OOIR: Observatory of International Research

Papers

(The median citation count of Immunity & Ageing is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	122
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	76
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	67
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	57
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	53
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	50
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	47
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	46
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	41
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	41
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	38
Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	35
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	33
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	32
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	29
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	28
Immune cell phenotypes and mortality in the Framingham Heart Study	27
The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells	26
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	26
Association of adipose tissue inflammation and physical fitness in older adults	25
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people	24
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis	23
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2	23
Correction to: Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults	23
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	22

Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	22
Systemic immune response in young and elderly patients after traumatic brain injury	22
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults	21
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	21
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2	20
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents	19
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis	18
Functional conservation in genes and pathways linking ageing and immunity	18
The role of blood related inflammatory factors on age-related macular degeneration (AMD)	17
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans	17
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons	17
Thymic function and survival at advance ages in nursing home residents from Southern Italy	16
Correction: Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast	16
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells	16
Multiple thymi and no thymic involution in naked mole rats?	16
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals	16
Inflammatory markers and physical frailty: towards clinical application	15
Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges	15
Different phenotypes of microglia in animal models of Alzheimer disease	15
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?	15
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study	15
Obesity accelerates age defects in B cells, and weight loss improves B cell function	14
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people	14
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis	14
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia	14
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies	14
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)	14
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	13
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus	13
Correction: The oldest unvaccinated Covid-19 survivors in South America	13
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging	13
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway	13
miR-181a-regulated pathways in T-cell differentiation and aging	13
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial	12
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation	12
Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans	12
Toll-like receptor 4 (TLR4): new insight immune and aging	12
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3	12
Aging and chronic inflammation: highlights from a multidisciplinary workshop	12
Impact of NAD+ metabolism on ovarian aging	11
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging	11
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics	11
Is mechanical loading essential for exercise to preserve the aging immune system?	11
An aging-related immune landscape in the hematopoietic immune system	11
A subset of gut leukocytes has telomerase-dependent “hyper-long” telomeres and require telomerase for function in zebrafish	11
Correction: A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	10
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice	10
High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study	10
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China	10
Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings	10

MicroRNAs: a crossroad that connects obesity to immunity and aging	10
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study	9
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats	9
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis	9
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration	9
Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity	9
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study	9
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities	9
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial	9
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study	9
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population	8
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression	8
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway	8
A description of the relationship in healthy longevity and aging-related disease: from gene to protein	8
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence	8
Frailty is related to serum inflammageing markers: results from the VITAL study	7
The role of autoantibodies in bridging obesity, aging, and immunosenescence	7
CD161 expression defines new human γδ T cell subsets	7
Inhibiting IL11: a novel approach to turning back the clock	7
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging	7
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions	7
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium	7
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk	7
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	6
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease	6
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	6
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal stu	6
Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks	6
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp	6
The relationship between biological aging and psoriasis: evidence from three observational studies	6
Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling	6
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor	6
Single-cell landscape of immunological responses in elderly patients with sepsis	6
Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study	6
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19	6
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	6
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?	6
Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction	6
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells	6
Immune aging in annual killifish	6
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses	6
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability	5
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution	5
Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration	5
The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study	5
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice	5
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study	5
Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study	5
Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study	5
Monocyte-driven inflamm-aging reduces intestinal barrier function in females	5
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults	5
Short-term intensive fasting enhances the immune function of red blood cells in humans	5
Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice	5
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway	4
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults	4
The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT	4
Immunosenescence and inflammaging in the aged horse	4
Quantification of dendritic cell subsets in human thymus tissues of various ages	4
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults	4
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort	4
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice	4
Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation	4
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	4
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	4
CMV infection, CD19+ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly	4
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna	4
Correction: Single-cell landscape of immunological responses in elderly patients with sepsis	4
Correction: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	4
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats	4
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	4
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients	4