OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Drug Delivery is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
Intranasal administration of antiseizure drugs using new formulation trends: one step closer to reach clinical trials	95
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	53
Electronically powered drug delivery devices: considerations and challenges	49
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	48
Ketamine-polymer based drug delivery system for prolonged analgesia: recent advances, challenges and future prospects	44
Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders	41
Expert opinion on antimicrobial therapies: is there enough scientific evidence to state that targeted therapies outperform non-targeted ones?	40
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	32
Metabolism and structure of PDA as the target for new therapies: possibilities and limitations for nanotechnology	32
Conjugates of amphotericin B to resolve challenges associated with its delivery	32
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	31
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	31
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	30
Compared implementation of the long-acting buprenorphine treatment buvidal in four European countries	27
The quest to deliver high-dose rifampicin: can the inhaled approach help?	27
Advanced approaches to overcome biological barriers in respiratory and systemic routes of administration for enhanced nucleic acid delivery to the lung	26
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	26
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	25
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	25
Hydrogels for brain repair: application to Parkinson’s disease	24
Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances	24
Small but powerful: will nanoparticles be the future state‐of‐the‐art therapy for IBD?	23
The impact of common pharmaceutical excipients on the gut microbiota	23
Iontophoresis for the cutaneous delivery of nanoentraped drugs	23
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	23

Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	23
Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: from preclinical to clinical studies	23
Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration	22
Fluorinated vectors for gene delivery	22
Therapeutic nanocarriers comprising extracellular matrix-inspired peptides and polysaccharides	21
Magnetoliposomes: recent advances in the field of controlled drug delivery	21
Peptide-based supramolecular assembly drugs toward cancer theranostics	21
The current paradigm for biologic initiation: a mixed-methods exploration of practices, unmet needs, and innovation opportunities in self-injection training	21
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	20
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	20
Nanoparticle-based drug delivery for the treatment of traumatic brain injury	20
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	19
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	19
Current advances in cell therapeutics: a biomacromolecules application perspective	19
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	19
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	19
Safety of recombinant human hyaluronidase PH20 for subcutaneous drug delivery	19
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	18
The industrial design, translation, and development strategies for long-acting peptide delivery	18
3D printing and computer-aided design techniques for drug delivery scaffolds in tissue engineering	17
Strategies for overcoming the biological barriers associated with the administration of inhaled monoclonal antibodies for lung diseases	17
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges	17
Thermosensitive liposomes: a promising step toward localised chemotherapy	17
Nasal delivery as a strategy for the prevention and treatment of COVID-19	16
In vitro modelling of intramuscular injection site events	16
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	16
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	15
Amorphous solid dispersion to facilitate the delivery of poorly water-soluble drugs: recent advances on novel preparation processes and technology coupling	15
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	15
Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation	15
How can nanoemulsions be used for photosensitizer drug delivery?	15
All-trans retinoic acid in anticancer therapy: how nanotechnology can enhance its efficacy and resolve its drawbacks	14
Evolution of microneedle applicators for vaccination: the role of the latch applicator in optimizing dissolving microneedle-based immunization	14
Exploring the transformability of polymer-lipid hybrid nanoparticles and nanomaterial-biology interplay to facilitate tumor penetration, cellular uptake and intracellular targeting of anticancer drugs	14
Recent advances in the application of clay-containing hydrogels for hemostasis and wound healing	14
An opinion on advanced cancer immunotherapy through innovations in PD-1 inhibitor delivery systems	14
Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies	14
How can we advance drug delivery options using extracellular vesicles for pregnant women to reduce preterm birth?	14
Barriers for orally inhaled therapeutic antibodies	13
Bridging the gap between fundamental research and product development of long acting injectable PLGA microspheres	13
Opportunities in combinational chemo-immunotherapy for breast cancer using nanotechnology: an emerging landscape	13
Exploring new frontiers in drug delivery with minimally invasive microneedles: fabrication techniques, biomedical applications, and regulatory aspects	13
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	13
Updated insight into the characterization of nano-emulsions	13
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	13
Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part I: biophysical considerations	12
Fungal quorum sensing molecules as potential drugs in the treatment of chronic wounds and their delivery	12
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	12
Recent advancements on in vitro blood-brain barrier model: A reliable and efficient screening approach for preclinical and clinical investigation	12
What is the future potential of microbially degradable systems in oral drug delivery to the colon?	12

Synthetic engineered bacteria for cancer therapy	12
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polar	12
Atropine in topical formulations for the management of anterior and posterior segment ocular diseases	12
Preclinical developments in the delivery of protein antigens for vaccination	11
The challenges of drug delivery to the esophagus and how to overcome them	11
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	11
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	11
Improved biopharmaceutical attributes of lumefantrine using choline mimicking drug delivery system: preclinical investigation on NK-65 P.berghei murine model	11
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	11
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	11
Targeting genetic tool for long non-coding RNA of cancer stem cells with aptamer-guided nanocarriers	11
Biopolymeric 3D printed implantable scaffolds as a potential adjuvant treatment for acute post-operative pain management	11
Advances in microsphere-based therapies for peritoneal carcinomatosis: challenges, innovations, and future prospects	11
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	11
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	11
Navigations of the targeting pathway of nanomedicines toward tumor	10
An insight into the role of liposomal therapeutics in the reversion of multiple sclerosis	10
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	10
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	10
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	10
Recent advances on small molecular gels: formation mechanism and their application in pharmaceutical fields	10
Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia:ex vivopermeation and clinical appraisal	9
Research progress in tumor targeted immunotherapy	9
Enzyme-responsive mannose-grafted magnetic nanoparticles for breast and liver cancer therapy and tumor-associated macrophage immunomodulation	9
Additive manufacturing of microneedles for sensing and drug delivery	9
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	9
Nanocarriers in topical photodynamic therapy	9
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	9
Transdermal delivery via medical device technologies	9
Characterizing regional drug delivery within the nasal airways	9
Drug loaded implantable devices to treat cardiovascular disease	9
Translational hurdles in anti-asthmatic nanomedicine development	9
Inhaled antifungal therapy: benefits, challenges, and clinical applications	9
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	9
Combinations of chemo-, immuno-, and gene therapies using nanocarriers as a multifunctional drug platform	9
Roadmap to discovery and early development of an mRNA loaded LNP formulation for liver therapeutic genome editing	9
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	9
An update on the latest strategies in retinal drug delivery	9
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	9