Protein Engineering Design & Selection

Papers
(The TQCC of Protein Engineering Design & Selection is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)
ArticleCitations
Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species59
Enhancing the Thermostability and solubility of a single-domain catalytic antibody31
Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies25
Improving plastic degrading enzymes via directed evolution25
Improving the production and stability of nanobodies22
Cyan fluorescent proteins derived from mNeonGreen22
Yeast biopanning against site-specific phosphorylations in tau13
Dissection of the MeCP2 repressor protein enables CRISPR platform optimization via localization engineering12
Enzyme design pioneer Steve Mayo: I was trying to capture the fundamental physics of the problem as a way to elucidate mechanisms11
Design of functional intrinsically disordered proteins10
Sequence-developability mapping of affibody and fibronectin paratopes via library-scale variant characterization9
Engineering of a lysosomal-targeted GAA enzyme9
Engineering enzyme activity using an expanded amino acid alphabet9
Correction to: Protease-stable DARPins as promising oral therapeutics8
Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells8
abYpap: improvements to the prediction of antibody VH/VL packing using gradient boosted regression7
Analysis of conformational stability of interacting residues in protein binding interfaces7
Engineering of a phosphotriesterase with improved stability and enhanced activity for detoxification of the pesticide metabolite malaoxon7
Modifying pH-sensitive PCSK9/LDLR interactions as a strategy to enhance hepatic cell uptake of low-density lipoprotein cholesterol (LDL-C)7
Effect of alanine versus serine at position 88 of human transthyretin mutants on the protein stability7
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