OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Drug repurposing approach to fight COVID-19	305
Drug resistance in cancer: mechanisms and tackling strategies	120
Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials	81
Overview of the possible role of vitamin C in management of COVID-19	77
Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19	68
Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy	68
Chemotherapy-induced peripheral neuropathy—part 2: focus on the prevention of oxaliplatin-induced neurotoxicity	61
Role of oxidative stress in epileptogenesis and potential implications for therapy	61
Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes	58
Thiadiazole derivatives as anticancer agents	50
Pharmacological properties of baicalin on liver diseases: a narrative review	49
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms	47
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention	46
Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis	44
In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis	44
Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future	43
Recent review of COVID-19 management: diagnosis, treatment and vaccination	40
Effects of curcumin on neurological diseases: focus on astrocytes	39
Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance	39
Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies	38
Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer’s disease	37
Efflux pump inhibitors: new updates	36
Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a three-arm randomized clinical trial	36
A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome	34
Pharmacological treatments of COVID-19	33

STAT3 transcription factor as target for anti-cancer therapy	33
Altered glucose metabolism and insulin resistance in cancer-induced cachexia: a sweet poison	31
Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury	31
Observational study of people infected with SARS-Cov-2, treated with amantadine	30
Effects and mechanisms of phthalates’ action on neurological processes and neural health: a literature review	30
Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a theoretical perspective	30
Oral antiviral treatments for COVID-19: opportunities and challenges	30
Recent progress in biologically active indole hybrids: a mini review	29
Intestinal drug transporters in pathological states: an overview	28
Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology	28
Molecular insights into the therapeutic promise of targeting HMGB1 in depression	27
Endogenous estrogens—breast cancer and chemoprevention	26
Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis	25
Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells	23
Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors	23
Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression	23
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease	23
Neuroprotection through G-CSF: recent advances and future viewpoints	23
Kynurenine pathway in kidney diseases	22
Clinical significance of fluid biomarkers in Alzheimer’s Disease	22
Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease	21
Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance	21
Pruritus in psoriasis and atopic dermatitis: current treatments and new perspectives	20
Targeting the CCL2-CCR2 axis in depressive disorders	20
The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis	20
Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β	19
Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer	19
Update on the neurodevelopmental theory of depression: is there any ‘unconscious code’?	18
Lidocaine as an element of multimodal analgesic therapy in major spine surgical procedures in children: a prospective, randomized, double-blind study	18
Influence of metformin on HIF-1 pathway in multiple myeloma	18
Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review	17
Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions	17
SARS-CoV-2 therapeutics: how far do we stand from a remedy?	17
The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death	17
Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation	17
Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy	17
Amantadine in the prevention of clinical symptoms caused by SARS-CoV-2	17
JNK signaling as a target for anticancer therapy	16
Sleep improvement is associated with the antidepressant efficacy of repeated-dose ketamine and serum BDNF levels: a post-hoc analysis	15
A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor	15
Alcohol and breast cancer	15
Modulating role of serotonergic signaling in sleep and memory	15
The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells	15
Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin	15
The immunosuppressive effect of the endocannabinoid system on the inflammatory phenotypes of macrophages and mesenchymal stromal cells: a comparative study	15
Favipiravir use for SARS CoV-2 infection	15
Nasal sprays for treating COVID-19: a scientific note	14
Proton pump inhibitor on susceptibility to COVID-19 and its severity: a systematic review and meta-analysis	14
Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression	14
Evaluation of some thiophene-based sulfonamides as potent inhibitors of carbonic anhydrase I and II isoenzymes isolated from human erythrocytes by kinetic and molecular modelling studies	14

Pharmacokinetics and tissue distribution of hydrazinocurcumin in rats	13
Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats	13
Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study	13
End-stage renal disease reduces the expression of drug-metabolizing cytochrome P450s	13
Reporting statistical methods and outcome of statistical analyses in research articles	13
N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research	12
Short-chain fatty acids–microbiota crosstalk in the coronavirus disease (COVID-19)	12
Evaluation of curcumin-loaded polymeric nanocapsules with different coatings in chick embryo model: influence on angiogenesis, teratogenesis and oxidative stress	12
The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells	12
Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders	12
Neurological consequences of COVID-19	12
The role of brain gaseous neurotransmitters in anxiety	12
Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies	12
Ortho-vanillin nanoparticle-doped glucan microspheres exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats	12
Chemical chaperones targeted to the endoplasmic reticulum (ER) and lysosome prevented neurodegeneration in a C9orf72 repeat expansion drosophila amyotrophic lateral sclerosis (ALS) model	12
A review of the effects of ticagrelor on adenosine concentration and its clinical significance	12
Fenofibrate ameliorates testicular damage in rats with streptozotocin-induced type 1 diabetes: role of HO-1 and p38 MAPK	12
Neuroprotective effects of mirtazapine and imipramine and their effect in pro- and anti-apoptotic gene expression in human neuroblastoma cells	12
GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders	11
The impact of exogenous vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia	11
Population pharmacokinetics of standard-dose meropenem in critically ill patients on continuous renal replacement therapy: a prospective observational trial	11
Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics	11
The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions	11
COVID-19: potential therapeutics for pediatric patients	11
An update on mode of action of metformin in modulation of meta-inflammation and inflammaging	11
Tropisetron attenuates pancreas apoptosis in the STZ-induced diabetic rats: involvement of SIRT1/NF-κB signaling	11
What is autism?	11
The effect of alpha lipoic acid on passive avoidance and social interaction memory, pain perception, and locomotor activity in REM sleep-deprived rats	11
Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: a comparative study	11
Influence of CYP2C9, VKORC1, and CYP4F2 polymorphisms on the pharmacodynamic parameters of warfarin: a cross-sectional study	10
Antiviral drug research for Japanese encephalitis: an updated review	10
Anxiolytic-like effects of mirogabalin, a novel ligand for α2δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fib	10
RETRACTED ARTICLE: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1–42 rat model of Alzheimer’s disease through modulations of hippocampal cAMP/cGMP/BDNF s	10
Artesunate inhibits melanoma progression in vitro via suppressing STAT3 signaling pathway	10
Cellular, synaptic, and network effects of chemokines in the central nervous system and their implications to behavior	10
Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors	10
Novel adenosine derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective	10
Opportunities and challenges in application of artificial intelligence in pharmacology	10
Antidepressant-like effects of cannabidiol in a rat model of early-life stress with or without adolescent cocaine exposure	10
Development and treatment of cognitive inflexibility in sub-chronic stress–re-stress (SRS) model of PTSD	10
Sigma receptors and neurological disorders	10
A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2	9
The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients	9
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells	9
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	9
The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice	9
Cell cycle arrest-mediated cell death by morin in MDA-MB-231 triple-negative breast cancer cells	9
Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission	9
Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain	9
Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis	9
Effects of the synthetic cannabinoid XLR-11 on the viability and migration rates of human brain microvascular endothelial cells in a clinically-relevant model	9