OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Systems Biology is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
The protein expression profile of ACE2 in human tissues	733
Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation	285
Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative models	251
SBML Level 3: an extensible format for the exchange and reuse of biological models	185
Integrated intra‐ and intercellular signaling knowledge for multicellular omics analysis	169
RNA velocity—current challenges and future perspectives	148
Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations	125
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder	108
Benchmarking AlphaFold ‐enabled molecular docking predictions for antibiotic discovery	106
A single cell atlas of the human liver tumor microenvironment	104
Mass spectrometry‐based protein–protein interaction networks for the study of human diseases	102
From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions	93
hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies	88
Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses	84
Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut	78
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks	78
Reproducibility in systems biology modelling	72
Predicting antigen specificity of single T cells based on TCR CDR 3 regions	71
Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial	68
Towards a mechanistic understanding of reciprocal drug–microbiome interactions	67
Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens	62
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery	62
Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans	60
Programmable CRISPR‐Cas transcriptional activation in bacteria	60
Evaluating the Arrhenius equation for developmental processes	59

Predicting cellular responses to complex perturbations in high‐throughput screens	56
A guidebook for DISCO tissue clearing	56
Protein complexes in cells by AI‐assisted structural proteomics	53
High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing	52
Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation	51
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms	51
Joint cell segmentation and cell type annotation for spatial transcriptomics	51
P recision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads	50
RNA polymerase II clusters form in line with surface condensation on regulatory chromatin	50
In vitro and in vivo identification of clinically approved drugs that modify ACE 2	47
Enhancing scientific discoveries in molecular biology with deep generative models	47
Predictive features of gene expression variation reveal mechanistic link with differential expression	46
Systematic analysis of bypass suppression of essential genes	45
Enabling high‐throughput biology with flexible open‐source automation	44
Proteome constraints reveal targets for improving microbial fitness in nutrient‐rich environments	44
Suboptimal resource allocation in changing environments constrains response and growth in bacteria	42
Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome	42
Conjugation dynamics depend on both the plasmid acquisition cost and the fitness cost	42