OOIR: Observatory of International Research

Papers

(The median citation count of Nanotoxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
The effect of natural biomolecules on yttrium oxide nanoparticles from a Daphnia magna survival rate perspective	60
Particulate matter constituents trigger the formation of extracellular amyloid β and Tau -containing plaques and neurite shortening in vitro	45
Potent lung tumor promotion by inhaled MWCNT	41
Polyethyleneimine/polyethylene glycol–conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: testing in frog embryo teratogenesis assay–Xenopusand mammalian ti	28
Assessment of acute and subacute toxicity, pharmacokinetics, and biodistribution of eugenol nanoparticles after oral exposure in Wistar rats	28
Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro	27
Lipid peroxidation metabolites associated with biomarkers of inflammation and oxidation stress in workers handling carbon nanotubes and metal oxide nanoparticles	24
Comparison of toxicity and cellular responses following pulmonary exposure to different types of nanofibers	23
Protein interaction, monocyte toxicity and immunogenic properties of cerium oxide crystals with 5% or 14% gadolinium, cobalt oxide and iron oxide nanoparticles – an interdisciplinary approach	21
Predicting the toxicity of nanoparticles using artificial intelligence tools: a systematic review	20
Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure	20
Cytotoxic evaluation of pure and doped iron oxide nanoparticles on cancer cells: a magnetic fluid hyperthermia perspective	19
Impact of polyethylene nanoplastics on human intestinal cells	16
MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells	15
Algal extracellular polymeric substances (algal-EPS) for mitigating the combined toxic effects of polystyrene nanoplastics and nano-TiO₂ in Chlorella sp.	15
Microplastics and nanoplastics science: collecting and characterizing airborne microplastics in fine particulate matter	15
Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics	15
Nanoparticle-protein corona complex: understanding multiple interactions between environmental factors, corona formation, and biological activity	15
Multiparametric in vitro genotoxicity assessment of different variants of amorphous silica nanomaterials in rat alveolar epithelial cells	14
Preclinical evaluation of early multi-organ toxicity induced by liposomal doxorubicin using ⁶⁷Ga-citrate	14
Enhanced toxicity of 2,2-bis(chloromethyl) trimethylene bis[bis(2-chloroethyl) phosphate] (V6) by nanopolystyrene particles towards HeLa cells	14
Biodistribution and histological analysis of iron oxide-dextran nanoparticles in wistar rats	14
Correction	14
Comparative study of the transcriptomes of Caco-2 cells cultured under dynamic vs. static conditions following exposure to titanium dioxide and zinc oxide nanomaterials	12
3D volume segmentation and reconstruction. Supervised image classification and automated quantification of superparamagnetic iron oxide nanoparticles in histology slides for safety assessment	12

Study on myocardial toxicity induced by lead halide perovskites nanoparticles	12
Size effect and mucus role on the intestinal toxicity of the E551 food additive and engineered silica nanoparticles	12
Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial in vitro model	12
Role of necroptosis of alveolar macrophages in acute lung inflammation of mice exposed to titanium dioxide nanoparticles	12
Nano-read-across predictions of toxicity of metal oxide engineered nanoparticles (MeOx ENPS) used in nanopesticides to BEAS-2B and RAW 264.7 cells	11
Mutagenicity of silver nanoparticles evaluated using whole-genome sequencing in mouse lymphoma cells	11
Toxicological impact of silver nanoparticles on soil microbial indicators in contaminated soil (pot experiment)	10
A follow-up study on workers involved in the graphene production process after the introduction of exposure mitigation measures: evaluation of genotoxic and oxidative effects	10
Different cellular mechanisms from low- and high-dose zinc oxide nanoparticles-induced heart tube malformation during embryogenesis	10
Probing the effects of dextran-coated CeO ₂ nanoparticles on lung fibroblasts using multivariate single-cell Raman spectroscopy	10
Immunotoxic effects of metal-based nanoparticles in fish and bivalves	10
Quercetin protective potential against nanoparticle-induced adverse effects	10
Perinatal exposure to silver nanoparticles reprograms immunometabolism and promotes pancreatic beta-cell death and kidney damage in mice	10
Gestational exposure to silver nanoparticles enhances immune adaptation and protection against streptozotocin-induced diabetic nephropathy in mice offspring	10
Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: Toxicity and changes in the proteome of breast, colon and prostate cancer cells	9
Graphene oxide influence in soil bacteria is dose dependent and changes at osmotic stress: growth variation, oxidative damage, antioxidant response, and plant growth promotion traits of a	8
A harmonized protocol for an international multicenter prospective study of nanotechnology workers: the NanoExplore cohort	8
AOP173 key event associated pathway predictor – online application for the prediction of benchmark dose lower bound (BMDLs) of a transcriptomic pathway involved in MWCNTs-induced lung fibrosis	8
Transgenic zebrafish larvae as a non-rodent alternative model to assess pro-inflammatory (neutrophil) responses to nanomaterials	8
Nanoparticles-encapsulated doxorubicin alleviates drug resistance of osteosarcoma via inducing ferroptosis	8
Exposure to gallium arsenide nanoparticles in a research facility: a case study using molecular beam epitaxy	8
Bioinformatics and machine learning to support nanomaterial grouping	8
Biomarkers of oxidative stress in urine and plasma of operators at six Singapore printing centers and their association with several metrics of printer-emitted nanoparticle exposures	7
In vivo assessment of topically applied silver nanoparticles on entire cornea: comprehensive FTIR study	7
8-Hydroxy-2′-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review	7
Biokinetics of carbon black, multi-walled carbon nanotubes, cerium oxide, silica, and titanium dioxide nanoparticles after inhalation: a review	7
X-ray spectrometry imaging and chemical speciation assisting to understand the toxic effects of copper oxide nanoparticles on zebrafish ( Danio rerio )	7
Developing Integrated Approaches for Testing and Assessment (IATAs) in order to support nanomaterial safety	6
Efficient predictions of cytotoxicity of TiO₂-based multi-component nanoparticles using a machine learning-based q-RASAR approach	6
Overview of potential adverse health effects of oral exposure to nanocellulose	6
In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice	6
Nanosized titanium dioxide elevates toxicity of cationic metals species for Daphnia – have aging and natural organic matter an unexpected impact?	6
Polystyrene nanoparticles: the mechanism of their genotoxicity in human peripheral blood mononuclear cells	6
The oxidative potential of nanomaterials: an optimized high-throughput protocol and interlaboratory comparison for the ferric reducing ability of serum (FRAS) assay	6
Modulating exosomal communication between macrophages and melanoma cancer cells via cyclodextrin-based nanosponges loaded with doxorubicin	6
Photocatalytic activity of nanoparticles: the development of the standardized measurement for physiological conditions	6
Carbon quantum dots in breast cancer modulate cellular migration via cytoskeletal and nuclear structure	5
Review of carbonaceous nanoparticles for antibacterial uses in various dental infections	5
Genotoxic hazard assessment of cerium oxide and magnesium oxide nanoparticles in Drosophila	5
Correction	5
In vitro and in silico study of mixtures cytotoxicity of metal oxide nanoparticles to Escherichia coli : a mechanistic	5
Immunological properties of silica nanoparticles: a structure–activity relationship study	5
Effects of titanium oxide nanoparticles on growth, biochemical composition, and photosystem mechanism of marine microalgae Isochrysis galbana COR-A3	5
Treatment of copper nanoparticles (CuNPs) for two spermatogenic cycles impairs testicular activity via down-regulating steroid receptors and inhibition of germ cell proliferation in a mice model	5
Distribution of gold nanoparticles into the brain: a systematic review and meta-analysis	4
Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures	4
Evaluating the antibacterial efficacy of a silver nanocomposite surface coating against nosocomial pathogens as an antibiofilm strategy to prevent hospital infections	4
Chitosan functionalization of metal- and carbon-based nanomaterials as an approach toward sustainability tomorrow	4
Proteome-wide analysis reveals molecular pathways affected by AgNP in a ROS-dependent manner	4
Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation	4

TiO₂ nanostructures – a double edged sword: current progress on their role in stem cells’ differentiation, cancer therapy, and their toxicity issues	4
Systematic review of mechanistic evidence for TiO ₂ nanoparticle-induced lung carcinogenicity	4
Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis	4
Harmonizing nanomaterial exposure methodologies in ecotoxicology: the effects of two innovative nanoclays in the freshwater microalgae Raphidocelis subcapitata	4
Use of single particle ICP-MS to estimate silver nanoparticle penetration through baby porcine mucosa	4
Intercellular transfer of mitochondria via tunneling nanotubes protects against cobalt nanoparticle-induced neurotoxicity and mitochondrial damage	4
Evaluation of the biodistribution and preliminary safety profile of a novel brain-targeted manganese dioxide-based nanotheranostic system for Alzheimer’s disease	4
Ferritinophagy was involved in long-term SiNPs exposure induced ferroptosis and liver fibrosis	4
Repeated intratracheal instillation of zinc oxide nanoparticles induced pulmonary damage and a systemic inflammatory response in cynomolgus monkeys	4
Reactive oxygen species production, genotoxicity and telomere length in FE1-Muta™Mouse lung epithelial cells exposed to carbon nanotubes	4
Impact of physico-chemical properties on the toxicological potential of reduced graphene oxide in human bronchial epithelial cells	3
Investigation of potential cytotoxicity of a water-soluble, red-fluorescent [70]fullerene nanomaterial in Drosophila melanogaster	3
Lung toxicity, deposition, and clearance of thermal spray coating particles with different metal profiles after inhalation in rats	3
Nano-graphene oxide particles induce inheritable anomalies through altered gene expressions involved in oocyte maturation	3
Machine learning predictions of concentration-specific aggregate hazard scores of inorganic nanomaterials in embryonic zebrafish	3
Knock-out mouse models and single particle ICP-MS reveal that SP-D and SP-A deficiency reduces agglomeration of inhaled gold nanoparticles in vivo without significant changes to overall lung clearance	3
Genoprotective role of pembrolizumab liposome in isolated lymphocytes from head and neck squamous cell carcinoma patients compared to those from healthy individuals in vitro	3
A bibliometric analysis of the recent achievements in pulmonary safety of nanoparticles	3
Impacts of ingested MWCNT-Embedded nanocomposites in Japanese medaka (Oryzias latipes)	3
Evaluation of anticancer activity of urotropine surface modified iron oxide nanoparticles using a panel of forty breast cancer cell lines	3
Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats	3
Food-grade titanium dioxide (E171) and zinc oxide nanoparticles induce mitochondrial permeability and cardiac damage after oral exposure in rats	3
Intraperitoneal hepatorenal toxicity of zinc oxide and nickel oxide nanoparticles in rats: a systematic review	3
Multiparametric cytotoxicity assessment: the effect of gold nanoparticle ligand functionalization on SKOV3 ovarian carcinoma cell death	2
Unswerving modeling of hepatotoxicity of cadmium containing quantum dots using amalgamation of quasiSMILES, index of ideality of correlation, and consensus modeling	2
MiR-5622-3p inhibits ZCWPW1 to induce apoptosis in silica-exposed mice and spermatocyte cells	2
Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium	2
Biomarkers of exposure and effect in human biomonitoring of metal-based nanomaterials: their use in primary prevention and health surveillance	2
An analysis on control banding-based methods used for occupational risk assessment of nanomaterials	2
Multiple pathways of alveolar macrophage death contribute to pulmonary inflammation induced by silica nanoparticles	2
Correction	2
Advances in nanotechnology for improving the targeted delivery and activity of amphotericin B (2011–2023): a systematic review	2
Nickel nanoparticles induce epithelial-mesenchymal transition in human bronchial epithelial cells via the HIF-1α/HDAC3 pathway	2
Evaluation of graphene-derived bone scaffold exposure to the calvarial bone_in-vitro and in-vivo studies	2
Analysis of carbon nanotube levels in organic matter: an inter-laboratory comparison to determine best practice	2
Metabolomics screening of serum biomarkers for occupational exposure of titanium dioxide nanoparticles	2
Exploring graphene-based materials’ genotoxicity: inputs of a screening method	2
Correction	2
Combination effect of nanoparticles on the acute pulmonary inflammogenic potential: additive effect and antagonistic effect	2
Dependence of diamond nanoparticle cytotoxicity on physicochemical parameters: comparative studies of glioblastoma, breast cancer, and hepatocellular carcinoma cell lines	2
Developmental neurotoxicity of silver nanoparticles: the current state of knowledge and future directions	2
Chronic toxicity of core–shell SiC/TiO ₂ (nano)-particles to Daphnia magna under environmentally relevant food rations in the presence	2