OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Acknowledgments	82
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system	64
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience	61
Correction to: The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	59
A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice	59
Atypical antipsychotic olanzapine inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells	52
The KCNQ channel inhibitor XE991 suppresses nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglion neurons	45
FNF-12, a novel benzylidene-chromanone derivative, attenuates inflammatory response in in vitro and in vivo asthma models mediated by M2-related Th2 cytokines via MAPK and NF-kB signaling	44
Potential drugs for the treatment of Alzheimer’s disease	42
The effect of poly I:C or LPS priming on the therapeutic efficacy of mesenchymal stem cells in an adjuvant-induced arthritis rat model	42
Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data	41
Chlorogenic acid reduces inflammation in murine model of acute pancreatitis	40
Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics	40
Luteolin for neurodegenerative diseases: a review	35
Correction to: The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients	35
Note from editors	35
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations	34
Correction to: The impact of atorvastatin on cardiometabolic risk factors in brothers of women with polycystic ovary syndrome	34
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran	33
β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo	32
Padsevonil suppresses seizures without inducing cell death in neonatal rats	29
Genotyping NUDT15*3 rs1166855232 reveals higher frequency of potential adverse effects of thiopurines in Natives and Mestizos from Mexico	27
Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices	26
Assessing the effects of 5-HT2A and 5-HT5A receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms	26
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats	26

Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis	25
The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells	25
Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model	25
Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder	24
The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols	23
The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds	22
Preclinical efficacy of cannabidiol for the treatment of early-life seizures	22
The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice	21
A review of serious adverse events linked with GLP-1 agonists in type 2 diabetes mellitus and obesity treatment	21
Pten knockout affects drug resistance differently in melanoma and kidney cancer	21
Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action	21
Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis	20
Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome	20
Comparative study of the binding between chlorogenic acid and four proteins by isothermal titration calorimetry, spectroscopy and docking methods	19
The impact of exogenous vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia	19
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect	18
Correction to: Functional approaches to the study of G-protein-coupled receptors in postmortem brain tissue: [35S]GTPγS binding assays combined with immunoprecipitation	18
Comprehensive evaluation of ibuprofenate amino acid isopropyl esters: insights into antioxidant activity, cytocompatibility, and cyclooxygenase inhibitory potential	18
Maternal feeding patterns affect the offspring’s brain: focus on serotonin 5-HT2C and 5-HT2A receptors	18
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum	17
The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients	16
Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay	16
COVID-19: potential therapeutics for pediatric patients	16
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction	16
Chronic restraint stress induces changes in the cerebral Galpha 12/13 and Rho-GTPase signaling network	16
Antidepressant-like effects of cannabidiol in a rat model of early-life stress with or without adolescent cocaine exposure	15
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts	15
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells	15
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse	15
Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines	14
Red cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis	14
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies	13
Antiviral drug research for Japanese encephalitis: an updated review	13
The emerging role of mechanical and topographical factors in the development and treatment of nervous system disorders: dark and light sides of the force	13
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic	13
Correction: Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	13
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver	12
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease	12
An association of ABCG8: rs11887534 polymorphism and HDL-cholesterol response to statin treatment in the Polish population	12
Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts	12
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments	12
The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus	12
KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain	12
Retraction Note to: Anti-inflammatory role of leptin in glial cells through p38 MAPK pathway inhibition	12
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives	11
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities	11
Role of the β2-adrenergic receptor in podocyte injury and recovery	11
Cannabinoids in the treatment of glioblastoma	11
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	11
Correction to: The oxidation and hypoglycaemic effect of sorafenib in streptozotocin-induced diabetic rats	10

Colonic inflammation induces changes in glucose levels through modulation of incretin system	10
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective	10
Advances in the anti-tumor mechanisms of saikosaponin D	10
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery	10
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	9
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia	9
The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	9
Multiple sclerosis: a narrative overview of current pharmacotherapies and emerging treatment prospects	9
Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry	9
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of col	9
Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury	9
Critical interactions between opioid and cannabinoid receptors during tolerance and physical dependence development to opioids in the murine gastrointestinal tract: proof of concept	9
Acetaminophen treatment evokes anticontractile effects in rat aorta by blocking L-type calcium channels	8
Sigma receptors and neurological disorders	8
Gαi-derived peptide binds the µ-opioid receptor	8
Investigating whether alcohol is transformed to norepinephrine or dopamine in the mouse brain	8
Recent review of COVID-19 management: diagnosis, treatment and vaccination	8
High-performance liquid chromatography with fluorescence detection for mycophenolic acid determination in saliva samples	8
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats	8
Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases	8
Lymphopenia associated with sphingosine 1-phosphate receptor modulators (S1PRMs) in multiple sclerosis: analysis of European pharmacovigilance data	8
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells	8
Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line	8
Hepatic drug-metabolizing enzymes and drug transporters in Wilson’s disease patients with liver failure	8
Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	8
Impact of levetiracetam and ethanol on memory, selected neurotransmitter levels, oxidative stress parameters, and essential elements in rats	7
Efficacy of COVID-19 vaccines: a systematic review and network meta-analysis of phase 3 randomized controlled trials	7
DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship	7
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases	7
Acyclic sesquiterpenes nerolidol and farnesol: mechanistic insights into their neuroprotective potential	7
Correction to: Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	7
Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents	7
Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review	7
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats	7
Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish	7
New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study	7
Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism	7
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity	7
Mitochondrial targeted antioxidants as potential therapy for huntington’s disease	7
The impact of rosuvastatin on hypothalamic–pituitary–testicular axis activity in metformin-treated and metformin-naïve men with low testosterone levels: a pilot study	7
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor	7
JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro	6
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats	6
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery	6
Effect of 28 days treatment of baricitinib on mechanical allodynia, osteopenia, and loss of nerve fibers in an experimental model of type-1 diabetes mellitus	6
Modulating role of serotonergic signaling in sleep and memory	6
Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions	6
The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke	6
Preclinical evaluation of a microtubule PET ligand [11C]MPC-6827 in tau and amyotrophic lateral sclerosis animal models	6
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway	6
Correction to: Selective cytotoxic and genotoxic activities of 5-(2-bromo-5- methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells	6
Evaluation of anti-inflammatory response of berberine-loaded gum nanocomplexes in carrageenan-induced acute paw edema in rats	6
Preclinical models of treatment-resistant depression: challenges and perspectives	6
CYP2C19 gene polymorphism in Ningxia	6
A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response	6
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain	6
Effects of magnolol on the liver antioxidant status in rats with diabetes	6
Atorvastatin attenuates the expression of damage-associated molecular patterns and inflammatory cytokines in patients with psoriasis	6
Cardiovascular safety of psychedelic medicine: current status and future directions	6
Effects of nano-curcumin on noise stress-induced hippocampus-dependent memory impairment: behavioral and electrophysiological aspects	6
Decreased efficacy of the ketamine and scopolamine-induced sustained antidepressant-like effects in rats receiving metformin	6