OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity & Ageing is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	242
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	107
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	64
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy	59
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	58
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	55
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	54
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	54
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	52
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	50
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	41
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	40
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	38
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	37
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	36
Immune cell phenotypes and mortality in the Framingham Heart Study	35
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	34
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	34
Systemic immune response in young and elderly patients after traumatic brain injury	33
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis	32
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	31
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people	31
Association of adipose tissue inflammation and physical fitness in older adults	31
The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity	29
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2	29

The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells	28
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol	26
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	26