Protein Engineering Design & Selection

Papers
(The TQCC of Protein Engineering Design & Selection is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)
ArticleCitations
Enhancing the Thermostability and solubility of a single-domain catalytic antibody62
Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species34
Improving plastic degrading enzymes via directed evolution28
Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies27
Improving the production and stability of nanobodies26
Cyan fluorescent proteins derived from mNeonGreen22
Rational design of selective bispecific EPO-R/CD131 agonists15
Yeast biopanning against site-specific phosphorylations in tau12
Dissection of the MeCP2 repressor protein enables CRISPR platform optimization via localization engineering12
Design of functional intrinsically disordered proteins10
Enzyme design pioneer Steve Mayo: I was trying to capture the fundamental physics of the problem as a way to elucidate mechanisms10
Engineering enzyme activity using an expanded amino acid alphabet9
Sequence-developability mapping of affibody and fibronectin paratopes via library-scale variant characterization9
Engineering of a lysosomal-targeted GAA enzyme9
Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells8
Correction to: Protease-stable DARPins as promising oral therapeutics7
abYpap: improvements to the prediction of antibody VH/VL packing using gradient boosted regression7
Modifying pH-sensitive PCSK9/LDLR interactions as a strategy to enhance hepatic cell uptake of low-density lipoprotein cholesterol (LDL-C)7
Effect of alanine versus serine at position 88 of human transthyretin mutants on the protein stability7
Analysis of conformational stability of interacting residues in protein binding interfaces7
Engineering of a phosphotriesterase with improved stability and enhanced activity for detoxification of the pesticide metabolite malaoxon7
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