OOIR: Observatory of International Research

Papers

(The median citation count of Immunity & Ageing is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-03-01 to 2024-03-01.)

Article	Citations
Role of immune cells in the removal of deleterious senescent cells	178
Gut microbiota as the key controllers of “healthy” aging of elderly people	157
Obesity and COVID-19: what makes obese host so vulnerable?	118
The immune response to influenza in older humans: beyond immune senescence	93
The lethal sex gap: COVID-19	61
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination	60
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people	60
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?	59
The correlation between the Th17/Treg cell balance and bone health	54
“The ancient and the new”: is there an interaction between cytomegalovirus and SARS-CoV-2 infection?	49
SARS-CoV-2 disease severity and diabetes: why the connection and what is to be done?	47
Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression	45
SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing	43
Genetic and environmental determinants of human TCR repertoire diversity	41
Macrophage function in the elderly and impact on injury repair and cancer	38
Can an effective SARS-CoV-2 vaccine be developed for the older population?	38
Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?	37
Autoimmune hemolytic anemia: current knowledge and perspectives	37
Functional conservation in genes and pathways linking ageing and immunity	36
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease	35
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study	33
Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice	33
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	27
miR-181a-regulated pathways in T-cell differentiation and aging	22
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19	22

First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects – a cohort study	21
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches	20
Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond	19
NF-κB, a culprit of both inflamm-ageing and declining immunity?	19
Unanticipated efficacy of SARS-CoV-2 vaccination in older adults	19
Aging and CMV discordance are associated with increased immune diversity between monozygotic twins	19
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics	19
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	18
In-depth immune cellular profiling reveals sex-specific associations with frailty	17
Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities	16
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?	16
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	15
Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis	15
Aging and chronic inflammation: highlights from a multidisciplinary workshop	14
Emergence of T cell immunosenescence in diabetic chronic kidney disease	14
Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity	14
An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients	13
Phenotypic and functional alterations of monocyte subsets with aging	13
Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation	13
Pathogen burden and leukocyte telomere length in the United States	13
Inflammation and cell-to-cell communication, two related aspects in frailty	13
Alterations of monocyte NF-κB p65/RelA signaling in a cohort of older medical patients, age-matched controls, and healthy young adults	13
A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases	12
Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22	11
Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases	11
Telomerase deficiency reflects age-associated changes in CD4+ T cells	10
T cells accumulate in non-diabetic islets during ageing	10
The impact of body mass index on adaptive immune cells in the human bone marrow	10
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults	10
Different phenotypes of microglia in animal models of Alzheimer disease	10
Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study	10
T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II	10
Neutralizing antibody and T cell responses against SARS-CoV-2 variants of concern following ChAdOx-1 or BNT162b2 boosting in the elderly previously immunized with CoronaVac vaccine	9
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial	9
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a ra	9
Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults	9
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study	8
MicroRNAs: a crossroad that connects obesity to immunity and aging	8
Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults	8
IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system	8
The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study	8
Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice	8
The age again in the eye of the COVID-19 storm: evidence-based decision making	8
Metabolic phenotype of B cells from young and elderly HIV individuals	8
Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis	8
The SENIEUR protocol and the efficacy of hepatitis B vaccination in healthy elderly persons by age, gender, and vaccine route	8
Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans	8
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis	8
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression	8
The diseased kidney: aging and senescent immunology	7

Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults	7
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation	7
A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	7
Effect of age and sex on immune checkpoint expression and kinetics in human T cells	7
Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls	7
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	7
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis	7
Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors	7
Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children	7
Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly	6
Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal	6
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	6
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp	6
ARID3a expression in human hematopoietic stem cells is associated with distinct gene patterns in aged individuals	6
Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation	6
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities	6
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	6
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?	6
“Inflammaging” and bone in the OsteoLaus cohort	6
Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells	6
Ageing attenuates bone healing by mesenchymal stem cells in a microribbon hydrogel with a murine long bone critical-size defect model	6
Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings	6
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity	6
Hypothetical COVID-19 protection mechanism: hints from centenarians	6
Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study	5
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging	5
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons	5
An evaluation of the recognised systemic inflammatory biomarkers of chronic sub-optimal inflammation provides evidence for inflammageing (IFA) during multiple sclerosis (MS)	5
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial	5
Glycyrrhizic acid inhibits myeloid differentiation of hematopoietic stem cells by binding S100 calcium binding protein A8 to improve cognition in aged mice	5
Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers	5
High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges	5
NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing	4
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?	4
A description of the relationship in healthy longevity and aging-related disease: from gene to protein	4
Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults	4
Reproducibility of serum cytokines in an elderly population	4
Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging	4
Frontline treatments in extremely elderly patients with diffuse large B-cell lymphoma: a population-based study in Taiwan, 2010–2015	4
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study	4
High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study	4
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals	4
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	4
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging	4
The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice	4
The oldest unvaccinated Covid-19 survivors in South America	4
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China	4
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients	4