Immunity & Ageing

Papers
(The TQCC of Immunity & Ageing is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease402
Transient immunostimulation with LPS promotes tissue repair in aged skin135
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice106
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)96
Clinical rationale for thymic restoration in adult immunosenescence75
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans75
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease75
Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile71
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy65
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective62
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease59
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy54
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study50
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions48
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review47
Aging, inflammaging and immunosenescence as risk factors of severe COVID-1946
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination43
Immune cell phenotypes and mortality in the Framingham Heart Study42
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome40
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα39
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis38
Obese plasma transfer accelerates cellular aging in the C57BL/6 mouse model38
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses36
The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity35
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis34
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people34
Systemic immune response in young and elderly patients after traumatic brain injury33
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol32
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS32
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis32
Association of adipose tissue inflammation and physical fitness in older adults31
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov230
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults28
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons28
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents28
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans27
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells27
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis27
The role of blood related inflammatory factors on age-related macular degeneration (AMD)27
Thymic function and survival at advance ages in nursing home residents from Southern Italy27
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study26
Respiratory virus immune response in the aged host26
Inflammatory markers and physical frailty: towards clinical application25
Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease25
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies25
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals25
Different phenotypes of microglia in animal models of Alzheimer disease25
Obesity accelerates age defects in B cells, and weight loss improves B cell function24
Impaired function of Vγ9Vδ2 T cells in frail elderly24
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia23
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus23
Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives23
Correction: The oldest unvaccinated Covid-19 survivors in South America23
Aging and chronic inflammation: highlights from a multidisciplinary workshop22
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation22
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)22
Immune cell signature in non-ischemic heart failure indicates chronic systemic immune activation with features of immunosenescence22
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway22
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging22
Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation21
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 321
Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study21
Toll-like receptor 4 (TLR4): new insight immune and aging21
Immune reconstitution efficacy and the risk factors of immune non-responsiveness after combined antiretroviral therapy in HIV-1 positive MSM and heterosexual population – a prospective cohort study20
Neutrophil-to-lymphocyte ratio as a sex-specific predictor of short-term mortality in hospitalised older adults with COVID-19: a pragmatic biomarker of inflammaging in acute vulnerability20
Algorithms for appropriate patient stratification in the face of a new SARS-CoV-2 pandemic20
Targeting immunosenesence promotes clearance of senescent cells20
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial20
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China20
Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans19
Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis19
An aging-related immune landscape in the hematopoietic immune system19
Impact of NAD+ metabolism on ovarian aging18
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging18
MicroRNAs: a crossroad that connects obesity to immunity and aging18
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