OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Biomaterialia is 76. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Antibacterial biohybrid nanofibers for wound dressings	381
β-tricalcium phosphate for bone substitution: Synthesis and properties	347
Nerve guide conduits for peripheral nerve injury repair: A review on design, materials and fabrication methods	275
Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs	216
Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss	202
Poloxamer: A versatile tri-block copolymer for biomedical applications	185
Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities	182
Hybrid cell membrane-coated nanoparticles: A multifunctional biomimetic platform for cancer diagnosis and therapy	180
3D and 4D printing in dentistry and maxillofacial surgery: Printing techniques, materials, and applications	178
Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing	149
Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies	146
Advancing bioinks for 3D bioprinting using reactive fillers: A review	140
From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases	139
A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes	138
Recent advances in PLGA-based biomaterials for bone tissue regeneration	134
Multi-material additive manufacturing technologies for Ti-, Mg-, and Fe-based biomaterials for bone substitution	126
A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model	121
The role of calcium phosphate surface structure in osteogenesis and the mechanisms involved	119
PEG-based thermosensitive and biodegradable hydrogels	118
Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects	118
In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications	117
An injectable hydrogel using an immunomodulating gelator for amplified tumor immunotherapy by blocking the arginase pathway	116
A biodegradable Zn-1Cu-0.1Ti alloy with antibacterial properties for orthopedic applications	116
The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time	115
Bone marrow mesenchymal stem cell-derived exosomes promote tendon regeneration by facilitating the proliferation and migration of endogenous tendon stem/progenitor cells	115

Strategies to use fibrinogen as bioink for 3D bioprinting fibrin-based soft and hard tissues	114
Additively manufactured biodegradable porous metals	112
Breast cancer models: Engineering the tumor microenvironment	109
3D bioprinting of mechanically tuned bioinks derived from cardiac decellularized extracellular matrix	107
Microfluidic organ-on-a-chip models of human liver tissue	106
The immune microenvironment in cartilage injury and repair	105
Co–culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches	103
Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges	103
Polypeptide-based self-healing hydrogels: Design and biomedical applications	101
3D bioprinting of graphene oxide-incorporated cell-laden bone mimicking scaffolds for promoting scaffold fidelity, osteogenic differentiation and mineralization	101
Microneedle-mediated transdermal drug delivery for treating diverse skin diseases	99
A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: In vitro and in vivo studies	99
Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform	99
Functionally engineered extracellular vesicles improve bone regeneration	98
The protein corona and its effects on nanoparticle-based drug delivery systems	98
3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects	98
A biodegradable multifunctional nanofibrous membrane for periodontal tissue regeneration	97
Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury	96
Dual stimuli-responsive metal-organic framework-based nanosystem for synergistic photothermal/pharmacological antibacterial therapy	95
Graphene and graphene oxide for bio-sensing: General properties and the effects of graphene ripples	94
Alginate/laponite hydrogel microspheres co-encapsulating dental pulp stem cells and VEGF for endodontic regeneration	94
A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation	93
Advancements in prophylactic and therapeutic nanovaccines	92
Micro/nano-hierarchical scaffold fabricated using a cell electrospinning/3D printing process for co-culturing myoblasts and HUVECs to induce myoblast alignment and differentiation	92
Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy	91
Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology	91
Scaffolds with controlled release of pro-mineralization exosomes to promote craniofacial bone healing without cell transplantation	90
Optimization of mechanical stiffness and cell density of 3D bioprinted cell-laden scaffolds improves extracellular matrix mineralization and cellular organization for bone tissue engineering	90
Enzyme-responsive polymeric micelles of cabazitaxel for prostate cancer targeted therapy	89
Orchestrating soft tissue integration at the transmucosal region of titanium implants	88
Calcium phosphate cements: Optimization toward biodegradability	88
VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1α-mediated enhancement of angiogenesis	88
Biodegradable Zn–Cu alloys show antibacterial activity against MRSA bone infection by inhibiting pathogen adhesion and biofilm formation	87
Injectable adaptive self-healing hyaluronic acid/poly (γ-glutamic acid) hydrogel for cutaneous wound healing	87
Peritoneal adhesions: Occurrence, prevention and experimental models	86
Tailored mechanical response and mass transport characteristic of selective laser melted porous metallic biomaterials for bone scaffolds	85
Multi-functional silica-based mesoporous materials for simultaneous delivery of biologically active ions and therapeutic biomolecules	85
Glucose-responsive multifunctional metal–organic drug-loaded hydrogel for diabetic wound healing	82
Chemical design of nanozymes for biomedical applications	81
Control of innate immune response by biomaterial surface topography, energy, and stiffness	81
Biofunctionalization of selective laser melted porous titanium using silver and zinc nanoparticles to prevent infections by antibiotic-resistant bacteria	80
Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis	80
Immunoadjuvants for cancer immunotherapy: A review of recent developments	80
pH-responsive silk fibroin-based CuO/Ag micro/nano coating endows polyetheretherketone with synergistic antibacterial ability, osteogenesis, and angiogenesis	80
2D Ti3C2TxMXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells	79
Understanding and optimizing the antibacterial functions of anodized nano-engineered titanium implants	79
An injectable, self-healing phenol-functionalized chitosan hydrogel with fast gelling property and visible light-crosslinking capability for 3D printing	79
A photo-crosslinkable cartilage-derived extracellular matrix bioink for auricular cartilage tissue engineering	77
Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer's disease mice	77
Highly tunable bioactive fiber-reinforced hydrogel for guided bone regeneration	77

Mesenchymal stem cell-laden, personalized 3D scaffolds with controlled structure and fiber alignment promote diabetic wound healing	76
A natural polymer-based porous sponge with capillary-mimicking microchannels for rapid hemostasis	76