FEBS Journal

Article	Citations
	385
Nizp1 is a specific NUP98‐NSD1 functional interactor that regulates NUP98‐NSD1‐dependent oncogenic programs	282
Table of Contents	211
Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	178
Infection‐induced inflammation from specific inborn errors of immunity to COVID‐19	167
Probing invadosomes: technologies for the analysis of invadosomes	145
Issue Information	136
Table of Contents	114
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase (GlgC) for glycogen synthesis in cyanobacteria	112
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	105
Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	96
Acidic pH irreversibly activates the signaling enzyme SARM1	95
Full activation of thermogenesis in brown adipocytes requires Basigin action	92
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	86
Obesity, white adipose tissue and cancer	85
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The biophysical and compositional properties of human basement membranes	83
Table of Contents	81
Table of Contents	79
Table of Contents	78
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	77
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	76
Regulation of cardiovascular and cardiac functions by caveolins	75
Regulation of bacterial Type III Secretion System export gate opening by substrates and the FliJ stalk of the flagellar ATPase	75
The FEBS Journal in 2025: in all science, error precedes the truth	74

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The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	72
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	70
Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation	69
Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis	67
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	66
Identification and functional analysis of a new type of Z,E‐mixed prenyl reductase from mycobacteria	61
A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	59
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	58
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity	58
Spatial and temporal key steps in early‐life intestinal immune system development and education	55
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	55
The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis	54
HOIL‐1‐catalysed, ester‐linked ubiquitylation restricts IL‐18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages	54
A novel hexameric NADP+‐reducing [FeFe] hydrogenase from Moorella thermoacetica	54
A guide to adhesion GPCR research	54
Lipofuscin labeling through biorthogonal strain‐promoted azide‐alkyne cycloaddition for the detection of senescent cells	53
The role of the gut microbiome in disorders of gut–brain interaction	53
SMAR1 and p53‐regulated lncRNA RP11‐431M3.1 enhances HIF1A translation via miR‐138 in colorectal cancer cells under oxidative stress	53
LRRK2 recruitment, activity, and function in organelles	53
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	52
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A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	52
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Table of Contents	51
Characterization of multiple lysophosphatidic acid acyltransferases in the plant pathogen Xanthomonas campestris	50
Table of Contents	50
Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab	49
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Table of Contents	46
Table of Contents	46
Table of Contents	46
Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitro	45
New links for meprin β within the protease web	44
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The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain	43
Multisubstrate‐based system: a kinetic mechanism study of catechol‐O‐methyltransferase	43
Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria (MAMs), is involved in de novo synthesis and remodelling of phospholipids	42
Salmonella‐driven intestinal edema in mice is characterized by tensed fibronectin fibers	41
The Immunity‐malignancy equilibrium in multiple myeloma: lessons from oncogenic events in plasma cells	41
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Issue Information	40
RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection	39
What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses	38
Histatin‐1 is an endogenous ligand of the sigma‐2 receptor	38
Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors	38
Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms	38
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm	37
The role of understudied post‐translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3	36
Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	36

Molecular mechanisms and biological roles of GOMED	36
Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes	36
The role of lysosomal membrane proteins in autophagy and related diseases	35
PRL‐3 promotes a positive feedback loop between STAT1/2‐induced gene expression and glycolysis in multiple myeloma	35
A guide to ferroptosis, the biological rust of cellular membranes	35
Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae	35
Motif‐driven protein binder design towards transferrin receptor helical domain	34
Fibrillation of α‐synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N‐terminal acetylation and familial Parkinson's disease mutations	34
Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease SmNuc1, explained by a structural study	34
Correcting cis‐trans‐transgressions in macromolecular structure models	34
Inflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison	34
Glow‐type conversion and characterization of a minimal luciferase via mutational analyses	33
Unsaturated fatty acids augment protein transport via the SecA:SecYEG translocon	33
Take a breath: oxygen sensing of epidermal differentiation	32
Traptamer screening: a new functional genomics approach to study virus entry and other cellular processes	32
AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells	32
Proteolytic cleavage of the TGFβ co‐receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me	31
A major conformational change of N‐terminal helices of Bacillus thuringiensisCry1Ab insecticidal protein is necessary for membrane insertion and toxicity	31
The largely unexplored biology of small proteins in pro‐ and eukaryotes	31
Acetylation of the influenza A virus polymerase subunit PA in the N‐terminal domain positively regulates its endonuclease activity	31
The CGA codon decoding through tRNAArg(ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae	31
FAM237A, rather than peptide PEN and proCCK56‐63, binds to and activates the orphan receptor GPR83	31
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Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases	31
Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase	31
Ionizing radiation inhibits zebrafish embryo hatching through induction of tissue inhibitors of metalloproteinases (TIMPs) expression	31
Words of advice: teaching macromolecular crystallography	30
Table of Contents	30
Corrigendum	30
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Structural and functional insights into the flexible β‐hairpin of glycerol dehydrogenase	30
Table of Contents	30
Role of the MOZ/MLL‐mediated transcriptional activation system for self‐renewal in normal hematopoiesis and leukemogenesis	29
Less is better: various means to reduce protein load in the endoplasmic reticulum	29
Structure‐based engineering of a short‐chain cis‐prenyltransferase to biosynthesize nonnatural all‐cis‐polyisoprenoids: molecular mechanisms for primer substrate recognition and ultimate	29
11‐Cl‐BBQ, a select modulator of AhR‐regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27Kip1	29
Cytoskeletal protein Zyxin in embryonic development: from controlling cell movements and pluripotency to regulating embryonic patterning	29
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation	28
New wine in old bottles: current progress on P5 ATPases	28
Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases	28
LRP1 is the cell‐surface endocytosis receptor for vaspin in adipocytes	28
MARCH8: the tie that binds to viruses	28
Capturing the RNA castle: Exploiting MicroRNA inhibition for wound healing	28
Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury	28
Issue Information	27
Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family	27
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma	27
Table of Contents	27
A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts	27
Biogenesis of fibrils requires C‐mannosylation of PMEL	26
Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae	26
Structural analysis of the peptidoglycan DL‐endopeptidase CwlO complexed with its inhibitory protein IseA	26
ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by zinc fingers 1–2 and recognition of γ‐globin −200 gene element by zinc fingers 1	26
Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors	26
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The ups and downs of elevator‐type di‐/tricarboxylate membrane transporters	25
Issue Information	25
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Interactions of the maternal microbiome with diet, stress, and infection influence fetal development	25
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin	24
Mosaic translation hypothesis: chimeric polypeptides produced via multiple ribosomal frameshifting as a basis for adaptability	24
ENKD1 is a centrosomal and ciliary microtubule‐associated protein important for primary cilium content regulation	24
Further diversity in the origins of fish antifreeze proteins	24
Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase	24
Impact of structural dynamics on biological functions of flaviviruses	24
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer	24
Is it possible to measure good science?	23
Maize CDKA2;1a and CDKB1;1 kinases have different requirements for their activation and participate in substrate recognition	23
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Structural and interaction analysis of human lipocalin‐type prostaglandin D synthase with the poorly water‐soluble drug NBQX	23
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A comparative study of N‐hydroxylating flavoprotein monooxygenases reveals differences in kinetics and cofactor binding	23
Model‐based robustness and bistability analysis for methylation‐based, epigenetic memory systems	23
Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity	23
Tudor staphylococcal nuclease (Tudor‐SN) regulates activation of quiescent hepatic stellate cells	23
Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML	22
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Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenaseCntAcatalytic site	22
Issue Information	22

M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation	22
Structural insights into α‐(1→6)‐linkage preference of GH97 glucodextranase from Flavobacterium johnsoniae	22
The m6A demethylase FTO promotes C/EBPβ‐LIP translation to perform oncogenic functions in breast cancer cells	21
No small matter: emerging roles for exosomal miRNAs in the immune system	21
Retraction statement: Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling	21
The environmental impact of extracellular matrix preparation	21
Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors	21
Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization	21
Corrigendum to ‘Cryo‐EM structure of MsbA in saposin‐lipid nanoparticles (Salipro) provides insights into nucleotide coordination’	21
Computational modelling of stem cell–niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing	21
Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player	21
Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease	21
A year in the molecular life sciences: 2024 highlights	20
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition	20
Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway	20
Bidirectional feedback between BCR signaling and actin cytoskeletal dynamics	20
Cycloserine enantiomers inhibit PLP‐dependent cysteine desulfurase SufS via distinct mechanisms	20
Contributions of PD‐L1 reverse signaling to dendritic cell trafficking	20
A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology	20
Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry	20
High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice	20
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation	19
AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation	19
Biogenesis of hepatitis B virus e antigen is driven by translocon‐associated protein complex and regulated by conserved cysteine residues within its signal peptide sequence	19
AMPK in the brain: its roles in glucose and neural metabolism	19
The emerging role of PKM in keratinocyte homeostasis and pathophysiology	19
Identification of a novel d‐amino acid aminotransferase involved in d‐glutamate biosynthetic pathways in the hyperthermophile Thermotoga maritima	19
A guide to time‐resolved structural analysis of light‐activated proteins	19
Atomic solution structure of Mycobacterium abscessusF‐ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor	19
Evidence for corrin biosynthesis in the last universal common ancestor	19
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Table of Contents	18
PAM: diverse roles in neuroendocrine cells, cardiomyocytes, and green algae	18
Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor DR2539	18
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis	18
Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor‐1	18
Understanding HAIs: Ally proteins in the fight against cancer	18
Issue Information	18
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15	18
Editor Profile: Nektarios Tavernarakis	18
Issue Information	18
GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators	17
The small molecule ZPD‐2 inhibits the aggregation and seeded polymerisation of C‐terminally truncated α‐Synuclein	17
Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?	17
Rewarding excellence: the 2024 FEBS Journal Richard Perham prize	17
Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia	17
Cell wall‐resident proteins with internal repeats (PIRs) show an inverted architecture in Neurospora crassa, but maintain their role as wall stabilizers	17
tRNA‐like structures and their functions	17
The c‐di‐AMP‐binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae	17
Sortilin regulates blood–brain barrier integrity	17
The dual roles of three MMPs and TIMP in innate immunity and metamorphosis in the silkworm, Bombyx mori	17
Context‐dependent roles of cellular senescence in normal, aged, and disease states	17
Recent advances on smart glycoconjugate vaccines in infections and cancer	16
Crystal structures of the SARS‐CoV‐2 nucleocapsid protein C‐terminal domain and development of nucleocapsid‐targeting nanobodies	16
Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma	16
Table of Contents	16
TBK1 is involved in M‐CSF‐induced macrophage polarization through mediating the IRF5/IRF4 axis	16
Dietary restriction and lifespan: adaptive reallocation or somatic sacrifice?	16
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma	16
PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	16
Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides	16
The universal role of adaptive transcription in health and disease	16
Gut microbiota in multiple sclerosis and animal models	16
Metalloprotease‐mediated cleavage of CD95 ligand	16
Effects of senescence on the tumour microenvironment and response to therapy	16
Table of Contents	16
Issue Information	16
Molecular regulators of HOXA9 in acute myeloid leukemia	16
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Issue Information	15
Table of Contents	15
The regulation of liquid‐liquid phase separated condensates containing nucleic acids	15
Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer	15
Crystal structures of free and ligand‐bound forms of the TetR/AcrR‐like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism	15
A cytosolic disulfide bridge‐supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A	15
DCBLD2 deletion increases hyperglycemia and induces vascular remodeling by inhibiting insulin receptor recycling in endothelial cells	15
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KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation	15
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening	15
Neurokinin‐1 receptor antagonist rolapitant suppresses anxiety and alcohol intake produced by repeated withdrawal episodes	15
Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia?	15
Issue Information	15
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Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord	14
Pinocembrin alleviates renal ischemia–reperfusion injury/unilateral ureteral obstruction (UUO)‐generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axi	14
Regulation of basal autophagy by calmodulin availability	14
Membrane anchoring of New Delhi metallo‐β‐lactamase‐1 alters the fitness of Escherichia coli and increases its susceptibility to colistin by inducing outer membrane destabilization	14
Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria	14
GR‐KLF15 pathway controls hepatic lipogenesis during fasting	14
Identification of an exosite at the neutrophil elastase/alpha‐1‐antitrypsin interface	14
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction‐associated steatohepatitis	14
Oxidative stress‐induced YAP1 expression is regulated by NCE102, CDA2, and BCS1	14
Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence	14
Editor Profile: Daniel Longley	14
Modeling CSF‐1 receptor deficiency diseases – how close are we?	14