OOIR: Observatory of International Research

Papers

(The TQCC of Molecular & Cellular Toxicology is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Long non-coding RNA DIRC3 suppresses trophoblast invasion in preeclampsia via upregulating HOXD10	151
Immunoredox model for interpretation and prediction of human diseases	49
Oleamide–PDMS copolymer for coating urinary catheters with anti-adhesive and anti-biofilm properties	28
Anti-tumor effect of novel amino acid Schiff base nickel (II) complexes on oral squamous cell carcinoma cells (CAL-27) in vitro	27
Subcutaneous toxicity of melittin-dKLA in ICR mice	26
miR-29 family inhibited the proliferation and migration of lung cancer cells by targeting SREBP-1	19
Silibinin alleviates DNA damage, mitochondrial dysfunction, and apoptosis caused by oxidative stress in human retinal pigment epithelial cells	18
The importance of multi-omics approaches for the health assessment of freshwater ecosystems	17
Study the effect of crocin on the expression of PAX2 and WT1 genes in renal tissues and serum levels of NGAL and cystatin C in cadmium-treated rats	15
LncRNA taurine up-regulated gene 1 participates in isoflurane induced neurotoxicity	13
Long non-coding RNA DLX6-AS1 accelerates lipopolysaccharides-induced human AC16 cardiomyocytes apoptosis by regulating miR-497/CaSR axis	12
RNA-binding protein SOX2 promotes distal metastasis and cisplatin resistance in non-small cell lung cancer by stabilizing CBLC	10
USP13 promotes proliferation and angiogenesis of diffuse large B-cell lymphoma cells by promoting MCL-1 expression	10
A method to measure the receptor-mediated Ca2+ transients in non-adherent THP-1 monocytes using gelatin methacryloyl for immobilization in a bath perfusion system	9
Review of synergistic anticancer effects of natural compounds combined with conventional therapeutics against chemoresistance and progression of pancreatic cancer	9
Long intergenic non-protein coding RNA 1436 accelerates cell proliferation, migration and adhesion properties of the MUM-2B cell line via microRNA-513a-5p/CUG Triplet repeat-binding protein 1 axis to	9
Dihydrotanshinone I ameliorated angiotensin II-induced mitochondrial damage and oxidative stress in vascular smooth muscle cells	8
NEAT1 promotes keratinocyte migration and proliferation during wound healing by regulating miR-26a-5p/LGR4 axis	8
USP38 protein alleviates neuroinflammation of cerebral ischemia–reperfusion injury via KDM5B expression	7
Oncheong-eum alleviated hepatic lipid accumulation and intestinal barrier disruption in nonalcoholic steatohepatitis in vivo model	7
Application of the adverse outcome pathway framework to predict the toxicity of chemicals in the semiconductor manufacturing industry	7
CircBLNK regulates tumor proliferation and apoptosis by miR-578/ING5 axis in non-small cell lung cancer	7
YTHDC1 inhibits cell proliferation and angiogenesis in cervical cancer by regulating m6A modification of SOCS4 mRNA	7
Nano-TiO2 removal using jellyfish extracts and an assessment of aquatic toxicity	6
Neuregulin-1 suppresses anti-apoptotic effect of Der p 38 on neutrophils by inhibition of cytokine secretion	6

Concurrent upregulation of immune checkpoint molecule genes in colorectal cancer	6
A novel immune-related LncRNA prognostic signature for cutaneous melanoma	6
ML385 suppresses the proliferation, migration, and invasion of thyroid carcinoma cells by impairing aerobic glycolysis	6
Sample management: a primary critical starting point for successful omics studies	6
Disulfiram inhibits LPS-induced TLR4/NF-κB signaling in spheroids derived from human colorectal cancer cells	6
The therapeutic potential of Laggera alata in alleviating inflammation and oxidative stress: insights into the miR-150-5p/TRIM8 axis	6
Codon optimization of the synthetic 3-ketosphinganine reductase (3KSR) protein for enhancing sphingolipid biosynthetic enzyme expression	5
circLETM1 upregulates KRT80 via adsorbing miR-143-3p and promotes the progression of colorectal cancer	5
SQSTM1/p62 confers resistance of intrahepatic cholangiocarcinoma cells to 5-Fluorouracil by promoting Nrf2 nuclear translocation	5
Circ_0101622 governs the miR-1179/RAB23 pathway to promote the aggressive progression of thyroid cancer	5
Circ_0008351 acts as ceRNA for miR-942-5p to inhibit the progression of gastric cancer depending on the activation of PTGDR2	5
VCAN activates JAK/STAT signaling pathway to promote the progression of LPS-induced acute pneumonia	5
A systematic review of the carcinogenicity of rats and mice by sex due to exposure to phenyl compounds	5
CTCF-mediated H3K27me3 enrichment on the LncRNA MALAT1 promoter regulates the cardiomyocytes from I/R-induced apoptosis through targeting miR-26b-5p	5
Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency	4
Reduced cellular process and developmental process genotoxicity of polystyrene nanoplastics in zebrafish embryogenesis using Aurelia aurita proteins	4
Circular RNA circ_0000877 serves as a miR-671-5p sponge to regulate diffuse large B-cell lymphoma development via HK2	4
LncRNA PVT1 upregulates FBN1 by sponging miR-30b-5p to aggravate pulpitis	4
Correction to: Network analysis to understand side effects of UVB on skin through transcriptomic approach	4
Lung neoplasm development in a mouse model exposed to fine particulate matter in Korea	4
MicroRNA-10a-5p targets SERPINE1 to suppress cell progression and epithelial–mesenchymal transition process in clear cell renal cell carcinoma	4
Gold nanoparticles: uptake in human mast cells and effect on cell viability, inflammatory mediators, and proliferation	4
Antioxidant and apoptotic activity of cocoa bean husk extract on prostate cancer cells	4
Knockdown of RBBP6 enhances radiosensitivity of gastric cancer cells through p53 pathway	4
Angelica dahurica attenuates melanogenesis in B16F0 cells by repressing Wnt/β-catenin signaling	4
Liver kinase B1 (LKB1) reduced inflammation and oxidative stress by regulating the AMPK/NLRP3 signaling pathway in LPS-induced lung injury	4
The effects of dantrolene and 2-aminoethoxydiphenyl borate (2-APB) on arsenic-induced osteoporosis	3
Induction of glioblastoma invasion triggered by system Xc−-mediated glutamate release	3
Hydrochloric acid-treated Bacillus subtilis ghosts induce IL-1 beta, IL-6, and TNF-alpha in murine macrophage	3
Therapeutic potential of snake venom, l-amino oxidase and sorafenib in hepatocellular carcinoma	3
Illuminating the hepatotoxic mechanism of norcantharidin in rats using metabolomics analysis	3
LGR4 protects PC12 against OGD/R-induced oxidative stress and apoptosis through activation of AKT/GSK3β	3
Benzo(a)pyrene-loaded gypsum dust-induced apoptosis of human bronchial epithelial cells through the Ahr signaling pathway	3
Influences of environmentally hazardous substances on atopic dermatitis: a review	3
Correction to: Binding of silver nanowaste using jellyfish immune reaction extract and an assessment of aquatic toxicity	3
MiR-214 inhibits apoptosis in thyroid epithelial follicular cells induced by amiodarone through the FASL/MAPK pathway	3
Efficacy of urinary trypsin inhibitor in the treatment of rats with severe sepsis and its effects on coagulation and immunity	3
Circ_0074027 regulates the progression of non-small cell lung cancer via miR-1304-5p/GJB2 axis	3
Stable expression of human Nav1.5 for high-throughput cardiac safety assessment	3
Flutriafol disrupts trophoblast function: mitochondrial dysfunction mediated cell cycle arrest and apoptosis	3
Sodium hydroxide-induced Weissella kimchii ghosts (WKGs) as immunostimulant	3
Kaempferol attenuates spinal cord injury by interfering inflammatory and oxidative stress by targeting the p53 protein: a molecular docking analysis	3
The effect of pesticides on the body of animals in the experiment	3
KLF9 promotes autophagy and apoptosis in T-cell acute lymphoblastic leukemia cells by inhibiting AKT/mTOR signaling pathway	3
Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin	3
Sensitive-stage embryo irradiation affects embryonic neuroblasts and adult motor function	3
The efficacy of Plantago asiatica L. water extract on lipid metabolism in a high-fat diet-induced obese C57BL/6 mice	3
Screening of serum exosome markers for colorectal cancer based on Boruta and multi-cluster feature selection algorithms	3
Scallop-derived plasmalogen attenuates amyloid beta-induced inflammation and apoptosis in SH-SY5Y cells	3
MicroRNA-5582-3p alleviates the progression of osteosarcoma via targeting FZD4	3

Sublethal effects of acetaminophen exposure on benthic aquatic animal (Hydra magnipapillata)	3
Mechanistic insight of mitochondrial dysfunctions in cardiovascular diseases with potential biomarkers	3
Biochemical and physiological responses of the water flea Moina macrocopa to microplastics: a multigenerational study	3
Tolylfluanid induces developmental toxicity via liver dysfunction in zebrafish embryos	3
Protective effects of Dioscorea polystachya ethanol extracts against lead acetate-induced oxidative DNA damage in MRC-5 cells	3
Integrated analysis of miRNA and mRNA expression profiles in diabetic mouse kidney treated to Korean Red Ginseng	2
The atypical protein kinase RIOK3 contributes to the phenotypic modulation of vascular smooth muscle cells in intracranial aneurysms	2
Transmembrane protein 106C accelerates the progression of breast cancer through the activation of PI3K/AKT/mTOR signaling	2
Role of CREB1 dysregulation in calcium oxalate monohydrate crystals-induced tubular epithelial cell injury	2
Acute effects of 4-EA-NBOMe, 3, 4-DCMP, LY-2183240 and AB-CHFUPYCA on the excitability of rat cortical primary cultured neurons	2
Chemically induced bacterial ghosts: a novel approach for advancing biomedical applications	2
MicroRNA-1271-5p suppresses the proliferation, invasion and migration of oral squamous cell carcinoma by inhibiting F13A1 expression	2
GSK621 ameliorates high glucose-induced renal injury by inducing autophagy via AMPK/ULK1 signaling pathway: an in vitro and in vivo study	2
Unveiling the toxicological impact of yeast vacuoles in Daphnia	2
CARD9 regulates myocardial inflammation, oxidative stress, and vascular dysfunction in hypertensive rats by activating MAPK/p38 pathway in combination with NOD2	2
Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases	2
Myricetin alleviates pancreatic microcirculation and inflammation in rats with severe acute pancreatitis through FOXO1 and NF-κB pathways	2
Fluorescence imaging of microplastics and nanoplastics in biological samples	2
The role of circSUCLG2 in mediating inflammatory response and bone remodeling imbalance in diabetic osteoporosis	2
Regulation of mast cell activation by extracellular vesicles in cow’s milk casein-induced allergic responses	2
Salvia microphylla essential oil reduces cell viability in cisplatin-resistant clear cell type ovarian cancer cells caused by mitochondrial dysfunction	2
Premature ovarian insufficiency associated with environmental chemical exposure among Korean women: a study based on the Korean National Environmental Health Survey (2009–2012)	2
Fucoidan ameliorates amyloid-β 42 oligomer-induced neuronal apoptosis by activating the PI3K/Akt signaling pathway and MAPK cascades in human neuroblastoma SH-SY5Y cells	2
LINC00174 targeting miR-486-5p/EIF5A2 is an oncogenic driver in oral squamous cell carcinoma	2
Evaluating the comparative MT1B, MT1F, MT1G, and MT1H expression in human pulmonary alveolar epithelial cells treated with polyhexamethylene guanidine-phosphate, chloromethylisothiazolinone/methylisot	2
Down-regulation of PTTG1 suppresses PDGF-BB-induced proliferation, migration and extracellular matrix production of airway smooth muscle cells (ASMCs) by regulating PI3K/AKT/mTOR signaling pathway	2
Secukinumab ameliorates postoperative cognitive dysfunction in aged mice by reducing meningeal aggregation of γδT cell	2
Importance of GWAS in finding un-targeted genetic association of sporadic Alzheimer’s disease	2
Capparis spinosa inhibits proliferation and fibrosis of myofibroblasts in systemic sclerosis through modulation of MAPK signaling	2
Shikonin alleviates testosterone-induced benign prostatic hyperplasia in rats via the Nrf2-ARE and NF-κB pathway	2
Bone marrow mesenchymal stem cell transplantation protects rats from myocardial infarction by regulating TXNIP/NLRP3 pathway-mediated inflammation and fibrosis	2
Multigenerational effect of maternal bisphenol A exposure on DNA methylation in F1 sperm	2
Circ_0000277 promotes the malignant progression of oesophageal squamous cell carcinoma through miR-1294-dependent regulation of DVL3	2
S-Adenosylmethionine enhances the inhibitory effect of gemcitabine against pancreatic cancer cells via suppression of the EGFR/AKT pathways	2
Knockdown of lncRNA EGFR-AS1 promotes autophagy-mediated ferroptosis in cervical cancer via regulating EGFR expression through miR-133b	2
Comparative analysis of transcriptional responses in tolerant and susceptible Pacific oysters to acute cold stress	2
HSP72 is a stimulus for activating toll-like receptor 2 in M2 macrophages leading to IL-6-mediated tumor malignancy	2
Ubiquitin ligase CHIP regulates neurological functional recovery after intracerebral hemorrhage through ubiquitination modification of FOXO1	2
Coal dust exposure induces proliferation and migration of human bronchial epithelial cells	2
Cucurbitacin-I exhibits anticancer activity by inducing apoptosis in SKOV3 human ovarian cancer cells	2
Anti-inflammatory activity of Akebia quinata D. extracts by inhibiting MAPK and NF-κB signaling pathways in LPS-induced RAW 264.7 cells according to extraction solvents	2
Single-cell transcriptomics to understand the cellular heterogeneity in toxicology	2
Up-regulation of PKCα and δ during beating cardiomyocyte differentiation of P19CL6 cells with suppressed apoptotic cell populations	2
Propofol alleviates ropivacaine-induced neurotoxicity through the MALAT1/EZH2/BDNF axis	2
Association of expression of GADD family genes and apoptosis in human kidney proximal tubular (HK-2) cells exposed to nephrotoxic drugs	2
Physical and biomimetic treatment methods to reduce microplastic waste accumulation	2
Evaluations of carcinogens from comparison of cancer slope factors: meta-analysis and systemic literature reviews	2
Matrine promotes trophoblast invasion and reduces inflammation via miR-19a-3p to prevent preeclampsia	2
FAM120A promotes angiogenesis in pancreatic cancer by increasing the mRNA expression of RHOA	2
Decreased LTBP2 expression inhibits proliferation and migration of glioma	2
Chronic toxic effects of fragmented polyvinyl chloride on the water flea Moina macrocopa	2
Valrubicin decreases cell proliferation in gastric cancer through the apoptosis induction	2
Serum metabolomic analysis in mice exposed to perfluorooctanoic acid and sodium p-perfluorous nonenoxybenzene sulfonate	2
Evaluation of the therapeutic efficacy of human skin equivalents manufactured through droplet-based bioprinting/nebulization technology	2
The mechanism of 5-aminolevulinic acid-photodynamic therapy pretreatment repressing keloid fibroblast proliferation and invasion by mediating forkhead box protein O6 (FoxO6) antioxidant stress	2