2
Expression of Tacr1 and Gpr83 by spinal projection neurons	2
Evodiamine attenuates chemotherapy-induced peripheral neuropathy by mediating macrophage M2 polarization and inhibiting the upregulation of the p38 MAPK-TRPV1 axis in rat dorsal root ganglia	2
RIN1 inhibited TRPV1-dependent pain sensitization in a mouse model of bone cancer pain	2
Sound-induced analgesia cannot always be observed in adult mice	2
MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury	2
Bradykinin B2 receptor triggers ITPR1-Mediated ER calcium release in trigeminal ganglion neurons to drive trigeminal neuropathic pain	2
Risk factors associated with chronic pain and fibromyalgia-like symptoms post-COVID hospitalization	2
Honokiol and analgesia: A mechanistic review on the current capacities and challenges	2
Causal associations of immune cell phenotypes with migraine: A mendelian randomization study	2
Copper chelator ammonium tetrathiomolybdate ameliorates the visceral hypersensitivity in dextran sulfate sodium-induced colitis mice	2
Dehydrocorydaline can be a suitable candidate for analgesic purposes: a review on the current preclinical evidence	2
Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund’s adjuvant	2
NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin	2
The pace of biological aging helps explain the association between insomnia and chronic low back pain	2
Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors	2
Newly discovered functions of miRNAs in neuropathic pain: Transitioning from recent discoveries to innovative underlying mechanisms	2
Stimulation of spinal afferents from skin activates parabrachial neurons that respond to taste	2
Orbital tightening assessment to evaluate pain and physical discomfort in chlorine-exposed rats: A machine learning based measurement approach	2
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part. 1: Behavior and single-cel	2
Olfactory ensheathing cell transplantation targets macrophage extracellular traps and NKCC1 to alleviate pain after spinal cord injury	2