OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity & Ageing is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	402
Transient immunostimulation with LPS promotes tissue repair in aged skin	135
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	106
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	96
Clinical rationale for thymic restoration in adult immunosenescence	75
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	75
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	75
Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile	71
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy	65
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	62
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	59
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	54
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	50
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	48
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	47
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	46
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	43
Immune cell phenotypes and mortality in the Framingham Heart Study	42
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	40
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	39
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	38
Obese plasma transfer accelerates cellular aging in the C57BL/6 mouse model	38
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	36
The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity	35
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	34

The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people	34
Systemic immune response in young and elderly patients after traumatic brain injury	33
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis	32
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol	32
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	32
Association of adipose tissue inflammation and physical fitness in older adults	31