Basic & Clinical Pharmacology & Toxicology

Article	Citations
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Patients' Attitudes Towards Deprescribing Differ Across Specific Cardiovascular and Diabetes Medication: A Survey Study Assessing Within‐Patient Differences	40
Artesunate alleviates intracerebral haemorrhage secondary injury by inducing ferroptosis in M1‐polarized microglia and suppressing inflammation through AMPK/mTORC1/GPX4 pathway	39
Register‐based study on prescription renewal without the prescriber meeting the patient	33
Nintedanib Lacks Efficacy in a Spirometry‐Confirmed and Bleomycin‐Induced Mouse Model of Idiopathic Pulmonary Fibrosis	31
Patients' Attitudes Towards Deprescribing and Associations With Patient‐Related Factors Across Two Hospital Settings	30
Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction	28
Antioxidant, Antiinflammatory and Antiapoptotic Effects of Lycopene in Rats With Vancomycin‐Induced Nephrotoxicity	28
Matrix metalloproteinases are associated with severity of disease among COVID‐19 patients: A possible pharmacological target	26
Lithium and the risk of chronic kidney disease: A population‐based case–control study	24
Copper fabric improves the metabolic profile of obese mice: Potential role of the gut microbiota	24
Electrochemical Point‐of‐Care Test for Assessing Serum Paracetamol Concentration: Comparison With Traditional Methods and Detection of Concomitant Drugs	23
How does deprescribing (not) reduce mortality? A review of a meta‐analysis in community‐dwelling older adults casts uncertainty over claimed benefits	22
The Pharmacokinetics, Pharmacological Mechanisms and Clinical Application of Zhenwu Decoction	21
A two‐decade review of butane toxicity as a substance of abuse	21
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Barriers and Facilitators to Pharmacist‐Led Deprescribing of Antihypertensives in Long‐Term Care: A Survey‐Based Study	21
Sp1‐Mettl14 Feedback Loop Promotes Ferroptosis in Mycobacterium tuberculosis –Infected Microglia b	20
A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge	20
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Cytotoxicity, genotoxicity and mutagenicity of mixed ternary mononuclear Mg complex based on valproic acid with 1,10‐phenanthroline in Saccharomyces cerevisiae and V79 cells	19

Vitamin D and SARS‐CoV‐2	19
The Patient Typology about deprescribing and medication‐related decisions: A quantitative exploration	19
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Sapanisertib attenuates pulmonary fibrosis by modulating Wnt5a/mTOR signalling	18
Impact of Tacrolimus Intra‐Patient Variability on Toxicity Development Among Lung Transplant Recipients	17
Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats	17
Preclinical safety and biodistribution assessment of Ad‐KCNH2‐G628S administered via atrial painting in New Zealand white rabbits	17
Drug metabolism and drug transport of the 100 most prescribed oral drugs	17
Pregnane X receptor activation induces liver enlargement and regeneration and simultaneously promotes the metabolic activity of CYP3A1/2 and CYP2C6/11 in rats	16
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications	16
The alleviatory effects of koumine on MSU‐induced gouty arthritis via the TLR4/NF‐κB/NLRP3 pathway	16
The Incidence of Benzodiazepine and Benzodiazepine‐Related Drug Use in People With and Without Parkinson's Disease—A Nationwide Cohort Study	16
Medication use among the oldest old in the Faroe Islands—A national cross‐sectional study	16
Increased Mitochondrial Superoxide Level Is Partially Associated With Vemurafenib‐Induced Renal Tubular Toxicity	15
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Prescribing and deprescribing trends in schizophrenia: An overview of inpatients in Belgium and in the Canadian province of Québec	15
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Liquiritigenin‐Rich Hydroalcoholic Extract of Brazilian Red Propolis Reduces Dyskinesia Induced by 3,4‐ Dihydroxyphenylalanine in Hemiparkinsonian Rats	14
Drugs targeting APOE4 that regulate beta‐amyloid aggregation in the brain: Therapeutic potential for Alzheimer's disease	14
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New Monitoring Recommendations for Digoxin During the Last Decade Are Associated With Decreased Serum Digoxin Concentrations in Patient Samples	14
Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells	13
Copper: From enigma to therapeutic target for neurological disorder	13
In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius	13
Bergaptol Alleviates Oxidative Stress and Inflammation in Intracerebral Haemorrhage Mice via JAK2/STAT3 and NF‐κB Pathways, Improving Neurological Function	13
Fluvoxamine Inhibited NLRP3 and NF‐κB Inflammatory Pathways and Maintained Genital Functions by Ameliorating CD‐MPR, KISS‐1, AQP4 and Claudin‐1 Expressions	13
Significant Antispastic Effect of Combined Fasudil and Isosorbide Dinitrate on Internal Mammary Artery in Coronary Artery Bypass Grafting	13
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Maternal Dyslipidaemia Aggravates Offspring Metabolic Dysfunction–Associated Steatotic Liver Disease	13
Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease	13
Metabolism studies of 4′Cl‐CUMYL‐PINACA, 4′F‐CUMYL‐5F‐PINACA and 4′F‐CUMYL‐5F‐PICA using human hepatocytes and LC‐QTOF‐MS analysis	13
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CYP2D6 Copy Number Variations Identified by KASP PCR	12
Further perspectives on statin use in patients with chronic kidney disease	12
S1PR3 Inactivation Aggravates Cerebrovascular Endothelial Cell Permeability Mediated by cPLA 2 and STAT3 Phosphorylation Under Oxidative Stress	12
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The stimulant cathine from Khat causes tachycardia indirectly in the rat	12
ChatGPT: First glance from a perspective of clinical pharmacology	12
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The Role of Hydroxychloroquine in the Management of Rheumatic Disorders: A Comprehensive Review	11
BCPT 2024 Prizes and Awards	11
Deprescribing in primary care without deterioration of health‐related outcomes: A real‐life, quality improvement project	11
Role of bradykinin and prostaglandin EP4 receptors in regulating TRPV1 channel sensitization in rat dorsal root ganglion neurons	11
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Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF‐β/PTHrP/RANKL pathway	11
Inappropriate polypharmacy management versus deprescribing: A review on their relationship	11
Advancing deprescribing: Learnings from the first international conference on deprescribing	11
Hyperfiltration and Metabolism Before and After a Low‐Calorie, Pre‐Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs	11

Review of the Delay of Chronic Kidney Disease Progression by Wuling San on Improving Renal Fibrosis	11
First‐in‐human study with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients	11
The state of deprescribing research: How did we get here?	11
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Effects of GLP‐1 Receptor Agonists in Alcohol Use Disorder	10
Development of an Artificial Intelligence Powered Medication Risk Score Calculator Application	10
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Assessment of Rivaroxaban Plasma Concentration Using Chromogenic Anti‐Xa Assays and UHPLC–MS/MS in Chinese Patients With Atrial Fibrillation	10
Optimizing autophagy modulation for enhanced TRAIL‐mediated therapy: Unveiling the superiority of late‐stage inhibition over early‐stage inhibition to overcome therapy resistance in cancer	10
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Ameliorative Role of β‐Caryophyllene on Antioxidant Biomarkers in a Paroxetine‐Induced Model of Male Sexual Dysfunction	9
Persistence to statin treatment: A cohort study in Lithuania	9
The Molecular and Clinical Impact of Atorvastatin Exposure on Paclitaxel Neurotoxicity in Sensory Neurons and Cancer Patients	9
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Making it happen: Development of an interprofessional deprescribing education programme	9
BCPT 2025 Prizes and Awards	9
Correction to Involvement of H 2 S, NO and BDNF‐TrkB signalling pathway in the protective effects of simvastatin against pentylenetetrazole‐induced k	9
Antagonism of Kinin Receptors B1 and B2 Attenuates Folic Acid‐Induced Tubulointerstitial Fibrosis in Mice	9
Somatostatin receptor ligands suppressed proliferation and lipogenesis in 3T3‐L1 preadipocytes	9
In vitro effect of hyoscine‐N‐butyl bromide and diclofenac sodium in human tuba uterina	9
Trends in Antithrombotic Therapy Initiation Among Patients With Stroke Pre‐ and Post–COVID‐19 in Sweden—An Interrupted Time Series Study	9
Questions in Healthcare Specifically Related to the Discipline of Pharmacy: A Descriptive Analysis of Queries to Drug Information Centres in Sweden	9
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Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes	8
Levothyroxine Treatment During Pregnancy: A Metabolomics Study	8
Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin‐induced pulmonary fibrosis in mice	8
Effect of stearyl alcohol on imiquimod‐induced psoriasis‐like skin inflammation in mice	8
Facilitating the Implementation of Physician‐Led Medication Reviews for Patients With Severe Mental Disorder and Diabetes: A Cost‐Minimization Analysis	8
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‘This Is My Decision’: A Qualitative Study of Individuals' Perspectives on Use of Semaglutide for Weight Loss	8
Efficacy of weekly versus daily cholecalciferol for repleting serum vitamin D (25(OH)D) deficiency: A systematic review and meta‐analysis of randomized controlled trials	8
Special Collection: Mechanisms of Vasodilatation Endothelium‐Dependent Hyperpolarization (MOVD/EDH2024)	8
Development of a Deprescribing Intervention for Proton Pump Inhibitors in Primary Care: A Co‐Design Approach With General Practitioners and Patients	8
From Hospital to Home: Patient Experiences With Medication Counselling for Colorectal Cancer	8
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Curcumin Alleviates Myocardial Ischaemia–Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis via the Nrf2/HO‐1 Pathway: An Integrated Network Pharmacology and Experimental St	8
Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended‐release microparticle formulation: A phase 1, dose‐ascending study in male volunteers	8
Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17	8
Dementia and neurodegenerative diseases: What is known and what is promising at the cellular and molecular level	8
Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers	8
Paroxetine alleviates ulcerative colitis in mice via restoring intestinal microbiota homeostasis and metabolism	8
Correction to ‘β‐LAPachone Ameliorates Doxorubicin‐Induced Cardiotoxicity via Regulating Autophagy and Nrf2 Signalling Pathways in Mice’	7
Gentiopicroside Attenuated Dopaminergic Neurodegeneration via Inhibiting Neuroinflammatory Responses and Ferroptosis in Experimental Models of Parkinson's Disease	7
Welcome to Basic & Clinical Pharmacology & Toxicology 2024	7
The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation	7
Plasma NGAL, suPAR, KIM‐1 and GDF‐15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients	7
Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high‐grade serous ovarian cancer	7
Ten deprescribing articles you should know about: A guide for newcomers to the field	7
Effects of rifampicin on porphyrin metabolism in healthy volunteers	7
Growth differentiation factor 15 is dispensable for acetaminophen‐induced liver injury in mice	7
Exploratory pharmacovigilance with machine learning in big patient data: A focused scoping review	7
Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells	7
Traditional Chinese Medicine for Inhibiting Ferroptosis in Ischemic‐Related Diseases	7
Gadoteric Acid Induces Dose‐Dependent DNA Damage and Enzyme Binding in Fibroblast Cells	7
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The effectiveness and safety of botulinum toxin injections for managing motor disorders of patients with Parkinson's disease: A meta‐analysis of randomized controlled trials	7
Therapeutic benefit of melatonin in 5‐fluorouracil‐induced renal and hepatic injury	7
Application of Artificial Intelligence in the Development of Traditional Chinese Medicine	7
High Throughput Pharmacovigilance Screening for Roflumilast Adverse Effects in Real‐World Settings: A Sequence Symmetry Analysis	6
Eugenol Alleviates Cerebral Ischemia–Reperfusion Injury in Mice by Promoting the Phagocytosis of Microglia via Up‐Regulating Tripartite Motif Protein 59	6
CYP3A4*22 and bleeding risk in ticagrelor users	6
Biomarkers of Parkinson's disease in perspective of early diagnosis and translation of neurotrophic therapies	6
Neuroprotective Effects of Esketamine in Central Nervous System Disorders: Mechanisms and Cellular Targets	6
Understanding Medication Errors Through Patient Complaints in a Danish University Hospital	6
Study of the mechanism underlying the role of PINK1/Parkin in the formic acid‐induced autophagy of PC12 cells	6
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The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease	6
Healthcare Providers' Perspectives on Antidepressant Discontinuation: A Focus Group Study	6
Multi‐Target Renal Protection of Wine‐Processed Polygonatum sibiricum Against Cisplatin‐Induced Nephrotoxicity: Integrated Phytochemistry, Network Pharmacology and Experimental Valid	6
LW‐AFC Protects Against Neurological and Neuropsychiatric Effects of SARS‐CoV‐2 Spike Protein in Mice	6
Limited sampling approach for model‐informed precision dosing of daptomycin to rapidly achieving the target area under the concentration‐time curve: A simulation study	6
Blood Pressure–Lowering Effects of Aldosterone Synthase Inhibitors—A Systematic Review	6
Insights Into Gut Barrier Dysfunction and Metabolic Alterations in Mycophenolate‐Induced Enteropathy	6
A review on the new age methodologies for early detection of Alzheimer's and Parkinson's disease	6
Triptolide alleviates collagen‐induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN‐STAT3 pathway	6
Association between patient attitudes towards deprescribing and subsequent prescription changes	6
Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell	6
Learnings From a Knowledge Mobilization Strategy to Integrate a Deprescribing Educational Curriculum Into Health Professional Programmes	6

Association Between Furosemide and Risk of Parkinson's Disease in a Nested Case–Control Study	6
Optimal dosing of gliclazide—A model‐based approach	6
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Categorization of deprescribing communication tools: A scoping review	6
Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma	6
Emergency Department Visits due to Medication Overdose in a Finnish University Hospital	6
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The role of decision tree and machine learning models for outcome prediction of bupropion exposure: A nationwide analysis of more than 14 000 patients in the United States	6
Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark	6
α‐Lipoic acid up‐regulates gene expression but reduces protein levels of fibroblast growth factor 21 in HepG2 cells	5
Phase I clinical trial evaluating the safety, tolerance, pharmacokinetics and pharmacodynamics of HSK21542 injection in healthy volunteers	5
Disease‐modifying therapies in multiple sclerosis: A focused review of rituximab	5
Retraction	5
Long‐Term Safety and Efficacy of AAV9 Vectors Expressing Human SMN1 Gene: A Preclinical Study	5
Efficacy and Safety of Clopidogrel With and Without a Proton Pump Inhibitor: A Systematic Review and Meta‐Analysis	5
GMI, a Fungal Immunomodulatory Protein From Ganoderma microsporum , Induces Different Cytotoxicity in Parental and Osimertinib‐Resistant EGFR‐Mutated Lun	5
Eugenol delays the onset of ouabain‐induced ventricular cardiac arrhythmias in guinea pigs	5
Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review	5
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Association Between Levels of the Acute Phase Proteins Alpha‐1‐Acid Glycoprotein and C‐Reactive Protein and Serum Concentrations of Clozapine: A Study of 1106 Therapeutic Drug Monitoring Samples	5
Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti‐diazepam‐induced ataxia action as a structure‐dependent feature	5
Direct oral anticoagulant concentrations and adherence in stroke patients	5
Adverse effects of an aldosterone synthase (CYP11B2) inhibitor, fadrozole (FAD286), on inflamed rat colon	5
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Cyclopeptide mushroom poisoning: A retrospective series of 204 patients	5
DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview	5
Carnosol attenuated atrophy of C2C12 myotubes induced by tumour‐derived exosomal miR‐183‐5p through inhibiting Smad3 pathway activation and keeping mitochondrial respiration	5
Effect of Acute Exposure of Swiss Mice to Chlorogenic Acid	5
Comparing different postoperative sedation strategies for patients in the intensive care unit after cardiac surgery: A systematic review of randomized controlled trials and network meta‐analysis	5
Should high‐dose N‐acetylcysteine be given in cases of massive paracetamol overdoses: A narrative review	5
The BCPT young researcher Nordic Prize 2022 goes to Associate Professor Tore Bjerregaard Stage	5
Vancomycin audit in the paediatric population: Patterns of use and appropriateness of therapeutic drug monitoring	5
Gastroprotective effect of sumatriptan against indomethacin‐, stress‐ and ethanol‐induced gastric damage in male rats: Possible modulatory role of 5‐hydroxytryptamine 1B/1D receptors and pro‐inflammat	5
Investigating the P53‐dependent anti‐cancer effect of ibutamoren in human cancer cell lines	5
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Dimetindene—Is the minimum toxic dose for children too strict?	5
Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders	5
Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Therapeutic Intervention	5
Review of clinical pharmacokinetics and pharmacodynamics of clonidine as an adjunct to opioids in palliative care	5
Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies	5
Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor	5
Per‐ and polyfluoroalkyl substances and cardiometabolic diseases: A review	5
The effects of cannabidiol against Methotrexate‐induced lung damage	5
Initiation of Anticoagulants During the COVID‐19 Pandemic in Sweden: An Interrupted Time Series Analysis	5
Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine	4
Pregnancy Outcomes After Semaglutide Exposure	4
Sildenafil attenuates oxidative stress and endothelial dysfunction in lead‐induced hypertension	4
A dose‐related positive effect of inhaled simvastatin‐loaded PLGA nanoparticles on paraquat‐induced pulmonary fibrosis in rats	4
Drug‐Induced Liver Injury Associated With Moxifloxacin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System and a Real‐World Retrospective Study	4
Diallyl trisulfide alleviates dextran sulphate sodium‐induced colitis in mice by inhibiting NLRP3 inflammasome activation via ROS/Trx‐1 pathway	4
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Scientific program	4
Sodium bicarbonate reverts electrophysiologic cardiotoxicity of ropivacaine faster than lipid emulsions in a porcine model	4
Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models	4
Gender balance in the editorial room: BCPT as model journal?	4
Letter from the editor	4
Models of Endocrine‐Disrupting Effects: Human Placental Steroidogenesis	4
Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats	4
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project	4
Population kinetic–pharmacodynamic analysis of serum potassium in patients receiving sulfamethoxazole/trimethoprim	4
Non‐recovery of vancomycin‐associated nephrotoxicity is related to worsening survival outcomes: Combined retrospective analyses of two real‐world databases	4
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Poisonings With Opioids and Benzodiazepines in Denmark: A Retrospective Study From the Danish Poison Information Centre	4
Tailoring an Implementation Strategy for Deprescribing as Part of a Comprehensive Geriatric Assessment (dCGA) in Long‐Term Care Facilities: A Roundtable Discussion	4
Retrospective identification of new psychoactive substances in patient samples submitted for clinical drug analysis	4
The role of peroxisome proliferator‐activated receptors in the regulation of bile acid metabolism	4
The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants	4
The Cardiovascular Safety of Antiparkinsonian Drugs—Analysis of Signals in the FDA Adverse Event Report System Database	4
Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice	4
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Environmental Aspects in Price and Reimbursement Decisions of Medicines—A Scoping Review	4
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Xiao‐Jie‐An Capsule Attenuates Oestrogen‐ and Progestogen‐Induced Mammary Gland Hyperplasia by Modulating Sex Hormone Levels and Reducing Inflammatory Response	4
Differences in the Inflammatory Response and Corticoid Responsiveness of Human Lung Macrophages and Parenchymal Explants Exposed to Cigarette Smoke Extracts	4
Assessing Condition‐Specific Adverse Event Profiles of Modafinil for Labelled and Off‐Label Uses: A Systematic Review and Meta‐Analysis	4
Safety evaluation of adenosine, lidocaine and magnesium (ALM) intranasal therapy toward human nasal epithelial cells in vitro	4
Self‐perceived learning outcomes of virtual and in‐person academic detailing among general practitioners in Norway	3
Improving CYP2C19 phenotyping using stereoselective omeprazole and 5‐hydroxy‐omeprazole metabolic ratios	3
CYP3A4*22 may increase bleeding risk in ticagrelor users	3
Deprescribing Tool for Older PeoPle with Limited‐life Expectancy (De‐TOPPLE) version 1: Development and validation using a modified Delphi technique	3
Cannabidiol reduces lipopolysaccharide‐induced nociception via endocannabinoid system activation	3
Metabolomics and Network Pharmacology Revealed the Mechanism of Feining Mixture Against Respiratory Syncytial Virus Pneumonia	3
Inhibition of efflux transporters by poly ADP‐ribose polymerase inhibitors	3
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Pharmacokinetics, bioequivalence and safety of two formulations of ticagrelor in healthy Chinese subjects: Effects of food	3
Traditional Chinese Medicine for Anti‐Arrhythmias: Mechanisms via Potassium Channels	3
Subchronic Exposure to Aripiprazole Subtly Impacts on Rodents' Sperm Quality and Fertility	3
Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room	3
Artesunate inhibits osteoclast differentiation by inducing ferroptosis and prevents iron overload‐induced bone loss	3
Maternal Exposure to Medications and the Risk of Congenital and Early‐Onset Hearing Loss in Children: A Systematic Review and a Meta‐Analysis	3
Alantolactone inhibits oesophageal adenocarcinoma cells through nuclear factor erythroid 2‐related factor 2‐mediated reactive oxygen species increment	3
Multidimensional Evaluation of Lisdexamfetamine: Pharmacology, Therapeutic Use, Toxicity and Forensic Implications	3
Effect of albumin infusion on oxidative albumin modification and albumin binding capacity in chronic liver failure	3
The Ever‐Expanding Influence of the Endothelial Nitric Oxide Synthase	3