OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization	42
A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation	33
Electroacupuncture may alleviate neuropathic pain via suppressing P2X7R expression	30
Modulation of microglial activation states by spinal cord stimulation in an animal model of neuropathic pain: Comparing high rate, low rate, and differential target multiplexed programming	26
Epigenetic modifications in neuropathic pain	25
Inflammation in pathogenesis of chronic pain: Foe and friend	24
Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain	21
Transcriptome analysis reveals dysregulation of inflammatory and neuronal function in dorsal root ganglion of paclitaxel-induced peripheral neuropathy rats	19
Trigeminal neuralgia and genetics: A systematic review	17
Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice	17
Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia	16
Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model	13
SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury	13
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction	13
Tricyclic antidepressants and selective serotonin reuptake inhibitors but not anticonvulsants ameliorate pain, anxiety, and depression symptoms in an animal model of central post-stroke pain	12
Cortical mechanisms in migraine	12
Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of neuropathic and inflammatory pain in adult female mice	12
P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models	12
Cellular and synaptic mechanisms for Parkinson’s disease-related chronic pain	12
MicroRNA-137-mediated inhibition of lysine-specific demethylase-1 prevents against rheumatoid arthritis in an association with the REST/mTOR axis	12
Characterisation of deep dorsal horn projection neurons in the spinal cord of the Phox2a::Cre mouse line	12
Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain	11
Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain	11
Mechanisms of acupuncture–electroacupuncture on inflammatory pain	11
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	10

Inhibiting spinal secretory phospholipase A₂ after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling	10
NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice	10
Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain	10
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels	10
Trigeminal neuropathic pain causes changes in affective processing of pain in rats	10
Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy	10
Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice	10
Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury	9
Ion channels and pain in Fabry disease	9
Cold pain sensitivity is associated with single-nucleotide polymorphisms of PAR2/F2RL1 and TRPM8	9
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	9
Epigenetic age predictors in community-dwelling adults with high impact knee pain	9
The interaction between P2X3 and TRPV1 in the dorsal root ganglia of adult rats with different pathological pains	9
Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats via induction of Nrf2-mediated mitochondrial biogenesis	9
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs	8
Distinct roles of GT1b and CSF-1 in microglia activation in nerve injury-induced neuropathic pain	8
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	8
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	8
Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress	8
Systemic administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity	8
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	8
Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain	8
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	8
Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice	8
Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis	7
BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury	7
Dysfunctional energy metabolisms in fibromyalgia compared with healthy subjects	7
Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model	7
Circulating sex steroids and bladder pain sensitivity in dysmenorrhea	7
CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats	7
Voxel-based quantitative susceptibility mapping revealed increased cerebral iron over the whole brain in chronic migraine	7
Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study	7
Analgesic effect of gastrin-releasing peptide in the dorsal horn	7
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production	7
Review of complex regional pain syndrome and the role of the neuroimmune axis	7
A role for gut microbiota in early-life stress-induced widespread muscle pain in the adult rat	7
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	7
Systematic analysis of inflammation and pain pathways in a mouse model of gout	6
Pain and aging: A unique challenge in neuroinflammation and behavior	6
Spinal GABAergic neurons are under feed-forward inhibitory control driven by Aδ and C fibers in Gad2 td-Tomato mice	6
Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain	6
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis	6
Neuropeptide W, an endogenous NPBW1 and NPBW2 ligand, produced an analgesic effect via activation of the descending pain modulatory system during a rat formalin test	6
Analgesic characteristics of a newly developed α₂δ ligand, mirogabalin, on inflammatory pain	6
The brinker repressor system regulates injury-induced nociceptive sensitization in Drosophila melanogaster	6
Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross	6
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia	6
Melatonin attenuated chronic visceral pain by reducing Na_v1.8 expression and nociceptive neuronal sensitization	5
Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord	5
Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats	5

Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	5
Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress	5
Sexual dimorphic role of the glucocorticoid receptor in chronic muscle pain produced by early-life stress	5
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	5
Increased nerve growth factor expression in the synovial tissues of patients with rotator cuff tears	5
Vascular endothelial growth factor-A/vascular endothelial growth factor2 signaling in spinal neurons contributes to bone cancer pain	5
An operant temperature sensory assay provides a means to assess thermal discrimination	5
Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief	5
LncRNA MEG3-TRPV1 signaling regulates chronic inflammatory pain in rats	4
Effects of GABA_B receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation	4
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	4
L-Acetylcarnitine causes analgesia in mice modeling Fabry disease by up-regulating type-2 metabotropic glutamate receptors	4
Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury	4
The increased iron deposition of the gray matter over the whole brain in chronic migraine: An exploratory quantitative susceptibility mapping study	4
Effects of administration of α₂ adrenergic receptor agonist into psoas major muscle on inflammatory pain induced by injection of complete Freund’s adjuvant in rats	4
Interferon-β suppresses inflammatory pain through activating µ-opioid receptor	4
Chemokine CCL7 mediates trigeminal neuropathic pain via CCR2/CCR3-ERK pathway in the trigeminal ganglion of mice	4
Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: An	4
Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: Preliminary observations	4
Abnormal neurometabolites in fibromyalgia patients: Magnetic resonance spectroscopy study	4
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	4
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	4
The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion	4
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	4
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	4
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	4
Extracellular signal-regulated kinase phosphorylation enhancement and Na_V1.7 sodium channel upregulation in rat dorsal root ganglia neurons contribute to resiniferatoxin-induced neuropathic	4
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity	4
Lack of correlation between spinal microgliosis and long-term development of tactile hypersensitivity in two different sciatic nerve crush injury	4
Seeding of breast cancer cell line (MDA-MB-231^LUC+) to the mandible induces overexpression of substance P and CGRP throughout the trigeminal ganglion and widespread peripheral sensory neuro	4
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	4
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	4
Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats	4
Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia	4
Expression of Piezo mRNA is unaffected in a rat model of knee osteoarthritis	4
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain	4
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis	4
Epitranscriptomic profiling of N4-acetylcytidine-related RNA acetylation in the spinal dorsal horn of rat with cancer-induced bone pain	3
Conventional, high frequency and differential targeted multiplexed spinal cord stimulation in experimental painful diabetic peripheral neuropathy: Pain behavior and role of the central inflammatory ba	3
The emerging role of kainate receptor functional dysregulation in pain	3
Offset analgesia is associated with opposing modulation of medial versus dorsolateral prefrontal cortex activations: A functional near-infrared spectroscopy study	3
Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats	3
Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund’s adjuvant	3
Electrophysiological properties of maxillary trigeminal Aβ-afferent neurons of rats	3
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	3
Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)	3
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	3
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone	3
Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner	3
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	3
Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation	3
Association of serotonin transporter-linked polymorphic region (5-HTTLPR) with heat pain stimulation and postoperative pain in gastric cancer patients	3
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	3
Newly discovered functions of miRNAs in neuropathic pain: Transitioning from recent discoveries to innovative underlying mechanisms	3
Contribution of immune cells to cancer-related neuropathic pain: An updated review	3