OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Drug Delivery is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	57
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	57
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	56
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	54
Artificial Intelligence’s role in colon-targeted drug delivery	53
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	52
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	45
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	41
How can nanoemulsions be used for photosensitizer drug delivery?	41
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	40
Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies	38
Iontophoresis for the cutaneous delivery of nanoentraped drugs	37
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	36
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	36
The quest to deliver high-dose rifampicin: can the inhaled approach help?	36
The challenges of drug delivery to the esophagus and how to overcome them	34
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	33
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	33
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	33
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	31
Novel formulations of metal-organic frameworks for controlled drug delivery	30
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	30
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	30
Future applications of self-immolative polymers in drug delivery	30
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	29

Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	28
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	28
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	27
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	27
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	27
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	27
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	27
Current status and prospect for future advancements of long-acting antibody formulations	26
Acetalated dextran: a novel delivery platform for particle-based vaccines	26
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	26
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	25
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	25
Current insights into drug-coated balloons for peripheral arterial disease	24
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	24
Potential bladder cancer therapeutic delivery systems: a recent update	22
Can radiopharmaceuticals be delivered by quantum dots?	22
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	22
Silica nanoparticles for brain cancer	22
Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris	21
3D printed dosage forms, where are we headed?	21
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	20
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	20
Nanotechnology-based formulations toward the improved topical delivery of anti-acne active ingredients	20
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	20
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	20
Oleuropein as a novel topical antipsoriatic nutraceutical: formulation in microemulsion nanocarrier and exploratory clinical appraisal	19
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	19
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	19
Platelets for advanced drug delivery in cancer	19
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	19
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	19
Targeted transport of biotherapeutics at the blood-brain barrier	18
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	18
Microneedles for oral mucosal delivery – Current trends and perspective on future directions	18
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	18
Untethered shape-changing devices in the gastrointestinal tract	18
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	18
Future applications of cyclic antimicrobial peptides in drug delivery	18
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	17
Development and approval of novel injectables: enhancing therapeutic innovations	17
Is electroporation the key to drug delivery in drug-resistant cancers?	17
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	17
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	16
Polymer-based thermoresponsive hydrogels for controlled drug delivery	16
Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity	16
Recent advances in drug delivery to the central nervous system by inhalation	16
Biphasic drug release from electrospun structures	16
Particle surface coating for dry powder inhaler formulations	16
An update on cell-penetrating peptides with intracellular organelle targeting	16
Lipid-based nanosystems for wound healing	16

Topical drug delivery to the retina: obstacles and routes to success	15
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	15
Polyphosphoester cubosomes: introducing a novel drug delivery system	15
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	15
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	14
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	14
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	14
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	14
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	14
An update on the latest strategies in retinal drug delivery	14
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	14
The impact of common pharmaceutical excipients on the gut microbiota	14
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	14
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	13
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	13
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	13
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis	13
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	13
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	13
Biopredictive tools for the development of injectable drug products	13
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	13
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	13
Inhaled antifungal therapy: benefits, challenges, and clinical applications	13
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	13
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	13
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	13
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	12
Solid lipid nanoparticles: a promising tool for insulin delivery	12
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	12
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	12
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	12
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	12
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	12
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	11
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	11
Improving antifungal lipid-based drug delivery against Candida : a review	11
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	11
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	11
Advances in engineering and delivery strategies for cytokine immunotherapy	11
Drug delivery systems for wound healing treatment of upper airway injury	11
Exploring space-energy matching via quantum-molecular mechanics modeling and breakage dynamics-energy dissipation via microhydrodynamic modeling to improve the screening efficiency of nanosuspension p	11
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	11