OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience	103
Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data	97
Acknowledgments	74
Potential drugs for the treatment of Alzheimer’s disease	66
Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results	63
A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice	63
Luteolin for neurodegenerative diseases: a review	61
The onset of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) with the use of decongestant agents: a European pharmacovigilance analysis	61
Note from editors	60
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran	59
Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis	58
Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices	57
Assessing the effects of 5-HT2A and 5-HT5A receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms	49
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats	44
Padsevonil suppresses seizures without inducing cell death in neonatal rats	44
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations	41
β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo	41
The HPA axis and kynurenine pathway: exploring the role of stress and neuroinflammation in treatment-resistant depression	38
Decoding the serotonin–alcohol crosstalk: the role of central serotonergic dysregulation in alcohol use disorder	36
Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder	35
The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice	34
Novel receptor tyrosine kinase-targeted strategies to overcome resistance in oral squamous cell carcinoma	30
Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder	30
Pten knockout affects drug resistance differently in melanoma and kidney cancer	29
Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action	29

Prospects and challenges in intracellular delivery of therapeutic proteins	28
The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds	28
Glutathione deficiency in the early postnatal developmental period as a neurodevelopmental animal model of schizophrenia	27
Preclinical efficacy of cannabidiol for the treatment of early-life seizures	26
AMPA receptor modulation in depression: from molecular mechanisms of plasticity to therapeutic translation	26
The ketogenic diet in Parkinson’s disease: a potential therapeutic strategy	25
The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols	25
Multi-target-directed drugs: new additions in 2025 and post-marketing safety surveillance of drugs marketed in 2022–2024	25
A review of serious adverse events linked with GLP-1 agonists in type 2 diabetes mellitus and obesity treatment	25
Palbociclib in endocrine-resistant metastatic breast cancer patients: gene polymorphism- based study	24
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum	24
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction	22
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect	22
Comprehensive evaluation of ibuprofenate amino acid isopropyl esters: insights into antioxidant activity, cytocompatibility, and cyclooxygenase inhibitory potential	22
The effect of salidroside, an active component of Rhodiola rosea, on the metabolic activity of rat and human cytochromes P450 in preclinical studies	22
The therapeutic potential of vitamin D supplementation in asthma	22
Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and − 9, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol	20
Elevated hypoxia-inducible factor-1α in pediatric patients with patent ductus arteriosus: a pilot study	20
The role of microbiota modulation in preventing Alzheimer’s disease- a review	20
Red cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis	19
Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome	19
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse	19
MIM1 – a selective Mcl-1 protein inhibitor augments the proapoptotic activity of moxifloxacin toward MDA-MB-231 triple-negative breast cancer cells – a preliminary in vitro study	18
Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay	18
Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the gut-brain axis	16
A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes	16
Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines	16
Italian regional data and oropharyngeal adverse events to drugs and vaccines: insights from a 3-year spontaneous reporting (2022–2024)	16
Dysregulation of store-operated calcium entry in fibroblast lines from adult and juvenile-onset Huntington’s disease patients	16
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts	15
Synthesis and evaluation of KR-12, an LL-37 fragment, and its short-chain fatty acid derivatives: selective cytotoxicity in colorectal cancer cells and anti-tumor efficacy in an azoxymethane/DSS-induc	15
Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts	15
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells	15
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies	15
Naringenin and quercetin alter mouse rod phototransduction kinetics in a manner consistent with phosphodiesterase-6 inhibition	15
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic	15
KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain	14
Retraction Note to: Anti-inflammatory role of leptin in glial cells through p38 MAPK pathway inhibition	14
Correction: Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	14
The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus	13
Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models	13
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver	13
Peptide-based strategies for overcoming taxol-resistance in cancer therapy – a narrative review	13
Advances in the anti-tumor mechanisms of saikosaponin D	12
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments	12
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives	12
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	12
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of col	12
The Sigma1 receptor antagonist CM304 potentiates the antinociceptive effects of the cannabinoid receptor agonist delta9-tetrahydrocannabinol in rats and mice	12
Cannabinoids in the treatment of glioblastoma	12

Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry	11
Recent review of COVID-19 management: diagnosis, treatment and vaccination	11
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery	11
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	11
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective	11
Role of the β2-adrenergic receptor in podocyte injury and recovery	11
Lymphopenia associated with sphingosine 1-phosphate receptor modulators (S1PRMs) in multiple sclerosis: analysis of European pharmacovigilance data	11
The cortisol axis and psychiatric disorders: an updated review	11
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities	11
Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases	10
Phase-specific involvement of BDNF–TrkB signaling in HSV-1–induced herpetic pain and its transition to postherpetic neuralgia-like pain	10
Multiple sclerosis: a narrative overview of current pharmacotherapies and emerging treatment prospects	10
A discovery-based proteomic approach of epidermal growth factor and growth hormone-releasing peptide-6 in a model of acute ischemic stroke	10
High-performance liquid chromatography with fluorescence detection for mycophenolic acid determination in saliva samples	10
Correction: Marizomib in the therapy of brain tumors—how far did we go and where do we stand?	10
Efficacy of COVID-19 vaccines: a systematic review and network meta-analysis of phase 3 randomized controlled trials	10
Mitochondrial targeted antioxidants as potential therapy for huntington’s disease	10
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats	10
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia	10
Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury	10
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats	9
Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line	9
Cobalt protoporphyrin IX induces transient, dose- and time-dependent granulocyte mobilization with mild metabolic effects in mice	9
The impact of muscarinic and mGlu receptors modulators on MK-801-induced impairments in NO-dependent processes both in vitro and in vivo	9
Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish	9
The impact of gadolinium doping on physicochemical properties and neuroprotective activity of polyacrylic acid conjugated cerium oxide nanoparticles – in vitro study of potential theranostics for neur	9
Thiazolidine derivative (LPSF/CR-35) modulates the production of IL-17A, IL-10, IL-4, TFN, CCL2 and CXCL8 in PBMC from systemic sclerosis patients	9
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor	9
Acyclic sesquiterpenes nerolidol and farnesol: mechanistic insights into their neuroprotective potential	9
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases	9
DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship	9
Investigating whether alcohol is transformed to norepinephrine or dopamine in the mouse brain	9
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity	9
Solcumin™: a functional hybrid particle with potent anti-inflammatory and antioxidant activities and enhanced storage stability	9
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia	9
Gαi-derived peptide binds the µ-opioid receptor	9
A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response	8
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain	8
CYP2C19 gene polymorphism in Ningxia	8
New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study	8
Atorvastatin attenuates the expression of damage-associated molecular patterns and inflammatory cytokines in patients with psoriasis	8
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats	8
Impact of levetiracetam and ethanol on memory, selected neurotransmitter levels, oxidative stress parameters, and essential elements in rats	8
Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions	8
Achieving target plasma concentrations of beta-lactam antibiotics in critically ill patients: a retrospective study of full-dose administration in the first 24 hours	8
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery	8
JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro	8
Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents	8
Effect of 28 days treatment of baricitinib on mechanical allodynia, osteopenia, and loss of nerve fibers in an experimental model of type-1 diabetes mellitus	8
Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia	8
Investigating the interaction between aryl hydrocarbon receptor and methotrexate: implications for treatment resistance in rheumatoid arthritis patients	8
Upadacitinib as rescue therapy for acute severe ulcerative colitis and severe Crohn’s disease – current knowledge and future directions	8
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway	8
Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents	8
Effects of magnolol on the liver antioxidant status in rats with diabetes	8