OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Systems Biology is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
State of the interactomes: an evaluation of molecular networks for generating biological insights	260
Dynamic human liver proteome atlas reveals functional insights into disease pathways	234
Exogenous prion-like proteins and their potential to trigger cognitive dysfunction	136
A split intein and split luciferase-coupled system for detecting protein-protein interactions	100
Development and validation of AI/ML derived splice-switching oligonucleotides	83
Stress‐sensitive dynamics of miRNAs and Elba1 in Drosophila embryogenesis	78
Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities	76
Systematic identification of 20S proteasome substrates	66
Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data	63
A transient mutational burst occurs during yeast colony development	60
Molecular Systems Biology at 20: reflecting on the past, envisioning the future	59
Enhancing nutritional niche and host defenses by modifying the gut microbiome	57
Progress and new challenges in image-based profiling	56
Author Correction: Spatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets	53
Author Correction: Systematic protein-protein interaction mapping for clinically relevant human GPCRs	52
Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy	50
Chromosome length is constrained by spindle scaling to ensure faithful mitosis in mammals	47
Unlocking CRISPR-Cas9 editing for widely diverse Dictyostelid species	46
A proximity proteomics pipeline with improved reproducibility and throughput	45
Dimensionality reduction methods for extracting functional networks from large‐scale CRISPR screens	44
Predicting cellular responses to complex perturbations in high‐throughput screens	43
What we can learn from deep space communication for reproducible bioimaging and data analysis	39
Comprehensive quantitative modeling of translation efficiency in a genome‐reduced bacterium	37
Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci	37
Author Correction: From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions	37

A novel combination therapy for ER+ breast cancer suppresses drug resistance via an evolutionary double-bind	35
Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks	35
Deep learning for protein structure prediction and design—progress and applications	33
Detection of PatIent-Level distances from single cell genomics and pathomics data with Optimal Transport (PILOT)	33
Systematic identification of structure-specific protein–protein interactions	33
Predicting natural variation in the yeast phenotypic landscape with machine learning	32
Author Correction: Predictive evolution of metabolic phenotypes using model-designed environments	32
Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community	32
CANTAO: guiding clustering and annotation in single-cell RNA sequencing using average overlap	32