Expert Opinion on Drug Delivery

Article	Citations
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	71
Artificial Intelligence’s role in colon-targeted drug delivery	68
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers f	61
All eyes on semifluorinated alkanes: a comprehensive review of the influence of semifluorinated alkane eyedrops on tear film stabilization and drug delivery in dry eye disease	60
How can nanoemulsions be used for photosensitizer drug delivery?	58
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	56
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	55
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	54
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	53
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	53
The quest to deliver high-dose rifampicin: can the inhaled approach help?	53
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	50
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	48
Iontophoresis for the cutaneous delivery of nanoentraped drugs	47
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	46
Current insights into polymeric micelles for nasal drug delivery	45
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	42
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	41
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	40
The challenges of drug delivery to the esophagus and how to overcome them	40
Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications	40
How can we optimize the delivery of IL-2 to traumatic brain injury patients?	40
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	38
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	38
Acetalated dextran: a novel delivery platform for particle-based vaccines	37

Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	36
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	36
Engineering polycaprolactone nanowires for pharmacologic efficacy	34
Progress and potential of nanobubbles for ultrasound-mediated drug delivery	33
Calcium carbonate in drug delivery: functional carrier design, applications, and data-driven perspectives	32
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	32
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	32
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	31
Future applications of self-immolative polymers in drug delivery	31
Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	30
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	29
Current status and prospect for future advancements of long-acting antibody formulations	29
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	29
Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery	29
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	28
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	28
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	27
Novel formulations of metal-organic frameworks for controlled drug delivery	27
Silica nanoparticles for brain cancer	27
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	26
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	26
Current insights into drug-coated balloons for peripheral arterial disease	26
3D printed dosage forms, where are we headed?	26
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	26
Potential bladder cancer therapeutic delivery systems: a recent update	26
Can radiopharmaceuticals be delivered by quantum dots?	26
Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations	25
How might intraluminal drug-delivery strategies be improved to enhance arteriovenous fistula maturation and patency?	25
Differential targeting of olfactory epithelium and respiratory epithelium in nose-to-brain drug delivery	25
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	25
Cyclodextrin-based carriers for targeted drug delivery	25
Emerging landscape of bioinformatics and artificial intelligence applications in cell-penetrating peptide-based delivery	25
The potential public health benefit of live-attenuated pertussis vaccines	25
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	24
What role might nanolipogels play in enhancing drug delivery?	24
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	23
Treating glioblastoma with dextrin-based polymers	23
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	23
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	22
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	22
Advancing the current state of gene therapies using adeno-associated virus vectors to treat atrial cardiomyopathy	22
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	22
Platelets for advanced drug delivery in cancer	22
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	21
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	21
Future applications of cyclic antimicrobial peptides in drug delivery	21
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	21
Is electroporation the key to drug delivery in drug-resistant cancers?	20
Recent advances in antibacterial nanoformulations for endodontic applications	20
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	20

Polyphosphoester cubosomes: introducing a novel drug delivery system	20
Lipid-based nanosystems for wound healing	19
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	19
Targeted transport of biotherapeutics at the blood-brain barrier	19
Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity	19
Biphasic drug release from electrospun structures	19
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	19
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	19
An update on cell-penetrating peptides with intracellular organelle targeting	18
Development and approval of novel injectables: enhancing therapeutic innovations	18
Microneedles for oral mucosal delivery – Current trends and perspective on future directions	18
Polymer-based thermoresponsive hydrogels for controlled drug delivery	18
Untethered shape-changing devices in the gastrointestinal tract	18
Recent advances in drug delivery to the central nervous system by inhalation	18
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	18
Particle surface coating for dry powder inhaler formulations	18
Drug and stem cells delivery to salivary glands – a concise review	17
Targeted delivery of therapeutics to the heart with calcium phosphate nanoparticles	17
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	17
Infusion-based drug delivery to the brain: what’s next?	17
Drug delivery and formulation development of hesperidin: a systematic review	17
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	17
The impact of common pharmaceutical excipients on the gut microbiota	17
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	16
Correction	16
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	16
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	16
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	16
An update on the latest strategies in retinal drug delivery	16
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	15
Engineering trafficking pathways to overcome immunosuppressive barriers in solid tumor immunotherapy	15
Development of ROS-responsive liposomes toward targeted drug delivery	15
Explicit analysis of in vivo , meterological and statistical hurdles in successful clinical translation of targeted nanomedicines and plausible remedial	15
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	15
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	15
Inhaled antifungal therapy: benefits, challenges, and clinical applications	14
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	14
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	14
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	14
A fluid and particle mechanics perspective of nasal drug delivery	14
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	14
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	14
Optimizing deferoxamine delivery through the skin for pressure ulcers	14
Nano-drug delivery system of natural products for disease prevention and treatment	14
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	14
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	14
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	14
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	13
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	13
Advanced nano-delivery systems in H. pylori eradication: targeting, efficacy, and clinical translation	13
Biopredictive tools for the development of injectable drug products	13
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	13
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	13
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	13
Future outcomes and current limitations of injectable implants for vocal fold scarring	13
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	13
Solid lipid nanoparticles: a promising tool for insulin delivery	13
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	13
Oncofetal chondroitin sulfate in cancer therapy: a promising target for anti-tumor drug delivery?	12
Improving antifungal lipid-based drug delivery against Candida : a review	12
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	12
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	12
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	12
Advances in engineering and delivery strategies for cytokine immunotherapy	12
Intra-articular targeted delivery of nanomaterials for the treatment of osteoarthritis: focusing on cell signaling pathway mechanisms	12
The potential of a high efficacy single shot injection of artemisinin combination for effective antimalarial therapy	12
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	12
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	12
Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer’s disease: current approaches and future perspectives	12
Drug delivery systems for wound healing treatment of upper airway injury	12
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	11
Cancer bone metastases and nanotechnology-based treatment strategies	11
Graphene quantum dots for breast cancer treatment	11
Redefining drug therapy: innovative approaches using catalytic compartments	11
Application of zein nanoparticles for the treatment of inflammatory bowel diseases	11
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	11
Topical curcumin in the treatment of denture stomatitis: a systematic review of clinical efficacy	11
Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery	11
Are inhaled mRNA vaccines safe and effective? A review of preclinical studies	11
Versatility of emulgel in topical drug delivery transforming its expedition from bench to bedside	11

Engineered exosomes derived from stem cells: a new brain-targeted strategy	11
siRNA therapeutics: insights, challenges, remedies and future prospects	11
Nano-sized drug delivery systems to potentiate the immune checkpoint blockade therapy	11
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: a review	11
Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals	10
RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions	10
Polypeptides as alternatives to PEGylation of therapeutic agents	10
Lessons learned from the SARS-CoV-2 pandemic; from nucleic acid nanomedicines, to clinical trials, herd immunity, and the vaccination divide	10
Current status of porous coordination networks (PCNs) derived porphyrin spacers for cancer therapy	10
A comprehensive review of the application of 3D-bioprinting in chronic wound management	10
Drug-eluting stents for the treatment of coronary artery disease: A review of recent advances	10
Research progress on detachable microneedles for advanced applications	10
Harness arsenic in medicine: current status of arsenicals and recent advances in drug delivery	10
Hydrogel formulations for orthotopic treatment of myocardial infarction	10
Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development	10
Combining experimental and computational techniques to understand and improve dry powder inhalers	10
Performance characterization of spring-actuated prefilled pen devices for lebrikizumab and dupilumab	9
Strategies for the delivery of RNA therapeutics to diseased heart tissue	9
Navigating the challenges in pediatric intranasal drug delivery	9
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	9
Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances	9
Metallic and lipid nanoparticles against multidrug resistant Candida : advances and translational hurdles	9
What is the potential of Fmoc-FF hydrogels for drug delivery?	9
Nasal delivery as a strategy for the prevention and treatment of COVID-19	9
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	9
Can nanoparticle-based intranasal delivery systems revolutionize treatment of central nervous system diseases?	9
Hydrogels for brain repair: application to Parkinson’s disease	9
Infusion therapies for Parkinson’s disease: where are we in 2025?	9
Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy	9
Potential of nanocarrier-mediated delivery of vancomycin for MRSA infections	9
Biodegradable and removable implants for controlled drug delivery and release application	9
3D printed biodegradable bilayer films: a promising frontier in liver cancer therapy	9
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	9
In vitro modelling of intramuscular injection site events	9
Role of nanotechnology in the prolonged release of drugs by the subcutaneous route	9
Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology	9
Clinical insights into extracellular vesicles for targeted myocardial drug delivery	9
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	8
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	8
The blood–brain barrier as a treatment target for neurodegenerative disorders	8
Drug-eluting resorbable coronary scaffolds: a review of recent advances	8
An expert opinion on phytocompounds delivery for leishmaniasis treatment	8
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	8
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	8
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	8
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	8
Polyphenol-conjugated polysaccharide nanoplatforms for enhanced therapeutic efficacy	8
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to	8
Assessment of the effectiveness of intranasal antiviral therapies in preclinical SARS-CoV-2 infection mouse models: a systematic review	8
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	8
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges	8
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	8
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	8
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	8
Preclinical developments in the delivery of protein antigens for vaccination	8
Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells	8
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy	7
Alternative routes for parenteral nucleic acid delivery and related hurdles: highlights in RNA delivery	7
Navigating the therapeutic landscape in advanced Parkinson’s disease: a comprehensive review from infusion therapies to stem cells	7
A semi-mechanistic pharmacokinetic/pharmacodynamic model for quantifying phage-antibiotic synergy against Pseudomonas aeruginosa	7
Design and labeling differences between generic and reference listed drug inhalers: human factors considerations in US FDA-approved devices	7
Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy	7
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation	7
Study of FA12 peptide-modified PEGylated liposomal doxorubicin (PLD) as an effective ligand to target Muc1 in mice bearing C26 colon carcinoma: in silico, in vitro, and in vivo study	7
TransCon human growth hormone for children with growth hormone deficiency: a technology evaluation	7
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity	7
High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD	7
Recent developments with pH-responsive lyotropic liquid crystalline lipid nanoparticles for targeted bioactive agent delivery	7
Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate	7
Advances in microneedles for non-transdermal applications	7
Challenges and opportunities in delivering oral peptides and proteins	7
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review	7
Adverse effects of intravenous LNP-mediated mRNA therapy in clinical trials: a systematic review and meta-analysis	7
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	7
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	7
A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina	7
Current trends in PLGA based long-acting injectable products: The industry perspective	7
Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations	6
Recent advances and future directions of propolis delivery	6
Progress of delivery methods for CRISPR-Cas9	6
An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing intracellular lipid transport mechani	6
Nanomedicine-based TRPV1 targeting for osteoarthritis therapy: promise and pitfalls	6
Challenges and considerations in liposomal hydrogels for the treatment of infection	6
Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment	6
Delivering monoclonal antibodies via inhalation: a systematic review of clinical trials in asthma and COPD	6
Advancements in ultrasound-mediated drug delivery for central nervous system disorders	6
Explicating the transformative role of artificial intelligence in designing targeted nanomedicine	6
Improving adherence by investigating the stability of dabigatran outside of the manufacturer’s original packaging: a New Zealand perspective	6
Current progress of miRNA-derivative nucleotide drugs: modifications, delivery systems, applications	6
Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery	6
An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA	6
Synthetic biodegradable polyesters for implantable controlled-release devices	6
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation	6
The use of nanocarriers for the treatment of Candida auris infections	6
Lipid carrier-based intranasal delivery of calcium channel blockers for Alzheimer’s disease	6