OOIR: Observatory of International Research

Papers

(The median citation count of Immunity & Ageing is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	365
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	126
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	85
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy	81
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	72
Transient immunostimulation with LPS promotes tissue repair in aged skin	71
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	69
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	61
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	59
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	56
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	53
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	48
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	46
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	45
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	45
Obese plasma transfer accelerates cellular aging in the C57BL/6 mouse model	44
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	44
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	44
Immune cell phenotypes and mortality in the Framingham Heart Study	42
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	38
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	36
Association of adipose tissue inflammation and physical fitness in older adults	36
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	35
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people	35
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	34

The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity	33
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis	32
Systemic immune response in young and elderly patients after traumatic brain injury	31
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2	30
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol	30
The role of blood related inflammatory factors on age-related macular degeneration (AMD)	29
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults	29
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents	28
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis	28
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans	27
Thymic function and survival at advance ages in nursing home residents from Southern Italy	26
Respiratory virus immune response in the aged host	26
Correction: Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast	26
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons	26
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study	25
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells	25
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals	25
Different phenotypes of microglia in animal models of Alzheimer disease	24
Inflammatory markers and physical frailty: towards clinical application	23
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia	23
Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease	23
Impaired function of Vγ9Vδ2 T cells in frail elderly	23
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation	22
Obesity accelerates age defects in B cells, and weight loss improves B cell function	22
Correction: The oldest unvaccinated Covid-19 survivors in South America	22
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies	22
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway	21
Immune cell signature in non-ischemic heart failure indicates chronic systemic immune activation with features of immunosenescence	21
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging	21
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus	21
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)	21
Toll-like receptor 4 (TLR4): new insight immune and aging	20
Algorithms for appropriate patient stratification in the face of a new SARS-CoV-2 pandemic	20
Aging and chronic inflammation: highlights from a multidisciplinary workshop	20
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3	20
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	20
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China	19
Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation	19
Immune reconstitution efficacy and the risk factors of immune non-responsiveness after combined antiretroviral therapy in HIV-1 positive MSM and heterosexual population – a prospective cohort study	19
Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study	19
A subset of gut leukocytes has telomerase-dependent “hyper-long” telomeres and require telomerase for function in zebrafish	19
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging	19
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial	18
Neutrophil-to-lymphocyte ratio as a sex-specific predictor of short-term mortality in hospitalised older adults with COVID-19: a pragmatic biomarker of inflammaging in acute vulnerability	18
Targeting immunosenesence promotes clearance of senescent cells	18
Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans	18
Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis	18
MicroRNAs: a crossroad that connects obesity to immunity and aging	18
Impact of NAD+ metabolism on ovarian aging	17
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice	17

An aging-related immune landscape in the hematopoietic immune system	17
Ageing with HIV-1: immunological challenges for effective vaccination	16
Gut-heart immuno-metabolic disruption associated with inflammaging and subclinical coronary artery disease in people with HIV on antiretroviral therapy	16
Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection	16
Correction: A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	16
The influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19	16
Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair	16
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport	16
Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity	15
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial	15
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis	15
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study	15
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats	15
Elicitation of protective immune responses against influenza a viruses in elderly ferrets by adjuvanted recombinant universal influenza hemagglutinin vaccines	14
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study	14
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium	14
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study	14
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration	14
Inhibiting IL11: a novel approach to turning back the clock	14
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities	14
The role of autoantibodies in bridging obesity, aging, and immunosenescence	14
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence	14
CD8⁺ T cell heterogeneity in aging: insights from single-cell profiling	13
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population	12
“Immunopause” no more: exercise to counter immunosenescence in aging	12
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway	12
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression	12
Frailty is related to serum inflammageing markers: results from the VITAL study	12
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk	11
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions	11
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal stu	10
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	10
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	10
Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling	10
The relationship between biological aging and psoriasis: evidence from three observational studies	10
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	10
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging	10
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor	10
Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction	9
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells	9
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study	9
Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks	9
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution	9
High-dose quadrivalent influenza vaccine in older adults with or without cardiovascular risk: a meta-analysis of randomized trials on 511,890 participants	9
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults	9
Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study	9
The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring	9
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses	9
Single-cell landscape of immunological responses in elderly patients with sepsis	9
Immune aging in annual killifish	9
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp	9
Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction	9
Correction: Single-cell landscape of immunological responses in elderly patients with sepsis	8
Monocyte-driven inflamm-aging reduces intestinal barrier function in females	8
The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study	8
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort	8
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice	8
Short-term intensive fasting enhances the immune function of red blood cells in humans	8
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway	8
Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration	8
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability	8
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults	7
Correction: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	7
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice	7
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer	7
Exercise-induced changes in circulatory aging-related biomarkers among older adults: longitudinal analysis of a multi-stage randomized clinical trial	7
Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment	7
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	7
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats	7
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	7
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice	7
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients	7
The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT	7
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna	7
Immunosenescence and inflammaging in the aged horse	7
Ageing and dysregulated lung immune responses in fatal COVID-19	7
Age-associated changes in the lymphoid tissues of Boa constrictor	7
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	7