OOIR: Observatory of International Research

Papers

(The median citation count of Immunity & Ageing is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Gut microbiota as the key controllers of “healthy” aging of elderly people	211
Obesity and COVID-19: what makes obese host so vulnerable?	139
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination	77
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people	64
Toll-like receptor 4 (TLR4): new insight immune and aging	54
Macrophage function in the elderly and impact on injury repair and cancer	50
Functional conservation in genes and pathways linking ageing and immunity	49
SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing	47
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease	45
Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice	44
Autoimmune hemolytic anemia: current knowledge and perspectives	44
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches	42
Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?	40
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	37
miR-181a-regulated pathways in T-cell differentiation and aging	33
Aging and chronic inflammation: highlights from a multidisciplinary workshop	33
Different phenotypes of microglia in animal models of Alzheimer disease	30
NF-κB, a culprit of both inflamm-ageing and declining immunity?	27
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics	27
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19	26
Aging and CMV discordance are associated with increased immune diversity between monozygotic twins	24
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	23
Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities	21
Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond	21
Phenotypic and functional alterations of monocyte subsets with aging	21

Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	21
Telomerase deficiency reflects age-associated changes in CD4+ T cells	20
Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study	20
Unanticipated efficacy of SARS-CoV-2 vaccination in older adults	19
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation	19
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?	18
Inflammation and cell-to-cell communication, two related aspects in frailty	18
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study	18
Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases	17
Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation	17
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults	16
Pathogen burden and leukocyte telomere length in the United States	15
An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients	14
The effect of metformin on senescence of T lymphocytes	14
The interplay between obesity, immunosenescence, and insulin resistance	14
Metabolic phenotype of B cells from young and elderly HIV individuals	13
A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases	12
MicroRNAs: a crossroad that connects obesity to immunity and aging	12
T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II	12
Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults	12
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp	12
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities	12
The diseased kidney: aging and senescent immunology	11
Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice	11
Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans	11
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia	11
The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study	11
T cells accumulate in non-diabetic islets during ageing	11
Obesity accelerates age defects in B cells, and weight loss improves B cell function	11
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial	11
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients	11
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis	11
Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly	10
Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults	10
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals	10
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	10
Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis	10
Neutralizing antibody and T cell responses against SARS-CoV-2 variants of concern following ChAdOx-1 or BNT162b2 boosting in the elderly previously immunized with CoronaVac vaccine	10
Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation	10
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity	10
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	10
Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls	10
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a ra	10
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	10
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging	9
The age again in the eye of the COVID-19 storm: evidence-based decision making	9
Frailty is related to serum inflammageing markers: results from the VITAL study	9
Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal	9
Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells	9
Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children	9

Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons	9
Effect of age and sex on immune checkpoint expression and kinetics in human T cells	9
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging	9
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	9
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression	9
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis	9
Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways	8
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	8
A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	8
Ageing attenuates bone healing by mesenchymal stem cells in a microribbon hydrogel with a murine long bone critical-size defect model	8
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?	8
Immunosenescence and inflammaging in the aged horse	8
The role of NLRP3 inflammasome in aging and age-related diseases	8
Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults	8
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	7
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China	7
An evaluation of the recognised systemic inflammatory biomarkers of chronic sub-optimal inflammation provides evidence for inflammageing (IFA) during multiple sclerosis (MS)	7
Hypothetical COVID-19 protection mechanism: hints from centenarians	7
Systemic immune response in young and elderly patients after traumatic brain injury	7
UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis	6
Glycyrrhizic acid inhibits myeloid differentiation of hematopoietic stem cells by binding S100 calcium binding protein A8 to improve cognition in aged mice	6
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial	6
NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing	6
Inflammatory markers and physical frailty: towards clinical application	6
The oldest unvaccinated Covid-19 survivors in South America	6
High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study	6
Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers	6
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)	6
A description of the relationship in healthy longevity and aging-related disease: from gene to protein	6
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study	6
Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings	6
Impact of NAD+ metabolism on ovarian aging	6
Quantification of dendritic cell subsets in human thymus tissues of various ages	6
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults	5
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study	5
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2	5
An aging-related immune landscape in the hematopoietic immune system	5
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	5
The intersection of biological sex and gender in adverse events following seasonal influenza vaccination in older adults	5
High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges	5
Immunosenescence in Caenorhabditis elegans	5
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?	5
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats	5
Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study	5
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice	5
Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging	5
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population	4
Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health	4
Does immunosenescence drive organismal ageing via inflammageing?	4
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability	4
Human endogenous retroviruses and ageing	4
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging	4
The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice	4
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study	4
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	4
Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing	4
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection	4
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model	4
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium	4
Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals	4
Transcriptional characteristics and functional validation of three monocyte subsets during aging	4
Decreased thymic output predicts progression of chronic kidney disease	4
Longitudinal association of cytokine-producing CMV-specific T cells with frailty in HIV-infected and -uninfected men who have sex with men	4
Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis	4