Basic & Clinical Pharmacology & Toxicology

Article	Citations
A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)	131
Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety	102
BCPT 2023 policy for experimental and clinical studies	101
Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi‐centre, non‐inferiority, randomized, controlled phase 3 clini	53
Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy	46
The tyrosine kinase inhibitor nilotinib inhibits SARS‐CoV‐2 in vitro	40
Drug metabolism and drug transport of the 100 most prescribed oral drugs	36
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide‐induced premature ovarian failure	30
3D human liver spheroids for translational pharmacology and toxicology	30
Boosting the oral bioavailability of anticancer drugs through intentional drug–drug interactions	27
Are older adults insufficiently included in clinical trials?—An umbrella review	24
Protective mechanism of Astragalus Polysaccharides against Cantharidin‐induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics	24
Methyl Palmitate—A suitable adjuvant for Sorafenib therapy to reduce in vivo toxicity and to enhance anti‐cancer effects on hepatocellular carcinoma cells	18
Acylated ghrelin protects against doxorubicin‐induced nephropathy by activating silent information regulator 1	17
Development of a risk prediction nomogram for disposition of acute toxic exposure patients to intensive care unit	17
Serotonin syndrome—A focused review	17
Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses	17
Curcumin attenuates renal interstitial fibrosis by regulating autophagy and retaining mitochondrial function in unilateral ureteral obstruction rats	16
Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells	16
Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies	16
Clinical predictors of nephrotoxicity associated with teicoplanin: Meta‐analysis and meta‐regression	15
Betaine—The dark knight of the brain	14
Antihistamine use during breastfeeding with focus on breast milk transfer and safety in humans: A systematic literature review	14
Causes of discrepancies between medications listed in the national electronic prescribing system and patients' actual use of medications	13
GABAA receptors as targets for anaesthetics and analgesics and promising candidates to help treat coronavirus infections: A mini‐review	13

The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: Physiological and pathophysiological implications	13
Retrospective identification of new psychoactive substances in patient samples submitted for clinical drug analysis	13
The therapeutic effects of cycloastragenol in ulcerative colitis by modulating SphK/MIP‐1α/miR‐143 signalling	13
Targeting 2‐arachidonoylglycerol signalling in the neurobiology and treatment of depression	13
Artesunate alleviates intracerebral haemorrhage secondary injury by inducing ferroptosis in M1‐polarized microglia and suppressing inflammation through AMPK/mTORC1/GPX4 pathway	12
Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases	12
Artesunate inhibits osteoclast differentiation by inducing ferroptosis and prevents iron overload‐induced bone loss	11
The comparison analysis of polyphyllin I and its analogues induced apoptosis of colon and lung cancer cells via mitochondrial dysfunction	10
The Effects of opioids on female fertility, pregnancy and the breastfeeding mother‐infant dyad: A Review	10
Prognostic value of liver and kidney function parameters and their correlation with the ratio of urine‐to‐plasma paraquat in patients with paraquat poisoning	10
High anticholinergic burden at admission associated with in‐hospital mortality in older patients: A comparison of 19 different anticholinergic burden scales	10
A two‐decade review of butane toxicity as a substance of abuse	10
“Biosimilar, so it looks alike, but what does it mean?” A qualitative study of Danish patients' perceptions of biosimilars	10
IMB5036 inhibits human pancreatic cancer growth primarily through activating necroptosis	10
Effects of a physician‐ and pharmacist‐managed clinic on pain management in cancer patients in China	10
Predictive biomarkers and clinical evidence	10
Multiple regulation and targeting effects of borneol in the neurovascular unit in neurodegenerative diseases	10
Olanzapine‐associated dose‐dependent alterations for weight and metabolic parameters in a prospective cohort	10
Current and emerging pharmacological targets for medical expulsive therapy	10
Use of GLP‐1 receptor agonists and subsequent risk of alcohol‐related events. A nationwide register‐based cohort and self‐controlled case series study	10
Renin–angiotensin system in intestinal inflammation—Angiotensin inhibitors to treat inflammatory bowel diseases?	10
Botulinum toxin A promotes the transdifferentiation of primary keloid myofibroblasts into adipocyte‐like cells	10
Post‐stroke epilepsy and antiepileptic drug use in men and women	9
Use of benzodiazepines and benzodiazepine‐related drugs in the Nordic countries between 2000 and 2020	9
The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?	9
Fingolimod ameliorates acetic acid‐induced ulcerative colitis: An insight into its modulatory impact on pro/anti‐inflammatory cytokines and AKT/mTOR signalling	9
Application of physiologically based pharmacokinetic modelling for the prediction of drug–drug interactions involving anlotinib as a perpetrator of cytochrome P450 enzymes	9
External validation of the Medication Risk Score in polypharmacy patients in general practice: A tool for prioritizing patients at greatest risk of potential drug‐related problems	9
Home therapy of COVID‐19 at the earliest may greatly prevent hospitalization	9
Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease	9
Salsalate reverses metabolic disorders in a mouse model of non‐alcoholic fatty liver disease through AMPK activation and caspase‐6 activity inhibition	9
The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non‐alcoholic steatohepatitis	9
Contribution of membrane transporters to chemotherapy‐induced cardiotoxicity	9
An update on emerging therapeutics to combat COVID‐19	8
Patient‐targeted interventions for opioid deprescribing: An overview of systematic reviews	8
Home pharmacological therapy in early COVID‐19 to prevent hospitalization and reduce mortality: Time for a suitable proposal	8
Drug‐drug interaction of atazanavir on UGT1A1‐mediated glucuronidation of molidustat in human	8
The role of high‐conductance calcium‐activated potassium channel in headache and migraine pathophysiology	8
The clinical role of serum albumin in Organophospate poisoning	8
Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System	8
The mitigating effect of para‐hydroxycinnamic acid in bleomycin‐induced pulmonary fibrosis in mice through targeting oxidative, inflammatory and fibrotic pathways	8
Triptolide alleviates collagen‐induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN‐STAT3 pathway	8
Pharmacogenetic testing to guide therapeutic decision‐making and improve outcomes for children undergoing anthracycline‐based chemotherapy	8
The alcohol marker phosphatidylethanol is closely related to AST, GGT, ferritin and HDL‐C	7
The state of deprescribing research: How did we get here?	7
Effects of saikosaponin‐d on CYP3A4 in HepaRG cell and protein‐ligand docking study	7
Risk of muscle toxicity events for daptomycin with and without statins: Analysis of the Japanese Adverse Event Report database	7
Piceatannol ameliorates behavioural, biochemical and histological aspects in cisplatin‐induced peripheral neuropathy in rats	7
DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview	7
Cannabidiol reduces lipopolysaccharide‐induced nociception via endocannabinoid system activation	7

Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers	7
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding	7
Cyclopeptide mushroom poisoning: A retrospective series of 204 patients	7
A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing	7
Intentional suspected suicide exposures by poisoning among adolescents from 2009 to 2018 reported to the Georgia Poison Center and compared nationally	7
A dose‐related positive effect of inhaled simvastatin‐loaded PLGA nanoparticles on paraquat‐induced pulmonary fibrosis in rats	7
Predictors of older patients' willingness to have medications deprescribed: A cross‐sectional study	6
Alpinetin delays high‐fat diet‐aggravated lung carcinogenesis	6
Monitoring paxillin in astrocytes reveals the significance of the adhesion G protein coupled receptor VLGR1/ADGRV1 for focal adhesion assembly	6
Sevoflurane inhibits neuroblastoma cell proliferation and invasion and induces apoptosis by miR‐144‐3p/YAP1 axis	6
Lithium and the risk of chronic kidney disease: A population‐based case–control study	6
Fluoroquinolones as a trigger for rupture of abdominal aortic aneurysm: A case‐crossover analysis	6
Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non‐expressors early after living donor kidney transplantation: Effect of interleukin 6–induced suppression of the cytochrome P450 3A	6
Benchmark dose and the adverse effects of exposure to pendimethalin at low dose in female rats	6
Rapid‐acting antidepressants and the regulation of TrkB neurotrophic signalling—Insights from ketamine, nitrous oxide, seizures and anaesthesia	6
Carnosol attenuated atrophy of C2C12 myotubes induced by tumour‐derived exosomal miR‐183‐5p through inhibiting Smad3 pathway activation and keeping mitochondrial respiration	6
Toxicological analysis of azide and cyanide for azide intoxications using gas chromatography	6
Effects of chronic cirrhosis induced by intraperitoneal thioacetamide injection on the protein content and Michaelis–Menten kinetics of cytochrome P450 enzymes in the rat liver microsomes	6
Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin‐induced pulmonary fibrosis in mice	6
The role of decision tree and machine learning models for outcome prediction of bupropion exposure: A nationwide analysis of more than 14 000 patients in the United States	6
Using population pharmacokinetic analyses of drugs metabolized by CYP2D6 to study the genotype–phenotype translation	6
LC‐MS‐sMRM method development and validation of different classes of pain panel drugs and analysis of clinical urine samples	6
Effects of Herba Erigerontis injection on pharmacodynamics and pharmacokinetics of warfarin in rats in vivo	6
The protection afforded by Berberine against chemotherapy‐mediated nephropathy in rats involves regulation of the antioxidant axis	6
Association between patient attitudes towards deprescribing and subsequent prescription changes	6
Advances in noninvasive measurement of liver function and physiology: The HepQuant DuO test	6
Senescent murine femoral arteries undergo vascular remodelling associated with accelerated stress‐induced contractility and reactivity to nitric oxide	6
Describing long‐term opioid use utilizing Nordic prescription registers—A Norwegian example	5
Biased signalling is structurally encoded as an autoproteolysis event in adhesion G protein‐coupled receptor Latrophilin‐3/ADGRL3	5
Combined treatment with FABP4 inhibitor ameliorates rosiglitazone‐induced liver steatosis in obese diabetic db/db mice	5
Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF‐β/PTHrP/RANKL pathway	5
Effects of the co‐administration of MK‐801 and clozapine on MiRNA expression profiles in rats	5
Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells	5
Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress	5
Pharmacokinetics of free and total mycophenolic acid in paediatric and adult renal transplant recipients: Exploratory analysis of the effects of clinical factors and gene variants	5
Summarizing studies using constitutive genetic deficiency to investigate behavioural influences of uptake 2 monoamine transporters	5
MCRT, a multifunctional ligand of opioid and neuropeptide FF receptors, attenuates neuropathic pain in spared nerve injury model	5
Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation	5
Combination of bis (α‐furancarboxylato) oxovanadium (IV) and metformin improves hepatic steatosis through down‐regulating inflammatory pathways in high‐fat diet‐induced obese C57BL/6J mice	5
Pro‐inflammatory cytokines/chemokines, TNF‐α, IL‐6 and MCP‐1, as biomarkers for the nephro‐ and pneumoprotective effect of silibinin after hepatic ischemia/reperfusion: Confirmation by immunohistochem	5
In vitro assessments predict that CYP3A4 contributes to a greater extent than CYP3A5 to prednisolone clearance	5
Delineation of the GPR15 receptor‐mediated Gα protein signalling profile in recombinant mammalian cells	5
ChatGPT: First glance from a perspective of clinical pharmacology	5
The mechanism of Epimedin B in treating osteoporosis as revealed by RNA sequencing‐based analysis	5
The adhesion G protein‐coupled receptor VLGR1/ADGRV1 controls autophagy	5
Exploratory pharmacovigilance with machine learning in big patient data: A focused scoping review	5
Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark	5
Classification of acute poisoning exposures with machine learning models derived from the National Poison Data System	5
Sildenafil attenuates oxidative stress and endothelial dysfunction in lead‐induced hypertension	5
Sacubitril/valsartan, sodium‐glucose cotransporter 2 inhibitors and vericiguat for congestive heart failure therapy	5
The adhesion G protein‐coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes	5
Reasons why older adults in three countries agreed with a deprescribing recommendation in a hypothetical vignette	5
Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5	5
Acute drug poisonings leading to hospitalization	5
Metabolism studies of 4′Cl‐CUMYL‐PINACA, 4′F‐CUMYL‐5F‐PINACA and 4′F‐CUMYL‐5F‐PICA using human hepatocytes and LC‐QTOF‐MS analysis	5
Acute liver failure requiring transplantation: A possible link to ulipristal acetate treatment?	5
Formate test for bedside diagnosis of methanol poisoning	5
The role and mechanism of the annexin A1 peptide Ac2‐26 in rats with cardiopulmonary bypass lung injury	5
No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients	5
Methamphetamine induces a low dopamine transporter expressing state without altering the total number of peripheral immune cells	5
Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core	5
The role of cytochrome P450 enzyme genetic variants in cannabis hyperemesis syndrome—A case report	4
Polypharmacy in polymorbid pregnancies and the risk of congenital malformations—A systematic review	4
Impact of CYP2D6 activity and cachexia progression on enantiomeric alteration of plasma tramadol and its demethylated metabolites and their relationships with central nervous system symptoms in head a	4
Effect of Roux‐en‐Y gastric bypass on the pharmacokinetic‐pharmacodynamic relationships of liquid and controlled‐release formulations of oxycodone	4
Preclinical safety evaluation of amphotericin A21: A novel antifungal	4
Dementia and depression: Biological connections with amyloid β protein	4
Statin use before and after the KDIGO Lipids in chronic kidney disease guideline: A population‐based interrupted time series analysis	4
Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats	4
Rifampicin induces the bone form of alkaline phosphatase in humans	4
CYP2D6*10 polymorphism and the enantioselective O‐desmethylation of S‐(+)‐ and R‐(‐)‐venlafaxine in Japanese psychiatric patients	4
How does deprescribing (not) reduce mortality? A review of a meta‐analysis in community‐dwelling older adults casts uncertainty over claimed benefits	4
Comparable risk of recurrent ventricular tachyarrhythmias in implantable cardioverter‐defibrillator recipients treated with single beta‐blocker or combined amiodarone	4
Process evaluation of a pharmacist‐led intervention aimed at deprescribing and appropriate use of cardiometabolic medication among adult people with type 2 diabetes	4
First‐in‐human study with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients	4
Illuminating the monoamine transporters: Fluorescently labelled ligands to study dopamine, serotonin and norepinephrine transporters	4
The protective effect of solidagenone from Solidago chilensis Meyen in a mouse model of airway inflammation	4
Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti‐diazepam‐induced ataxia action as a structure‐dependent feature	4
Potential drug‐drug interactions in acute poisonings managed in the intensive care unit: Occurrence, risk factors and relationship to patient severity on admission	4
Biases in reporting of adverse effects in clinical trials, and potential impact on safety assessments in systematic reviews and therapy guidelines	4

Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells	4
Disease activity and therapeutic drug monitoring of polyglutamates of methotrexate after daily or weekly administration of low‐dose methotrexate in patients recently diagnosed with rheumatoid arthriti	4
Ondansetron in pregnancy revisited: Assessment and pregnancy labelling by the European Medicines Agency (EMA) & Pharmacovigilance Risk Assessment Committee (PRAC)	4
Short‐term mortality following tramadol poisonings in Denmark	4
Language‐agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records	4
Anakinra and dexamethasone treatment of idarubicin‐induced mucositis and diarrhoea in rats	4
Network pharmacology‐based dissection of the underlying mechanisms of dyspnoea induced by zedoary turmeric oil	4
Ranolazine exerts atrial antiarrhythmic effects in a rat model of monocrotaline‐induced pulmonary hypertension	4
Deprescribing in primary care without deterioration of health‐related outcomes: A real‐life, quality improvement project	4
CYP3A4*22 may increase bleeding risk in ticagrelor users	4
Antitumour effect of odoroside A and its derivative on human leukaemia cells through the ROS/JNK pathway	4
Structural clarity is brought to adhesion G protein‐coupled receptor tethered agonism	4
Deprescribing in a multimorbid older adult: A case vignette study among community pharmacists and primary care physicians	4
Vitamin D and SARS‐CoV‐2	4
Changes in oral corticosteroid use in asthma treatment—A 20‐year Danish nationwide drug utilisation study	4
Influence of single nucleotide polymorphism of LAT1 on therapeutic response to gabapentinoids in Pakistani patients with neuropathic pain	4
Methylophiopogonanone A is a naturally occurring broad‐spectrum inhibitor against human UDP‐glucuronosyltransferases: Inhibition behaviours and implication in herb‐drug interactions	4
Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders	4
Advancing deprescribing: Learnings from the first international conference on deprescribing	4