FEBS Journal

Article	Citations
	95
Table of Contents	83
Issue Information	81
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The FEBS Journal in 2025: in all science, error precedes the truth	68
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	68
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Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	62
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	62
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	61
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	58
Exploring the roles of conserved context‐dependent cis‐regulatory elements ( cdCREs ) in multicellularity, human health and disease	56
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	53
The biophysical and compositional properties of human basement membranes	48
KU80 suppresses endonuclease G activity to preserve genomic integrity	48
Biogenesis of TNF ‐α‐insights into proteostasis and inflammation	47
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity	43
The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	43
Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin	42
The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis	41
A novel hexameric NADP+‐reducing [FeFe] hydrogenase from Moorella thermoacetica	41
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	40
A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	40
Nizp1 is a specific NUP98 ‐ NSD1 functional interactor that regulates NUP	39
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	38

Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	38
Impact of N‐linked glycans on the dual short fibulin/ LTBP ‐4 axes regulating elastogenesis	37
The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus	36
Lysine demethylase 4A : from chromatin to centrosomes	36
Detection of endogenous LINE ‐1 ORF2p and its potent reverse transcriptase activity in the	36
Tissue integrity at the root of Metazoa – transcriptional landscape of whole‐body regeneration in sponges	35
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Obesity, white adipose tissue and cancer	33
SMAR1 and p53‐regulated lncRNA RP11 ‐ 431M3 .1 enhances	33
The role of the gut microbiome in disorders of gut–brain interaction	33
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	33
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	33
Sialic acid biophore directed design of enhanced affinity HN protein from Newcastle disease virus	32
RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF ‐β signaling	32
Full activation of thermogenesis in brown adipocytes requires Basigin action	31
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	31
Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N ‐methyltransferases	31
Mechanism for synthesis of isomaltooligosaccharides from maltooligosaccharides by GH 15 α‐glucan 4(6)‐α‐glucosyltransferase	30
Regulation of cardiovascular and cardiac functions by caveolins	30
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase ( GlgC ) for glycogen synthesis in cyanobacteria	30
Prebiotic aqueous reactions catalyzed by native nickel without hydrogen	30
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Table of Contents	29
Table of Contents	28
Table of Contents	28
Table of Contents	28
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Take a breath: oxygen sensing of epidermal differentiation	27
New links for meprin β within the protease web	27
A major conformational change of N‐terminal helices of Bacillus thuringiensis Cry1Ab insecticidal protein is necessary for	26
Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitr	26
Fibrillation of α‐synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N‐terminal acetylation and familial Parkinson's disease mutations	25
Multisubstrate‐based system: a kinetic mechanism study of catechol‐ O ‐methyltransferase	25
Characterization of multiple lysophosphatidic acid acyltransferases in the plant pathogen Xanthomonas campestris	25
New insights into macrophage heterogeneity in renal injury and repair	24
Modifying inhibitor specificity for homologous enzymes by machine learning	24
Alternative substrate‐assisted hydrolysis pathways of posttransfer editing by prokaryotic leucyl‐ tRNA synthetase	24
Understanding how enzymes work: the journey to ensemble–function studies	24
Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins	24
Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae	24
Issue Information	23
A guide to ferroptosis, the biological rust of cellular membranes	23
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What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses	23
Structural and functional dissection of the WH2 / DAD motif of INF2	23
Proteolytic cleavage of the TGFβ co‐receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me	23
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm	23
Issue Information	23
RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection	22
The SARS ‐ CoV ‐2 spike protein interacts with HAX1	22

Redirecting TRIM21 with TRIMTACs for the targeted degradation of multimeric proteins	22
FAM237A , rather than peptide PEN and proCCK56 ‐63, binds to and ac	22
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes	22
Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation	22
Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH si	21
Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa	21
A guide to building the matrisome interactome: from computational predictions to experimental validation	21
Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease	20
Salmonella ‐driven intestinal edema in mice is characterized by tensed fibronectin fibers	20
The CGA codon decoding through tRNA Arg	20
Glow‐type conversion and characterization of a minimal luciferase via mutational analyses	20
Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria (MAMs), is involved in de novo synthesis and remodelling of phospholipids	20
Plasmodium mitochondrial exodeoxyribonucleases, Exo mit1 and Exo mit2 ,	20
Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors	20
Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes	20
Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab	19
The role of lysosomal membrane proteins in autophagy and related diseases	19
Correction to “Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase ( GH1 ) from Antarctic	19
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Ionizing radiation inhibits zebrafish embryo hatching through induction of tissue inhibitors of metalloproteinases ( TIMP s) expression	19
Multifaceted multivalency with a hub protein	19
Table of Contents	19
AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells	19
Issue Information	18
Single‐cell atlas of B cell heterogeneity in lacrimal IgG4 ‐related disorders: Unraveling the transition from inflammatory exhaustion to clonal malig	18
Anti‐cancer drugs targeting the NADH ‐binding site of VDAC rewire channel electrophysiology and pa	18
CDK14 is a critical regulator of haematopoietic stem and progenitor cell maintenance and post‐transplantation proliferation	18
Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and t	18
The interaction between NPMc + and Orai1 induces abnormal calcium influx to facilitate leukemogenesis	18
Words of advice: teaching macromolecular crystallography	18
A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts	18
ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis	18
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Ageing versus developmental silencing: Answers from the epigenome	17
Structural and functional insights into the flexible β‐hairpin of glycerol dehydrogenase	17
Issue Information	17
Further diversity in the origins of fish antifreeze proteins	17
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Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro	17
Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family	17
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin	16
Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors	16
Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury	16
Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity	16
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma	16
Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/ DOT1L histone	16
ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by zinc fingers 1–2 and recognition of γ‐globin −200 gene element by zinc fingers 1	16
A new metabolic path in type 3 rickets	16
11‐Cl‐BBQ , a select modulator of AhR ‐regulated transcription, suppresses lung cancer cell growth via activation of p	16
Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase	16
Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins	16
Research highlights	15
The deubiquitinating enzyme USP 8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing	15
Protein tandem repeats that produce frameshifts can generate new structural states and functions	15
LRP1 is the cell‐surface endocytosis receptor for vaspin in adipocytes	15
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Biogenesis of fibrils requires C‐mannosylation of PMEL	15
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer	15
Less is better: various means to reduce protein load in the endoplasmic reticulum	15
Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae	15
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Interactions of the maternal microbiome with diet, stress, and infection influence fetal development	15
Surface loops may provide additional function necessary for enzyme‐to‐pseudoenzyme transition in the fungal metallocarboxypeptidase family	15
Structural analysis of the peptidoglycan DL‐endopeptidase CwlO complexed with its inhibitory protein IseA	15
PEMT ‐mediated phospholipid imbalance promotes age‐associated metabolic dysfunction‐associated steatotic liver disease progression	15
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation	15
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The emerging role of PKM in keratinocyte homeostasis and pathophysiology	14
Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity	14
The m6A demethylase FTO promotes C/ EBPβ ‐	14
Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player	14
Derivatives of MOPS : promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition	14
Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site	14
Corrigendum to ‘ Cryo‐EM structure of MsbA in saposin‐lipid nanoparticles (Salipro) provides insig	14
Is it possible to measure good science?	14
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier	14
Crystal structure and biophysical characterisation of the enterococcal foldase PpiC , a cross‐opsonic antigen against gram‐positive nosocomial pathog	14
Tudor staphylococcal nuclease (Tudor‐ SN ) regulates activation of quiescent hepatic stellate cells	14

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomou	14
Structural insights into α‐(1→6)‐linkage preference of GH 97 glucodextranase from Flavobacterium johnsoniae	14
Maize CDKA2 ;1a and CDKB1 ;1 kinases have different requirements for their activation and particip	14
The environmental impact of extracellular matrix preparation	14
Gal‐1 promotes lung cancer cell survival by enhancing PARP1 / H1 .2 interaction to promote	14
Understanding the catalytic mechanism of the triazine hydrolase from Arthrobacter aurescens TC1	14
A year in the molecular life sciences: 2024 highlights	14
Uncovering a previously unknown function of polyphosphate in polyadenylated RNA ‐induced amyloidogenesis of Hfq	14
Structural and interaction analysis of human lipocalin‐type prostaglandin D synthase with the poorly water‐soluble drug NBQX	14
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Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors	14
Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 prote	13
Evidence for corrin biosynthesis in the last universal common ancestor	13
Atomic solution structure of Mycobacterium abscessusF‐ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor	13
Issue Information	13
The small molecule ZPD ‐2 inhibits the aggregation and seeded polymerisation of C‐terminally truncated α‐Synuclein	13
Phosphatidic acid induces cytoskeletal rearrangements through the Src‐ FAK ‐ R ho	13
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation	13
Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML	13
Issue Information	13
Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway	13
Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease	13
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources	13
Limited roles of the miR ‐17‐92 cluster in the regulation of T‐cell apoptosis	13
Investigating the molecular mechanisms underlying the anti‐ CRISPR function of AcrIIA13b protein	13
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma	13
Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway	13
Rewarding excellence: the 2024 FEBS Journal Richard Perham prize	12
The antihypertensive agent ACT ‐132577 alleviates cuproptosis and pressure‐overload‐induced vascular remodelling by modulation of the NEDD4‐LCTR1‐cop	12
Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐ FAD charge transfer and catalytic asymmetry in a homo	12
PU .1 and TGF ‐β signaling activate the cell‐surface expression of CD103	12
Structural characterization of endogenous microprotein EMBOW reveals an alternative MRT motif for	12
The c‐di‐ AMP ‐binding protein CbpB modulates the level of ppGpp	12
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A comprehensive overview of yeast libraries and their role in advancing cell biology	12
Mutant p53 affects the mitochondrial proteome, promoting mitochondrial fragmentation and OXPHOS in pancreatic ductal adenocarcinoma cells	12
Metalloprotease‐mediated cleavage of CD95 ligand	12
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis	12
Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor	12
Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat	12
Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia	12
Structural and functional dissection of human neurolysin through alanine‐scanning mutagenesis	12
Gut microbiota in multiple sclerosis and animal models	12
Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia?	11
Phytoplankton cell‐states: multiparameter fluorescence lifetime flow‐based monitoring reveals cellular heterogeneity	11
Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor	11
Identification of an exosite at the neutrophil elastase/alpha‐1‐antitrypsin interface	11
Structural dynamics of the N‐terminal SH2 domain of PI3K in its free and	11
Table of Contents	11
Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering	11
Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses	11
Cell wall‐resident proteins with internal repeats ( PIR s) show an inverted architecture in Neurospora crassa	11
Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?	11
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening	11
TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells	11
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction‐associated steatohepatitis	11
DCBLD2 deletion increases hyperglycemia and induces vascular remodeling by inhibiting insulin receptor recycling in endothelial cells	11
Staufen‐2 functions as a cofactor for enhanced Rev‐mediated nucleocytoplasmic trafficking of HIV ‐1 genomic RNA	11
Issue Information	11
Table of Contents	11
Effects of senescence on the tumour microenvironment and response to therapy	11
A DNA mimic jams the Cas9 scissors	11
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Issue Information	11
Crystal structures of free and ligand‐bound forms of the TetR / AcrR‐like regulator	11
Characterization of the carboxy‐terminal domain of the GPN ‐loop GTPase Npa3 reveals an intrinsica	11
Editor Profile: Daniel Longley	11
One ring closer to a closure: the crystal structure of the ES 3 hydroxym	11
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40	11
Table of Contents	11
Issue Information	11
PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	11
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15	11
Context‐dependent roles of cellular senescence in normal, aged, and disease states	11
Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord	10
GR‐KLF15 pathway controls hepatic lipogenesis during fasting	10
The chemoreceptor controlling the Wsp‐like transduction pathway in Halomonas titanicaeKHS3 binds and responds to purine derivatives	10
Mitochondrial derived vesicles‐ Quo Vadis?	10
Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells	10
A metastasis‐associated pannexin‐1 mutant (Panx1 1‐89 ) forms a minimalist ATP release channel	10
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The universal role of adaptive transcription in health and disease	10
Membrane anchoring of New Delhi metallo‐β‐lactamase‐1 alters the fitness of Escherichia coli and increases its susceptibility to colistin by inducing out	10
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism	10
Transgenic selection and underlying mechanisms in apicomplexan parasites	10
Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link	10
Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides	10
Pinocembrin alleviates renal ischemia–reperfusion injury/unilateral ureteral obstruction (UUO)‐generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axi	10
The role of compartmentalized β‐AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes	10
Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction	10
Structural and thermodynamic analyses of a novel β‐1,2‐glucan binding mode in the ABC transporter solute‐binding protein Chy400_4166 from	10
Autophagy of the ER: the secretome finds the lysosome	10
Biochemical characterization and mutational analysis of the tetrameric DABA transaminase E ct	10
Lung organoids as a human system for Mycobacteria infection modeling and drug testing	10
TDP ‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models	10