OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity & Ageing is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	157
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	80
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	67
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	54
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy	49
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	49
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	45
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	44
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	40
Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	39
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	32
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	32
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	30
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	29
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	29
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	28
Immune cell phenotypes and mortality in the Framingham Heart Study	28
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	27
The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells	25
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	25
Association of adipose tissue inflammation and physical fitness in older adults	24
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2	24
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people	23
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	23
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	23

The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity	23
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	23