OOIR: Observatory of International Research

Papers

(The median citation count of Particle and Fibre Toxicology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature	275
The plastic brain: neurotoxicity of micro- and nanoplastics	271
Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy	186
Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis	159
Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale	137
Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health	93
Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies	90
Cardiovascular health impacts of wildfire smoke exposure	86
Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction	83
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway	74
Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia	73
The critical role of endothelial function in fine particulate matter-induced atherosclerosis	72
Recent insights on indirect mechanisms in developmental toxicity of nanomaterials	62
Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies	61
Coronas of micro/nano plastics: a key determinant in their risk assessments	49
Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO2 nanoparticles in an ex vivo placental perfusion model	49
Consequences of nano and microplastic exposure in rodent models: the known and unknown	48
Airborne particulate matter (PM2.5) triggers ocular hypertension and glaucoma through pyroptosis	46
Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine	46
Ultrasmall iron oxide nanoparticles cause significant toxicity by specifically inducing acute oxidative stress to multiple organs	45
The mechanism of cell death induced by silver nanoparticles is distinct from silver cations	45
Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice	43
Quartz crystal microbalances (QCM) are suitable for real-time dosimetry in nanotoxicological studies using VITROCELL®Cloud cell exposure systems	41
Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model	40
In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT	39

Amorphous silica nanoparticles accelerated atherosclerotic lesion progression in ApoE−/− mice through endoplasmic reticulum stress-mediated CD36 up-regulation in macrophage	38
Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities	37
Influence of wood species on toxicity of log-wood stove combustion aerosols: a parallel animal and air-liquid interface cell exposure study on spruce and pine smoke	37
Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages	37
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells	36
Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in mice	35
Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties	35
Skin damage induced by zinc oxide nanoparticles combined with UVB is mediated by activating cell pyroptosis via the NLRP3 inflammasome–autophagy–exosomal pathway	34
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes	34
Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells	33
Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage	31
PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis	31
Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes	31
Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat	30
Toxicity of particles emitted by fireworks	30
A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence	29
Exposure to diesel exhaust particles results in altered lung microbial profiles, associated with increased reactive oxygen species/reactive nitrogen species and inflammation, in C57Bl/6 wildtype mice	29
Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1)	28
Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation	28
Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system	26
Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19	25
Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes	24
Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults	24
Retained particle surface area dose drives inflammation in rat lungs following acute, subacute, and subchronic inhalation of nanomaterials	24
Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer	23
Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin	23
Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure	22
Oral toxicity of titanium dioxide P25 at repeated dose 28-day and 90-day in rats	21
Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions	21
Nitrogen-doped graphene quantum dots induce ferroptosis through disrupting calcium homeostasis in microglia	21
Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure	21
The combined effect of food additive titanium dioxide and lipopolysaccharide on mouse intestinal barrier function after chronic exposure of titanium dioxide-contained feedstuffs	21
Controlled human exposures to wood smoke: a synthesis of the evidence	21
Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure	20
Occupational exposure to carbon black nanoparticles increases inflammatory vascular disease risk: an implication of an ex vivo biosensor assay	19
Omega-3 fatty acids attenuate cardiovascular effects of short-term exposure to ambient air pollution	19
Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats	19
Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats	18
Silica-coated magnetic nanoparticles activate microglia and induce neurotoxic d-serine secretion	17
The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method	17
Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice	16
Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?	16
Combined exposure to fine particulate matter and high glucose aggravates endothelial damage by increasing inflammation and mitophagy: the involvement of vitamin D	16
Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in r	16
Nanomaterial- and shape-dependency of TLR2 and TLR4 mediated signaling following pulmonary exposure to carbonaceous nanomaterials in mice	16
Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice	16
The pro-inflammatory effects of combined exposure to diesel exhaust particles and mineral particles in human bronchial epithelial cells	15
Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review	15
Respirable stone particles differ in their ability to induce cytotoxicity and pro-inflammatory responses in cell models of the human airways	15
Titanium dioxide nanoparticles enhance thrombosis through triggering the phosphatidylserine exposure and procoagulant activation of red blood cells	15

Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies	15
Biotransformation of rare earth oxide nanoparticles eliciting microbiota imbalance	14
Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo	14
Toxicological evaluation of exhaust emissions from light-duty vehicles using different fuel alternatives in sub-freezing conditions	14
Prolonged exposure to traffic-related particulate matter and gaseous pollutants implicate distinct molecular mechanisms of lung injury in rats	13
Differential effects of intense exercise and pollution on the airways in a murine model	13
Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation	13
Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects	13
Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF-κB-dependent pathway in lung epithelial cells	12
Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study	12
Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats	12
Chronic exposure to diesel exhaust may cause small airway wall thickening without lumen narrowing: a quantitative computerized tomography study in Chinese diesel engine testers	12
Chemistry, lung toxicity and mutagenicity of burn pit smoke-related particulate matter	12
Surface functionalization and size modulate the formation of reactive oxygen species and genotoxic effects of cellulose nanofibrils	12
Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation	12
Exposure to environmentally relevant concentrations of ambient fine particulate matter (PM2.5) depletes the ovarian follicle reserve and causes sex-dependent cardiovascular changes in apolipoprotein E	12
Digital research data: from analysis of existing standards to a scientific foundation for a modular metadata schema in nanosafety	12
Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes	11
Time course of pulmonary inflammation and trace element biodistribution during and after sub-acute inhalation exposure to copper oxide nanoparticles in a murine model	11
Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages	11
Airborne particulate matters induce thrombopoiesis from megakaryocytes through regulating mitochondrial oxidative phosphorylation	11
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile	11
Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models	11
Oxidative stress generated by polycyclic aromatic hydrocarbons from ambient particulate matter enhance vascular smooth muscle cell migration through MMP upregulation and actin reorganization	11
Landscape of lipidomic metabolites in gut-liver axis of Sprague–Dawley rats after oral exposure to titanium dioxide nanoparticles	11
Oxygenated polycyclic aromatic hydrocarbons from ambient particulate matter induce electrophysiological instability in cardiomyocytes	11
Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress	10
Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study	10
Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion	10
Silica-coated magnetic-nanoparticle-induced cytotoxicity is reduced in microglia by glutathione and citrate identified using integrated omics	10
Aluminium oxide nanoparticles compromise spatial memory performance and proBDNF-mediated neuronal function in the hippocampus of rats	10
Respiratory and systemic impacts following MWCNT inhalation in B6C3F1/N mice	10
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats	10
Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study	10
Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty	10
Dose–response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats	9
Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation	9
Compositional and structural analysis of engineered stones and inorganic particles in silicotic nodules of exposed workers	9
Short- and long-term polystyrene nano- and microplastic exposure promotes oxidative stress and divergently affects skin cell architecture and Wnt/beta-catenin signaling	9
Even lobar deposition of poorly soluble gold nanoparticles (AuNPs) is similar to that of soluble silver nanoparticles (AgNPs)	8
Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation	8
Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction	8
Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker	8
Acute phase response following pulmonary exposure to soluble and insoluble metal oxide nanomaterials in mice	8
The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice	8