OOIR: Observatory of International Research

Papers

(The median citation count of Nanotoxicology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
miR-21 mediates nickel nanoparticle-induced pulmonary injury and fibrosis	57
8-Hydroxy-2′-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review	48
Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure	45
Organ-specific toxicity of magnetic iron oxide-based nanoparticles	45
Interaction of nanoparticles with biological macromolecules: a review of molecular docking studies	44
Human hazard potential of nanocellulose: quantitative insights from the literature	43
Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo	43
Nanoparticle-protein corona complex: understanding multiple interactions between environmental factors, corona formation, and biological activity	36
Correlation intensity index: mathematical modeling of cytotoxicity of metal oxide nanoparticles	33
Occupational exposure to graphene and silica nanoparticles. Part I: workplace measurements and samplings	30
Toxicity of nanoplastics during the embryogenesis of the ascidian Ciona robusta (Phylum Chordata)	30
Sex differences in the acute and subchronic lung inflammatory responses of mice to nickel nanoparticles	28
In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice	28
Safety assessment of cerium oxide nanoparticles: combined repeated-dose toxicity with reproductive/developmental toxicity screening and biodistribution in rats	25
Comparative study of nanoparticle uptake and impact in murine lung, liver and kidney tissue slices	25
Multi-walled carbon nanotubes trigger lysosome-dependent cell death (pyroptosis) in macrophages but not in neutrophils	24
Nanopolystyrene beads affect motility and reproductive success of oyster spermatozoa (Crassostrea gigas)	24
Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice	23
A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment	23
Metabolomics profiling to investigate nanomaterial toxicity in vitro and in vivo	23
Drosophila as a model for assessing nanopesticide toxicity	23
CuS–NiS₂ nanomaterials for MRI guided phototherapy of gastric carcinoma via triggering mitochondria-mediated apoptosis and MLKL/CAPG-mediated necroptosis	22
Biomedical nanomaterials: applications, toxicological concerns, and regulatory needs	21
Microplastics and nanoplastics science: collecting and characterizing airborne microplastics in fine particulate matter	21
Occupational exposure to graphene and silica nanoparticles. Part II: pilot study to identify a panel of sensitive biomarkers of genotoxic, oxidative and inflammatory effects on suitable biological mat	21

Acute reproductive toxicology after intratesticular injection of silver nanoparticles (AgNPs) in Wistar rats	20
In vivo percutaneous permeation of gold nanomaterials in consumer cosmetics: implication in dermal safety assessment of consumer nanoproducts	20
A combined microRNA and proteome profiling to investigate the effect of ZnO nanoparticles on neuronal cells	20
Pulmonary toxicity of synthetic amorphous silica – effects of porosity and copper oxide doping	20
miR-205/IRAK2 signaling pathway is associated with urban airborne PM_2.5-induced myocardial toxicity	20
Reactive oxygen species production, genotoxicity and telomere length in FE1-Muta™Mouse lung epithelial cells exposed to carbon nanotubes	19
The sp³/sp² carbon ratio as a modulator of in vivo and in vitro toxicity of the chemically purified detonation-synthesized nanodiamond via the reactive oxyge	19
Metallic-nanoparticle release systems for biomedical implant surfaces: effectiveness and safety	19
Antibacterial application and toxicity of metal–organic frameworks	18
Rationale and decision rules behind the ECETOC NanoApp to support registration of sets of similar nanoforms within REACH	18
Neutrophil activation by nanomaterials in vitro: comparing strengths and limitations of primary human cells with those of an immortalized (HL-60) cell line	18
Time-course effect of ultrasmall superparamagnetic iron oxide nanoparticles on intracellular iron metabolism and ferroptosis activation	17
Ecotoxicological assessment of commercial boron nitride nanotubes toward Xenopus laevis tadpoles and host-associated gut microbiota	16
Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial in vitro model	16
Intercellular transfer of mitochondria via tunneling nanotubes protects against cobalt nanoparticle-induced neurotoxicity and mitochondrial damage	16
Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload	16
Responses to iron oxide and zinc oxide nanoparticles in echinoderm embryos and microalgae: uptake, growth, morphology, and transcriptomic analysis	16
Effects of titanium dioxide nanoparticles on nutrient absorption and metabolism in rats: distinguishing the susceptibility of amino acids, metal elements, and glucose	15
Interaction of nanoparticles with endotoxin Importance in nanosafety testing and exploitation for endotoxin binding	15
Efficient predictions of cytotoxicity of TiO₂-based multi-component nanoparticles using a machine learning-based q-RASAR approach	15
The impact of nanotechnology in the current universal COVID-19 crisis. Let’s not forget nanosafety!	15
Inhaled multi-walled carbon nanotubes differently modulate global gene and protein expression in rat lungs	14
The nanomaterial-induced bystander effects reprogrammed macrophage immune function and metabolic profile	14
Colonizing microbiota protect zebrafish larvae against silver nanoparticle toxicity	14
Unswerving modeling of hepatotoxicity of cadmium containing quantum dots using amalgamation of quasiSMILES, index of ideality of correlation, and consensus modeling	14
MiR-939-5p suppresses PM_2.5-induced endothelial injury via targeting HIF-1α in HAECs	14
Surface atomic arrangement of nanomaterials affects nanotoxicity	14
Polystyrene nanoplastics exposure caused defective neural tube morphogenesis through caveolae-mediated endocytosis and faulty apoptosis	13
Organomodified nanoclays induce less inflammation, acute phase response, and genotoxicity than pristine nanoclays in mice lungs	13
Comparative acute intravenous toxicity study of triple polymer-layered magnetic nanoparticles with bare magnetic nanoparticles in Swiss albino mice	13
Multiple pathways of alveolar macrophage death contribute to pulmonary inflammation induced by silica nanoparticles	13
Characterization of the nano–bio interaction between metallic oxide nanomaterials and freshwater microalgae using flow cytometry	12
Carbon nanotubes promote alveolar macrophages toward M2 polarization mediated epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation	12
Quantifying the relative contribution of particulate versus dissolved silver to toxicity and uptake kinetics of silver nanowires in lettuce: impact of size and coating	12
Impact of copper oxide particle dissolution on lung epithelial cell toxicity: response characterization using global transcriptional analysis	12
Immunotoxic effects of metal-based nanoparticles in fish and bivalves	12
Nanoceria distribution and effects are mouse-strain dependent	11
Role of inflammation in the malignant transformation of pleural mesothelial cells induced by multi-walled carbon nanotubes	11
Quantitative measurement of carbon nanotubes in rat lung	11
Creating sets of similar nanoforms with the ECETOC NanoApp: real-life case studies	11
Machine learning predictions of concentration-specific aggregate hazard scores of inorganic nanomaterials in embryonic zebrafish	11
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death	11
Toxicological effects of zinc oxide nanoparticle exposure: an in vitro comparison between dry aerosol air-liquid interface and submerged exposure systems	11
MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells	11
Overview of potential adverse health effects of oral exposure to nanocellulose	10
Dosimetry in vitro – exploring the sensitivity of deposited dose predictions vs. affinity, polydispersity, freeze-thawing, and analytical methods	10
Polystyrene nanoparticles: the mechanism of their genotoxicity in human peripheral blood mononuclear cells	9
Manganese dioxide nanosheets induce mitochondrial toxicity in fish gill epithelial cells	9
Broiler welfare is preserved by long-term low-dose oral exposure to zinc oxide nanoparticles: preliminary study	9
Role of necroptosis of alveolar macrophages in acute lung inflammation of mice exposed to titanium dioxide nanoparticles	9

Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles	9
Amorphous silica nanoparticles caused lung injury through the induction of epithelial apoptosis via ROS/Ca ²⁺ /DRP1-mediated mitochondrial fission signaling	9
Perinatal exposure to silver nanoparticles reprograms immunometabolism and promotes pancreatic beta-cell death and kidney damage in mice	9
Enhanced antioxidant capacity prevents epitranscriptomic and cardiac alterations in adult offspring gestationally-exposed to ENM	8
Metabolomics screening of serum biomarkers for occupational exposure of titanium dioxide nanoparticles	8
Mechanisms of nanotoxicity – biomolecule coronas protect pathological fungi against nanoparticle-based eradication	8
Combination effect of nanoparticles on the acute pulmonary inflammogenic potential: additive effect and antagonistic effect	8
Use of single particle ICP-MS to estimate silver nanoparticle penetration through baby porcine mucosa	8
Amino-nanopolystyrene exposures of oyster (Crassostrea gigas) embryos induced no apparent intergenerational effects	8
Distribution of gold nanoparticles into the brain: a systematic review and meta-analysis	8
Assessment of primary and inflammation-driven genotoxicity of carbon black nanoparticles in vitro and in vivo	7
Vacancy-induced toxicity of CoSe₂ nanomaterials in rat lung macrophages	7
Modeling and mechanistic understanding of cytotoxicity of metal oxide nanoparticles (MeOxNPs) to Escherichia coli: categorization and data gap filling for untested metal oxides	7
Nano-safety research lessons for dealing with aerosol transmissions of COVID-19	7
Evaluation of the skin-sensitizing potential of gold nanoparticles and the impact of established dermal sensitivity on the pulmonary immune response to various forms of gold	7
Comparative assessments of the biodistribution and toxicity of oxidized single-walled carbon nanotubes dispersed with two different reagents after intravenous injection	6
Acute exposure to C60 fullerene damages pulmonary mitochondrial function and mechanics	6
Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation	6
Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure	6
PM_2.5 induce the defective efferocytosis and promote atherosclerosis via HIF-1α activation in macrophage	6
The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard	6
In vitro effects of cobalt and chromium nanoparticles on human platelet function	6
Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro	6
‘Trojan-Horse’ stress-granule formation mediated by manganese oxide nanoparticles	6
Some data on the comparative and combined toxic activity of nanoparticles containing lead and cadmium with special attention to their vasotoxicity	6
Nano-read-across predictions of toxicity of metal oxide engineered nanoparticles (MeOx ENPS) used in nanopesticides to BEAS-2B and RAW 264.7 cells	6
Pre-conceptional exposure to multiwalled carbon nanotubes suppresses antibody production in mouse offspring	5
Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium	5
Transgenic zebrafish larvae as a non-rodent alternative model to assess pro-inflammatory (neutrophil) responses to nanomaterials	5
Silver nanoparticles compromise the development of mouse pubertal mammary glands through disrupting internal estrogen signaling	5
Silver nanoparticles suppress forskolin-induced syncytialization in BeWo cells	5
Engineered aluminum nanoparticle induces mitochondrial deformation and is predicated on cell phenotype	5
Integrated approaches to testing and assessment for grouping nanomaterials following dermal exposure	5
Graphene oxide influence in soil bacteria is dose dependent and changes at osmotic stress: growth variation, oxidative damage, antioxidant response, and plant growth promotion traits of a	5
Treatment of copper nanoparticles (CuNPs) for two spermatogenic cycles impairs testicular activity via down-regulating steroid receptors and inhibition of germ cell proliferation in a mice model	5
Effects of dietary exposure to the engineered nanomaterials CeO₂, SiO₂, Ag, and TiO₂ on the murine gut microbiome	5
Assessing regulated cell death modalities as an efficient tool for in vitro nanotoxicity screening: a review	5
Ferritinophagy was involved in long-term SiNPs exposure induced ferroptosis and liver fibrosis	5
Multi-walled carbon nanotubes induce IL-1β secretion by activating hemichannels-mediated ATP release in THP-1 macrophages	5
A harmonized protocol for an international multicenter prospective study of nanotechnology workers: the NanoExplore cohort	5