BMC Biology

Article	Citations
Changing turn-over rates regulate abundance of tryptophan, GS biosynthesis, IAA transport and photosynthesis proteins in Arabidopsis growth defense transitions	166
Functional characterization of the second feedback loop in the circadian clock of the Antarctic krill Euphausia superba	145
CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation	74
Telomerase subunit Est2 marks internal sites that are prone to accumulate DNA damage	74
Cuticular competing endogenous RNAs regulate insecticide penetration and resistance in a major agricultural pest	64
Wolbachia incompatible insect technique program optimization over large spatial scales using a process-based model of mosquito metapopulation dynamics	61
Author Correction: Satellitome comparison of two oedipodine grasshoppers highlights the contingent nature of satellite DNA evolution	60
A whole-body atlas of BMP signaling activity in an adult sea anemone	59
Circannual breeding and methylation are impacted by the equinox in Peromyscus	59
Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring F1 hybrids	58
Incomplete lineage sorting and introgression among genera and species of Liliaceae tribe Tulipeae: insights from phylogenomics	56
A muscle exercise research revolution powered by -omics at single cell and nucleus resolution	55
Integration of large and diverse angiosperm DNA fragments into Asian Gnetum mitogenomes	54
Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition	53
Fossil-calibrated molecular clock data enable reconstruction of steps leading to differentiated multicellularity and anisogamy in the Volvocine algae	52
Flexible and stretchable polymer optical fibers for chronic brain and vagus nerve optogenetic stimulations in free-behaving animals	51
The Sapria himalayana genome provides new insights into the lifestyle of endoparasitic plants	50
Single-cell transcriptomics and time-series metabolite profiling reveal the spatiotemporal regulation of flavonoid biosynthesis genes and phytohormone homeostasis by PAP1 in Arabidopsis	49
Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs	48
Assessing the role of Piscine orthoreovirus in disease and the associated risk for wild Pacific salmon	47
Back to the roots, desiccation and radiation resistances are ancestral characters in bdelloid rotifers	46
Increased interaction between endoplasmic reticulum and mitochondria following sleep deprivation	46
DualNetM: an adaptive dual network framework for inferring functional-oriented markers	46
Experimental demonstration of tethered gene drive systems for confined population modification or suppression	46
Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank	45

Evolutionary dynamics of mitochondrial genomes and intracellular transfers among diploid and allopolyploid cotton species	43
Histone modifications and DNA methylation act cooperatively in regulating symbiosis genes in the sea anemone Aiptasia	43
Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients	42
The gut symbiont Sphingomonas mediates imidacloprid resistance in the important agricultural insect pest Aphis gossypii Glover	40
Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong–Mien speakers	40
Single-cell transcriptomic dynamics of scallop heart reveals the heterogeneous response to heat stress	39
Multidimensional associations between nutrient intake and healthy ageing in humans	39
Temporal dynamics of apoptosis-induced proliferation in pupal wing development: implications for regenerative ability	39
Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development	39
The mrp-3 gene is involved in haem efflux and detoxification in a blood-feeding nematode	39
Hibernation reduces GABA signaling in the brainstem to enhance motor activity of breathing at cool temperatures	39
The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells	38
Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease	38
A systematic review of the development and application of home cage monitoring in laboratory mice and rats	37
Construction and characterization of a genome-scale ordered mutant collection of Bacteroides thetaiotaomicron	37
Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis	37
Camelot: a computer-automated micro-extensometer with low-cost optical tracking	37
Rapid and sensitive single-cell RNA sequencing with SHERRY2	34
PACmn for improved optogenetic control of intracellular cAMP	34
A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC	34
Avian interferon regulatory factor (IRF) family reunion: IRF3 and IRF9 found	34
ERF49 mediates brassinosteroid regulation of heat stress tolerance in Arabidopsis thaliana	33
Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns	33
CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72	33
Population transcriptogenomics highlights impaired metabolism and small population sizes in tree frogs living in the Chernobyl Exclusion Zone	33
Next steps after airing disagreement on a scientific issue with policy implications: a meta-analysis, multi-lab replication and adversarial collaboration	32
GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion	32
Differentially expressed chaperone genes reveal a stress response required for unidirectional regeneration in the basal chordate Ciona	32
Astrocytes in CA1 modulate schema establishment in the hippocampal-cortical neuron network	31
The genome and sex-dependent responses to temperature in the common yellow butterfly, Eurema hecabe	31
Temperature-dependent dynamics of energy stores in Drosophila	31
Reference genomes of channel catfish and blue catfish reveal multiple pericentric chromosome inversions	31
Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase	31
Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes	31
A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1	30
A single-cell transcriptomic atlas of all cell types in the brain of 5xFAD Alzheimer mice in response to dietary inulin supplementation	30
Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis	30
Decidual stromal cells-derived exosomes incured insufficient migration and invasion of trophoblast because of abnormal ubiquitination and degradation of Snail mediated by miR-92b-3p/USP28	30
Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development	29
RNA multi-omics in single cells reveal rhythmical RNA reshaping during human and mouse oocyte maturation	29
Proton export upregulates aerobic glycolysis	29
Chromosome-level genome assemblies of four wild peach species provide insights into genome evolution and genetic basis of stress resistance	29
Maternal genetic origin of Chao Lay coastal maritime populations from Thailand	29
Viral predation pressure on coral reefs	29
Expression divergence of expansin genes drive the heteroblasty in Ceratopteris chingii	29
Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus	29
Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness	29
The broad use of the Pm8 resistance gene in wheat resulted in hypermutation of the AvrPm8 gene in the powdery mildew pathogen	28
Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates	28
An expanded odorant-binding protein mediates host cue detection in the parasitic wasp Baryscapus dioryctriae basis of the chromosome-level genome assembly analysis	28

Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization	28
Genomic insights into biased allele loss and increased gene numbers after genome duplication in autotetraploid Cyclocarya paliurus	28
Synthetic Micrographs of Bacteria (SyMBac) allows accurate segmentation of bacterial cells using deep neural networks	28
Chromosome-level assemblies from diverse clades reveal limited structural and gene content variation in the genome of Candida glabrata	28
Selection on the promoter regions plays an important role in complex traits during duck domestication	27
Single-cell RNA-seq analysis of rat molars reveals cell identity and driver genes associated with dental mesenchymal cell differentiation	27
Author Correction: Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly	27
Microplastics and soil microbiomes	27
Deep time extinction of largest insular ant predators and the first fossil Neoponera (Formicidae: Ponerinae) from Miocene age Dominican amber	27
Rare but specific: 5-bp composite motifs define SMAD binding in BMP signaling	27
Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites	27
Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes	27
How much do we know about the function of mammalian genes?	27
Two decades taken at speed: genomics, cell biology, ecology, and evolution of protists	27
Hybridisation has shaped a recent radiation of grass-feeding aphids	26
CircRNA identification and feature interpretability analysis	26
Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition and drought tolerance in Arabidopsis	26
Transcriptomic evidence for visual adaptation during the aquatic to terrestrial metamorphosis in leopard frogs	26
Comparative genomics of Ascetosporea gives new insight into the evolutionary basis for animal parasitism in Rhizaria	26
Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle	26
An ensemble deep learning framework for multi-class LncRNA subcellular localization with innovative encoding strategy	26
A novel small molecule, AS1, reverses the negative hedonic valence of noxious stimuli	26
Egg-laying by female Aedes aegypti shapes the bacterial communities of breeding sites	26
Lineage tracing shows that cell size asymmetries predict the dorsoventral axis in the sea star embryo	26
An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis	25
The pangenome of the wheat pathogen Pyrenophora tritici-repentis reveals novel transposons associated with necrotrophic effectors ToxA and ToxB	25
Unravelling the hidden side of laundry: malodour, microbiome and pathogenome	25
The divergent ER-mitochondria encounter structures (ERMES) are conserved in parabasalids but lost in several anaerobic lineages with hydrogenosomes	25
Genomic analyses support locally derived crown-of-thorns seastar outbreaks in the Pacific	25
Meta-analysis reveals the vaginal microbiome is a better predictor of earlier than later preterm birth	24
Gene flow and an anomaly zone complicate phylogenomic inference in a rapidly radiated avian family (Prunellidae)	24
The impact of insertion bias into piRNA clusters on the invasion of transposable elements	24
The genome and comparative transcriptome of the euryhaline model ciliate Paramecium duboscqui reveal adaptations to environmental salinity	24
Bio-informed synthesis of marine-sourced indole derivatives: suppressing gram-negative bacteria biofilm and virulence	24
DNA methylation haplotype block signatures responding to Staphylococcus aureus subclinical mastitis and association with production and health traits	24
CRISPR/Cas9-mediated gene knockout and interallelic gene conversion in human induced pluripotent stem cells using non-integrative bacteriophage-chimeric retrovirus-like particles	23
Haplotype-resolved genomes of two buckwheat crops provide insights into their contrasted rutin concentrations and reproductive systems	23
Optimizing dsRNA sequences for RNAi in pest control and research with the dsRIP web platform	23
Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families	23
The Musa troglodytarum L. genome provides insights into the mechanism of non-climacteric behaviour and enrichment of carotenoids	23
The pharyngeal taste organ of a blood-feeding insect functions in food recognition	23
orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control	23
The chromosome-level genome and key genes associated with mud-dwelling behavior and adaptations of hypoxia and noxious environments in loach (Misgurnus anguillicaudatus)	23
Non-invasive measurements of respiration and heart rate across wildlife species using Eulerian Video Magnification of infrared thermal imagery	23
Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data	23
Global patterns of genomic and phenotypic variation in the invasive harlequin ladybird	23
A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics	23
CRISPR-based genome editing of a diurnal rodent, Nile grass rat (Arvicanthis niloticus)	22
Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1	22
Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogene	22
Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140	22
An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients	22
Spatial and temporal heterogeneity in the lineage progression of fine oligodendrocyte subtypes	22
Cont-ID: detection of sample cross-contamination in viral metagenomic data	22
Weathered granites and soils harbour microbes with lanthanide-dependent methylotrophic enzymes	22
Species co-occurrence and management intensity modulate habitat preferences of forest birds	22
Range-wide population genomics of common seadragons shows secondary contact over a former barrier and insights on illegal capture	22
Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer’s disease	21
Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon	21
Monoamine oxidases activity maintains endometrial monoamine homeostasis and participates in embryo implantation and development	21
Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan	21
Plastid phylogenomic insights into relationships of all flowering plant families	21
MUS81 cleaves TOP1-derived lesions and other DNA–protein cross-links	21
Accurate prediction of drug-protein interactions by maintaining the original topological relationships among embeddings	21
The neglected burden of chronic hypoxia on the resistance of glioblastoma multiforme to first-line therapies	21
Morphology and mechanical behavior of diatoms in wet and dry states studied using nano-XCT	21
Developing long-term conservation priority planning for medicinal plants in China by combining conservation status with diversity hotspot analyses and climate change prediction	21
Transcriptome analysis reveals PTBP1 as a key regulator of circRNA biogenesis	21
The genomes of Vischeria oleaginous microalgae shed light on the molecular basis of hyper-accumulation of lipids	20
Comparative transcriptomic analysis provides insights into the genetic networks regulating oil differential production in oil crops	20
The function of wing bullae in mayflies (Insecta: Ephemeroptera) reveals new insights into the early evolution of Pterygota	20
The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis	20
Protists and protistology in the Anthropocene: challenges for a climate and ecological crisis	20
Sex or poison? Genetic pest management in the 21st century	20
NeuroScale: evolutional scale-based protein language models enable prediction of neuropeptides	20
Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells	20
VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17	20
YModPred: an interpretable prediction method for multi-type RNA modification sites in S. cerevisiae based on deep learning	20
Evolution of left–right asymmetry in the sensory system and foraging behavior during adaptation to food-sparse cave environments	20
Author Correction: Synchronization of inspiratory burst onset along the ventral respiratory column in the neonate mouse is mediated by electrotonic coupling	20

Identifying effective evolutionary strategies-based protocol for uncovering reaction kinetic parameters under the effect of measurement noises	20
Circulating miRNA repertoire as a biomarker of metabolic and reproductive states in rainbow trout	20
20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1	20
Functional characterization of four opsins and two G alpha subtypes co-expressed in the molluscan rhabdomeric photoreceptor	20
Evolutionary genomics of socially polymorphic populations of Pogonomyrmex californicus	20
Two decades of population genomics: will we ever agree on bacterial species?	20
PFTK1 kinase regulates axogenesis during development via RhoA activation	20
The precedence effect in spatial hearing manifests in cortical neural population responses	20
Nitrogen fixation by diverse diazotrophic communities can support population growth of arboreal ants	20
ADARs regulate cuticle collagen expression and promote survival to pathogen infection	19
The Sino-Himalayan flora evolved from lowland biomes dominated by tropical floristic elements	19
Resolving biology’s dark matter: species richness, spatiotemporal distribution, and community composition of a dark taxon	19
Deep learning-based behavioral profiling of rodent stroke recovery	19
Lessons in immune adaptations to hypoxia revealed by comparative and evolutionary physiology	19
Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains	19
The crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses	19
TRPM4 regulates hilar mossy cell loss in temporal lobe epilepsy	18
OrgaMapper: a robust and easy-to-use workflow for analyzing organelle positioning	18
Lipases are differentially regulated by hormones to maintain free fatty acid homeostasis for insect brain development	18
Latitude-driven adaptive evolution of body length in diverse pig breeds across China	18
MvGraphDTA: multi-view-based graph deep model for drug-target affinity prediction by introducing the graphs and line graphs	18
Modular evolution of secretion systems and virulence plasmids in a bacterial species complex	18
Hologenome analysis reveals independent evolution to chemosymbiosis by deep-sea bivalves	18
Targeting the gut-lung axis by synbiotic feeding to infants in a randomized controlled trial	18
A simple high-throughput method for automated detection of Drosophila melanogaster light-dependent behaviours	18
Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans	18
Publisher Correction to: An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization	17
Unveiling the ventral morphology of a rare early Cambrian great appendage arthropod from the Chengjiang biota of China	17
Epigenetic silencing and genome dynamics determine the fate of giant virus endogenizations in Acanthamoeba	17
Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response	17
Toward efficient and high-fidelity metagenomic data from sub-nanogram DNA: evaluation of library preparation and decontamination methods	17
Unprecedented variation pattern of plastid genomes and the potential role in adaptive evolution in Poales	17
Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat	17
Experimental evidence for enzymatic cell wall dissolution in a microbial protoplast feeder (Orciraptor agilis, Viridiraptoridae)	17
Single-base resolution quantitative genome methylation analysis in the model bacterium Helicobacter pylori by enzymatic methyl sequencing (EM-Seq) reveals influence of strain, growth phase, and methyl	17
AmpHGT: expanding prediction of antimicrobial activity in peptides containing non-canonical amino acids using multi-view constrained heterogeneous graph transformer	17
Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis	17
Behavioral differences among domestic cats in the response to cat-attracting plants and their volatile compounds reveal a potential distinct mechanism of action for actinidine	17
The rapid developments of membrane protein structure biology over the last two decades	17
The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews	17
Caenorhabditis elegans exhibits positive gravitaxis	17
A novel aminotransferase gene and its regulator acquired in Saccharomyces by a horizontal gene transfer event	17
Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability	17
Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy	17
Publisher Correction: Attractive and repulsive effects of sensory history concurrently shape visual perception	17
Genome-wide identification and analysis of a cotton secretome reveals its role in resistance against Verticillium dahliae	17
Cranial base synostosis in mice caused by upregulation of Wnt following partial inhibition of Shh	17
Screens in fly and beetle reveal vastly divergent gene sets required for developmental processes	16
An HSP90 cochaperone Ids2 maintains the stability of mitochondrial DNA and ATP synthase	16
KLF13 promotes ferroptosis and chemosensitivity in lung adenocarcinoma	16
Griottes: a generalist tool for network generation from segmented tissue images	16
Folate regulates RNA m5C modification and translation in neural stem cells	16
FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells	16
Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation	16
Ephrin-B2 deletion in GABAergic neurons induces cognitive deficits associated with single-nucleus transcriptomic differences in the prefrontal cortex	16
Escherichia cryptic clade I is an emerging source of human intestinal pathogens	16
Sex-limited chromosomes and non-reproductive traits	16
The genome of a sea spider corroborates a shared Hox cluster motif in arthropods with a reduced posterior tagma	16
Enhancer-promoter interaction maps provide insights into skeletal muscle-related traits in pig genome	16
Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome	16
Targeted C•G-to-T•A base editing with TALE-cytosine deaminases in plants	16
MultiCycPermea: accurate and interpretable prediction of cyclic peptide permeability using a multimodal image-sequence model	16
Highly distinct genetic programs for peripheral nervous system formation in chordates	16
Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice	16
Single-mitochondrion sequencing uncovers distinct mutational patterns and heteroplasmy landscape in mouse astrocytes and neurons	16
Novel high-resolution targeted sequencing of the cervicovaginal microbiome	16
Protein secretion zones during overexpression of amylase within the Gram-positive cell wall	16
The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors	16
A novel protein encoded by circRsrc1 regulates mitochondrial ribosome assembly and translation during spermatogenesis	16
Phylogenomic analysis of Syngnathidae reveals novel relationships, origins of endemic diversity and variable diversification rates	16
The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures	16
Correction: Synthetic Micrographs of Bacteria (SyMBac) allows accurate segmentation of bacterial cells using deep neural networks	15
Co-option of the limb patterning program in cephalopod eye development	15
Leveraging the predictive power of 3D organoids in dogs to develop new treatments for man and man’s best friend	15
Ancient genomes from the Tang Dynasty capital reveal the genetic legacy of trans-Eurasian communication at the eastern end of Silk Road	15
Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations	15
Pangenome analysis reveals transposon-driven genome evolution in cotton	15
Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice	15
A unique effector secreted by Pseudozyma flocculosa mediates its biocontrol activity	15
Ancient genomes in Southwest China revealed genetic interactions among diverse populations in the historical period	15
Dissecting thrombus-directed chemotaxis and random movement in neutrophil near-thrombus motion in flow chambers	15
Wide-scale geographical analysis of genetic ancestry in the South African Coloured population	15
Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny	15
Global phylogenomic assessment of Leptoseris and Agaricia reveals substantial undescribed diversity at mesophotic depths	15
Guanine crystal formation by bacteria	15
Comparative macrogenomics reveal plateau adaptation of gut microbiome in cervids	15
Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma	15
Author Correction: Unique sperm haplotypes are associated with phenotypically different sperm subpopulations in Astyanax fish	15
Taxonomy-aware, sequence similarity ranking reliably predicts phage–host relationships	15
Author Correction: Novel function of single-target regulator NorR involved in swarming motility and biofilm formation revealed in Vibrio alginolyticus	15
HNF-DDA: subgraph contrastive-driven transformer-style heterogeneous network embedding for drug–disease association prediction	15
Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice	15
Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice	15
A CD24+CD271+ melanoma cancer stem cell possesses hybrid characteristics of its single marker counterparts and promotes invasion and therapeutic resistance	15
Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex	15