BMC Biology

Article	Citations
CD4+ and CD8+ regulatory T cell characterization in the rat using a unique transgenic Foxp3-EGFP model	152
Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma	148
Fast vocal-motor tracking of escaping prey in echolocating bats	121
YHSeqY3000 panel captures all founding lineages in the Chinese paternal genomic diversity database	85
Expression of a pheromone binding protein affected by timeless gene governs female mating behavior in Bactrocera dorsalis	77
Unveiling the thermotolerance mechanism of Pichia kudriavzevii LC375240 through transcriptomic and genetic analyses	69
PPARα regulates YAP protein levels and activity by affecting its ubiquitination modification	63
Proteomic analysis reveals the alleviation of follicular development defects in offspring mice under DEHP exposure by melatonin	62
CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation	61
Phylotranscriptomics points to multiple independent origins of multicellularity and cellular differentiation in the volvocine algae	60
Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest	54
Highly flexible metabolism of the marine euglenozoan protist Diplonema papillatum	53
Fossil-calibrated molecular clock data enable reconstruction of steps leading to differentiated multicellularity and anisogamy in the Volvocine algae	53
A primary cell wall cellulose-dependent defense mechanism against vascular pathogens revealed by time-resolved dual transcriptomics	53
Neuromolecular responses in disrupted mutualistic cleaning interactions under future environmental conditions	51
Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny	51
Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake	51
SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells	50
A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation	50
Evolutionary dynamics of mitochondrial genomes and intracellular transfers among diploid and allopolyploid cotton species	49
Identification of cell subpopulations associated with disease phenotypes from scRNA-seq data using PACSI	47
Species-specific blood–brain barrier permeability in amphibians	46
A whole-body atlas of BMP signaling activity in an adult sea anemone	46
Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells	44
A high-performance computational workflow to accelerate GATK SNP detection across a 25-genome dataset	44

Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures	39
Author Correction: Novel function of single-target regulator NorR involved in swarming motility and biofilm formation revealed in Vibrio alginolyticus	39
An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans	39
Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex	38
Molecular mechanisms underlying the neural correlates of working memory	38
Sex- and social context-dependent differences in mice fine head movement during social interactions	38
JNK signaling provides a novel therapeutic target for Rett syndrome	37
Taxonomy-aware, sequence similarity ranking reliably predicts phage–host relationships	37
Flexible and stretchable polymer optical fibers for chronic brain and vagus nerve optogenetic stimulations in free-behaving animals	37
Skin-penetrating nematodes exhibit life-stage-specific interactions with host-associated and environmental bacteria	37
The visual pathway in sea spiders (Pycnogonida) displays a simple serial layout with similarities to the median eye pathway in horseshoe crabs	37
Anaerobic derivates of mitochondria and peroxisomes in the free-living amoeba Pelomyxa schiedti revealed by single-cell genomics	36
Dopamine D1- and D2-like receptors oppositely regulate lifespan via a dietary restriction mechanism in Caenorhabditis elegans	35
Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones	34
Optimization of the antimicrobial peptide Bac7 by deep mutational scanning	34
Fragmentation in mitochondrial genomes in relation to elevated sequence divergence and extreme rearrangements	34
Comparative 3D genome architecture in vertebrates	34
Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition	33
Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3	33
Structure modeling hints at a granular organization of the Golgi ribbon	33
Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney	33
Reconstruction of gene innovation associated with major evolutionary transitions in the kingdom Fungi	32
A gene deriving from the ancestral sex chromosomes was lost from the X and retained on the Y chromosome in eutherian mammals	32
Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs	32
Ileum tissue single-cell mRNA sequencing elucidates the cellular architecture of pathophysiological changes associated with weaning in piglets	32
Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank	31
Asynchronous embryonic germ cell development leads to a heterogeneity of postnatal ovarian follicle activation and may influence the timing of puberty onset in mice	31
Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice	31
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium	30
Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus	30
Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development	30
Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic notothenioids	29
Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides	29
Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera)	29
Transposable element expansion and low-level piRNA silencing in grasshoppers may cause genome gigantism	29
Circadian rhythms in the plant host influence rhythmicity of rhizosphere microbiota	29
Histone modifications and DNA methylation act cooperatively in regulating symbiosis genes in the sea anemone Aiptasia	28
Epigenetic regulation of human-specific gene expression in the prefrontal cortex	28
Establishment and characterization of canine mammary tumoroids for translational research	28
Integrative single-cell RNA-seq and ATAC-seq analysis of myogenic differentiation in pig	28
A muscle exercise research revolution powered by -omics at single cell and nucleus resolution	27
Changing turn-over rates regulate abundance of tryptophan, GS biosynthesis, IAA transport and photosynthesis proteins in Arabidopsis growth defense transitions	27
Two zinc finger proteins, VdZFP1 and VdZFP2, interact with VdCmr1 to promote melanized microsclerotia development and stress tolerance in Verticillium dahliae	27
The Sapria himalayana genome provides new insights into the lifestyle of endoparasitic plants	27
Leveraging the predictive power of 3D organoids in dogs to develop new treatments for man and man’s best friend	27
The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates	27
Asymmetric and parallel subgenome selection co-shape common carp domestication	27
Imputation strategies for genomic prediction using nanopore sequencing	27
Functional characterization of NBS-LRR genes reveals an NBS-LRR gene that mediates resistance against Fusarium wilt	26
Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations	26

Loss of splicing factor IK impairs normal skeletal muscle development	26
The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila	26
Expression profiles of the autism-related SHANK proteins in the human brain	26
A cornucopia of research resources for the fourth rodent malaria parasite species	26
The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation	26
Dissecting thrombus-directed chemotaxis and random movement in neutrophil near-thrombus motion in flow chambers	25
Single-cell RNA sequencing integrated with bulk RNA sequencing analysis identifies a tumor immune microenvironment-related lncRNA signature in lung adenocarcinoma	25
Recognition of nonself is necessary to activate Drosophila’s immune response against an insect parasite	25
Publisher Correction: Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures	25
Functional analysis of the mating type genes in Verticillium dahliae	25
Spatio-temporal characterization of phenotypic resistance in malaria vector species	25
A network of transcription factors in complex with a regulating cell cycle cyclin orchestrates fungal oxidative stress responses	25
The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish	25
Endosomal protein DENND10/FAM45A integrates extracellular vesicle release with cancer cell migration	25
Chronic temperature stress inhibits reproduction and disrupts endocytosis via chaperone titration in Caenorhabditis elegans	24
Modality-specific effects of threat on self-motion perception	24
The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon	24
Non-human peptides revealed in blood reflect the composition of intestinal microbiota	24
Early inhibition of BRD4 facilitates iPSC reprogramming via accelerating rDNA dynamic expression	24
Integration of large and diverse angiosperm DNA fragments into Asian Gnetum mitogenomes	24
Predicting intercellular communication based on metabolite-related ligand-receptor interactions with MRCLinkdb	24
Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo	24
Vimentin-mediated buffering of internal integrin β1 pool increases survival of cells from anoikis	24
Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids	24
The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice	24
Parental energy-sensing pathways control intergenerational offspring sex determination in the nematode Auanema freiburgensis	24
Insights into the structure-function relationship of the NorQ/NorD chaperones from Paracoccus denitrificans reveal shared principles of interacting MoxR AAA+/VWA domain proteins	23
Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation	23
Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens	23
PharmRL: pharmacophore elucidation with deep geometric reinforcement learning	23
Independent, but still observant—dog breeds selected for functional independence learn better from a conspecific demonstrator than cooperative breeds in a detour task	23
A unique effector secreted by Pseudozyma flocculosa mediates its biocontrol activity	23
Guanine crystal formation by bacteria	23
Back to the roots, desiccation and radiation resistances are ancestral characters in bdelloid rotifers	23
Contrasting outcomes of genome reduction in mikrocytids and microsporidians	23
Adaptive learning and recall of motor-sensory sequences in adult echolocating bats	23
An alternating active-dormitive strategy enables disadvantaged prey to outcompete the perennially active prey through Parrondo’s paradox	23
Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube	23
Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling	23
Assessing the role of Piscine orthoreovirus in disease and the associated risk for wild Pacific salmon	23
The genome of the pygmy right whale illuminates the evolution of rorquals	23
α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions	23
Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice	23
Global analysis of neuropeptide receptor conservation across phylum Nematoda	23
Global phylogenomic assessment of Leptoseris and Agaricia reveals substantial undescribed diversity at mesophotic depths	22
Differential functions of RhoGDIβ in malignant transformation and progression of urothelial cell following N-butyl-N-(4-hydmoxybutyl) nitrosamine exposure	22
Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients	22
The influence of immune challenges on the mean and variance in reproductive investment: a meta-analysis of the terminal investment hypothesis	22
Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice	22
CmNAC25 targets CmMYB6 to positively regulate anthocyanin biosynthesis during the post-flowering stage in chrysanthemum	22
Regulatory changes associated with the head to trunk developmental transition	22
Spatial biology of Ising-like synthetic genetic networks	21
High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding	21
Uncovering bacterial-mammalian cell interactions via single-cell tracking	21
Functional characterization of the second feedback loop in the circadian clock of the Antarctic krill Euphausia superba	21
Apomixis and genetic background affect distinct traits in Hieracium pilosella L. grown under competition	21
The subcellular distribution of miRNA isoforms, tRNA-derived fragments, and rRNA-derived fragments depends on nucleotide sequence and cell type	21
A mucus layer derived from porcine intestinal organoid air–liquid interface monolayer attenuates swine enteric coronavirus infection by antiviral activity of Muc2	21
Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage	21
An intelligent workflow for sub-nanoscale 3D reconstruction of intact synapses from serial section electron tomography	21
Comparative genomics of the primary endosymbiont Buchnera aphidicola in aphid hosts and their coevolutionary relationships	21
Directional selection coupled with kin selection favors the establishment of senescence	21
Stage-specific expression of an odorant receptor underlies olfactory behavioral plasticity in Spodoptera littoralis larvae	21
Eurasian spruce bark beetle detects lanierone using a highly expressed specialist odorant receptor, present in several functional sensillum types	21
Olfactory sensitivity differentiates morphologically distinct worker castes in Camponotus floridanus	20
Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro	20
Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish	20
Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks	20
Gut microbe Lactiplantibacillus plantarum undergoes different evolutionary trajectories between insects and mammals	20
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development	20
TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration	20
Modality-specific sensory and decisional carryover effects in duration perception	20
Comparative gene retention analysis in barley, wild emmer, and bread wheat pangenome lines reveals factors affecting gene retention following gene duplication	20
Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0	20
A hyperspectral open-source imager (HOSI)	19
Correction to: Resilin matrix distribution, variability and function in Drosophila	19
Introgression drives adaptation to the plateau environment in a subterranean rodent	19
Ancient genomes from the Tang Dynasty capital reveal the genetic legacy of trans-Eurasian communication at the eastern end of Silk Road	19
Muscle miRNAs are influenced by sex at baseline and in response to exercise	19
Author Correction: Unique sperm haplotypes are associated with phenotypically different sperm subpopulations in Astyanax fish	19

Author Correction: Genomic characterization of the world’s longest selection experiment in mouse reveals the complexity of polygenic traits	19
Uncovering the history of recombination and population structure in western Canadian stripe rust populations through mating type alleles	19
Author Correction: Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate	19
Author Correction: Satellitome comparison of two oedipodine grasshoppers highlights the contingent nature of satellite DNA evolution	19
The golden genome annotation of Ganoderma lingzhi reveals a more complex scenario of eukaryotic gene structure and transcription activity	19
Author Correction: Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus	19
OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation	18
Competition-based screening helps to secure the evolutionary stability of a defensive microbiome	18
Multidimensional associations between nutrient intake and healthy ageing in humans	18
Experimental infection with the hookworm, Necator americanus, is associated with stable gut microbial diversity in human volunteers with relapsing multiple sclerosis	18
Pangenome analysis reveals transposon-driven genome evolution in cotton	18
Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload	18
Cyclic stretch enhances neutrophil extracellular trap formation	18
Microbial diversity and ecological complexity emerging from environmental variation and horizontal gene transfer in a simple mathematical model	18
Time of day as a critical variable in biology	18
Isolation and characterisation of novel Methanocorpusculum species indicates the genus is ancestrally host-associated	18
mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth	18
APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types	18
Life on a leaf: the epiphyte to pathogen continuum and interplay in the phyllosphere	18
Wolbachia incompatible insect technique program optimization over large spatial scales using a process-based model of mosquito metapopulation dynamics	18
Increased interaction between endoplasmic reticulum and mitochondria following sleep deprivation	18
Integrative single-cell RNA-seq analysis of vascularized cerebral organoids	18
Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration	18
Experimental demonstration of tethered gene drive systems for confined population modification or suppression	18
Transcriptomic underpinnings of high and low mirror aggression zebrafish behaviours	18
A new lineage of non-photosynthetic green algae with extreme organellar genomes	18
Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes	17
Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity	17
Dissection of a sensorimotor circuit underlying pathogen aversion in C. elegans	17
An expanded odorant-binding protein mediates host cue detection in the parasitic wasp Baryscapus dioryctriae basis of the chromosome-level genome assembly analysis	17
The stem rust fungus Puccinia graminis f. sp. tritici induces centromeric small RNAs during late infection that are associated with genome-wide DNA methylation	17
Plasma membrane integrity: implications for health and disease	17
A unique self-truncation of bacterial GH5 endoglucanases leads to enhanced activity and thermostability	17
The gut symbiont Sphingomonas mediates imidacloprid resistance in the important agricultural insect pest Aphis gossypii Glover	17
Fruit bats adjust their foraging strategies to urban environments to diversify their diet	17
LADS: a powerful vaccine platform for cancer immunotherapy and prevention	17
Attention to visual motion suppresses neuronal and behavioral sensitivity in nearby feature space	17
Co-option of the limb patterning program in cephalopod eye development	17
Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong–Mien speakers	17
Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals	17
Selection on the promoter regions plays an important role in complex traits during duck domestication	17
Insights into Treponema pallidum genomics from modern and ancient genomes using a novel mapping strategy	16
The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus	16
The Calicophoron daubneyi genome provides new insight into mechanisms of feeding, eggshell synthesis and parasite-microbe interactions	16
AnomalGRN: deciphering single-cell gene regulation network with graph anomaly detection	16
ARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner	16
Adaptive evolution of stress response genes in parasites aligns with host niche diversity	16
Tokay gecko tail regeneration involves temporally collinear expression of HOXC genes and early expression of satellite cell markers	16
Co-habiting ants and silverfish display a converging feeding ecology	16
Recent expansion of metabolic versatility in Diplonema papillatum, the model species of a highly speciose group of marine eukaryotes	16
Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation	16
Harnessing ferroptosis for precision oncology: challenges and prospects	16
Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps	16
Animal welfare research is fascinating, ethical, and useful—but how can it be more rigorous?	16
Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites	16
Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals	16
Integrated transcriptomic analysis reveals evolutionary and developmental characteristics of tendon ossification in teleost	16
Breaking muscle: neurotoxic and myotoxic effects of Central American snake venoms and the relative efficacies of antivenom and varespladib	16
Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase	15
Effects of genetic ablation and pharmacological inhibition of HuR on gene expression, iron metabolism, and hormone levels	15
Comprehensive analysis of the Kinetoplastea intron landscape reveals a novel intron-containing gene and the first exclusively trans-splicing eukaryote	15
Author Correction: Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration	15
Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection	15
Dynamics and drivers of fungal communities in a multipartite ant-plant association	15
Single-cell genomics unveils a canonical origin of the diverse mitochondrial genomes of euglenozoans	15
Mechanical stimulation in plants: molecular insights, morphological adaptations, and agricultural applications in monocots	15
The haploid induction ability analysis of various mutation of OsMATL and OsDMPs in rice	15
Publisher Correction to: Palaeoecological differences underlie rare co-occurrence of Miocene European primates	15
Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation	15
Convergent evolution of noncoding elements associated with short tarsus length in birds	15
TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae	15
Holistic description of new deep sea megafauna (Cephalopoda: Cirrata) using a minimally invasive approach	15
A distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo	15
Urban fruit bats give birth earlier in the season compared to rural fruit bats	15
Unraveling the role of satellite DNAs in the evolution of the giant XY sex chromosomes of the flea beetle Omophoita octoguttata (Coleoptera, Chrysomelidae)	15
Temperature-dependent dynamics of energy stores in Drosophila	15
Author Correction to: Mixotrophic chemosynthesis in a deep-sea anemone from hydrothermal vents in the Pescadero Basin, Gulf of California	15
Disruption of left-right axis specification in Ciona induces molecular, cellular, and functional defects in asymmetric brain structures	15
Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes	15
The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells	15
Intricate response dynamics enhances stimulus discrimination in the resource-limited C. elegans chemosensory system	14
Phylogenomics analysis of Scutellaria (Lamiaceae) of the world	14
Type-B response regulator RRB12 regulates nodule formation in Lotus japonicus	14
Functional analyses of phosphatidylserine/PI(4)P exchangers with diverse lipid species and membrane contexts reveal unanticipated rules on lipid transfer	14
Nanoscale characterization of drug-induced microtubule filament dysfunction using super-resolution microscopy	14
Rapid evolution of mitochondrion-related genes in haplodiploid arthropods	14
The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding	14
Inheritance of the reduced mitochondria of Giardia intestinalis is coupled to the flagellar maturation cycle	14
PACmn for improved optogenetic control of intracellular cAMP	14
Spatiotemporal characterization of extracellular matrix maturation in human artificial stromal-epithelial tissue substitutes	14
A workflow for streamlined acquisition and correlation of serial regions of interest in array tomography	14
Expanded gene and taxon sampling of diplomonads shows multiple switches to parasitic and free-living lifestyle	14
An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum	14
A novel human protein-coding locus identified using a targeted RNA enrichment technique	14
A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1	14