OOIR: Observatory of International Research

Papers

(The TQCC of Protein Engineering Design & Selection is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
A multivalent antibody assembled from different building blocks using tag/catcher systems: a case study	19
Masked inverse folding with sequence transfer for protein representation learning	17
Bispecific antibodies—effects of point mutations on CH3-CH3 interface stability	15
The shortest path method (SPM) webserver for computational enzyme design	9
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids	9
Engineering enzyme activity using an expanded amino acid alphabet	8
Non-canonical amino acids as a tool for the thermal stabilization of enzymes	7
An easy-to-use high-throughput selection system for the discovery of recombinant protein binders from alternative scaffold libraries	7
Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species	6
Improving plastic degrading enzymes via directed evolution	5
Physics-based approach to extend a de novo TIM barrel with rationally designed helix-loop-helix motifs	5
Strategies for enriching and characterizing proteins with inhibitory properties on the yeast surface	4
Engineering of a lysosomal-targeted GAA enzyme	3
Modular and integrative activity reporters enhance biochemical studies in the yeast ER	3
Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells	3
Correction to: Engineering the enzyme toolbox to tailor glycosylation in small molecule natural products and protein biologics	3
Engineering Pseudomonas aeruginosa arylsulfatase for hydrolysis of α-configured steroid sulfates	3
Protein sequence design on given backbones with deep learning	3
Sequence-activity mapping via depletion reveals striking mutational tolerance and elucidates functional motifs in Tur1a antimicrobial peptide	3
Sequence-developability mapping of affibody and fibronectin paratopes via library-scale variant characterization	3
Immortalization and functional screening of natively paired human T cell receptor repertoires	3
DexDesign: an OSPREY-based algorithm for designing de novo D-peptide inhibitors	3