OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Neuroinflammation is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs	476
Maternal immunoglobulin G affects brain development of mouse offspring	464
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice	402
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes	289
Integrative imaging and transcriptomics implicate neutrophils in microvascular no-reflow after stroke	237
Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling	230
Altered phenotype and gene expression of regulatory T cells (Tregs) in children with Autism, and the relationship with comorbid gastrointestinal symptoms	217
Correction to: Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats	202
Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway	199
Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system	184
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation	169
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis	142
IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis	137
Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis	132
Toxoplasma gondii drives myeloid immune cell recruitment to amyloid plaques in Alzheimer’s model mice	129
Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress	126
Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy	124
Peripheral immunosuppressive and immunostimulatory signatures of severity and pain in spinal cord injury	124
Carotid artery vascular stenosis causes the blood-CSF barrier damage and neuroinflammation	123
Inflammation in Neuronal Intranuclear Inclusion Disease (NIID): mechanisms, biomarkers, and therapeutic implications	121
Clonally expanded HSP-specific T cells contribute to glaucomatous neurodegeneration via the mTORC1 pathway	116
Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats	115
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α	110
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies	110
Gut microbiota and their influence in brain cancer milieu	110

Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response	109
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model	109
Neuroimmune programming of childhood trauma: comorbid mechanisms and developmental origins of depression and autoimmune diseases	109
Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina	106
Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway	105
Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury	105
LXR agonism for CNS diseases: promises and challenges	101
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice	97
HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy	97
Phosphatidate phosphatase Lipin1 alters mitochondria-associated endoplasmic reticulum membranes (MAMs) homeostasis: effects which contribute to the development of diabetic encephalopathy	97
How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells	94
The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study	94
Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway	87
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis	86
Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy	84
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease	81
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway	81
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress	81
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway	80
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS	78
Immune imbalance between T helper 1, T helper 17 and regulatory T cells fuels amyotrophic lateral sclerosis pathogenesis: disease trajectory, diagnosis and therapeutic implications	78
Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis	77
Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries	77
Single−cell transcriptomic landscape of sciatic nerve after transection injury	77
Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice	77
CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling	76
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease	75
Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry	73
A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders	72
Correction: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice	72
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease	72
Tumor immunogenicity shapes CNS immune niches and CD8⁺ T cell fate in glioblastoma	71
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease	70
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems	70
Lysosomal cholesteryl ester hydrolysis drives white matter repair by reprogramming microglia into a novel reparative state	70
BMAL1-GPX3 axis in the choroid plexus mitigates Aβ pathology in an amyloid mouse model	70
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection	69
Biomarkers of progressive multiple sclerosis decrease following autologous hematopoietic stem cell transplantation	69
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells	68
TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure	68
Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition	67
H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection	67
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway	67