Tissue Engineering and Regenerative Medicine

Article	Citations
Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes	119
The Antioxidant Effect of Small Extracellular Vesicles Derived from Aloe vera Peels for Wound Healing	58
Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing	50
Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration	50
Comparison of Autogenous Tooth Materials and Other Bone Grafts	50
Exosomes from IL-1β-Primed Mesenchymal Stem Cells Inhibited IL-1β- and TNF-α-Mediated Inflammatory Responses in Osteoarthritic SW982 Cells	46
Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review	42
Thermosensitive Hydrogel Loaded with Primary Chondrocyte-Derived Exosomes Promotes Cartilage Repair by Regulating Macrophage Polarization in Osteoarthritis	39
Strategies to Enhance Extracellular Vesicle Production	38
Influences of Xeno-Free Media on Mesenchymal Stem Cell Expansion for Clinical Application	35
Advances in the Development of Anti-Adhesive Biomaterials for Tendon Repair Treatment	34
Extracellular Vesicles in Regenerative Medicine: Potentials and Challenges	32
Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment	31
Mucosal Vaccine Delivery Using Mucoadhesive Polymer Particulate Systems	30
Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1α Signaling Pathway	30
Liver Organoids: Formation Strategies and Biomedical Applications	30
Mesenchymal Stem Cell Transplantation for Ischemic Diseases: Mechanisms and Challenges	25
Not Stromal Vascular Fraction (SVF) or Nanofat, but Total Stromal-Cells (TOST): A New Definition. Systemic Review of Mechanical Stromal-Cell Extraction Techniques	25
Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation	25
Comparative Analysis of MSC-Derived Exosomes Depending on Cell Culture Media for Regenerative Bioactivity	24
Role of Stromal Cell-Derived Factor-1 in Endothelial Progenitor Cell-Mediated Vascular Repair and Regeneration	23
Electrospinning Fabrication Methods to Incorporate Laminin in Polycaprolactone for Kidney Tissue Engineering	22
A Comprehensive Cancer-Associated MicroRNA Expression Profiling and Proteomic Analysis of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes	22
New Approaches for Enhancement of the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Diseases	21
Three-Dimensional Bioprinting Scaffolding for Nasal Cartilage Defects: A Systematic Review	21

Microfluidic Systems for Assisted Reproductive Technologies: Advantages and Potential Applications	19
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis	19
The Application of Decellularized Adipose Tissue Promotes Wound Healing	19
The Concept of Early Osteoarthritis and Its Significance in Regenerative Medicine	18
Mesenchymal Stem Cells Derived from Wharton’s Jelly Can Differentiate into Schwann Cell-Like Cells and Promote Peripheral Nerve Regeneration in Acellular Nerve Grafts	18
Intestinal Peyer’s Patches: Structure, Function, and In Vitro Modeling	18
Regenerative Potential of Platelet Rich Fibrin (PRF) in Socket Preservation in Comparison with Conventional Treatment Modalities: A Systematic Review and Meta-Analysis	18
Comparison of the Infant and Adult Adipose-Derived Mesenchymal Stem Cells in Proliferation, Senescence, Anti-oxidative Ability and Differentiation Potential	17
Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging	16
Effect of PDGF-B Gene-Activated Acellular Matrix and Mesenchymal Stem Cell Transplantation on Full Thickness Skin Burn Wound in Rat Model	16
Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy	15
PLGA Microspheres Containing Hydrophobically Modified Magnesium Hydroxide Particles for Acid Neutralization-Mediated Anti-Inflammation	15
IL-10 Deficiency Aggravates Renal Inflammation, Fibrosis and Functional Failure in High-Fat Dieted Obese Mice	15
Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy	14
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Pass through the Filtration Barrier and Protect Podocytes in a 3D Glomerular Model under Continuous Perfusion	14
Cyclic Stretching Induces Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes through Nuclear-Mechanotransduction	14
Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Management of COVID19-Associated Lung Injury: A Review on Publications, Clinical Trials and Patent Landscape	14
Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation	13
Immunomodulatory Biomaterials and Emerging Analytical Techniques for Probing the Immune Micro-Environment	13
Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering	13
Extracorporeal Shock Wave Combined with Teriparatide-Loaded Hydrogel Injection Promotes Segmental Bone Defects Healing in Osteoporosis	13
Peripheral Nerve Regeneration Using a Nerve Conduit with Olfactory Ensheathing Cells in a Rat Model	13
Three-Dimensional Cell Cultures as a Research Platform in Lung Diseases and COVID-19	13
An Insight of Nanomaterials in Tissue Engineering from Fabrication to Applications	13
Progress of Polysaccharide-Contained Polyurethanes for Biomedical Applications	13
Preparation and In Vitro Characterization of Gelatin Methacrylate for Corneal Tissue Engineering	13
Decellularized Human Adipose Tissue as an Alternative Graft Material for Bone Regeneration	13
Development and Application of Three-Dimensional Bioprinting Scaffold in the Repair of Spinal Cord Injury	12
Novel Marine Organism-Derived Extracellular Vesicles for Control of Anti-Inflammation	12
Acellular Scaffolds as Innovative Biomaterial Platforms for the Management of Diabetic Wounds	12
Secretome of Stem Cells: Roles of Extracellular Vesicles in Diseases, Stemness, Differentiation, and Reprogramming	12
Heparin Immobilization of Tissue Engineered Xenogeneic Small Diameter Arterial Scaffold Improve Endothelialization	12
Nigella Sativa-Coated Hydroxyapatite Scaffolds: Synergetic Cues to Stimulate Myoblasts Differentiation and Offset Infections	11
Engineering of Extracellular Vesicles Based on Payload Changes for Tissue Regeneration	11
Surface-Modifying Effect of Zwitterionic Polyurethane Oligomers Complexed with Metal Ions on Blood Compatibility	11
Tissue-Engineered Hydroxyapatite Bone Scaffold Impregnated with Osteoprogenitor Cells Promotes Bone Regeneration in Sheep Model	11
Hyaluronic Acid Coating on Hydrophobic Tracheal Scaffold Enhances Mesenchymal Stem Cell Adhesion and Tracheal Regeneration	10
Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Photoreceptors and Establishing a Sodium Iodate-Induced Retinal Degeneration Rat Model	10
Fat Graft with Allograft Adipose Matrix and Magnesium Hydroxide-Incorporated PLGA Microspheres for Effective Soft Tissue Reconstruction	10
The Application of Cartilage Tissue Engineering with Cell-Laden Hydrogel in Plastic Surgery: A Systematic Review	10
Immunomodulation for Tissue Repair and Regeneration	10
The Biocompatibility of Multi-Source Stem Cells and Gelatin-Carboxymethyl Chitosan-Sodium Alginate Hybrid Biomaterials	10
Tissue-Engineered 3D In Vitro Disease Models for High-Throughput Drug Screening	10
Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice	10
Atorvastatin Pretreatment Ameliorates Mesenchymal Stem Cell Migration through miR-146a/CXCR4 Signaling	10
Research Progress of Three-Dimensional Bioprinting Artificial Cardiac Tissue	9
Enhanced Bone Regeneration by Bone Morphogenetic Protein-2 after Pretreatment with Low-Intensity Pulsed Ultrasound in Distraction Osteogenesis	9
The Role of Low-Frequency Electromagnetic Fields on Mesenchymal Stem Cells Differentiation: A Systematic Review	9
Nanomaterial-Based Scaffolds for Tissue Engineering Applications: A Review on Graphene, Carbon Nanotubes and Nanocellulose	9
Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin	9

The Therapeutic Potential of Amniotic Fluid-Derived Stem Cells on Busulfan-Induced Azoospermia in Adult Rats	9
rhBMP-2-Conjugated Three-Dimensional-Printed Poly(l-lactide) Scaffold is an Effective Bone Substitute	9
Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices	9
The Combination of Concentrated Growth Factor and Adipose-Derived Stem Cell Sheet Repairs Skull Defects in Rats	9
Intra-Articular Atelocollagen Injection for the Treatment of Articular Cartilage Defects in Rabbit Model	9
Synergistic Effect of Whitlockite Scaffolds Combined with Alendronate to Promote Bone Regeneration	8
M2 Macrophage-Derived Concentrated Conditioned Media Significantly Improves Skin Wound Healing	8
The Therapeutic Effects of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Scleroderma	8
Regenerating the Pulp–Dentine Complex Using Autologous Platelet Concentrates: A Critical Appraisal of the Current Histological Evidence	8
Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood–Brain Barrier	8
The Neuropeptide Spexin Promotes the Osteoblast Differentiation of MC3T3-E1 Cells via the MEK/ERK Pathway and Bone Regeneration in a Mouse Calvarial Defect Model	8
Graded-Three-Dimensional Cell-Encapsulating Hydrogel as a Potential Biologic Scaffold for Disc Tissue Engineering	8
Gymnemic Acid Ameliorates Pancreatic β-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for β-Cell Regeneration	8
Modeling Human Gonad Development in Organoids	8
Three Dimensional Bioprinting for Hepatic Tissue Engineering: From In Vitro Models to Clinical Applications	8
Kartogenin Promotes the BMSCs Chondrogenic Differentiation in Osteoarthritis by Down-Regulation of miR-145-5p Targeting Smad4 Pathway	8
Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation	8
A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids	8
Growth and Differentiation of Circulating Stem Cells After Extensive Ex Vivo Expansion	8
Combinatorial Effect of Mesenchymal Stem Cells and Extracellular Vesicles in a Hydrogel on Cartilage Regeneration	7
Advances in Research on Stem Cell-Based Pulp Regeneration	7
Secretoneurin, a Neuropeptide, Enhances Bone Regeneration in a Mouse Calvarial Bone Defect Model	7
Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: A Systematic Review and Meta-analysis	7
Enhancement of Immune Responses Elicited by Nanovaccines through a Cross-Presentation Pathway	7
Vessel-Derived Decellularized Extracellular Matrices (VdECM): Novel Bio-Engineered Materials for the Wound Healing	7
Application of Polarization Sensitive-Optical Coherence Tomography to the Assessment of Phase Retardation in Subpleural Cancer in Rabbits	7
Effect of Human Umbilical Cord Matrix-Derived Mesenchymal Stem Cells on Bisphosphonate-Related Osteonecrosis of the Jaw	7
Tailoring Hydrogel Composition and Stiffness to Control Smooth Muscle Cell Differentiation in Bioprinted Constructs	7
In Situ-Forming Collagen/poly-γ-glutamic Acid Hydrogel System with Mesenchymal Stem Cells and Bone Morphogenetic Protein-2 for Bone Tissue Regeneration in a Mouse Calvarial Bone Defect Model	7
Advanced In Vitro Three-Dimensional Skin Models of Atopic Dermatitis	7
Human Fetal Cartilage-Derived Progenitor Cells Exhibit Anti-Inflammatory Effect on IL-1β-Mediated Osteoarthritis Phenotypes In Vitro	7
Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs	7
Nitric Oxide Produced by the Antioxidant Activity of Verapamil Improves the Acute Wound Healing Process	7
The Progress of Stem Cell Therapy in Myocardial-Infarcted Heart Regeneration: Cell Sheet Technology	7
The Combination of Platelet Rich Plasma Gel, Human Umbilical Mesenchymal Stem Cells and Nanohydroxyapatite/polyamide 66 Promotes Angiogenesis and Bone Regeneration in Large Bone Defect	7
A Comparative Study of an Anti-Thrombotic Small-Diameter Vascular Graft with Commercially Available e-PTFE Graft in a Porcine Carotid Model	7
Transplantation of PSA-NCAM-Positive Neural Precursors from Human Embryonic Stem Cells Promotes Functional Recovery in an Animal Model of Spinal Cord Injury	7
Corneal Repair with Adhesive Cell Sheets of Fetal Cartilage-Derived Stem Cells	6
The Effect of the Mechanical Properties of the 3D Printed Gelatin/Hyaluronic Acid Scaffolds on hMSCs Differentiation Towards Chondrogenesis	6
Mechanical Stimulation and Diameter of Fiber Scaffolds Affect the Differentiation of Rabbit Annulus Fibrous Stem Cells	6
Development of Matrix Metalloproteinases-Mediated Extracellular Matrix Remodeling in Regenerative Medicine: A Mini Review	6
Comparative Study of Two Common In Vitro Models for the Pancreatic Islet with MIN6	6
Fabrication and Characterization of Graphene Oxide-Coated Plate for Efficient Culture of Stem Cells	6
Bone Regeneration with 3D-Printed Hybrid Bone Scaffolds in a Canine Radial Bone Defect Model	6
Clinical Reference Strategy for the Selection of Treatment Materials for Maxillofacial Bone Transplantation: A Systematic Review and Network Meta-Analysis	6
Various Three-Dimensional Culture Methods and Cell Types for Exosome Production	6
Adenosine-Prefabricated Adipose Tissue Improves Fat Graft Survival by Promoting VEGF-Dependent Angiogenesis	6
Validation of the Osteomyelitis Induced by Methicillin-Resistant Staphylococcus aureus (MRSA) on Rat Model with Calvaria Defect	6
Near-infrared Transillumination and Photodynamic Therapy Using Hypericin in Animal Laryngeal Tumors	6
Selective Serotonin Reuptake Inhibitor Promotes Bone-Tendon Interface Healing in a Rotator Cuff Tear Rat Model	6
Intra-Articular Injection of miR-29a-3p of BMSCs Promotes Cartilage Self-Repairing and Alleviates Pain in the Rat Osteoarthritis	6
The Progress of Decellularized Scaffold in Stomatology	6
Temporal Modulation of DNA Methylation and Gene Expression in Monolayer and 3D Spheroids of Dental Pulp Stem Cells during Osteogenic Differentiation: A Comparative Study	6
Three-Dimensional Modeling of the Structural Microenvironment in Post-Traumatic War Wounds	6
Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells	6
Exosomal microRNAs from Mesenchymal Stem Cells: Novel Therapeutic Effect in Wound Healing	6
A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage	5
Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method	5
Comparison of the Angiogenic Ability between SHED and DPSC in a Mice Model with Critical Limb Ischemic	5
Remodeling and Restraining Lung Tissue Damage Through the Regulation of Respiratory Immune Responses	5
Surface Creasing-Induced Micropatterned GelMA Using Heating-Hydration Fabrication for Effective Vascularization	5
Acoustic and Magnetic Stimuli-Based Three-Dimensional Cell Culture Platform for Tissue Engineering	5
Silica-Capped and Gold-Decorated Silica Nanoparticles for Enhancing Effect of Gold Nanoparticle-Based Photothermal Therapy	5
Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells	5
From In Vitro to Perioperative Vascular Tissue Engineering: Shortening Production Time by Traceable Textile-Reinforcement	5
A Vitronectin-Derived Peptide Restores Ovariectomy-Induced Bone Loss by Dual Regulation of Bone Remodeling	5
Laser-Structured Si and PLGA Inhibit the Neuro2a Differentiation in Mono- and Co-Culture with Glia	5
Implantation of Bone Marrow Mesenchymal Stem Cells into Small Intestinal Submucosa Improves Bile Duct Injury in Rabbits	5
Current Modalities for Fracture Healing Enhancement	5
Combined Mesenchymal Stem Cells and Cartilage Acellular Matrix Injection Therapy for Osteoarthritis in Goats	5
MMP13-Overexpressing Mesenchymal Stem Cells Enhance Bone Tissue Formation in the Presence of Collagen Hydrogel	5
Osteogenic Response of MC3T3-E1 and Raw264.7 in the 3D-Encapsulated Co-Culture Environment	5
Effects of Androgen Receptor Overexpression on Chondrogenic Ability of Rabbit Articular Chondrocytes	5
Restoration of Immune Privilege in Human Dermal Papillae Controlling Epithelial-Mesenchymal Interactions in Hair Formation	5
Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel	5
Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration	5
IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis	5
Reactive Oxygen Species Scavenging Hydrogel Regulates Stem Cell Behavior and Promotes Bone Healing in Osteoporosis	5
Applications of Bacterial Cellulose-Based Composite Materials in Hard Tissue Regenerative Medicine	5
Multilayered Cell Sheets of Cardiac Reprogrammed Cells for the Evaluation of Drug Cytotoxicity	4

Wnt/β-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells	4
Transplantation of Differentiated Tonsil-Derived Mesenchymal Stem Cells Ameliorates Murine Duchenne Muscular Dystrophy via Autophagy Activation	4
Injectable and Cell-Laden Hydrogel in the Contained Bone Defect Animal Model: A Systematic Review	4
Use of Human Gingival Fibroblasts for Pre-Vascularization Strategies in Oral Tissue Engineering	4
Matrix Metalloproteinase 1 as a Marker of Tonsil-Derived Mesenchymal Stem Cells to Assess Bone Marrow Cell Migration	4
Functional Analysis of Induced Human Ballooned Hepatocytes in a Cell Sheet-Based Three Dimensional Model	4
Preparation and Biocompatibility Study of Contrast-Enhanced Hernia Mesh Material	4
Modulation of 3D Bioprintability in Polysaccharide Bioink by Bioglass Nanoparticles and Multiple Metal Ions for Tissue Engineering	4
Scaffold Engineering with Flavone-Modified Biomimetic Architecture for Vascular Tissue Engineering Applications	4
Development of Hetero-Cell Type Spheroids Via Core–Shell Strategy for Enhanced Wound Healing Effect of Human Adipose-Derived Stem Cells	4
Comparative Evaluation of Connective Tissue Graft with Pouch/Tunnel Technique versus Connective Tissue Graft with Coronally Advanced Tunnel Flap for the Treatment of Maxillary Recession Cases in Sever	4
Identification of Stem Cell-Like Cells in the Ovary	4
TGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13	4
Role of Klotho and N-acetylcysteine in Oxidative Stress Associated with the Vitrification of Ovarian Tissue Cytoprotective Function of Klotho in Cryopreservation	4
Enhancing the Angiogenic and Proliferative Capacity of Dermal Fibroblasts with Mulberry (Morus alba. L) Root Extract	4
Regenerative Strategies in Treatment of Peripheral Nerve Injuries in Different Animal Models	4
Development of a Novel Perfusion Rotating Wall Vessel Bioreactor with Ultrasound Stimulation for Mass-Production of Mineralized Tissue Constructs	4
Biotherapeutic Applications of Platelet-Rich Plasma in Regenerative Medicine	4
A Combination of Surgical and Chemical Induction in a Rabbit Model for Osteoarthritis of the Knee	4
Rapid Differentiation of Human Embryonic Stem Cells into Testosterone-Producing Leydig Cell-Like Cells In vitro	4
Long Noncoding RNA FBXL19-AS1-Mediated Ulcerative Colitis-Associated Intestinal Epithelial Barrier Defect	4
Therapeutic Extracellular Vesicles from Tonsil-Derived Mesenchymal Stem Cells for the Treatment of Retinal Degenerative Disease	4
Polydeoxyribonucleotide and Polynucleotide Improve Tendon Healing and Decrease Fatty Degeneration in a Rat Cuff Repair Model	4
The Intrinsic Relation between the Hydrogel Structure and In Vivo Performance of Hyaluronic Acid Dermal Fillers: A Comparative Study of Four Typical Dermal Fillers	4
Effect of TNF-α and IL-6 on Compact Bone-Derived Cells	4
Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co-ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal	4
Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate	4
Promotion of Platelet Production by Co-Transplantation of Mesenchymal Stem Cells in Bone Marrow Transplantation	4
Mesenchymal Stem Cell Extracellular Vesicles from Tissue-Mimetic System Enhance Epidermal Regeneration via Formation of Migratory Cell Sheets	4