Basic & Clinical Pharmacology & Toxicology

Article	Citations
BCPT policy for experimental and clinical studies	246
Camostat mesylate against SARS‐CoV‐2 and COVID‐19—Rationale, dosing and safety	99
A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)	93
Mesenchymal stem cell–derived small extracellular vesicles and bone regeneration	47
COVID‐19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?	39
BCPT 2023 policy for experimental and clinical studies	37
The tyrosine kinase inhibitor nilotinib inhibits SARS‐CoV‐2 in vitro	37
Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy	36
Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi‐centre, non‐inferiority, randomized, controlled phase 3 clini	35
Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges	35
C‐phycocyanin protects against ethanol‐induced gastric ulcers in rats: Role of HMGB1/NLRP3/NF‐κB pathway	29
Drug metabolism and drug transport of the 100 most prescribed oral drugs	28
3D human liver spheroids for translational pharmacology and toxicology	24
Risk of squamous cell carcinoma of the lip and cutaneous melanoma in older Australians using hydrochlorothiazide: A population‐based case‐control study	24
Impact of gene polymorphisms in drug‐metabolizing enzymes and transporters on trough concentrations of rivaroxaban in patients with atrial fibrillation	22
Ageing and longevity genes in cardiovascular diseases	20
Voriconazole therapeutic drug monitoring in critically ill patients improves efficacy and safety of antifungal therapy	19
The protective effect of modafinil on vincristine‐induced peripheral neuropathy in rats: A possible role for TRPA1 receptors	19
Boosting the oral bioavailability of anticancer drugs through intentional drug–drug interactions	19
Protective mechanism of Astragalus Polysaccharides against Cantharidin‐induced liver injury determined in vivo by liquid chromatography/mass spectrometry metabolomics	19
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide‐induced premature ovarian failure	19
Bufalin inhibits ovarian carcinoma via targeting mTOR/HIF‐α pathway	18
Eugenol and its association with levodopa in 6‐hydroxydopamine‐induced hemiparkinsonian rats: Behavioural and neurochemical alterations	17
Are older adults insufficiently included in clinical trials?—An umbrella review	17
Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases	17

Curcumin attenuates renal interstitial fibrosis by regulating autophagy and retaining mitochondrial function in unilateral ureteral obstruction rats	14
Complex effect of continuous curcumin exposure on human bone marrow‐derived mesenchymal stem cell regenerative properties through matrix metalloproteinase regulation	14
Development of a risk prediction nomogram for disposition of acute toxic exposure patients to intensive care unit	14
Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies	14
Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses	14
Dendrobine attenuates gestational diabetes mellitus in mice by inhibiting Th17 cells	13
Polygalasaponin F inhibits neuronal apoptosis induced by oxygen‐glucose deprivation and reoxygenation through the PI3K/Akt pathway	13
Methyl Palmitate—A suitable adjuvant for Sorafenib therapy to reduce in vivo toxicity and to enhance anti‐cancer effects on hepatocellular carcinoma cells	13
SIRT1/IGFBPrP1/TGF β1 axis involved in cucurbitacin B ameliorating concanavalin A‐induced mice liver fibrosis	13
Acylated ghrelin protects against doxorubicin‐induced nephropathy by activating silent information regulator 1	12
Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome?	12
Retrospective identification of new psychoactive substances in patient samples submitted for clinical drug analysis	11
Clinical predictors of nephrotoxicity associated with teicoplanin: Meta‐analysis and meta‐regression	11
Antihistamine use during breastfeeding with focus on breast milk transfer and safety in humans: A systematic literature review	11
Placental transfer of pesticides studied in human placental perfusion	11
Baicalin inhibits Salmonella typhimurium‐induced inflammation and mediates autophagy through TLR4/MAPK/NF‐κB signalling pathway	11
GABAA receptors as targets for anaesthetics and analgesics and promising candidates to help treat coronavirus infections: A mini‐review	10
Riluzole: Anti‐invasive effects on rat prostate cancer cells under normoxic and hypoxic conditions	10
Targeting 2‐arachidonoylglycerol signalling in the neurobiology and treatment of depression	10
Causes of discrepancies between medications listed in the national electronic prescribing system and patients' actual use of medications	9
Cohort selection in register‐based studies of direct oral anticoagulant users with atrial fibrillation: An inevitable trade‐off between selection bias and misclassification	9
Serotonin syndrome—A focused review	9
Involvement of H2S, NO and BDNF‐TrkB signalling pathway in the protective effects of simvastatin against pentylenetetrazole‐induced kindling and cognitive impairments in mice	9
Predictive biomarkers and clinical evidence	9
Botulinum toxin A promotes the transdifferentiation of primary keloid myofibroblasts into adipocyte‐like cells	9
Contribution of membrane transporters to chemotherapy‐induced cardiotoxicity	9
Supratheraputic rivaroxaban levels: A persistent drug‐drug interaction after discontinuation of amiodarone	9
External validation of the Medication Risk Score in polypharmacy patients in general practice: A tool for prioritizing patients at greatest risk of potential drug‐related problems	9
Antidepressant effects of 3‐(3,4‐methylenedioxy‐5‐trifluoromethyl phenyl)‐2E‐propenoic acid isobutyl amide involve TSPO‐mediated mitophagy signalling pathway	9
DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women	9
Renin‐angiotensin system blockade modulates both the peripheral and central components of neuropathic pain in rats: Role of calcitonin gene–related peptide, substance P and nitric oxide	9
Osmium absorption after osmium tetroxide skin and eye exposure	9
Olanzapine‐associated dose‐dependent alterations for weight and metabolic parameters in a prospective cohort	8
IMB5036 inhibits human pancreatic cancer growth primarily through activating necroptosis	8
Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models	8
Prognostic value of liver and kidney function parameters and their correlation with the ratio of urine‐to‐plasma paraquat in patients with paraquat poisoning	8
The clinical role of serum albumin in Organophospate poisoning	8
Home therapy of COVID‐19 at the earliest may greatly prevent hospitalization	8
The comparison analysis of polyphyllin I and its analogues induced apoptosis of colon and lung cancer cells via mitochondrial dysfunction	8
Post‐stroke epilepsy and antiepileptic drug use in men and women	8
Bromodomain 4 is a potent prognostic marker associated with immune cell infiltration in breast cancer	8
Absorption, distribution, metabolism and excretion of molidustat in healthy participants	8
The effect of acetylsalicylic acid and pentoxifylline in guinea pigs with non‐alcoholic steatohepatitis	8
Pharmacokinetic interactions between clozapine and sertraline in smokers and non‐smokers	8
A novel risk assessment model of contrast‐induced nephropathy after percutaneous coronary intervention in patients with diabetes	8
Targeting the DNA repair enzymes MTH1 and OGG1 as a novel approach to treat inflammatory diseases	8
Liraglutide treatment improves endothelial function in the Ldlr−/− mouse model of atherosclerosis and affects genes involved in vascular remodelling and inflammation	8
The therapeutic effects of cycloastragenol in ulcerative colitis by modulating SphK/MIP‐1α/miR‐143 signalling	8
“I simply don't know, because I don't know which drugs I get”: Perspectives on deprescribing among older adults with limited life expectancy and their relatives	8
Nitrate and nitrite‐based therapy to attenuate cardiovascular remodelling in arterial hypertension	8

Application of physiologically based pharmacokinetic modelling for the prediction of drug–drug interactions involving anlotinib as a perpetrator of cytochrome P450 enzymes	7
The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: Physiological and pathophysiological implications	7
Drug‐drug interaction of atazanavir on UGT1A1‐mediated glucuronidation of molidustat in human	7
Salsalate reverses metabolic disorders in a mouse model of non‐alcoholic fatty liver disease through AMPK activation and caspase‐6 activity inhibition	7
Renin–angiotensin system in intestinal inflammation—Angiotensin inhibitors to treat inflammatory bowel diseases?	7
The Effects of opioids on female fertility, pregnancy and the breastfeeding mother‐infant dyad: A Review	7
Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System	7
Pharmacogenetic testing to guide therapeutic decision‐making and improve outcomes for children undergoing anthracycline‐based chemotherapy	7
An update on emerging therapeutics to combat COVID‐19	7
Pharmacogenetic studies of thiopurine methyltransferase genotype‐phenotype concordance and effect of methotrexate on thiopurine metabolism	7
A two‐decade review of butane toxicity as a substance of abuse	7
Effects of a physician‐ and pharmacist‐managed clinic on pain management in cancer patients in China	7
Home pharmacological therapy in early COVID‐19 to prevent hospitalization and reduce mortality: Time for a suitable proposal	7
Fingolimod ameliorates acetic acid‐induced ulcerative colitis: An insight into its modulatory impact on pro/anti‐inflammatory cytokines and AKT/mTOR signalling	7
Steady‐state pharmacokinetic and pharmacodynamic profiling of colistin in critically ill patients with multi‐drug–resistant gram‐negative bacterial infections, along with differences in clinical, micr	7
Melatonin ameliorates the sleep disorder induced by surgery under sevoflurane anaesthesia in aged mice	7
Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease	7
Thal protects against paraquat‐induced lung injury through a microRNA‐141/HDAC6/IκBα‐NF‐κB axis in rat and cell models	6
“Biosimilar, so it looks alike, but what does it mean?” A qualitative study of Danish patients' perceptions of biosimilars	6
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding	6
Gonadal sex and animal experimentation: Perfection vs. 3R principle?	6
Toxicological analysis of azide and cyanide for azide intoxications using gas chromatography	6
High anticholinergic burden at admission associated with in‐hospital mortality in older patients: A comparison of 19 different anticholinergic burden scales	6
Benchmark dose and the adverse effects of exposure to pendimethalin at low dose in female rats	6
Nucleoredoxin interaction with flightless‐I/actin complex is differentially altered in alcoholic liver disease	6
Sevoflurane inhibits neuroblastoma cell proliferation and invasion and induces apoptosis by miR‐144‐3p/YAP1 axis	6
Use of benzodiazepines and benzodiazepine‐related drugs in the Nordic countries between 2000 and 2020	6
Randomised trial of telephone counselling to improve participants' adherence to prescribed drugs in a vascular screening trial	6
Multiple regulation and targeting effects of borneol in the neurovascular unit in neurodegenerative diseases	6
The alcohol marker phosphatidylethanol is closely related to AST, GGT, ferritin and HDL‐C	6
Current and emerging pharmacological targets for medical expulsive therapy	6
Artesunate inhibits osteoclast differentiation by inducing ferroptosis and prevents iron overload‐induced bone loss	6
Fluoroquinolones as a trigger for rupture of abdominal aortic aneurysm: A case‐crossover analysis	6
A dose‐related positive effect of inhaled simvastatin‐loaded PLGA nanoparticles on paraquat‐induced pulmonary fibrosis in rats	6
Acute liver failure requiring transplantation: A possible link to ulipristal acetate treatment?	5
Four phase 1 trials to evaluate the safety and pharmacokinetic profile of single and repeated dosing of SCO‐101 in adult male and female volunteers	5
Risk of muscle toxicity events for daptomycin with and without statins: Analysis of the Japanese Adverse Event Report database	5
Maternal waterpipe tobacco smoke exposure during lactation induces hormonal and biochemical changes in rat dams and offspring	5
LC‐MS‐sMRM method development and validation of different classes of pain panel drugs and analysis of clinical urine samples	5
Alpinetin delays high‐fat diet‐aggravated lung carcinogenesis	5
DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview	5
Betaine—The dark knight of the brain	5
Acute drug poisonings leading to hospitalization	5
Effects of Herba Erigerontis injection on pharmacodynamics and pharmacokinetics of warfarin in rats in vivo	5
Association between patient attitudes towards deprescribing and subsequent prescription changes	5
The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?	5
Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers	5
Predictors of older patients' willingness to have medications deprescribed: A cross‐sectional study	5
The adhesion G protein‐coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes	5
Reasons why older adults in three countries agreed with a deprescribing recommendation in a hypothetical vignette	5
A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing	5
Patient‐targeted interventions for opioid deprescribing: An overview of systematic reviews	5
Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress	5
Citrus fruit‐derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin	5
Monitoring paxillin in astrocytes reveals the significance of the adhesion G protein coupled receptor VLGR1/ADGRV1 for focal adhesion assembly	5
A novel rat model of ocular hypertension by a single intracameral injection of cross‐linked hyaluronic acid hydrogel (Healaflow®)	5
Classification of acute poisoning exposures with machine learning models derived from the National Poison Data System	5
Combination of bis (α‐furancarboxylato) oxovanadium (IV) and metformin improves hepatic steatosis through down‐regulating inflammatory pathways in high‐fat diet‐induced obese C57BL/6J mice	5
Use of GLP‐1 receptor agonists and subsequent risk of alcohol‐related events. A nationwide register‐based cohort and self‐controlled case series study	5
Pro‐inflammatory cytokines/chemokines, TNF‐α, IL‐6 and MCP‐1, as biomarkers for the nephro‐ and pneumoprotective effect of silibinin after hepatic ischemia/reperfusion: Confirmation by immunohistochem	5
How patients in Denmark acquire their medicines: overview, data sources and implications for pharmacoepidemiology	5
ChatGPT: First glance from a perspective of clinical pharmacology	5
Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark	4
Antipsychotics inhibit the mitochondrial bioenergetics of pancreatic beta cells isolated from CD1 mice	4
The role and mechanism of the annexin A1 peptide Ac2‐26 in rats with cardiopulmonary bypass lung injury	4
Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin‐induced pulmonary fibrosis in mice	4
Changes in oral corticosteroid use in asthma treatment—A 20‐year Danish nationwide drug utilisation study	4
Short‐term mortality following tramadol poisonings in Denmark	4
Effects of saikosaponin‐d on CYP3A4 in HepaRG cell and protein‐ligand docking study	4
Sacubitril/valsartan, sodium‐glucose cotransporter 2 inhibitors and vericiguat for congestive heart failure therapy	4
The protective effect of solidagenone from Solidago chilensis Meyen in a mouse model of airway inflammation	4
Effects of chronic cirrhosis induced by intraperitoneal thioacetamide injection on the protein content and Michaelis–Menten kinetics of cytochrome P450 enzymes in the rat liver microsomes	4
Combined treatment with FABP4 inhibitor ameliorates rosiglitazone‐induced liver steatosis in obese diabetic db/db mice	4
Rapid‐acting antidepressants and the regulation of TrkB neurotrophic signalling—Insights from ketamine, nitrous oxide, seizures and anaesthesia	4
The mechanism of Epimedin B in treating osteoporosis as revealed by RNA sequencing‐based analysis	4
Intentional suspected suicide exposures by poisoning among adolescents from 2009 to 2018 reported to the Georgia Poison Center and compared nationally	4
Ondansetron in pregnancy revisited: Assessment and pregnancy labelling by the European Medicines Agency (EMA) & Pharmacovigilance Risk Assessment Committee (PRAC)	4
Methamphetamine induces a low dopamine transporter expressing state without altering the total number of peripheral immune cells	4
Language‐agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records	4
Letrozole targets the human ether‐a‐go‐go–related gene potassium current in glioblastoma	4

Why do general practitioners disregard direct to healthcare professional communication? A user‐oriented evaluation to improve drug safety communication	4
Impact of timing of the anorexigen sibutramine administration on reproductive end‐points of male rats	4
The role of cytochrome P450 enzyme genetic variants in cannabis hyperemesis syndrome—A case report	4
Describing long‐term opioid use utilizing Nordic prescription registers—A Norwegian example	4
Structural clarity is brought to adhesion G protein‐coupled receptor tethered agonism	4
Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF‐β/PTHrP/RANKL pathway	4
Statin use before and after the KDIGO Lipids in chronic kidney disease guideline: A population‐based interrupted time series analysis	4
Formate test for bedside diagnosis of methanol poisoning	4
No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients	4
Rifampicin induces the bone form of alkaline phosphatase in humans	4
Summarizing studies using constitutive genetic deficiency to investigate behavioural influences of uptake 2 monoamine transporters	4
Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non‐expressors early after living donor kidney transplantation: Effect of interleukin 6–induced suppression of the cytochrome P450 3A	4
Lithium and the risk of chronic kidney disease: A population‐based case–control study	4
Piceatannol ameliorates behavioural, biochemical and histological aspects in cisplatin‐induced peripheral neuropathy in rats	4
Methylophiopogonanone A is a naturally occurring broad‐spectrum inhibitor against human UDP‐glucuronosyltransferases: Inhibition behaviours and implication in herb‐drug interactions	4
First‐in‐human study with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients	4
The counterregulatory response to hypoglycaemia in the pig	4
Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5	4
Dose and efficacy of repeated administrations of digoxin‐specific antibody fragments: Case report of foxglove poisoning	4
The adhesion G protein‐coupled receptor VLGR1/ADGRV1 controls autophagy	4