OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention	65
Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes	59
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms	58
Pharmacological properties of baicalin on liver diseases: a narrative review	57
Oral antiviral treatments for COVID-19: opportunities and challenges	47
Recent review of COVID-19 management: diagnosis, treatment and vaccination	46
In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis	45
Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer’s disease	45
Recent progress in biologically active indole hybrids: a mini review	43
Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a three-arm randomized clinical trial	42
Altered glucose metabolism and insulin resistance in cancer-induced cachexia: a sweet poison	39
Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury	37
A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome	36
Effects and mechanisms of phthalates’ action on neurological processes and neural health: a literature review	36
Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a theoretical perspective	35
Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology	34
Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors	33
Endogenous estrogens—breast cancer and chemoprevention	32
Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression	30
Targeting the CCL2-CCR2 axis in depressive disorders	30
Neuroprotection through G-CSF: recent advances and future viewpoints	30
Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease	29
The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells	27
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease	26
Kynurenine pathway in kidney diseases	25

Pruritus in psoriasis and atopic dermatitis: current treatments and new perspectives	24
Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review	23
Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance	22
Alcohol and breast cancer	22
The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis	21
Opportunities and challenges in application of artificial intelligence in pharmacology	21
JNK signaling as a target for anticancer therapy	21
The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death	20
Modulating role of serotonergic signaling in sleep and memory	19
Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin	19
Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression	19
Amantadine in the prevention of clinical symptoms caused by SARS-CoV-2	19
Neurological consequences of COVID-19	19
Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics	19
Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions	19
Sleep improvement is associated with the antidepressant efficacy of repeated-dose ketamine and serum BDNF levels: a post-hoc analysis	18
Molecular mechanism of ferulic acid and its derivatives in tumor progression	18
A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2	18
Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies	18
N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research	17
SARS-CoV-2 therapeutics: how far do we stand from a remedy?	17
Proton pump inhibitor on susceptibility to COVID-19 and its severity: a systematic review and meta-analysis	17
GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders	17
Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders	17
Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study	16
Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics	16
Pharmacokinetics and tissue distribution of hydrazinocurcumin in rats	16
Update on the neurodevelopmental theory of depression: is there any ‘unconscious code’?	16
What is autism?	15
Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders	15
Anticancer effect of terpenes: focus on malignant melanoma	15
Cellular, synaptic, and network effects of chemokines in the central nervous system and their implications to behavior	15
Sigma receptors and neurological disorders	15
A review of the effects of ticagrelor on adenosine concentration and its clinical significance	15
Nasal sprays for treating COVID-19: a scientific note	15
The role of brain gaseous neurotransmitters in anxiety	15
Evaluation of curcumin-loaded polymeric nanocapsules with different coatings in chick embryo model: influence on angiogenesis, teratogenesis and oxidative stress	14
Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis	14
Development and treatment of cognitive inflexibility in sub-chronic stress–re-stress (SRS) model of PTSD	14
COVID-19: potential therapeutics for pediatric patients	14
Antiviral drug research for Japanese encephalitis: an updated review	13
Chemical chaperones targeted to the endoplasmic reticulum (ER) and lysosome prevented neurodegeneration in a C9orf72 repeat expansion drosophila amyotrophic lateral sclerosis (ALS) model	13
Artesunate inhibits melanoma progression in vitro via suppressing STAT3 signaling pathway	13
Short-chain fatty acids–microbiota crosstalk in the coronavirus disease (COVID-19)	13
Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia	12
Antidepressant-like effects of cannabidiol in a rat model of early-life stress with or without adolescent cocaine exposure	12
The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells	12
Alleviating neuropathy of diabetic foot ulcer by co-delivery of venlafaxine and matrix metalloproteinase drug-loaded cellulose nanofiber sheets: production, in vitro characterization and clinical tria	12
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	12
Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors	12

Novel adenosine derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective	12
An update on mode of action of metformin in modulation of meta-inflammation and inflammaging	12
Sodium–glucose cotransporter inhibitors and kidney fibrosis: review of the current evidence and related mechanisms	12
Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery	12
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells	12
The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients	11
Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells	11
Memantine hydrochloride: a drug to be repurposed against Chikungunya virus?	11
Cell cycle arrest-mediated cell death by morin in MDA-MB-231 triple-negative breast cancer cells	11
RETRACTED ARTICLE: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1–42 rat model of Alzheimer’s disease through modulations of hippocampal cAMP/cGMP/BDNF s	11
The impact of exogenous vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia	11
Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission	11
Influence of CYP2C9, VKORC1, and CYP4F2 polymorphisms on the pharmacodynamic parameters of warfarin: a cross-sectional study	10
Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts	10
Atypical antipsychotic olanzapine inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells	10
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases	10
Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis	10
The effect of tocilizumab on cytokine release syndrome in COVID-19 patients	10
DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship	10
2-Mercaptoethanol protects against DNA double-strand breaks after kidney ischemia and reperfusion injury through GPX4 upregulation	9
Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat	9
Mindfulness meditation and psychedelics: potential synergies and commonalities	9
Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes	9
Modulation of allergic contact dermatitis via gut microbiota modified by diet, vitamins, probiotics, prebiotics, and antibiotics	9
Involvement of the ventral, but not dorsal, hippocampus in anxiety-like behaviors in mice exposed to the elevated plus maze: participation of CRF1 receptor and PKA pathway	9
Antipsychotic drug—aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms	9
Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures	9
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration	9
Cannabinoids and their derivatives in struggle against melanoma	9
Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia	8
Apoptotic and antioxidant effects in HCT-116 colorectal carcinoma cells by a spiro-acridine compound, AMTAC-06	8
Surface-functionalized curcumin-loaded polymeric nanocapsules could block apomorphine-induced behavioral changes in rats	8
Chemokine (C–C motif) ligand 5 (RANTES) concentrations in the peripheral blood of patients with a depressive disorder	8
Integrative opioid-GABAergic neuronal mechanisms regulating dopamine efflux in the nucleus accumbens of freely moving animals	8
Polypharmacology: promises and new drugs in 2022	8
Perspectives on glucocorticoid treatment for COVID-19: a systematic review	8
Effect of statins on lipid metabolism-related microRNA expression in HepG2 cells	8
Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages	8
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic	7
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect	7
Efficacy of COVID-19 vaccines: a systematic review and network meta-analysis of phase 3 randomized controlled trials	7
Health-related quality of life in survivors of severe COVID-19 infection	7
Simultaneous determination of four antibiotics in human urine and hair samples employing a simple and efficient dispersive micro solid-phase extraction-high performance liquid chromatography	7
How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme	7
Therapeutic potential of autophagy in immunity and inflammation: current and future perspectives	7
Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model	7
Incidence and control of steroid-induced hyperglycaemia in hospitalised patients at a tertiary care centre for lung diseases	7
M-134, a novel HDAC6-selective inhibitor, markedly improved arthritic severity in a rodent model of rheumatoid arthritis when combined with tofacitinib	7
The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory	7
Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain	7
Impaired metabolic effects of metformin in men with early-onset androgenic alopecia	7
Evaluation of effects of chronic nasal steroid use on rhinological symptoms of COVID-19 with SNOT-22 questionnaire	7
Anti-inflammatory and antibacterial effects of human cathelicidin active fragment KR-12 in the mouse models of colitis: a novel potential therapy of inflammatory bowel diseases	7
Production and therapeutic use of astaxanthin in the nanotechnology era	7