OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Systems Biology is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
The protein expression profile of ACE2 in human tissues	693
Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation	243
Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative models	207
SBML Level 3: an extensible format for the exchange and reuse of biological models	170
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease	151
Integrated intra‐ and intercellular signaling knowledge for multicellular omics analysis	147
Thermal proteome profiling for interrogating protein interactions	141
RNA velocity—current challenges and future perspectives	125
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation	123
Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome	120
Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations	116
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder	90
A single cell atlas of the human liver tumor microenvironment	88
Mass spectrometry‐based protein–protein interaction networks for the study of human diseases	86
Benchmarking AlphaFold ‐enabled molecular docking predictions for antibiotic discovery	85
From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions	83
scClassify: sample size estimation and multiscale classification of cells using single and multiple reference	79
hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies	77
Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses	73
Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut	73
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks	71
Predicting antigen specificity of single T cells based on TCR CDR 3 regions	65
Reproducibility in systems biology modelling	65
Slower growth of Escherichia coli leads to longer survival in carbon starvation due to a decrease in the maintenance rate	60
Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens	60

Towards a mechanistic understanding of reciprocal drug–microbiome interactions	60
Identification of genomic enhancers through spatial integration of single‐cell transcriptomics and epigenomics	58
Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial	55
Programmable CRISPR‐Cas transcriptional activation in bacteria	54
Evaluating the Arrhenius equation for developmental processes	54
Programming Escherichia coli to function as a digital display	53
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery	52
A guidebook for DISCO tissue clearing	49
Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation	48
Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans	48
In vitro and in vivo identification of clinically approved drugs that modify ACE 2	47
Learning causal networks using inducible transcription factors and transcriptome‐wide time series	47
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms	46
Joint cell segmentation and cell type annotation for spatial transcriptomics	45
High‐throughput, microscope‐based sorting to dissect cellular heterogeneity	45
High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing	45
Enhancing scientific discoveries in molecular biology with deep generative models	44
Systematic analysis of bypass suppression of essential genes	44
P recision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads	43