Expert Opinion on Drug Delivery

Article	Citations
How can nanoemulsions be used for photosensitizer drug delivery?	115
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	88
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	81
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	71
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	67
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers f	61
Artificial Intelligence’s role in colon-targeted drug delivery	60
Iontophoresis for the cutaneous delivery of nanoentraped drugs	56
All eyes on semifluorinated alkanes: a comprehensive review of the influence of semifluorinated alkane eyedrops on tear film stabilization and drug delivery in dry eye disease	56
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	53
The quest to deliver high-dose rifampicin: can the inhaled approach help?	53
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	53
An update on the port delivery system with ranibizumab for retinal diseases	50
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	50
Theranostic metallic nanoconjugates for colorectal cancer: targeting strategies, imaging modalities, and translational challenges	49
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	45
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	44
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	42
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	41
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	41
Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications	41
How can we optimize the delivery of IL-2 to traumatic brain injury patients?	39
Current insights into polymeric micelles for nasal drug delivery	38
Future applications of self-immolative polymers in drug delivery	37
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	37

Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	36
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	36
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	35
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	35
Current status and prospect for future advancements of long-acting antibody formulations	35
Engineering polycaprolactone nanowires for pharmacologic efficacy	35
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	34
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	34
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	32
Acetalated dextran: a novel delivery platform for particle-based vaccines	32
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	32
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	32
Penetration enhancer–containing vesicles (PEVs): from deformable liposomes to barrier-modulating delivery platforms across multiple administration routes	32
Peptide amphiphile nanofibers: advanced drug delivery platforms for cardiovascular therapeutics	31
Mechanistic and translational frontiers on “VEGF and TKI inhibitor axitinib” : unfolding drug delivery approaches and opportunities in cancer therapy	30
Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery	30
Calcium carbonate in drug delivery: functional carrier design, applications, and data-driven perspectives	29
What role might nanolipogels play in enhancing drug delivery?	29
Progress and potential of nanobubbles for ultrasound-mediated drug delivery	29
How might intraluminal drug-delivery strategies be improved to enhance arteriovenous fistula maturation and patency?	29
The potential public health benefit of live-attenuated pertussis vaccines	28
Potential bladder cancer therapeutic delivery systems: a recent update	27
Current insights into drug-coated balloons for peripheral arterial disease	27
Can radiopharmaceuticals be delivered by quantum dots?	27
Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations	27
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	26
3D printed dosage forms, where are we headed?	26
Differential targeting of olfactory epithelium and respiratory epithelium in nose-to-brain drug delivery	26
Silica nanoparticles for brain cancer	26
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	26
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	25
Cyclodextrin-based carriers for targeted drug delivery	25
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	24
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	24
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	23
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	23
Advancing the current state of gene therapies using adeno-associated virus vectors to treat atrial cardiomyopathy	23
Emerging landscape of bioinformatics and artificial intelligence applications in cell-penetrating peptide-based delivery	23
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	23
Treating glioblastoma with dextrin-based polymers	23
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	23
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	23
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	23
Topical film-forming systems for antifungal delivery: emerging strategies and in-depth evaluation	22
Future applications of cyclic antimicrobial peptides in drug delivery	22
Platelets for advanced drug delivery in cancer	22
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	22
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	21
Development and approval of novel injectables: enhancing therapeutic innovations	21
Polymer-based thermoresponsive hydrogels for controlled drug delivery	21

Particle surface coating for dry powder inhaler formulations	21
Polyphosphoester cubosomes: introducing a novel drug delivery system	21
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	21
Lipid-based nanosystems for wound healing	21
Biphasic drug release from electrospun structures	20
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	20
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	20
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	19
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	19
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	19
Is electroporation the key to drug delivery in drug-resistant cancers?	19
Smart delivery systems for magnetic hyperthermia: the role of thermoresponsive drug delivery	19
Recent advances in antibacterial nanoformulations for endodontic applications	19
Microneedles for oral mucosal delivery – Current trends and perspective on future directions	19
Untethered shape-changing devices in the gastrointestinal tract	19
Targeted transport of biotherapeutics at the blood-brain barrier	19
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	18
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	18
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	18
Drug and stem cells delivery to salivary glands – a concise review	18
Infusion-based drug delivery to the brain: what’s next?	18
Where do we stand now regarding protein nanoparticles? Perspectives from the Six Thinking Hats framework	18
The impact of common pharmaceutical excipients on the gut microbiota	17
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	17
Targeted delivery of therapeutics to the heart with calcium phosphate nanoparticles	17
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	17
Drug delivery and formulation development of hesperidin: a systematic review	17
Correction	16
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	16
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	16
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	16
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	16
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	16
An update on the latest strategies in retinal drug delivery	16
Redox responsive cyclodextrin-based drug delivery systems: a special insight to glutathione responsive CD-nanosponges	16
Engineering trafficking pathways to overcome immunosuppressive barriers in solid tumor immunotherapy	16
A fluid and particle mechanics perspective of nasal drug delivery	15
Inhaled antifungal therapy: benefits, challenges, and clinical applications	15
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	15
Development of ROS-responsive liposomes toward targeted drug delivery	15
Optimizing deferoxamine delivery through the skin for pressure ulcers	15
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	15
Nano-drug delivery system of natural products for disease prevention and treatment	15
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	14
Recent advances in microneedle technology in transdermal drug delivery systems	14
Biopredictive tools for the development of injectable drug products	14
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	14
Explicit analysis of in vivo , meterological and statistical hurdles in successful clinical translation of targeted nanomedicines and plausible remedial	14
Future outcomes and current limitations of injectable implants for vocal fold scarring	14
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	14
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	14
Advanced nano-delivery systems in H. pylori eradication: targeting, efficacy, and clinical translation	14
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	13
Rethinking probiotic delivery: new hope for preventing necrotizing enterocolitis	13
Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer’s disease: current approaches and future perspectives	13
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	13
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	13
Oncofetal chondroitin sulfate in cancer therapy: a promising target for anti-tumor drug delivery?	13
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	13
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	13
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	13
Solid lipid nanoparticles: a promising tool for insulin delivery	13
Intra-articular targeted delivery of nanomaterials for the treatment of osteoarthritis: focusing on cell signaling pathway mechanisms	13
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	13
Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery	12
The potential of a high efficacy single shot injection of artemisinin combination for effective antimalarial therapy	12
Drug delivery systems for wound healing treatment of upper airway injury	12
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	12
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	12
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	12
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	12
Advances in engineering and delivery strategies for cytokine immunotherapy	12
Improving antifungal lipid-based drug delivery against Candida : a review	12
Bioconjugates for breast cancer theranostics: improving target selectivity and treatment efficacy	12
Are inhaled mRNA vaccines safe and effective? A review of preclinical studies	11
RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions	11
Cancer bone metastases and nanotechnology-based treatment strategies	11
Engineered exosomes derived from stem cells: a new brain-targeted strategy	11
Graphene quantum dots for breast cancer treatment	11
Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development	11

Evaluation of in vitro blood-brain barrier models in central nervous system new drug development: methodological challenges and translational perspective	11
Metallic and lipid nanoparticles against multidrug resistant Candida : advances and translational hurdles	11
User acceptability and ease of use of the MedRing, a new personalized vaginal drug delivery and monitoring device	11
siRNA therapeutics: insights, challenges, remedies and future prospects	11
Versatility of emulgel in topical drug delivery transforming its expedition from bench to bedside	11
Application of zein nanoparticles for the treatment of inflammatory bowel diseases	11
Lessons learned from the SARS-CoV-2 pandemic; from nucleic acid nanomedicines, to clinical trials, herd immunity, and the vaccination divide	11
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: a review	11
Redefining drug therapy: innovative approaches using catalytic compartments	11
Polypeptides as alternatives to PEGylation of therapeutic agents	11
Topical curcumin in the treatment of denture stomatitis: a systematic review of clinical efficacy	11
Clinical insights into extracellular vesicles for targeted myocardial drug delivery	11
Research progress on detachable microneedles for advanced applications	10
Hydrogel formulations for orthotopic treatment of myocardial infarction	10
Harness arsenic in medicine: current status of arsenicals and recent advances in drug delivery	10
Potential of nanocarrier-mediated delivery of vancomycin for MRSA infections	10
3D printed biodegradable bilayer films: a promising frontier in liver cancer therapy	10
Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology	10
A comprehensive review of the application of 3D-bioprinting in chronic wound management	10
Biodegradable and removable implants for controlled drug delivery and release application	10
Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy	10
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	10
Role of nanotechnology in the prolonged release of drugs by the subcutaneous route	10
Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals	10
Current status of porous coordination networks (PCNs) derived porphyrin spacers for cancer therapy	10
Performance characterization of spring-actuated prefilled pen devices for lebrikizumab and dupilumab	10
What is the potential of Fmoc-FF hydrogels for drug delivery?	10
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	10
Infusion therapies for Parkinson’s disease: where are we in 2025?	9
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	9
Strategies for the delivery of RNA therapeutics to diseased heart tissue	9
Polyphenol-conjugated polysaccharide nanoplatforms for enhanced therapeutic efficacy	9
Navigating the challenges in pediatric intranasal drug delivery	9
Nasal delivery as a strategy for the prevention and treatment of COVID-19	9
Assessment of the effectiveness of intranasal antiviral therapies in preclinical SARS-CoV-2 infection mouse models: a systematic review	9
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	9
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	9
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	9
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	9
Can nanoparticle-based intranasal delivery systems revolutionize treatment of central nervous system diseases?	9
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	9
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	9
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	9
The blood–brain barrier as a treatment target for neurodegenerative disorders	9
Key aspects to optimize inhalation therapy in people with respiratory diseases: a review integrating clinical, technological, and educational evidence	9
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	9
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	9
Hydrogels for brain repair: application to Parkinson’s disease	9
In vitro modelling of intramuscular injection site events	9
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	9
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	9
Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate	8
Review of the first on-body injector (OBI) for the subcutaneous delivery of an oncology drug: isatuximab in multiple myeloma	8
Adverse effects of intravenous LNP-mediated mRNA therapy in clinical trials: a systematic review and meta-analysis	8
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review	8
A semi-mechanistic pharmacokinetic/pharmacodynamic model for quantifying phage-antibiotic synergy against Pseudomonas aeruginosa	8
Drug-eluting resorbable coronary scaffolds: a review of recent advances	8
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation	8
Recent developments with pH-responsive lyotropic liquid crystalline lipid nanoparticles for targeted bioactive agent delivery	8
High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD	8
Alternative routes for parenteral nucleic acid delivery and related hurdles: highlights in RNA delivery	8
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy	8
A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina	8
Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy	8
Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells	8
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	8
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to	8
Advances in microneedles for non-transdermal applications	8
Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment	8
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity	8
Navigating the therapeutic landscape in advanced Parkinson’s disease: a comprehensive review from infusion therapies to stem cells	8
Challenges and opportunities in delivering oral peptides and proteins	8
Study of FA12 peptide-modified PEGylated liposomal doxorubicin (PLD) as an effective ligand to target Muc1 in mice bearing C26 colon carcinoma: in silico, in vitro, and in vivo study	8
An expert opinion on phytocompounds delivery for leishmaniasis treatment	8
Design and labeling differences between generic and reference listed drug inhalers: human factors considerations in US FDA-approved devices	8
Preclinical developments in the delivery of protein antigens for vaccination	8
Challenges and considerations in liposomal hydrogels for the treatment of infection	7
Attenuating amygdalin (vitamin B17) toxicity for potential therapeutic uses: insights into controlled release technology-based formulations as a strategy for improving clinical safety	7
Lipid carrier-based intranasal delivery of calcium channel blockers for Alzheimer’s disease	7
Synthetic biodegradable polyesters for implantable controlled-release devices	7
An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA	7
Recent advances and future directions of propolis delivery	7
Every nano-step counts: a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy	7
Delivering monoclonal antibodies via inhalation: a systematic review of clinical trials in asthma and COPD	7
Progress of delivery methods for CRISPR-Cas9	7
Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery	7
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation	7
Preparation of targeted theranostic red blood cell membranes-based nanobubbles for treatment of colon adenocarcinoma	7
Recent advances in mucus-penetrating nanomedicines for oral treatment of colonic diseases	7
An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing intracellular lipid transport mechani	7
Advancements in ultrasound-mediated drug delivery for central nervous system disorders	7
Building respirable powder architectures: utilizing polysaccharides for precise control of particle morphology for enhanced pulmonary drug delivery	7
The use of nanocarriers for the treatment of Candida auris infections	7
Explicating the transformative role of artificial intelligence in designing targeted nanomedicine	7
Nanomedicine-based TRPV1 targeting for osteoarthritis therapy: promise and pitfalls	7