FEBS Journal

Article	Citations
	87
Table of Contents	79
Issue Information	78
	69
The FEBS Journal in 2025: in all science, error precedes the truth	67
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A novel hexameric NADP+‐reducing [FeFe] hydrogenase from Moorella thermoacetica	62
The role of the gut microbiome in disorders of gut–brain interaction	61
Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin	60
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	60
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	57
A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	53
Sialic acid biophore directed design of enhanced affinity HN protein from Newcastle disease virus	50
Prebiotic aqueous reactions catalyzed by native nickel without hydrogen	49
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	47
The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	45
Obesity, white adipose tissue and cancer	44
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity	43
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	42
Mechanism for synthesis of isomaltooligosaccharides from maltooligosaccharides by GH 15 α‐glucan 4(6)‐α‐glucosyltransferase	42
Biogenesis of TNF ‐α‐insights into proteostasis and inflammation	42
The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis	41
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	40
Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	40
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	39

Regulation of cardiovascular and cardiac functions by caveolins	38
Lysine demethylase 4A : from chromatin to centrosomes	37
Exploring the roles of conserved context‐dependent cis‐regulatory elements ( cdCREs ) in multicellularity, human health and disease	37
Nizp1 is a specific NUP98 ‐ NSD1 functional interactor that regulates NUP	35
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	35
Lipofuscin labeling through biorthogonal strain‐promoted azide‐alkyne cycloaddition for the detection of senescent cells	35
Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	35
RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF ‐β signaling	35
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	34
Full activation of thermogenesis in brown adipocytes requires Basigin action	34
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase ( GlgC ) for glycogen synthesis in cyanobacteria	33
Impact of N‐linked glycans on the dual short fibulin/ LTBP ‐4 axes regulating elastogenesis	33
SMAR1 and p53‐regulated lncRNA RP11 ‐ 431M3 .1 enhances	33
The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus	33
Detection of endogenous LINE ‐1 ORF2p and its potent reverse transcriptase activity in the	32
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	31
The biophysical and compositional properties of human basement membranes	31
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Tissue integrity at the root of Metazoa – transcriptional landscape of whole‐body regeneration in sponges	30
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	30
Table of Contents	29
KU80 suppresses endonuclease G activity to preserve genomic integrity	29
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Table of Contents	28
Table of Contents	28
Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH si	28
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Table of Contents	28
New links for meprin β within the protease web	28
Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors	27
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes	27
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Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae	26
Salmonella ‐driven intestinal edema in mice is characterized by tensed fibronectin fibers	26
Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease	25
Issue Information	25
FAM237A , rather than peptide PEN and proCCK56 ‐63, binds to and ac	24
A guide to building the matrisome interactome: from computational predictions to experimental validation	24
RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection	24
Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa	23
Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes	23
Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria (MAMs), is involved in de novo synthesis and remodelling of phospholipids	23
Issue Information	23
Fibrillation of α‐synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N‐terminal acetylation and familial Parkinson's disease mutations	22
AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells	22
Correction to “Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase ( GH1 ) from Antarctic	22
A major conformational change of N‐terminal helices of Bacillus thuringiensis Cry1Ab insecticidal protein is necessary for	22
Multifaceted multivalency with a hub protein	22
The SARS ‐ CoV ‐2 spike protein interacts with HAX1	22
Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitr	22

Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	22
Multisubstrate‐based system: a kinetic mechanism study of catechol‐ O ‐methyltransferase	21
Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation	21
Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins	21
A guide to ferroptosis, the biological rust of cellular membranes	21
Alternative substrate‐assisted hydrolysis pathways of posttransfer editing by prokaryotic leucyl‐ tRNA synthetase	21
Characterization of multiple lysophosphatidic acid acyltransferases in the plant pathogen Xanthomonas campestris	21
Redirecting TRIM21 with TRIMTACs for the targeted degradation of multimeric proteins	21
Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab	20
Plasmodium mitochondrial exodeoxyribonucleases, Exo mit1 and Exo mit2 ,	20
What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses	20
Understanding how enzymes work: the journey to ensemble–function studies	20
Proteolytic cleavage of the TGFβ co‐receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me	20
Structural and functional dissection of the WH2 / DAD motif of INF2	20
Take a breath: oxygen sensing of epidermal differentiation	20
Glow‐type conversion and characterization of a minimal luciferase via mutational analyses	20
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm	20
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The CGA codon decoding through tRNA Arg	19
Modifying inhibitor specificity for homologous enzymes by machine learning	19
Table of Contents	19
Ionizing radiation inhibits zebrafish embryo hatching through induction of tissue inhibitors of metalloproteinases ( TIMP s) expression	19
The role of lysosomal membrane proteins in autophagy and related diseases	19
New insights into macrophage heterogeneity in renal injury and repair	19
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ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis	18
Words of advice: teaching macromolecular crystallography	18
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer	18
Interactions of the maternal microbiome with diet, stress, and infection influence fetal development	18
Issue Information	18
PEMT ‐mediated phospholipid imbalance promotes age‐associated metabolic dysfunction‐associated steatotic liver disease progression	18
The deubiquitinating enzyme USP 8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing	18
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma	18
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Structural and functional insights into the flexible β‐hairpin of glycerol dehydrogenase	17
Ageing versus developmental silencing: Answers from the epigenome	17
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Further diversity in the origins of fish antifreeze proteins	17
Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family	17
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin	17
Issue Information	17
Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro	17
Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity	16
Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins	16
Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase	16
11‐Cl‐BBQ , a select modulator of AhR ‐regulated transcription, suppresses lung cancer cell growth via activation of p	16
Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors	16
Less is better: various means to reduce protein load in the endoplasmic reticulum	16
A new metabolic path in type 3 rickets	16
Single‐cell atlas of B cell heterogeneity in lacrimal IgG4 ‐related disorders: Unraveling the transition from inflammatory exhaustion to clonal malig	16
Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/ DOT1L histone	16
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation	15
A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts	15
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The environmental impact of extracellular matrix preparation	15
Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury	15
ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by zinc fingers 1–2 and recognition of γ‐globin −200 gene element by zinc fingers 1	15
The interaction between NPMc + and Orai1 induces abnormal calcium influx to facilitate leukemogenesis	15
Protein tandem repeats that produce frameshifts can generate new structural states and functions	15
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Research highlights	15
Surface loops may provide additional function necessary for enzyme‐to‐pseudoenzyme transition in the fungal metallocarboxypeptidase family	15
Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae	15
Structural analysis of the peptidoglycan DL‐endopeptidase CwlO complexed with its inhibitory protein IseA	15
LRP1 is the cell‐surface endocytosis receptor for vaspin in adipocytes	15
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Anti‐cancer drugs targeting the NADH ‐binding site of VDAC rewire channel electrophysiology and pa	15
Biogenesis of fibrils requires C‐mannosylation of PMEL	15
Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway	14
The m6A demethylase FTO promotes C/ EBPβ ‐	14
Tudor staphylococcal nuclease (Tudor‐ SN ) regulates activation of quiescent hepatic stellate cells	14
Is it possible to measure good science?	14
Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site	14
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A year in the molecular life sciences: 2024 highlights	14
The emerging role of PKM in keratinocyte homeostasis and pathophysiology	14
Uncovering a previously unknown function of polyphosphate in polyadenylated RNA ‐induced amyloidogenesis of Hfq	14
Structural and interaction analysis of human lipocalin‐type prostaglandin D synthase with the poorly water‐soluble drug NBQX	14

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomou	14
Crystal structure and biophysical characterisation of the enterococcal foldase PpiC , a cross‐opsonic antigen against gram‐positive nosocomial pathog	14
Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player	14
Maize CDKA2 ;1a and CDKB1 ;1 kinases have different requirements for their activation and particip	14
Corrigendum to ‘ Cryo‐EM structure of MsbA in saposin‐lipid nanoparticles (Salipro) provides insig	14
Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors	13
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier	13
Issue Information	13
Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease	13
Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity	13
Structural insights into α‐(1→6)‐linkage preference of GH 97 glucodextranase from Flavobacterium johnsoniae	13
Understanding the catalytic mechanism of the triazine hydrolase from Arthrobacter aurescens TC1	13
Gal‐1 promotes lung cancer cell survival by enhancing PARP1 / H1 .2 interaction to promote	13
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A DNA mimic jams the Cas9 scissors	13
Phosphatidic acid induces cytoskeletal rearrangements through the Src‐ FAK ‐ R ho	13
Investigating the molecular mechanisms underlying the anti‐ CRISPR function of AcrIIA13b protein	13
Atomic solution structure of Mycobacterium abscessusF‐ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor	13
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources	13
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation	13
Limited roles of the miR ‐17‐92 cluster in the regulation of T‐cell apoptosis	13
Issue Information	13
Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML	13
Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 prote	13
Evidence for corrin biosynthesis in the last universal common ancestor	13
Derivatives of MOPS : promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition	13
The c‐di‐ AMP ‐binding protein CbpB modulates the level of ppGpp	12
Structural and functional dissection of human neurolysin through alanine‐scanning mutagenesis	12
Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐ FAD charge transfer and catalytic asymmetry in a homo	12
Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway	12
Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?	12
Gut microbiota in multiple sclerosis and animal models	12
Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat	12
Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor	12
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma	12
Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering	12
Cell wall‐resident proteins with internal repeats ( PIR s) show an inverted architecture in Neurospora crassa	12
Rewarding excellence: the 2024 FEBS Journal Richard Perham prize	12
Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia	12
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis	12
Mutant p53 affects the mitochondrial proteome, promoting mitochondrial fragmentation and OXPHOS in pancreatic ductal adenocarcinoma cells	12
Metalloprotease‐mediated cleavage of CD95 ligand	12
The small molecule ZPD ‐2 inhibits the aggregation and seeded polymerisation of C‐terminally truncated α‐Synuclein	12
Table of Contents	11
Oxidative stress‐induced YAP1 expression is regulated by NCE102, CDA2, and BCS1	11
The role of compartmentalized β‐AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes	11
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Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides	11
Table of Contents	11
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15	11
Structural characterization of endogenous microprotein EMBOW reveals an alternative MRT motif for	11
A comprehensive overview of yeast libraries and their role in advancing cell biology	11
Issue Information	11
Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia?	11
The chemoreceptor controlling the Wsp‐like transduction pathway in Halomonas titanicaeKHS3 binds and responds to purine derivatives	11
Editor Profile: Daniel Longley	11
Effects of senescence on the tumour microenvironment and response to therapy	11
Issue Information	11
The antihypertensive agent ACT ‐132577 alleviates cuproptosis and pressure‐overload‐induced vascular remodelling by modulation of the NEDD4‐LCTR1‐cop	11
Dietary restriction and lifespan: adaptive reallocation or somatic sacrifice?	11
Issue Information	11
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Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria	11
Pinocembrin alleviates renal ischemia–reperfusion injury/unilateral ureteral obstruction (UUO)‐generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axi	11
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening	11
PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	11
PU .1 and TGF ‐β signaling activate the cell‐surface expression of CD103	11
Context‐dependent roles of cellular senescence in normal, aged, and disease states	11
Table of Contents	11
New insights into the mechanism of iron transport through the bacterial Ftr system present in pathogens	10
Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link	10
Characterization of the carboxy‐terminal domain of the GPN ‐loop GTPase Npa3 reveals an intrinsica	10
TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells	10
Research highlights: Hidden gems	10
A metastasis‐associated pannexin‐1 mutant (Panx1 1‐89 ) forms a minimalist ATP release channel	10
Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression	10
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40	10
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction‐associated steatohepatitis	10
Staufen‐2 functions as a cofactor for enhanced Rev‐mediated nucleocytoplasmic trafficking of HIV ‐1 genomic RNA	10
Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor	10
The universal role of adaptive transcription in health and disease	10
Crystal structures of free and ligand‐bound forms of the TetR / AcrR‐like regulator	10
Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord	10
Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer	10
Identification of an exosite at the neutrophil elastase/alpha‐1‐antitrypsin interface	10
In conversation with Małgorzata Kosla	10
TBK1 is involved in M‐CSF‐induced macrophage polarization through mediating the IRF5/IRF4 axis	10
Structural dynamics of the N‐terminal SH2 domain of PI3K in its free and	10
Biochemical characterization and mutational analysis of the tetrameric DABA transaminase E ct	10
TDP ‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models	10
Lung organoids as a human system for Mycobacteria infection modeling and drug testing	10
Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells	10
One ring closer to a closure: the crystal structure of the ES 3 hydroxym	10
DCBLD2 deletion increases hyperglycemia and induces vascular remodeling by inhibiting insulin receptor recycling in endothelial cells	10
Correction to “Bimodal substrate binding in the active site of the glycosidase BcX ”	9