OOIR: Observatory of International Research

Papers

(The TQCC of FEBS Journal is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
A guide to the composition and functions of the extracellular matrix	478
Signaling pathways and defense mechanisms of ferroptosis	291
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics	208
Multifunctional intracellular matrix metalloproteinases: implications in disease	200
ADP‐ribosyltransferases, an update on function and nomenclature	180
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization	124
A guide to the regulation of selective autophagy receptors	123
Cellular senescence: all roads lead to mitochondria	122
The structural basis of accelerated host cell entry by SARS‐CoV‐2†	114
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise	113
A guide to the Michaelis–Menten equation: steady state and beyond	109
The blood–retina barrier in health and disease	105
AMPK, metabolism, and vascular function	94
A guide to studying protein aggregation	93
Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme	91
Hallmarks of the aging T‐cell system	86
The mitochondrial permeability transition: Recent progress and open questions	83
Global functions of O‐glycosylation: promises and challenges in O‐glycobiology	81
Immunogenicity and humanization of single‐domain antibodies	81
The role of PARP1 in neurodegenerative diseases and aging	79
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal	76
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications	71
Epithelial‐to‐mesenchymal‐like transition events in melanoma	71
Transposable element regulation and expression in cancer	70
Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins	70

Nrf2 and oxidative stress in liver ischemia/reperfusion injury	70
The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology	68
Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID‐19 patients	67
The multifaceted role of TRAIL signaling in cancer and immunity	66
AgRP neurons: Regulators of feeding, energy expenditure, and behavior	65
Targeting dormant tumor cells to prevent cancer recurrence	65
The role of structural dynamics in GPCR‐mediated signaling	64
Roles of neutrophil granule proteins in orchestrating inflammation and immunity	63
A guide to membrane protein X‐ray crystallography	63
Migrasome biogenesis and functions	62
New roles for desmin in the maintenance of muscle homeostasis	62
Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity	61
Nuclear speckles: dynamic hubs of gene expression regulation	61
Interferon‐γ induces retinal pigment epithelial cell Ferroptosis by a JAK1‐2/STAT1/SLC7A11 signaling pathway in Age‐related Macular Degeneration	61
Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease	61
Elastic fibers: formation, function, and fate during aging and disease	60
Tumor‐associated macrophages in immunotherapy	59
The intricate balance between microRNA‐induced mRNA decay and translational repression	59
Protein S‐Palmitoylation: advances and challenges in studying a therapeutically important lipid modification	59
Alternative systems for misfolded protein clearance: life beyond the proteasome	59
Understanding the role of cysteine in ferroptosis: progress & paradoxes	59
Long‐term plasticity in the hippocampus: maintaining within and ‘tagging’ between synapses	58
LD‐transpeptidases: the great unknown among the peptidoglycan cross‐linkers	57
The role of cellular senescence and SASP in tumour microenvironment	57
AMPK in the brain: its roles in glucose and neural metabolism	56
LRRK2 recruitment, activity, and function in organelles	55
Aberrant phase separation and cancer	55
The state of CD44 activation in cancer progression and therapeutic targeting	53
Insights into the H₂O₂‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases	53
Structural and biochemical properties of L‐asparaginase	51
The largely unexplored biology of small proteins in pro‐ and eukaryotes	50
Durotaxis: the mechanical control of directed cell migration	48
Molecular mechanisms regulating Proteinase‐Activated Receptors (PARs)	48
Energy metabolism in brown adipose tissue	47
Host PDZ‐containing proteins targeted by SARS‐CoV‐2	47
Enzyme nomenclature and classification: the state of the art	47
Recent advances on smart glycoconjugate vaccines in infections and cancer	47
Clinical advances in targeting epigenetics for cancer therapy	47
Analytical methods for the investigation of enzyme‐catalyzed degradation of polyethylene terephthalate	47
Human guanylate binding proteins: nanomachines orchestrating host defense	47
New targets for drug design: importance of nsp14/nsp10 complex formation for the 3’‐5’ exoribonucleolytic activity on SARS‐CoV‐2	46
Autophagy at the interface of endothelial cell homeostasis and vascular disease	46
Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer	46
Pediatric high‐grade glioma: moving toward subtype‐specific multimodal therapy	46
Allosteric coupling and biased agonism in G protein‐coupled receptors	44
FOXOs: masters of the equilibrium	44
Venn diagram analysis overestimates the extent of circadian rhythm reprogramming	44
Tryptophan and its metabolites in normal physiology and cancer etiology	43
Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis	43
Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies	42

Apoptosis – Fueling the oncogenic fire	42
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism	42
Collagen VI as a driver and disease biomarker in human fibrosis	42
Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity‐dependent regulatory mechanisms	41
Protein cysteine palmitoylation in immunity and inflammation	41
Signaling and function of cardiac autonomic nervous system receptors: Insights from the GPCR signalling universe	41
Calcium signaling in cancer progression and therapy	41
Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ	41
New insights into the organization and regulation of the apical polarity network in mammalian epithelial cells	41
Past, present and future of zebrafish in epilepsy research	40
The gate to metastasis: key players in cancer cell intravasation	40
The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter	39
The lysosomal membrane—export of metabolites and beyond	39
Cancers associated with human gammaherpesviruses	39
Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease	38
Targeting the molecular & cellular pillars of human aging with exercise	38
CCCP‐induced mitochondrial dysfunction – characterization and analysis of integrated stress response to cellular signaling and homeostasis	38
Interpreting the role of the striatum during multiple phases of motor learning	38
The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID‐19 infection	37
A tale of two proteins: PACT and PKR and their roles in inflammation	37
Iron and liver cancer: an inseparable connection	36
Structure and function of p62/SQSTM1 in the emerging framework of phase separation	36
Autophagy and tumorigenesis	35
EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms	35
HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes	34
Druggable genome and precision medicine in cancer: current challenges	34
The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review	34
Overview of antiviral drug candidates targeting coronaviral 3C‐like main proteases	34
Beyond energy storage: roles of glycogen metabolism in health and disease	34
Viruses join the circular RNA world	33
A double‐edged sword: reactive oxygen species (ROS) during the rice blast fungus and host interaction	33
A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology	33
Function of pH‐dependent transcription factor PacC in regulating development, pathogenicity, and mycotoxin biosynthesis of phytopathogenic fungi	33
Metabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes	33
The role of goblet cells in viral pathogenesis	33
Molecular and spatial mechanisms governing STING signalling	32
Second sialic acid‐binding site of influenza A virus neuraminidase: binding receptors for efficient release	32
Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1–42 aggregates	32
Alveolar epithelial cell‐derived Sonic hedgehog promotes pulmonary fibrosis through OPN‐dependent alternative macrophage activation	32
BRD4andMYC: power couple in transcription and disease	32
Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk	32
Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections	32
Cholesterol metabolism pathways – are the intermediates more important than the products?	31
TRPV4 integrates matrix mechanosensing with Ca²⁺ signaling to regulate extracellular matrix remodeling	31
A guide to genetically encoded tools for the study of H₂O₂	31
Chloroplast protein import machinery and quality control	31
A recent update on small‐molecule kinase inhibitors for targeted cancer therapy and their therapeutic insights from mass spectrometry‐based proteomic analysis	31
Tools to study and target the Siglec–sialic acid axis in cancer	31
The duality of PRDM proteins: epigenetic and structural perspectives	31
From stretch to deflection: the importance of context in the activation of mammalian, mechanically activated ion channels	31
Secretory proteins of Mycobacterium tuberculosis and their roles in modulation of host immune responses: focus on therapeutic targets	31
Revisiting preeclampsia: a metabolic disorder of the placenta	31
Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts	31
UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD	30
A guide to time‐resolved structural analysis of light‐activated proteins	30
Histone deacetylase 7: a signalling hub controlling development, inflammation, metabolism and disease	30
Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation	30
Insights into muscle stem cell dynamics during postnatal development	30
Astrocyte–synapse interactions and cell adhesion molecules	30
Understanding MCL1: from cellular function and regulation to pharmacological inhibition	30
Molecular events underlying the cell‐to‐cell transmission of α‐synuclein	30
Oncogenic dysregulation of pre‐mRNA processing by protein kinases: challenges and therapeutic opportunities	30
Stress granules: regulators or by‐products?	30
Mitochondrial matrix proteases: quality control and beyond	29
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif	29
Exosomal and vesicle‐free tau seeds—propagation and convergence in endolysosomal permeabilization	29
Bottom‐up reconstitution of focal adhesion complexes	29
Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis	29
Autophagy in the retinal pigment epithelium: a new vision and future challenges	29
Targeting ER stress in the hepatic tumor microenvironment	28
Oncohistones: a roadmap to stalled development	28
Cancer cell metabolism connects epigenetic modifications to transcriptional regulation	28
Microalgal protein AstaP is a potent carotenoid solubilizer and delivery module with a broad carotenoid binding repertoire	28
Membrane protein biogenesis at the ER: the highways and byways	28
Voltage‐gated calcium channel nanodomains: molecular composition and function	28
Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases	28
Imaging the future: the emerging era of single‐cell spatial proteomics	27
Crystal structure of the full‐length LysR‐type transcription regulator CbnR in complex with promoter DNA	27
Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast	27
Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?	27

Oxygen regulation of TET enzymes	27
Efficient polyethylene terephthalate degradation at moderate temperature: a protein engineering study of LC‐cutinase highlights the key role of residue 243	27
Emerging glyco‐based strategies to steer immune responses	26
Palmitic acid‐induced ferroptosis via CD36 activates ER stress to break calcium‐iron balance in colon cancer cells	26
In vivo glial trans‐differentiation for neuronal replacement and functional recovery in central nervous system	26
Modeling CSF‐1 receptor deficiency diseases – how close are we?	26
Interneuron development and dysfunction	26
Allosteric communication regulates ligand‐specific GPCR activity	26
Cellular senescence in the tumor microenvironment and context‐specific cancer treatment strategies	26
Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells	25
Mammalian circadian networks mediated by the suprachiasmatic nucleus	25
SARS‐CoV‐2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion	25
Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex	25
Immune and vascular contributions to organogenesis of the testis and ovary	25
The role of RNA‐binding proteins in mediating adaptive responses in Gram‐positive bacteria	25
Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	25
Muscle cell‐derived cytokines in skeletal muscle regeneration	24
Untangling senescent and damage‐associated microglia in the aging and diseased brain	24
The ups and downs of growth hormone secretagogue receptor signaling	24
Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics	24
A guide to adhesion GPCR research	23
Metabolically induced intracellular pH changes activate mitophagy, autophagy, and cell protection in familial forms of Parkinson's disease	23
Goodnight, astrocyte: waking up to astroglial mechanisms in sleep	23
p53 in senescence – it's a marathon, not a sprint	23
Understanding how kinesin motor proteins regulate postsynaptic function in neuron	23
p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities	23
Recent progress in the mechanistic understanding of NET formation in neutrophils	23
Par‐3 family proteins in cell polarity & adhesion	23
A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress	23
PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	23
Cellular and molecular pathways controlling muscle size in response to exercise	23
Regulatory noncoding RNAs: functions and applications in health and disease	23
Targeting tumour necrosis factor to ameliorate viral pneumonia	23
Hepsin: a multifunctional transmembrane serine protease in pathobiology	22
How to be a good peer reviewer of scientific manuscripts	22
Full circle: a brief history of cohesin and the regulation of gene expression	22
Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms	22
Mechanism, specificity, and function of FANCD2‐FANCI ubiquitination and deubiquitination	22
Plant programmed cell death meets auxin signalling	22
Cannabinoid control of hippocampal functions: the where matters	22
Caspase‐9 acts as a regulator of necroptotic cell death	22
Development of new therapeutic options for the treatment of uveal melanoma	22
Complement cascade functions during brain development and neurodegeneration	22
Surviving death: emerging concepts of RIPK3 and MLKL ubiquitination in the regulation of necroptosis	22
The receptor for advanced glycation end products is a sensor for cell‐free heme	22
Mass spectrometry‐based characterization of histones in clinical samples: applications, progress, and challenges	22
Prenatal exercise in fetal development: a placental perspective	21
Emerging role of lncRNA ELDR in development and cancer	21
Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges	21
Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma	21
AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation	21
ATG16L1 functions in cell homeostasis beyond autophagy	21
Therapeutic opportunities for senolysis in cardiovascular disease	21
The transcriptional regulation of normal and malignant blood cell development	21
Building and sustaining mentor interactions as a mentee	21
Mitochondrial sirtuins in stem cells and cancer	20
Regulation of Notch signaling by E3 ubiquitin ligases	20
Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites	20
Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage	20
Multifaceted roles of mitochondrial stress responses under ETC dysfunction – repair, destruction and pathogenesis	20
A‐to‐I RNA editing of Filamin A regulates cellular adhesion, migration and mechanical properties	20
The intestinal immune system and gut barrier function in obesity and ageing	20
Gut microbiota imbalance mediates intestinal barrier damage in high‐altitude exposed mice	20
Heterotypic interactions in amyloid function and disease	20
20 years of DNA Polymerase μ, the polymerase that still surprises	20
Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions	20
PRE‐driven protein NMR structures: an alternative approach in highly paramagnetic systems	19
cGAS‐STING pathway: post‐translational modifications and functions in sterile inflammatory diseases	19
Coordination of transcription and processing of tRNA	19
Hunger‐driven adaptive prioritization of behavior	19
Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue	19
Approaching transglutaminase from Streptomyces bacteria over three decades	19
Molecular regulators of HOXA9 in acute myeloid leukemia	19
Protonation status and control mechanism of flavin–oxygen intermediates in the reaction of bacterial luciferase	19
The role of the Hippo pathway in heart disease	19
Novel small molecules targeting bZIP23 TF improve stomatal conductance and photosynthesis under mild drought stress by regulating ABA	19
Notch signalling: multifaceted role in development and disease	19
G‐quadruplex regulation of neural gene expression	19
PPARα at the crossroad of metabolic–immune regulation in cancer	19
The emerging role of dipeptidyl peptidase 3 in pathophysiology	19
Amino acid metabolism, redox balance and epigenetic regulation in cancer	19
Fatty acid metabolism in adaptive immunity	19
Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control	18
HOIL‐1‐catalysed, ester‐linked ubiquitylation restricts IL‐18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages	18
Characterization of G4 DNA formation in mitochondrial DNA and their potential role in mitochondrial genome instability	18
Emerging roles of ferroptosis in infectious diseases	18
Cellular force‐sensing through actin filaments	18
Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence	18
Microglia phagocytose oligodendrocyte progenitor cells and synapses during early postnatal development: implications for white versus gray matter maturation	18
A guide to UFMylation, an emerging posttranslational modification	18
Regulation and function of the palmitoyl‐acyltransferase ZDHHC5	18
Biological implications of decapping: beyond bulk mRNA decay	17
Salivary biomarkers in cardiovascular disease: An insight into the current evidence	17
Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes‐Jensen syndrome	17
Microbial recognition regulates intestinal epithelial growth in homeostasis and disease	17