OOIR: Observatory of International Research

Papers

(The median citation count of Immunity & Ageing is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	140
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	80
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	67
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	54
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	53
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy	48
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	47
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	42
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	42
Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	39
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	38
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	36
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	32
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	30
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	29
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	29
Immune cell phenotypes and mortality in the Framingham Heart Study	28
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	27
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	26
The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells	25
Association of adipose tissue inflammation and physical fitness in older adults	24
Correction to: Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults	24
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2	23
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis	23
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	22

Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	22
Systemic immune response in young and elderly patients after traumatic brain injury	22
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults	21
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people	21
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	21
The role of blood related inflammatory factors on age-related macular degeneration (AMD)	19
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans	19
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis	19
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2	19
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents	19
Thymic function and survival at advance ages in nursing home residents from Southern Italy	18
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons	18
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals	17
Correction: Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast	17
Multiple thymi and no thymic involution in naked mole rats?	17
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies	16
Inflammatory markers and physical frailty: towards clinical application	16
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study	16
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells	16
Different phenotypes of microglia in animal models of Alzheimer disease	16
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia	15
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)	15
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people	15
Correction: The oldest unvaccinated Covid-19 survivors in South America	15
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis	15
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?	15
Obesity accelerates age defects in B cells, and weight loss improves B cell function	15
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	14
miR-181a-regulated pathways in T-cell differentiation and aging	14
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus	14
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway	14
Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans	13
Aging and chronic inflammation: highlights from a multidisciplinary workshop	13
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3	13
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation	13
Toll-like receptor 4 (TLR4): new insight immune and aging	13
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging	13
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice	12
A subset of gut leukocytes has telomerase-dependent “hyper-long” telomeres and require telomerase for function in zebrafish	12
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics	12
Impact of NAD+ metabolism on ovarian aging	12
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging	12
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China	12
MicroRNAs: a crossroad that connects obesity to immunity and aging	12
Is mechanical loading essential for exercise to preserve the aging immune system?	12
An aging-related immune landscape in the hematopoietic immune system	11
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial	11
Correction: A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	11
Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings	11
Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity	11

High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study	11
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study	11
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial	10
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis	10
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study	10
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats	10
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study	10
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence	10
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities	10
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration	10
Inhibiting IL11: a novel approach to turning back the clock	9
The role of autoantibodies in bridging obesity, aging, and immunosenescence	9
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway	9
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium	9
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population	9
Frailty is related to serum inflammageing markers: results from the VITAL study	8
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions	8
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression	8
A description of the relationship in healthy longevity and aging-related disease: from gene to protein	8
CD161 expression defines new human γδ T cell subsets	8
The relationship between biological aging and psoriasis: evidence from three observational studies	7
Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling	7
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	7
Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction	7
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk	7
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	7
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal stu	7
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?	7
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging	7
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	7
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease	7
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor	7
Single-cell landscape of immunological responses in elderly patients with sepsis	6
Short-term intensive fasting enhances the immune function of red blood cells in humans	6
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19	6
Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study	6
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp	6
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults	6
Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice	6
Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study	6
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses	6
Immune aging in annual killifish	6
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution	6
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study	6
The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study	6
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells	6
Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks	6
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability	5
Monocyte-driven inflamm-aging reduces intestinal barrier function in females	5
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort	5
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice	5
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna	5
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice	5
Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study	5
Correction: Single-cell landscape of immunological responses in elderly patients with sepsis	5
Correction: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	5
Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration	5
The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring	5
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway	5
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults	5
The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT	5
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	4
Immunosenescence and inflammaging in the aged horse	4
NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing	4
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer	4
Quantification of dendritic cell subsets in human thymus tissues of various ages	4
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults	4
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	4
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	4
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice	4
Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches	4
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients	4
Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation	4
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice	4
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients	4
p16Ink4a-induced senescence in cultured mast cells as a model for ageing reveals significant morphological and functional changes	4
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats	4