OOIR: Observatory of International Research

Papers

(The median citation count of FEBS Journal is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Table of Contents	395
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Table of Contents	220
Issue Information	206
Table of Contents	150
Table of Contents	134
Table of Contents	111
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The FEBS Journal in 2025: in all science, error precedes the truth	104
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SMAR1 and p53‐regulated lncRNA RP11‐431M3.1 enhances HIF1A translation via miR‐138 in colorectal cancer cells under oxidative stress	100
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	95
Impact of N‐linked glycans on the dual short fibulin/LTBP‐4 axes regulating elastogenesis	74
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	65
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	65
A guide to adhesion GPCR research	62
A novel hexameric NADP⁺‐reducing [FeFe] hydrogenase from Moorella thermoacetica	59
Lysine demethylase 4A : from chromatin to centrosomes	59
The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis	59
The role of the gut microbiome in disorders of gut–brain interaction	56
A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	54
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	53
Nizp1 is a specific NUP98‐NSD1 functional interactor that regulates NUP98‐NSD1‐dependent oncogenic programs	50
Identification and functional analysis of a new type of Z,E‐mixed prenyl reductase from mycobacteria	49
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity	49

Lipofuscin labeling through biorthogonal strain‐promoted azide‐alkyne cycloaddition for the detection of senescent cells	48
Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin	48
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase (GlgC) for glycogen synthesis in cyanobacteria	48
Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease	47
Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	46
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	46
Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	45
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	44
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	42
Full activation of thermogenesis in brown adipocytes requires Basigin action	41
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	41
Regulation of cardiovascular and cardiac functions by caveolins	40
The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	38
Regulation of bacterial Type III Secretion System export gate opening by substrates and the FliJ stalk of the flagellar ATPase	38
Obesity, white adipose tissue and cancer	38
The biophysical and compositional properties of human basement membranes	38
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	37
The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus	37
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	37
Table of Contents	36
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Table of Contents	34
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Glow‐type conversion and characterization of a minimal luciferase via mutational analyses	33
Table of Contents	33
Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria (MAMs), is involved in de novo synthesis and remodelling of phospholipids	33
The CGA codon decoding through tRNA^Arg(ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae	33
Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease SmNuc1, explained by a structural study	32
Take a breath: oxygen sensing of epidermal differentiation	32
New links for meprin β within the protease web	32
Motif‐driven protein binder design towards transferrin receptor helical domain	31
The SARS‐CoV‐2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR	31
Characterization of multiple lysophosphatidic acid acyltransferases in the plant pathogen Xanthomonas campestris	30
Issue Information	30
Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae	30
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Salmonella‐driven intestinal edema in mice is characterized by tensed fibronectin fibers	29
Correction to “Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase (GH1) from Antarctic Marinomonas sp. ef1”	29
Multisubstrate‐based system: a kinetic mechanism study of catechol‐O‐methyltransferase	29
AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells	28
Modifying inhibitor specificity for homologous enzymes by machine learning	28
A guide to ferroptosis, the biological rust of cellular membranes	28
Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitro	28
Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	28
Ionizing radiation inhibits zebrafish embryo hatching through induction of tissue inhibitors of metalloproteinases (TIMPs) expression	27
The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain	27
Structural and functional dissection of the WH2/DAD motif of INF2, a formin linked to human inherited degenerative disorders	27
A major conformational change of N‐terminal helices of Bacillus thuringiensisCry1Ab insecticidal protein is necessary for membrane insertion and toxicity	27
Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases	26

Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa	26
What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses	26
RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection	26
Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors	26
Alternative substrate‐assisted hydrolysis pathways of posttransfer editing by prokaryotic leucyl‐tRNA synthetase	26
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm	25
Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab	25
Molecular mechanisms and biological roles of GOMED	25
Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH si	24
Structural and functional insights into the flexible β‐hairpin of glycerol dehydrogenase	24
Fibrillation of α‐synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N‐terminal acetylation and familial Parkinson's disease mutations	24
The role of lysosomal membrane proteins in autophagy and related diseases	24
Proteolytic cleavage of the TGFβ co‐receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me	24
FAM237A, rather than peptide PEN and proCCK56‐63, binds to and activates the orphan receptor GPR83	24
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Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes	24
Table of Contents	23
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Table of Contents	23
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Words of advice: teaching macromolecular crystallography	22
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma	22
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer	22
Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors	22
Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase	22
Issue Information	21
Cytoskeletal protein Zyxin in embryonic development: from controlling cell movements and pluripotency to regulating embryonic patterning	21
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation	21
Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae	21
Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury	21
ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by zinc fingers 1–2 and recognition of γ‐globin −200 gene element by zinc fingers 1	21
Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase	21
Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family	21
ENKD1 is a centrosomal and ciliary microtubule‐associated protein important for primary cilium content regulation	21
A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts	20
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Further diversity in the origins of fish antifreeze proteins	20
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Issue Information	20
Protein tandem repeats that produce frameshifts can generate new structural states and functions	20
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin	19
Ageing versus developmental silencing: Answers from the epigenome	19
Structural analysis of the peptidoglycan DL‐endopeptidase CwlO complexed with its inhibitory protein IseA	19
Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity	19
Interactions of the maternal microbiome with diet, stress, and infection influence fetal development	19
Impact of structural dynamics on biological functions of flaviviruses	19
Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro	19
Mosaic translation hypothesis: chimeric polypeptides produced via multiple ribosomal frameshifting as a basis for adaptability	18
The deubiquitinating enzyme USP 8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing	18
11‐Cl‐BBQ, a select modulator of AhR‐regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27^Kip1	18
Structure‐based engineering of a short‐chain cis‐prenyltransferase to biosynthesize nonnatural all‐cis‐polyisoprenoids: molecular mechanisms for primer substrate recognition and ultimate	18
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Biogenesis of fibrils requires C‐mannosylation of PMEL	18
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LRP1 is the cell‐surface endocytosis receptor for vaspin in adipocytes	18
Less is better: various means to reduce protein load in the endoplasmic reticulum	18
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Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization	18
Is it possible to measure good science?	17
Structural and interaction analysis of human lipocalin‐type prostaglandin D synthase with the poorly water‐soluble drug NBQX	17
The environmental impact of extracellular matrix preparation	17
Tudor staphylococcal nuclease (Tudor‐SN) regulates activation of quiescent hepatic stellate cells	17
Corrigendum to ‘Cryo‐EM structure of MsbA in saposin‐lipid nanoparticles (Salipro) provides insights into nucleotide coordination’	17
Retraction statement: Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling	17
The emerging role of PKM in keratinocyte homeostasis and pathophysiology	17
Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML	17
Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors	17
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A year in the molecular life sciences: 2024 highlights	17
Maize CDKA2;1a and CDKB1;1 kinases have different requirements for their activation and participate in substrate recognition	17
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Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition	17
Gal‐1 promotes lung cancer cell survival by enhancing PARP1/H1.2 interaction to promote DNA repair upon DNA damage response	17
M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation	17
Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway	16
High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice	16
The m6A demethylase FTO promotes C/EBPβ‐LIP translation to perform oncogenic functions in breast cancer cells	16
A comparative study of N‐hydroxylating flavoprotein monooxygenases reveals differences in kinetics and cofactor binding	16
Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry	16

Atomic solution structure of Mycobacterium abscessusF‐ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor	16
Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenaseCntAcatalytic site	16
Cycloserine enantiomers inhibit PLP‐dependent cysteine desulfurase SufS via distinct mechanisms	16
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation	16
Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease	15
Identification of a novel d‐amino acid aminotransferase involved in d‐glutamate biosynthetic pathways in the hyperthermophile Thermotoga maritima	15
Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player	15
Issue Information	15
Structural insights into α‐(1→6)‐linkage preference of GH97 glucodextranase from Flavobacterium johnsoniae	15
Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity	15
Evidence for corrin biosynthesis in the last universal common ancestor	15
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The small molecule ZPD‐2 inhibits the aggregation and seeded polymerisation of C‐terminally truncated α‐Synuclein	15
Investigating the molecular mechanisms underlying the anti‐ CRISPR function of AcrIIA13b protein	15
Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross‐opsonic antigen against gram‐positive nosocomial pathogens	15
AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation	15
Issue Information	15
Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor DR2539	14
PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	14
Dietary restriction and lifespan: adaptive reallocation or somatic sacrifice?	14
Rewarding excellence: the 2024 FEBS Journal Richard Perham prize	14
Biogenesis of hepatitis B virus e antigen is driven by translocon‐associated protein complex and regulated by conserved cysteine residues within its signal peptide sequence	14
Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat	14
The c‐di‐AMP‐binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae	14
Cell wall‐resident proteins with internal repeats (PIRs) show an inverted architecture in Neurospora crassa, but maintain their role as wall stabilizers	14
Understanding HAIs: Ally proteins in the fight against cancer	14
PU.1 and TGF‐β signaling activate the cell‐surface expression of CD103 in mast cells and dendritic cells: opposite roles of GATA2 in the expression of mucos	14
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis	14
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma	14
Mutant p53 affects the mitochondrial proteome, promoting mitochondrial fragmentation and OXPHOS in pancreatic ductal adenocarcinoma cells	13
Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer	13
Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering	13
Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma	13
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Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?	13
Gut microbiota in multiple sclerosis and animal models	13
Effects of senescence on the tumour microenvironment and response to therapy	13
Context‐dependent roles of cellular senescence in normal, aged, and disease states	13
Metalloprotease‐mediated cleavage of CD95 ligand	13
Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor‐1	13
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15	13
GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators	13
The dual roles of three MMPs and TIMP in innate immunity and metamorphosis in the silkworm, Bombyx mori	13
Lung organoids as a human system for Mycobacteria infection modeling and drug testing	12
Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor	12
Issue Information	12
Table of Contents	12
KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation	12
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening	12
The chemoreceptor controlling the Wsp‐like transduction pathway in Halomonas titanicaeKHS3 binds and responds to purine derivatives	12
Mitochondrial derived vesicles‐ Quo Vadis?	12
Identification of an exosite at the neutrophil elastase/alpha‐1‐antitrypsin interface	12
The critical role of the aldehyde dehydrogenase PauC in spermine, spermidine, and diaminopropane toxicity in Pseudomonas aeruginosa: Its possible use as a drug target	12
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Table of Contents	12
Issue Information	12
Membrane anchoring of New Delhi metallo‐β‐lactamase‐1 alters the fitness of Escherichia coli and increases its susceptibility to colistin by inducing outer membrane destabilization	12
Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression	12
Regulation of basal autophagy by calmodulin availability	12
One ring closer to a closure: the crystal structure of the ES₃ hydroxymethylbilane synthase intermediate	12
Issue Information	12
Table of Contents	12
A metastasis‐associated pannexin‐1 mutant (Panx1^1‐89) forms a minimalist ATP release channel	12
Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer	12
Molecular regulators of HOXA9 in acute myeloid leukemia	11
Regulation of intrinsic and extrinsic metabolic pathways in tumour‐associated macrophages	11
Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides	11
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction‐associated steatohepatitis	11
Characterization of the carboxy‐terminal domain of the GPN‐loop GTPase Npa3 reveals an intrinsically disordered region and phosphorylation‐dependent regulation in the absence of	11
DCBLD2 deletion increases hyperglycemia and induces vascular remodeling by inhibiting insulin receptor recycling in endothelial cells	11
Oxidative stress‐induced YAP1 expression is regulated by NCE102, CDA2, and BCS1	11
Viscosity regulates cell spreading and cell‐extracellular matrix interactions	11
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation	11
Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia?	11
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models	11
GR‐KLF15 pathway controls hepatic lipogenesis during fasting	11
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TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells	11
Neurokinin‐1 receptor antagonist rolapitant suppresses anxiety and alcohol intake produced by repeated withdrawal episodes	11
Editor Profile: Daniel Longley	11
Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord	11
New insights into the mechanism of iron transport through the bacterial Ftr system present in pathogens	11
Phytoplankton cell‐states: multiparameter fluorescence lifetime flow‐based monitoring reveals cellular heterogeneity	11
TBK1 is involved in M‐CSF‐induced macrophage polarization through mediating the IRF5/IRF4 axis	11
In conversation with Małgorzata Kosla	11
Pinocembrin alleviates renal ischemia–reperfusion injury/unilateral ureteral obstruction (UUO)‐generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axi	11
The role of compartmentalized β‐AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes	11
Tryptophan and its metabolites in normal physiology and cancer etiology	11
Structural dynamics of the N‐terminal SH2 domain of PI3K in its free and CD28‐bound states	11
Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria	11
Structural characterization of the thermal unfolding pathway of human VEGFR1 D2 domain	10
Translation regulation in response to stress	10
Extracellular vesicles promote autophagy in human microglia through lipid raft‐dependent mechanisms	10
Identification of diverse lipid‐binding modes in the groove of zinc α₂ glycoprotein reveals its functional versatility	10
CDC7 inhibition drives an inflammatory response and a p53‐dependent senescent‐like state in breast epithelial cells	10