Protein Engineering Design & Selection

Papers
(The TQCC of Protein Engineering Design & Selection is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)
ArticleCitations
Enhancing the Thermostability and solubility of a single-domain catalytic antibody70
Improving plastic degrading enzymes via directed evolution40
Rational design of selective bispecific EPO-R/CD131 agonists35
Improving the production and stability of nanobodies29
Yeast biopanning against site-specific phosphorylations in tau25
Dissection of the MeCP2 repressor protein enables CRISPR platform optimization via localization engineering21
Enzyme design pioneer Steve Mayo: I was trying to capture the fundamental physics of the problem as a way to elucidate mechanisms15
Design of functional intrinsically disordered proteins14
Experimental analyses of RFdiffusion designed Miniproteins for binding to SARS-CoV-2 nucleocapsid protein11
Engineering enzyme activity using an expanded amino acid alphabet10
A his-to-Gln mutation in catechol 2,3-dioxygenase catalyzes 2,3-dihydroxybenzoic acid cleavage by an intradiol pathway10
Integrating machine learning tools in protein design: a case of MHETase engineering for PET biodeconstruction9
Sequence-developability mapping of affibody and fibronectin paratopes via library-scale variant characterization9
abYpap: improvements to the prediction of antibody VH/VL packing using gradient boosted regression8
Engineering of a lysosomal-targeted GAA enzyme8
Analysis of conformational stability of interacting residues in protein binding interfaces8
Usage of a split CH2 domain as building block for new antibody formats8
Engineering of a phosphotriesterase with improved stability and enhanced activity for detoxification of the pesticide metabolite malaoxon7
Effect of alanine versus serine at position 88 of human transthyretin mutants on the protein stability7
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