OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Neuroinflammation is 65. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs	416
Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway	409
Correction to: Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats	401
Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress	321
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes	244
Inflammation in Neuronal Intranuclear Inclusion Disease (NIID): mechanisms, biomarkers, and therapeutic implications	210
Maternal immunoglobulin G affects brain development of mouse offspring	201
Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis	187
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies	168
Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system	162
Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation	160
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway	156
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model	154
Phosphatidate phosphatase Lipin1 alters mitochondria-associated endoplasmic reticulum membranes (MAMs) homeostasis: effects which contribute to the development of diabetic encephalopathy	133
Carotid artery vascular stenosis causes the blood-CSF barrier damage and neuroinflammation	133
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice	125
The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study	116
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis	114
How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells	109
Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy	104
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation	104
Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis	103
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis	103
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α	103
IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis	101

Marine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish	100
Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats	99
Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury	99
Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina	98
LXR agonism for CNS diseases: promises and challenges	98
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice	98
Gut microbiota and their influence in brain cancer milieu	96
Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway	96
Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway	94
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease	91
HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy	90
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response	90
Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry	89
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway	89
Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries	88
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease	88
Correction: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice	87
Cardiac arrest triggers IL-17-mediated neuroinflammation and astrocyte polarization: insights into pathogenesis and intervention	83
Inflammasomes at the crossroads of traumatic brain injury and post-traumatic epilepsy	83
CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling	83
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS	80
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection	79
A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders	79
Single−cell transcriptomic landscape of sciatic nerve after transection injury	78
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems	77
Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice	77
Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation	76
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease	76
Immune response and pathogen invasion at the choroid plexus in the onset of cerebral toxoplasmosis	76
Biomarkers of progressive multiple sclerosis decrease following autologous hematopoietic stem cell transplantation	75
Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation	74
Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury	73
Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer’s disease-like neuroinflammation triggered by periodontal disease	70
Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition	69
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress	68
Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances	68
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway	68
α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect	68
Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia	66
Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis	66
Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia	65