Expert Opinion on Drug Delivery

Article	Citations
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	57
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	57
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	56
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	54
Artificial Intelligence’s role in colon-targeted drug delivery	53
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	52
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	45
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	41
How can nanoemulsions be used for photosensitizer drug delivery?	41
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	40
Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies	38
Iontophoresis for the cutaneous delivery of nanoentraped drugs	37
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	36
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	36
The quest to deliver high-dose rifampicin: can the inhaled approach help?	36
The challenges of drug delivery to the esophagus and how to overcome them	34
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	33
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	33
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	33
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	31
Novel formulations of metal-organic frameworks for controlled drug delivery	30
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	30
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	30
Future applications of self-immolative polymers in drug delivery	30
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	29

Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	28
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	28
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	27
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	27
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	27
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	27
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	27
Acetalated dextran: a novel delivery platform for particle-based vaccines	26
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	26
Current status and prospect for future advancements of long-acting antibody formulations	26
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	25
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	25
Current insights into drug-coated balloons for peripheral arterial disease	24
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	24
Potential bladder cancer therapeutic delivery systems: a recent update	22
Can radiopharmaceuticals be delivered by quantum dots?	22
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	22
Silica nanoparticles for brain cancer	22
Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris	21
3D printed dosage forms, where are we headed?	21
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	20
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	20
Nanotechnology-based formulations toward the improved topical delivery of anti-acne active ingredients	20
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	20
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	20
Oleuropein as a novel topical antipsoriatic nutraceutical: formulation in microemulsion nanocarrier and exploratory clinical appraisal	19
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	19
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	19
Platelets for advanced drug delivery in cancer	19
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	19
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	19
Microneedles for oral mucosal delivery – Current trends and perspective on future directions	18
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	18
Untethered shape-changing devices in the gastrointestinal tract	18
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	18
Future applications of cyclic antimicrobial peptides in drug delivery	18
Targeted transport of biotherapeutics at the blood-brain barrier	18
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	18
Development and approval of novel injectables: enhancing therapeutic innovations	17
Is electroporation the key to drug delivery in drug-resistant cancers?	17
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	17
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	17
Polymer-based thermoresponsive hydrogels for controlled drug delivery	16
Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity	16
Recent advances in drug delivery to the central nervous system by inhalation	16
Biphasic drug release from electrospun structures	16
Particle surface coating for dry powder inhaler formulations	16
An update on cell-penetrating peptides with intracellular organelle targeting	16
Lipid-based nanosystems for wound healing	16
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	16

Topical drug delivery to the retina: obstacles and routes to success	15
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	15
Polyphosphoester cubosomes: introducing a novel drug delivery system	15
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	15
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	14
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	14
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	14
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	14
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	14
An update on the latest strategies in retinal drug delivery	14
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	14
The impact of common pharmaceutical excipients on the gut microbiota	14
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	14
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	13
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	13
Biopredictive tools for the development of injectable drug products	13
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	13
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	13
Inhaled antifungal therapy: benefits, challenges, and clinical applications	13
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	13
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	13
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	13
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	13
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	13
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	13
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis	13
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	12
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	12
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	12
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	12
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	12
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	12
Solid lipid nanoparticles: a promising tool for insulin delivery	12
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	11
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	11
Advances in engineering and delivery strategies for cytokine immunotherapy	11
Drug delivery systems for wound healing treatment of upper airway injury	11
Exploring space-energy matching via quantum-molecular mechanics modeling and breakage dynamics-energy dissipation via microhydrodynamic modeling to improve the screening efficiency of nanosuspension p	11
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	11
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	11
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	11
Improving antifungal lipid-based drug delivery against Candida : a review	11
Redefining drug therapy: innovative approaches using catalytic compartments	10
Engineered exosomes derived from stem cells: a new brain-targeted strategy	10
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	10
Cancer bone metastases and nanotechnology-based treatment strategies	10
Combining experimental and computational techniques to understand and improve dry powder inhalers	10
Lessons learned from the SARS-CoV-2 pandemic; from nucleic acid nanomedicines, to clinical trials, herd immunity, and the vaccination divide	10
Research progress on detachable microneedles for advanced applications	10
Drug-eluting stents for the treatment of coronary artery disease: A review of recent advances	10
Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery	10
Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer’s disease: current approaches and future perspectives	10
Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development	10
Polypeptides as alternatives to PEGylation of therapeutic agents	10
Potential of nanocarrier-mediated delivery of vancomycin for MRSA infections	10
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: a review	10
Versatility of emulgel in topical drug delivery transforming its expedition from bench to bedside	10
Nano-sized drug delivery systems to potentiate the immune checkpoint blockade therapy	10
Interdependency of influential parameters in therapeutic nanomedicine	10
siRNA therapeutics: insights, challenges, remedies and future prospects	10
Are inhaled mRNA vaccines safe and effective? A review of preclinical studies	10
Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals	10
Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy	9
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	9
RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions	9
Oral delivery of solid lipid nanoparticles: underlining the physicochemical characteristics and physiological condition affecting the lipolysis rate	9
Port delivery system: a novel drug delivery platform to treat retinal diseases	9
Demystifying particle-based oral vaccines	9
Current status of porous coordination networks (PCNs) derived porphyrin spacers for cancer therapy	9
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	9
Orodispersible tablets for pediatric drug delivery: current challenges and recent advances	9
A comprehensive review of the application of 3D-bioprinting in chronic wound management	9
Hydrogel formulations for orthotopic treatment of myocardial infarction	9
Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology	9
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	9
Biodegradable and removable implants for controlled drug delivery and release application	9
Role of nanotechnology in the prolonged release of drugs by the subcutaneous route	9
Intervention of 3D printing in health care: transformation for sustainable development	9
Harness arsenic in medicine: current status of arsenicals and recent advances in drug delivery	9
Performance characterization of spring-actuated prefilled pen devices for lebrikizumab and dupilumab	9

Hydrogels for brain repair: application to Parkinson’s disease	8
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	8
The blood–brain barrier as a treatment target for neurodegenerative disorders	8
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges	8
Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances	8
All-trans retinoic acid in anticancer therapy: how nanotechnology can enhance its efficacy and resolve its drawbacks	8
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	8
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	8
In vitro modelling of intramuscular injection site events	8
Nasal delivery as a strategy for the prevention and treatment of COVID-19	8
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	8
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	7
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	7
Drug-eluting resorbable coronary scaffolds: a review of recent advances	7
An expert opinion on phytocompounds delivery for leishmaniasis treatment	7
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	7
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	7
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	7
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	7
Preclinical developments in the delivery of protein antigens for vaccination	7
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	7
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	7
Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells	7
Challenges and opportunities in delivering oral peptides and proteins	6
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation	6
Study of FA12 peptide-modified PEGylated liposomal doxorubicin (PLD) as an effective ligand to target Muc1 in mice bearing C26 colon carcinoma: in silico, in vitro, and in vivo study	6
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review	6
Recent advances in mucus-penetrating nanomedicines for oral treatment of colonic diseases	6
Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery	6
Self-preserving gelatin emulgel containing whole cell probiotic for topical use: preclinical safety, efficacy, and germination studies	6
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy	6
Alternative routes for parenteral nucleic acid delivery and related hurdles: highlights in RNA delivery	6
Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy	6
A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina	6
TransCon human growth hormone for children with growth hormone deficiency: a technology evaluation	6
Delivering monoclonal antibodies via inhalation: a systematic review of clinical trials in asthma and COPD	6
Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment	6
Advancements in ultrasound-mediated drug delivery for central nervous system disorders	6
Synthetic biodegradable polyesters for implantable controlled-release devices	6
Advances in microneedles for non-transdermal applications	6
High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD	6
Every nano-step counts: a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy	6
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity	6
Progress of delivery methods for CRISPR-Cas9	6
Current progress of miRNA-derivative nucleotide drugs: modifications, delivery systems, applications	6
An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA	6
Challenges and considerations in liposomal hydrogels for the treatment of infection	6
An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing intracellular lipid transport mechani	6
Current trends in PLGA based long-acting injectable products: The industry perspective	6
Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate	6
Building respirable powder architectures: utilizing polysaccharides for precise control of particle morphology for enhanced pulmonary drug delivery	5
Microfabrication of controlled release osmotic drug delivery systems assembled from designed elements	5
Preparation of targeted theranostic red blood cell membranes-based nanobubbles for treatment of colon adenocarcinoma	5
Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles	5
An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment	5
Molecular insights into the antineoplastic potential of apigenin and its derivatives: paving the way for nanotherapeutic innovations	5
Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery	5
Recent advances in targeted drug delivery for the treatment of pancreatic ductal adenocarcinoma	5
Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion	5
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation	5
Photodynamic therapy of cancer using graphene nanomaterials	5
Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth	5
Lipoplexes and polyplexes as nucleic acids delivery nanosystems: The current state and future considerations	5
Exploring new frontiers in drug delivery with minimally invasive microneedles: fabrication techniques, biomedical applications, and regulatory aspects	4
Combinations of chemo-, immuno-, and gene therapies using nanocarriers as a multifunctional drug platform	4
Recent advances on small molecular gels: formation mechanism and their application in pharmaceutical fields	4
Translational hurdles in anti-asthmatic nanomedicine development	4
Advances in ophthalmic drug delivery technology for postoperative management after cataract surgery	4
3D printing and computer-aided design techniques for drug delivery scaffolds in tissue engineering	4
Current advances in cell therapeutics: a biomacromolecules application perspective	4
Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders	4
Improving adherence by investigating the stability of dabigatran outside of the manufacturer’s original packaging: a New Zealand perspective	4
Bridging the gap between fundamental research and product development of long acting injectable PLGA microspheres	4
Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases	4
4D printing chemical stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications – part 2	4
Local delivery of steroids to inner ear via medical device INCAT (the Inner Ear Catheter) in partial deafness patients during cochlear implantation – preliminary results and a feasibility study	4
Biopolymeric 3D printed implantable scaffolds as a potential adjuvant treatment for acute post-operative pain management	4
The industrial design, translation, and development strategies for long-acting peptide delivery	4
Fungal quorum sensing molecules as potential drugs in the treatment of chronic wounds and their delivery	4
Dry powder inhalation, part 2: the present and future	4
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polar	4
Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation	4
Transfersomes: a next-generation drug delivery system for topical ocular drug delivery	4
Nanocarriers in topical photodynamic therapy	4
Nanoparticle-based drug delivery for the treatment of traumatic brain injury	4
Advances in microsphere-based therapies for peritoneal carcinomatosis: challenges, innovations, and future prospects	4
Electronically powered drug delivery devices: considerations and challenges	4
An opinion on advanced cancer immunotherapy through innovations in PD-1 inhibitor delivery systems	4
3D printed personalized therapies for pediatric patients affected by adrenal insufficiency	4
Extrusion-based systems for topical and transdermal drug delivery	4
Barriers for orally inhaled therapeutic antibodies	4