OOIR: Observatory of International Research

Papers

(The TQCC of FEBS Journal is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
A guide to the composition and functions of the extracellular matrix	329
Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study	290
A guide to assessing cellular senescence in vitro and in vivo	252
Glycolysis – a key player in the inflammatory response	250
Rab family of small GTPases: an updated view on their regulation and functions	221
A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2	184
Signaling pathways and defense mechanisms of ferroptosis	178
A guide to plasma membrane solute carrier proteins	167
A guide to: generation and design of nanobodies	155
New insights into the activities and toxicities of the old anticancer drug doxorubicin	147
Multifunctional intracellular matrix metalloproteinases: implications in disease	142
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics	135
ADP‐ribosyltransferases, an update on function and nomenclature	135
Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing	131
Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts	126
Resistin in metabolism, inflammation, and disease	108
The structural basis of accelerated host cell entry by SARS‐CoV‐2†	107
Exosomes as mediators of immune regulation and immunotherapy in cancer	104
Sympathetic activation: a potential link between comorbidities and COVID‐19	96
Calnexin cycle – structural features of the ER chaperone system	93
A guide to the regulation of selective autophagy receptors	91
Evolution of new enzymes by gene duplication and divergence	86
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization	85
Cellular senescence: all roads lead to mitochondria	78
Hallmarks of the aging T‐cell system	71

A guide to the Michaelis–Menten equation: steady state and beyond	71
The role of PARP1 in neurodegenerative diseases and aging	71
The mitochondrial permeability transition: Recent progress and open questions	69
AMPK, metabolism, and vascular function	63
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise	62
Transposable element regulation and expression in cancer	62
Global functions of O‐glycosylation: promises and challenges in O‐glycobiology	62
Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID‐19 patients	61
The blood–retina barrier in health and disease	59
Nrf2 and oxidative stress in liver ischemia/reperfusion injury	58
Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme	57
The role of structural dynamics in GPCR‐mediated signaling	57
The multifaceted role of TRAIL signaling in cancer and immunity	57
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications	56
Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease	56
A guide to studying protein aggregation	56
Immunogenicity and humanization of single‐domain antibodies	56
Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins	55
Epithelial‐to‐mesenchymal‐like transition events in melanoma	54
Targeting dormant tumor cells to prevent cancer recurrence	52
Protein S‐Palmitoylation: advances and challenges in studying a therapeutically important lipid modification	52
A guide to membrane protein X‐ray crystallography	51
Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase	51
Oxygen‐sensing mechanisms in cells	51
The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes	50
New roles for desmin in the maintenance of muscle homeostasis	50
Tumor‐associated macrophages in immunotherapy	49
Alternative systems for misfolded protein clearance: life beyond the proteasome	49
LD‐transpeptidases: the great unknown among the peptidoglycan cross‐linkers	48
Understanding the role of cysteine in ferroptosis: progress & paradoxes	48
Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity	47
Insights into the H₂O₂‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases	47
AgRP neurons: Regulators of feeding, energy expenditure, and behavior	47
Nuclear speckles: dynamic hubs of gene expression regulation	47
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal	46
New targets for drug design: importance of nsp14/nsp10 complex formation for the 3’‐5’ exoribonucleolytic activity on SARS‐CoV‐2	46
Host PDZ‐containing proteins targeted by SARS‐CoV‐2	45
Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease	45
Nicotine and the nicotinic cholinergic system in COVID‐19	45
Plant protein phosphatases: What do we know about their mechanism of action?	44
Structural and biochemical properties of L‐asparaginase	43
Molecular mechanisms regulating Proteinase‐Activated Receptors (PARs)	43
COVID‐19, cilia, and smell	43
LRRK2 recruitment, activity, and function in organelles	43
Aberrant phase separation and cancer	42
Progress and outlook in studying the substrate specificities of PARPs and related enzymes	42
Long‐term plasticity in the hippocampus: maintaining within and ‘tagging’ between synapses	41
Regulation of adipocyte thermogenesis: mechanisms controlling obesity	41
Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1	41
Human guanylate binding proteins: nanomachines orchestrating host defense	41

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2	41
Elastic fibers: formation, function, and fate during aging and disease	41
The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology	41
Interferon‐γ induces retinal pigment epithelial cell Ferroptosis by a JAK1‐2/STAT1/SLC7A11 signaling pathway in Age‐related Macular Degeneration	40
Pediatric high‐grade glioma: moving toward subtype‐specific multimodal therapy	40
Autophagy at the interface of endothelial cell homeostasis and vascular disease	40
Durotaxis: the mechanical control of directed cell migration	40
Matrix stiffness‐mediated effects on macrophages polarization and their LOXL2 expression	40
Clinical advances in targeting epigenetics for cancer therapy	39
Recent advances on smart glycoconjugate vaccines in infections and cancer	39
Past, present and future of zebrafish in epilepsy research	39
Venn diagram analysis overestimates the extent of circadian rhythm reprogramming	39
Roles of neutrophil granule proteins in orchestrating inflammation and immunity	39
Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies	38
Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer	38
Enzymes, pseudoenzymes, and moonlighting proteins: diversity of function in protein superfamilies	38
Endocrine regulation of immunity in insects	38
Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis	38
FOXOs: masters of the equilibrium	37
AMPK in the brain: its roles in glucose and neural metabolism	37
NET formation – mechanisms and how they relate to other cell death pathways	37
Energy metabolism in brown adipose tissue	36
New insights into the organization and regulation of the apical polarity network in mammalian epithelial cells	36
How does fascin promote cancer metastasis?	36
The role of cellular senescence and SASP in tumour microenvironment	36
Analytical methods for the investigation of enzyme‐catalyzed degradation of polyethylene terephthalate	36
The largely unexplored biology of small proteins in pro‐ and eukaryotes	36
Migrasome biogenesis and functions	36
Signaling and function of cardiac autonomic nervous system receptors: Insights from the GPCR signalling universe	36
The intricate balance between microRNA‐induced mRNA decay and translational repression	36
Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease	35
Ligand‐centered assessment of SARS‐CoV‐2 drug target models in the Protein Data Bank	35
Silibinin induces metabolic crisis in triple‐negative breast cancer cells by modulating EGFR‐MYC‐TXNIP axis: potential therapeutic implications	35
Apoptosis – Fueling the oncogenic fire	35
The state of CD44 activation in cancer progression and therapeutic targeting	35
Allosteric coupling and biased agonism in G protein‐coupled receptors	35
A tale of two proteins: PACT and PKR and their roles in inflammation	34
Collagen VI as a driver and disease biomarker in human fibrosis	34
The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID‐19 infection	34
Home, sweet home: how mucus accommodates our microbiota	34
Diverse and pivotal roles of neddylation in metabolism and immunity	33
Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis	33
The multifaceted role of cell cycle regulators in the coordination of growth and metabolism	33
The characteristics and roles of β‐TrCP1/2 in carcinogenesis	33
Calcium signaling in cancer progression and therapy	33
Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ	33
Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis	33
Noncoding RNAs in vascular smooth muscle cell function and neointimal hyperplasia	32
Serum response factor‐cofactor interactions and their implications in disease	32
COVID‐19 breakthroughs: separating fact from fiction	32
The gate to metastasis: key players in cancer cell intravasation	32
Cancers associated with human gammaherpesviruses	32
Myeloid‐derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p‐STAT3 signalling pathway	31
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism	31
Long non coding RNA SLC26A4‐AS1 exerts antiangiogenic effects in human glioma by upregulating NPTX1 via NFKB1 transcriptional factor	31
Protein cysteine palmitoylation in immunity and inflammation	31
Novel FMRP interaction networks linked to cellular stress	30
Viruses join the circular RNA world	30
Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity‐dependent regulatory mechanisms	30
Alveolar epithelial cell‐derived Sonic hedgehog promotes pulmonary fibrosis through OPN‐dependent alternative macrophage activation	29
The co‐existence of cold activity and thermal stability in an Antarctic GH42 β‐galactosidase relies on its hexameric quaternary arrangement	29
Role of post‐translational modifications in the acquisition of drug resistance in Mycobacterium tuberculosis	29
Tryptophan and its metabolites in normal physiology and cancer etiology	29
A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology	29
EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms	28
Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA‐296‐5p/CXCL10 axis	28
Cholesterol metabolism pathways – are the intermediates more important than the products?	28
The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review	28
Spage2vec: Unsupervised representation of localized spatial gene expression signatures	28
Words of Advice: teaching enzyme kinetics	28
Enzyme nomenclature and classification: the state of the art	28
Membrane protein biogenesis at the ER: the highways and byways	27
Molecular and spatial mechanisms governing STING signalling	27
Oncogenic dysregulation of pre‐mRNA processing by protein kinases: challenges and therapeutic opportunities	27
Beyond energy storage: roles of glycogen metabolism in health and disease	27
Supply and demand—heme synthesis, salvage and utilization by Apicomplexa	27
CRY1‐CBS binding regulates circadian clock function and metabolism	27
Structure and function of p62/SQSTM1 in the emerging framework of phase separation	27
The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress	27
Using unnatural amino acids to selectively label proteins for cellular imaging: a cell biologist viewpoint	27

The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter	27
Pharmacological inhibition and knockdown of O‐GlcNAcase reduces cellular internalization of α‐synuclein preformed fibrils	27
Recent progress of bacterial FtsZ inhibitors with a focus on peptides	27
Targeting the molecular & cellular pillars of human aging with exercise	26
TRPV4 integrates matrix mechanosensing with Ca²⁺ signaling to regulate extracellular matrix remodeling	26
A guide to genetically encoded tools for the study of H₂O₂	26
Metabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes	26
Model membrane systems to reconstitute immune cell signaling	26
Druggable genome and precision medicine in cancer: current challenges	26
Insights into muscle stem cell dynamics during postnatal development	26
Overview of antiviral drug candidates targeting coronaviral 3C‐like main proteases	26
Tools to study and target the Siglec–sialic acid axis in cancer	26
The discovery of dystrophin, the protein product of the Duchenne muscular dystrophy gene	26
Molecular events underlying the cell‐to‐cell transmission of α‐synuclein	25
Autophagy in the retinal pigment epithelium: a new vision and future challenges	25
Mitochondrial matrix proteases: quality control and beyond	25
The heparan sulfate proteoglycan syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase—Wnt signaling axis	25
SARS‐CoV‐2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion	25
Iron and liver cancer: an inseparable connection	25
The duality of PRDM proteins: epigenetic and structural perspectives	25
Autophagy is responsible for the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis thaliana	25
Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?	25
The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans	25
The lysosomal membrane—export of metabolites and beyond	24
Vimentin S‐glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitro	24
CCCP‐induced mitochondrial dysfunction – characterization and analysis of integrated stress response to cellular signaling and homeostasis	24
Targeting evolution to inhibit antibiotic resistance	24
Imaging the future: the emerging era of single‐cell spatial proteomics	24
Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration	24
Bottom‐up reconstitution of focal adhesion complexes	24
Microalgal protein AstaP is a potent carotenoid solubilizer and delivery module with a broad carotenoid binding repertoire	23
A guide to time‐resolved structural analysis of light‐activated proteins	23
Driving CARs with alternative navigation tools – the potential of engineered binding scaffolds	23
Function of pH‐dependent transcription factor PacC in regulating development, pathogenicity, and mycotoxin biosynthesis of phytopathogenic fungi	23
Autophagy and tumorigenesis	23
Roles of dopamine and glutamate co‐release in the nucleus accumbens in mediating the actions of drugs of abuse	23
Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections	23
The role of goblet cells in viral pathogenesis	23
Interpreting the role of the striatum during multiple phases of motor learning	23
Second sialic acid‐binding site of influenza A virus neuraminidase: binding receptors for efficient release	23
Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid‐related diseases	23
In vivo glial trans‐differentiation for neuronal replacement and functional recovery in central nervous system	23
Tumor markers as an entry for SARS‐CoV‐2 infection?	22
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif	22
HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes	22
Exosomal and vesicle‐free tau seeds—propagation and convergence in endolysosomal permeabilization	22
Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts	22
Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation	22
Hepsin: a multifunctional transmembrane serine protease in pathobiology	22
Allosteric communication regulates ligand‐specific GPCR activity	22
HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscle	22
Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1–42 aggregates	22
Protein structural and mechanistic basis of progeroid laminopathies	22
Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex	22
Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast	22
Vitamin D to prevent COVID‐19: recommendations for the design of clinical trials	22
Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells	22
A double‐edged sword: reactive oxygen species (ROS) during the rice blast fungus and host interaction	22
Stress granules: regulators or by‐products?	22
A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress	22
Emerging glyco‐based strategies to steer immune responses	21
Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics	21
Par‐3 family proteins in cell polarity & adhesion	21
Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases	21
Voltage‐gated calcium channel nanodomains: molecular composition and function	21
Microtubule‐associated proteins and emerging links to primary cilium structure, assembly, maintenance, and disassembly	21
Targeting ER stress in the hepatic tumor microenvironment	21
Cholesterol‐containing lipid nanodiscs promote an α‐synuclein binding mode that accelerates oligomerization	21
Genome‐wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin–antitoxin systems as a major substrate class	21
Involvement of Wnt signaling in primary cilia assembly and disassembly	21
Modeling CSF‐1 receptor deficiency diseases – how close are we?	21
From stretch to deflection: the importance of context in the activation of mammalian, mechanically activated ion channels	21
Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death	21
Revisiting preeclampsia: a metabolic disorder of the placenta	21
Enzyme promiscuity and evolution in light of cellular metabolism	20
A recent update on small‐molecule kinase inhibitors for targeted cancer therapy and their therapeutic insights from mass spectrometry‐based proteomic analysis	20
Understanding MCL1: from cellular function and regulation to pharmacological inhibition	20
Mass spectrometry‐based characterization of histones in clinical samples: applications, progress, and challenges	20
Cancer cell metabolism connects epigenetic modifications to transcriptional regulation	20
The dead phosphatases society: a review of the emerging roles of pseudophosphatases	20
Roles of cell fusion between mesenchymal stromal/stem cells and malignant cells in tumor growth and metastasis	20
The role of RNA‐binding proteins in mediating adaptive responses in Gram‐positive bacteria	20
Goodnight, astrocyte: waking up to astroglial mechanisms in sleep	20
p53 in senescence – it's a marathon, not a sprint	20
Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk	20
Marine cyanobacteria tune energy transfer efficiency in their light‐harvesting antennae by modifying pigment coupling	20
Mammalian circadian networks mediated by the suprachiasmatic nucleus	19
Interneuron development and dysfunction	19
Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions	19
Understanding how kinesin motor proteins regulate postsynaptic function in neuron	19
Enzymology of the pathway for ATP production by arginine breakdown	19
Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites	19
Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	19
Targeting tumour necrosis factor to ameliorate viral pneumonia	19
The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection	19