OOIR: Observatory of International Research

Papers

(The TQCC of Immunity & Ageing is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?	64
CMV infection, CD19+ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly	63
Quantification of dendritic cell subsets in human thymus tissues of various ages	49
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model	45
CD161 expression defines new human γδ T cell subsets	42
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults	40
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice	37
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia	33
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people	33
Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 year	30
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults	27
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients	27
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer	26
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	23
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk	21
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions	21
Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling	21
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?	21
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	20
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	20
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal stu	19
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	19
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes	18
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity	18
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	18

Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	17
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging	17
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	16
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging	14
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease	14
Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages	13
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	12
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	12
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis	12
Obesity accelerates age defects in B cells, and weight loss improves B cell function	12
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?	12
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies	11
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	11
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)	11
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches	11
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a ra	11
Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults	11
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses	11
Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges	11
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	11
Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis	11
Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children	11
Correction: Heat‑killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans	10
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor	10
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	10
Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing	10
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway	10
Toll-like receptor 4 (TLR4): new insight immune and aging	10
Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	10
Towards a better preclinical cancer model – human immune aging in humanized mice	10
The age again in the eye of the COVID-19 storm: evidence-based decision making	10
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	10
Correction: The oldest unvaccinated Covid-19 survivors in South America	10
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging	9
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling	9
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	9
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice	9
The interplay between obesity, immunosenescence, and insulin resistance	9
Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction	9
Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging	9
Single-cell landscape of immunological responses in elderly patients with sepsis	9
Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis	9
Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation	9
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells	9
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging	8
p16Ink4a-induced senescence in cultured mast cells as a model for ageing reveals significant morphological and functional changes	8
CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy	8
Aging and chronic inflammation: highlights from a multidisciplinary workshop	8
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection	8
Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa	8

Metabolic phenotype of B cells from young and elderly HIV individuals	8
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	8